Article ; Online: Propranolol therapy for hemangiomas in infants with neonatal abstinence syndrome may produce intolerable side effects.
2022 Volume 39, Issue 2, Page(s) 273–274
Abstract: We report three infants with infantile hemangioma who experienced severe agitation and diarrhea following propranolol administration. Propranolol, a non-selective β-adrenergic receptor blocker, is the first-line treatment for infantile hemangiomas. All ... ...
| Abstract | We report three infants with infantile hemangioma who experienced severe agitation and diarrhea following propranolol administration. Propranolol, a non-selective β-adrenergic receptor blocker, is the first-line treatment for infantile hemangiomas. All three infants were exposed to opioids in utero and experienced neonatal abstinence syndrome at birth. We hypothesize that chronic opioid exposure in utero may cause protracted upregulation of β2-adrenergic receptors in the central nervous system, resulting in increased susceptibility to adverse reactions to propranolol. |
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| MeSH term(s) | Adrenergic beta-Antagonists/adverse effects ; Hemangioma/drug therapy ; Hemangioma, Capillary/drug therapy ; Humans ; Iatrogenic Disease ; Infant ; Infant, Newborn ; Neonatal Abstinence Syndrome/drug therapy ; Neonatal Abstinence Syndrome/etiology ; Propranolol/adverse effects ; Skin Neoplasms/drug therapy ; Treatment Outcome |
| Chemical Substances | Adrenergic beta-Antagonists ; Propranolol (9Y8NXQ24VQ) |
| Language | English |
| Publishing date | 2022-02-17 |
| Publishing country | United States |
| Document type | Case Reports |
| ZDB-ID | 605539-4 |
| ISSN | 1525-1470 ; 0736-8046 |
| ISSN (online) | 1525-1470 |
| ISSN | 0736-8046 |
| DOI | 10.1111/pde.14929 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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