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  1. Article ; Online: Thiocarbonyl Derivatives of Natural Chlorins: Synthesis Using Lawesson's Reagent and a Study of Their Properties.

    Pogorilyy, Viktor / Ostroverkhov, Petr / Efimova, Valeria / Plotnikova, Ekaterina / Bezborodova, Olga / Diachkova, Ekaterina / Vasil'ev, Yuriy / Pankratov, Andrei / Grin, Mikhail

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms into their ... ...

    Abstract The development of sulfur-containing pharmaceutical compounds is important in the advancement of medicinal chemistry. Photosensitizers (PS) that acquire new properties upon incorporation of sulfur-containing groups or individual sulfur atoms into their structure are not neglected, either. In this work, a synthesis of sulfur-containing derivatives of natural chlorophyll
    MeSH term(s) Chlorophyll A ; Organothiophosphorus Compounds/chemistry ; Sulfur
    Chemical Substances 2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide (A4125MQ8RX) ; chlorin (2683-84-3) ; Chlorophyll A (YF5Q9EJC8Y) ; Organothiophosphorus Compounds ; Sulfur (70FD1KFU70)
    Language English
    Publishing date 2023-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy.

    Suvorov, Nikita / Pogorilyy, Viktor / Diachkova, Ekaterina / Vasil'ev, Yuri / Mironov, Andrey / Grin, Mikhail

    International journal of molecular sciences

    2021  Volume 22, Issue 12

    Abstract: The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this ... ...

    Abstract The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.
    MeSH term(s) Amino Acid Sequence ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Cations ; Chlorophyll/chemistry ; Chlorophyll/pharmacology ; Photochemotherapy ; Porphyrins/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Cations ; Porphyrins ; Chlorophyll (1406-65-1) ; chlorin (2683-84-3)
    Language English
    Publishing date 2021-06-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22126392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Advantages of combined photodynamic therapy in the treatment of oncological diseases.

    Grin, Mikhail / Suvorov, Nikita / Ostroverkhov, Petr / Pogorilyy, Viktor / Kirin, Nikita / Popov, Alexander / Sazonova, Anna / Filonenko, Elena

    Biophysical reviews

    2022  Volume 14, Issue 4, Page(s) 941–963

    Abstract: When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even synergistic effect can be realized. Combination treatment regimens are aimed at increasing the ... ...

    Abstract When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even synergistic effect can be realized. Combination treatment regimens are aimed at increasing the efficiency and, above all, at the complete eradication of the tumor, which can be achieved either by suppressing the survival mechanisms in PDT-resistant tumor cells or by pre-attenuation of tumor cells so that they become more susceptible to subsequent PDT. Photodynamic therapy is an approved medical technology for the treatment of various malignant neoplasms, and several precancerous and non-cancer diseases. To date, numerous data have been published on the combined use of PDT with traditional and innovative methods of treatment. This review considers research in this area in recent years.
    Language English
    Publishing date 2022-06-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-022-00962-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The First Selenoanhydride in the Series of Chlorophyll a Derivatives, Its Stability and Photoinduced Cytotoxicity.

    Pogorilyy, Viktor / Plyutinskaya, Anna / Suvorov, Nikita / Diachkova, Ekaterina / Vasil'ev, Yuriy / Pankratov, Andrei / Mironov, Andrey / Grin, Mikhail

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 23

    Abstract: In this work, we obtained the first selenium-containing chlorin with a chalcogen atom in exlocycle E. It was shown that the spectral properties were preserved in the target compound and the stability increased at two different pH values, in comparison ... ...

    Abstract In this work, we obtained the first selenium-containing chlorin with a chalcogen atom in exlocycle E. It was shown that the spectral properties were preserved in the target compound and the stability increased at two different pH values, in comparison with the starting purpurin-18. The derivatives have sufficiently high fluorescence and singlet oxygen quantum yields. The photoinduced cytotoxicity of sulfur- and selenium-anhydrides of chlorin p
    MeSH term(s) Animals ; Cell Line, Tumor ; Chlorophyll A/analogs & derivatives ; Chlorophyll A/pharmacology ; Mice ; Organoselenium Compounds/chemistry ; Organoselenium Compounds/pharmacology ; Photosensitizing Agents/chemistry ; Photosensitizing Agents/pharmacology ; Porphyrins/chemistry ; Porphyrins/pharmacology ; Sarcoma/drug therapy
    Chemical Substances Organoselenium Compounds ; Photosensitizing Agents ; Porphyrins ; chlorin (2683-84-3) ; Chlorophyll A (YF5Q9EJC8Y)
    Language English
    Publishing date 2021-12-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26237298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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