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Article ; Online: Beyond BMI: Exploring Body Composition's Role in Long Term Outcome of Elective Abdominal Aortic Aneurysm Repair.

Westenberg, Lisa B / Pol, Robert A

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2023 Volume 67, Issue 2, Page(s) 357–358

MeSH term(s)	Humans ; Body Mass Index ; Endovascular Procedures ; Aortic Aneurysm, Abdominal/diagnostic imaging ; Aortic Aneurysm, Abdominal/surgery ; Body Composition ; Elective Surgical Procedures ; Treatment Outcome ; Retrospective Studies ; Risk Factors ; Blood Vessel Prosthesis Implantation/adverse effects ; Postoperative Complications/surgery
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Letter
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2023.08.068
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 381: Show issues

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Article ; Online: Central Body Fat Distribution and Kidney Function after Living Kidney Donation.

Westenberg, Lisa B / Pol, Robert A / van der Weijden, Jessica / de Borst, Martin H / Bakker, Stephan J L / van Londen, Marco

Clinical journal of the American Society of Nephrology : CJASN

2024 Volume 19, Issue 4, Page(s) 503–513

Abstract: Background: In most screening guidelines, high body mass index (BMI) is considered a contraindication for kidney donation. New insights suggest that central body fat distribution might provide greater power in assessing kidney risk. This study aimed to ... ...

Abstract	Background: In most screening guidelines, high body mass index (BMI) is considered a contraindication for kidney donation. New insights suggest that central body fat distribution might provide greater power in assessing kidney risk. This study aimed to determine whether BMI and central body fat distribution measures are associated with long-term kidney function after donor nephrectomy. We hypothesized that higher BMI, waist circumference (WC), and waist-to-height ratio (WHtR) were associated with lower kidney function long term after donation. Methods: The study population consisted of living kidney donors. BMI, WC, and WHtR were measured during donor screening. The outcome postdonation kidney function was assessed using measured GFR (mGFR) (mGFR, 125 I-iothalamate infusion) at 3 months ( n =1042), 5 years ( n =556), and 10 years ( n =210) of follow-up. Primary multivariable linear regression analyses were performed with BMI and WC and secondary analyses with WHtR. Linear mixed models were performed to investigate change in postdonation eGFR. Results: The donor age was 52±11 years, and 48% were male. The mean BMI was 26.1±3.6 kg/m 2 , and WC was 91±11 cm. Higher predonation BMI was associated with lower mGFR throughout follow-up: -1.35 (95% confidence interval [CI], -1.95 to -0.80), -1.55 (95% CI, -2.50 to -0.65), and -2.35 (95% CI, -4.10 to -0.60) ml/min per m 2 per 5 kg/m 2 higher BMI at 3 months, 5, and 10 years after donation, respectively, adjusted for sex, age, and predonation GFR. For WC, differences in mGFR were -1.30 (95% CI, -1.70 to -0.90), -1.50 (95% CI, -2.20 to -0.80), and -1.70 (95% CI, -3.00 to -0.50) ml/min per m 2 per 10 cm higher WC at 3 months, 5, and 10 years after donation, respectively. In male donors, BMI and WC were significantly associated with a negative postdonation change in eGFR. Conclusions: Higher BMI and WC were independently associated with lower GFR (long term) after living kidney donation.
MeSH term(s)	Humans ; Male ; Adult ; Middle Aged ; Female ; Kidney ; Kidney Transplantation/adverse effects ; Glomerular Filtration Rate ; Body Mass Index ; Donor Selection ; Living Donors ; Risk Factors ; Waist Circumference
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2226665-3
ISSN	1555-905X ; 1555-9041
ISSN (online)	1555-905X
ISSN	1555-9041
DOI	10.2215/CJN.0000000000000403
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Article ; Online: Defining sarcopenia and myosteatosis: the necessity for consensus on a technical standard and standardized cut-off values.

Westenberg, Lisa B / Zorgdrager, Marcel / Viddeleer, Alain R / Pol, Robert A

Journal of cachexia, sarcopenia and muscle

2022 Volume 13, Issue 2, Page(s) 1429–1430

MeSH term(s)	Body Composition ; Consensus ; Humans ; Muscle, Skeletal/pathology ; Sarcopenia/diagnosis ; Sarcopenia/etiology ; Sarcopenia/pathology
Language	English
Publishing date	2022-02-26
Publishing country	Germany
Document type	Letter ; Comment
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.12961
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Article ; Online: Do treats facilitate the interpretation of findings on caloric restriction?

Oudmaijer, Christiaan Albert Johan / Pol, Robert A / Minnee, Robert C / Vermeij, Wilbert / Ijzermans, Jan N M

BMJ nutrition, prevention & health

2023 Volume 6, Issue 2, Page(s) 374–382

Abstract: Introduction: Food can build social bonds and enhance interpersonal relationships. An area of research perhaps at odds with food abundance, is caloric restriction (CR), intermittent fasting (IF) or short-term fasting (STF). We aimed to study the impact ... ...

Abstract	Introduction: Food can build social bonds and enhance interpersonal relationships. An area of research perhaps at odds with food abundance, is caloric restriction (CR), intermittent fasting (IF) or short-term fasting (STF). We aimed to study the impact of offering treats on the audience during presentations on IF and STF and whether this impacted the audience's reception of the subject. The contradiction of the tempting nature of sharing brownies juxtaposed with the potential health benefits presented is a light-hearted subject in a world where nutritional intake and health outcomes are the object of intense academic discussion. Objective: Investigate how treats influence hospital personnel interpretation of information presented on the potential benefits of CR, IF and STF. Methods: This trial consists of a cross-sectional study (CSS) and a randomised controlled trial (RCT) conducted at three study centres. The CSS involved a survey administered to healthcare professionals to assess their knowledge, experience and willingness regarding IF and/or STF. In the RCT, brownies were randomly provided to healthcare staff attending a scientific meeting on restricting calories. Results: 135 participants were included in the CSS and 64 participants joined the randomised experiment. We found that the randomisation had no statistically significant effect. Only 2 out of 64 were aware of the irony of the provided treatment. In the CSS, participants most often cited the expected beneficial effects on their short-term and long-term health as important reasons for adhering to IF and/or STF. Perceiving fasting as beneficial was mostly influenced by knowledge on the topic and previously adhering to a fasting diet. Discussion: In this light-hearted, holiday-inspired exploratory study, we found that providing your audience with treats does not influence participants' opinion of you or your research, even when it focuses on the benefits of reducing calorie intake. The recipients of the treat will remain critical of presented findings, and due to prior experiences will be receptive to the counterintuitive topic of fasting.
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ISSN	2516-5542
ISSN (online)	2516-5542
DOI	10.1136/bmjnph-2023-000830
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Article ; Online: Frailty should determine type of anesthesia in reducing postoperative delirium after vascular surgery and not vice versa.

Pol, Robert A

Journal of cardiothoracic and vascular anesthesia

2014 Volume 28, Issue 6, Page(s) e61–2

MeSH term(s)	Anesthesia/adverse effects ; Delirium/psychology ; Female ; Humans ; Male ; Postoperative Complications/psychology ; Vascular Surgical Procedures/adverse effects ; Vascular Surgical Procedures/psychology
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	1067317-9
ISSN	1532-8422 ; 1053-0770
ISSN (online)	1532-8422
ISSN	1053-0770
DOI	10.1053/j.jvca.2014.06.032
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Zs.A 2203: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 31: Show issues

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Article ; Online: Pathophysiological Changes in the Hemostatic System and Antithrombotic Management in Kidney Transplant Recipients.

van den Berg, Tamar A J / Nieuwenhuijs-Moeke, Gertrude J / Lisman, Ton / Moers, Cyril / Bakker, Stephan J L / Pol, Robert A

Transplantation

2023 Volume 107, Issue 6, Page(s) 1248–1257

Abstract: Nowadays, the main cause for early graft loss is renal graft thrombosis because kidney transplant outcomes have improved drastically owing to advances in immunological techniques and immunosuppression. However, data regarding the efficacy of ... ...

Abstract	Nowadays, the main cause for early graft loss is renal graft thrombosis because kidney transplant outcomes have improved drastically owing to advances in immunological techniques and immunosuppression. However, data regarding the efficacy of antithrombotic therapy in the prevention of renal graft thrombosis are scarce. Adequate antithrombotic management requires a good understanding of the pathophysiological changes in the hemostatic system in patients with end-stage kidney disease (ESKD). Specifically, ESKD and dialysis disrupt the fine balance between pro- and anticoagulation in the body, and further changes in the hemostatic system occur during kidney transplantation. Consequently, kidney transplant recipients paradoxically are at risk for both thrombosis and bleeding. This overview focuses on the pathophysiological changes in hemostasis in ESKD and kidney transplantation and provides a comprehensive summary of the current evidence for antithrombotic management in (adult) kidney transplant recipients.
MeSH term(s)	Adult ; Humans ; Kidney Transplantation/adverse effects ; Fibrinolytic Agents ; Hemostatics ; Kidney Failure, Chronic/etiology ; Thrombosis/complications ; Hemostasis
Chemical Substances	Fibrinolytic Agents ; Hemostatics
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004452
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: Transplant Outcomes After Exposure of Deceased Kidney Donors to Contrast Medium.

Chotkan, Kinita A / Hilbrands, Luuk B / Putter, Hein / Konjin, Cynthia / Schaefer, Brigitte / Beenen, Ludo F M / Pol, Robert A / Braat, Andries E

Transplantation

2023 Volume 108, Issue 1, Page(s) 252–260

Abstract: Background: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied.: Methods: A retrospective ... ...

Abstract	Background: The administration of contrast medium is associated with acute kidney injury; however, the effect of exposure of a deceased organ donor to contrast medium on kidney transplant outcomes has been poorly studied. Methods: A retrospective analysis of all deceased kidney donors between 2011 and 2021 and their corresponding recipients in the Netherlands was conducted. Multivariable analyses were performed to assess the associations between contrast medium exposure and delayed graft function (DGF)/graft survival. Linear mixed models were used to assess the differences in mean estimated glomerular filtration rate values in recipients 1 to 6 y after transplantation. Results: In total, 2177 donors and 3638 corresponding kidney graft recipients were included. Twenty-four percent of the donors (n = 520) were exposed to contrast medium, corresponding to 23% of recipients (n = 832). DGF was observed in 36% (n = 1321) and primary nonfunction in 3% (n = 122) of recipients. DGF rates for donation after brain death (DBD) and donation after circulatory death (DCD) donors showed no significant effect of contrast medium exposure ( P = 0.15 and P = 0.60 for DBD and DCD donors, respectively). In multivariable analyses, contrast medium administration was not significantly associated with a higher DGF risk (odds ratio 1.06; 95% confidence interval, 0.86-1.36; P = 0.63) nor was a significant predictor for death-censored graft failure (hazard ratio 1.01; 95% confidence interval, 0.77-1.33; P = 0.93). Linear mixed models showed no difference in mean estimated glomerular filtration rate values in recipients 1 to 6 y posttransplantation ( P = 0.78). Conclusions: This study indicates that contrast medium administration in DBD and DCD donors has no negative effect on early and long-term kidney graft function.
MeSH term(s)	Humans ; Kidney Transplantation/adverse effects ; Tissue and Organ Procurement ; Retrospective Studies ; Graft Survival ; Tissue Donors ; Brain Death ; Delayed Graft Function/etiology
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004745
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article ; Online: The Many Faces of Frailty in Vascular Surgery.

Banning, Louise B D / Visser, Linda / Pol, Robert A

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2019 Volume 57, Issue 6, Page(s) 892–893

MeSH term(s)	Aged ; Frail Elderly ; Frailty ; Humans ; Specialties, Surgical ; Vascular Surgical Procedures
Language	English
Publishing date	2019-02-28
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2018.12.035
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Zs.A 2283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Pancreas transplantation in patient with long-standing diabetes mellitus: How to judge fitness for transplant?

Benjamens, Stan / Leemkuil, Marjolein / Pol, Robert A

Clinical transplantation

2019 Volume 33, Issue 11, Page(s) e13726

MeSH term(s)	Cardiovascular Diseases/prevention & control ; Diabetes Mellitus/surgery ; Disease Management ; Humans ; Pancreas Transplantation/methods ; Patient Selection
Language	English
Publishing date	2019-10-21
Publishing country	Denmark
Document type	Letter
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.13726
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Article ; Online: Pre-Transplant Hyperparathyroidism and Graft or Patient Outcomes After Kidney Transplantation.

Rodrigues, Fernanda Guedes / Van Der Plas, Willemijn Y / Sotomayor, Camilo German / Van Der Vaart, Amarens / Kremer, Daan / Pol, Robert A / Kruijff, Schelto / Heilberg, Ita Pfeferman / Bakker, Stephan J L / De Borst, Martin H

Transplant international : official journal of the European Society for Organ Transplantation

2024 Volume 37, Page(s) 11916

Abstract: The impact of pre-transplant parathyroid hormone (PTH) levels on early or long-term kidney function after kidney transplantation is subject of debate. We assessed whether severe hyperparathyroidism is associated with delayed graft function (DGF), death- ... ...

Abstract	The impact of pre-transplant parathyroid hormone (PTH) levels on early or long-term kidney function after kidney transplantation is subject of debate. We assessed whether severe hyperparathyroidism is associated with delayed graft function (DGF), death-censored graft failure (DCGF), or all-cause mortality. In this single-center cohort study, we studied the relationship between PTH and other parameters related to bone and mineral metabolism, including serum alkaline phosphatase (ALP) at time of transplantation with the subsequent risk of DGF, DCGF and all-cause mortality using multivariable logistic and Cox regression analyses. In 1,576 kidney transplant recipients (51.6 ± 14.0 years, 57.3% male), severe hyperparathyroidism characterized by pre-transplant PTH ≥771 pg/mL (>9 times the upper limit) was present in 121 patients. During 5.2 [0.2-30.0] years follow-up, 278 (15.7%) patients developed DGF, 150 (9.9%) DCGF and 432 (28.6%) died. A higher pre-transplant PTH was not associated with DGF (HR 1.06 [0.90-1.25]), DCGF (HR 0.98 [0.87-1.13]), or all-cause mortality (HR 1.02 [0.93-1.11]). Results were consistent in sensitivity analyses. The same applied to other parameters related to bone and mineral metabolism, including ALP. Severe pre-transplant hyperparathyroidism was not associated with an increased risk of DGF, DCGF or all-cause mortality, not supporting the need of correction before kidney transplantation to improve graft or patient survival.
MeSH term(s)	Humans ; Male ; Female ; Kidney Transplantation/adverse effects ; Cohort Studies ; Hyperparathyroidism/complications ; Parathyroid Hormone ; Minerals ; Graft Survival ; Risk Factors ; Delayed Graft Function/etiology ; Graft Rejection ; Retrospective Studies
Chemical Substances	Parathyroid Hormone ; Minerals
Language	English
Publishing date	2024-02-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2024.11916
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