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  1. Book ; Online: Chapter 2 Conscious and Unconscious Qualities

    Polák, Michal

    Conceptual Relations between Phenomenality, What-It's-Likeness, and Consciousness

    2024  

    Keywords Philosophy of mind ; Psychology ; Cognition & cognitive psychology ; attention; higher-order theories of consciousness; inattentional blindness; masking; mental qualities; neurophenomenal structuralism; phenomenal content; unconscious mental states
    Language English
    Size 1 electronic resource (21 pages)
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English
    HBZ-ID HT030613110
    ISBN 9781032529745 ; 1032529741
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Transition of Care

    Polak, Michel

    From Childhood to Adulthood in Endocrinology, Gynecology, and Diabetes

    (Endocrine Development ; Vol.33)

    2018  

    Author's details editors, Michel Polak, Philippe Touraine
    Series title Endocrine Development ; Vol.33
    Keywords Endocrinology ; Pediatrics ; Andrology ; Diabetes ; Fertility ; Genetics ; Gynecology ; Hospital Care ; Metabolic Diseases ; Metabolism ; Neuroendocrinology ; Obesity ; Pediatric Endocrinology ; Psychology ; Reproduction
    Language English
    Size 1 online resource (VIII + 164 pages), 14 figures, 3 in color, 11 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online ; E-Book
    Note Your key source for managing the transition period
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020068929
    ISBN 9783318061437 ; 9783318061420 ; 3318061433 ; 3318061425
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Adherence and quality of life in children receiving rhGH treatment.

    Gonzalez-Briceño, L / Viaud, M / Polak, M

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2023  Volume 28, Issue 8S1, Page(s) 8S3–8S8

    Abstract: Short stature may have a major impact on quality of life (QoL), not only during adulthood but also during childhood. Treatment by growth hormone may induce improvement in QoL through height gain, as shown in recent articles, with an increase in general ... ...

    Abstract Short stature may have a major impact on quality of life (QoL), not only during adulthood but also during childhood. Treatment by growth hormone may induce improvement in QoL through height gain, as shown in recent articles, with an increase in general health-related and also height-specific QoL assessed by self-reports and parental reports. In a paper published by our team, we show altered general-health QoL in patients with very short stature (≤ -3 SD) and an improvement in general and height-specific scales in the complete population (≤ -2 SD) after one year of recombinant human growth hormone (rhGH) treatment, perceived both by children and their parents, with a moderate positive correlation with height gain. Adequate results in terms of height gain depend on different factors: the patient's age, underlying condition for which rhGH is prescribed and dose of rhGH treatment, among others. Daily injections may cause a significant burden for the child and family, and may alter adequate adherence to treatment. Identifying positive and negative factors in the patient and in the healthcare providers-patient team and encouraging a shared decision-making process are important for improving the patient's adherence to treatment. New long-acting forms of rhGH that will be available in the next few years may play an important part in improving treatment-related QoL and adherence to treatment. © 2022 French Society of Pediatrics. Published by Elsevier Masson SAS. All rights reserved.
    Language English
    Publishing date 2023-10-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/S0929-693X(22)00036-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3942: Show issues Location:
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  4. Article ; Online: Nest Concealment and Nest Defence by Two Passerines: Effect of Protective Nesting Association.

    Polak, Marcin

    Zoological studies

    2019  Volume 58, Page(s) e15

    Abstract: Selection of favourable micro-habitat conditions at nest-sites and nest defence can be important anti- predatory strategies in open-cup nesting birds. In response to nest predation risks, some species of birds appear to form protective nesting ... ...

    Abstract Selection of favourable micro-habitat conditions at nest-sites and nest defence can be important anti- predatory strategies in open-cup nesting birds. In response to nest predation risks, some species of birds appear to form protective nesting associations in which both may gain benefits due to mutual warning and nest defence. Despite the many studies assessing the impact of various factors on nest defence and nest placement, how interactions between species while breeding can modify these strategies is still poorly understood. Here I evaluate whether nesting associations in two species influence nest defence intensity and nest-site selection. An observational approach was used to analyse the defensive behaviours of the Barred Warbler
    Language English
    Publishing date 2019-07-12
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2105348-0
    ISSN 1810-522X ; 1021-5506
    ISSN (online) 1810-522X
    ISSN 1021-5506
    DOI 10.6620/ZS.2019.58-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Isotopic Depletion Increases the Spatial Resolution of FPOP Top-Down Mass Spectrometry Analysis.

    Polák, Marek / Černý, Jiří / Novák, Petr

    Analytical chemistry

    2024  Volume 96, Issue 4, Page(s) 1478–1487

    Abstract: Protein radical labeling, like fast photochemical oxidation of proteins (FPOP), coupled to a top-down mass spectrometry (MS) analysis offers an alternative analytical method for probing protein structure or protein interaction with other biomolecules, ... ...

    Abstract Protein radical labeling, like fast photochemical oxidation of proteins (FPOP), coupled to a top-down mass spectrometry (MS) analysis offers an alternative analytical method for probing protein structure or protein interaction with other biomolecules, for instance, proteins and DNA. However, with the increasing mass of studied analytes, the MS/MS spectra become complex and exhibit a low signal-to-noise ratio. Nevertheless, these difficulties may be overcome by protein isotope depletion. Thus, we aimed to use protein isotope depletion to analyze FPOP-oxidized samples by top-down MS analysis. For this purpose, we prepared isotopically natural (IN) and depleted (ID) forms of the FOXO4 DNA binding domain (FOXO4-DBD) and studied the protein-DNA interaction interface with double-stranded DNA, the insulin response element (IRE), after exposing the complex to hydroxyl radicals. As shown by comparing tandem mass spectra of natural and depleted proteins, the ID form increased the signal-to-noise ratio of useful fragment ions, thereby enhancing the sequence coverage by more than 19%. This improvement in the detection of fragment ions enabled us to detect 22 more oxidized residues in the ID samples than in the IN sample. Moreover, less common modifications were detected in the ID sample, including the formation of ketones and lysine carbonylation. Given the higher quality of ID top-down MSMS data set, these results provide more detailed information on the complex formation between transcription factors and DNA-response elements. Therefore, our study highlights the benefits of isotopic depletion for quantitative top-down proteomics. Data are available via ProteomeXchange with the identifier PXD044447.
    MeSH term(s) Tandem Mass Spectrometry ; Proteins/analysis ; DNA ; Ions ; Isotopes
    Chemical Substances Proteins ; DNA (9007-49-2) ; Ions ; Isotopes
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c03759
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4033: Show issues Location:
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  6. Article ; Online: Early life regulation of inflammation in atopic dermatitis by microRNA.

    Polak, M E

    The British journal of dermatology

    2020  Volume 184, Issue 3, Page(s) 391–392

    Language English
    Publishing date 2020-09-20
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/bjd.19475
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    Ui VI Zs.23: Show issues Location:
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  7. Article ; Online: The Thermal Stability of Asymmetric Separated Configurations inside Alloy Nanoparticles: Atomic-Scale Modeling of Pd-Ir Nanophase Diagrams.

    Polak, Micha / Rubinovich, Leonid

    ACS nano

    2022  

    Abstract: Compared to alloy bulk phase diagrams, the experimental determination of phase diagrams for alloy nanoparticles (NPs), which are useful in various nanotechnological applications, involves significant technical difficulties, making theoretical modeling a ... ...

    Abstract Compared to alloy bulk phase diagrams, the experimental determination of phase diagrams for alloy nanoparticles (NPs), which are useful in various nanotechnological applications, involves significant technical difficulties, making theoretical modeling a feasible alternative. Yet, being quite challenging, modeling of separation nanophase diagrams is scarce in the literature. The task of predicting comprehensive nanophase diagrams for Pd-Ir face-centered cubic-based three cuboctahedra is facilitated in this study by combining the computationally efficient statistical-mechanical Free-energy Concentration Expansion Method, which includes short-range order (SRO) with coordination-dependent bond-energy variations as part of the input and with rotationally symmetric site grouping for extra efficiency. This nanosystem has been chosen mainly because of the very small atomic mismatch that simplifies the modeling, e.g., in the assessment of vibrational entropy contributions based in this work on fitting to the Pd-Ir experimental bulk critical temperature. This entropic effect, together with SRO, leads to significant destabilization of low-T Quasi-Janus (QJ) asymmetric configurations of the NP core, which transform to symmetric partially mixed nanophases. First-order and second-order intracore transitions are predicted for dilute and intermediate-range compositions, respectively. Caloric curves computed for the former case yield the NP-size dependent transition latent heat, and in the latter case critical temperatures exhibit a specific scaling behavior. The computed separation diagrams and intracore solubility diagrams reflect enhanced elemental mixing in smaller QJ nanophases. In addition to these diagrams, the revealed near-surface compositional variations are likely to be pertinent to the utilization of Pd-Ir NPs, e.g., in catalysis.
    Language English
    Publishing date 2022-12-09
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c05419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Neurocentrist identity theory and neuro-phenomenal typing: A commentary on Manzotti's, "The boundaries and location of consciousness as identity theories deem fit".

    Marvan, Tomáš / Polák, Michal

    Frontiers in psychology

    2022  Volume 13, Page(s) 1058325

    Language English
    Publishing date 2022-11-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.1058325
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  9. Article ; Online: Letter to the Editor From Banigé and Polak: "Population-based TSH Screening of Newborns for Hyperthyroidism: It May Be Feasible, But Is It Justified?"

    Banigé, Maïa / Polak, Michel

    The Journal of clinical endocrinology and metabolism

    2022  Volume 107, Issue 8, Page(s) e3536–e3537

    MeSH term(s) Humans ; Hyperthyroidism/diagnosis ; Infant, Newborn ; Mass Screening ; Thyrotropin ; Thyroxine
    Chemical Substances Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2022-05-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgac284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Éditorial. Diabètes sucrés, actualités.

    Polak, M

    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie

    2013  Volume 20 Suppl 4, Page(s) S109

    Title translation Editorial. Diabetes mellitus, update.
    MeSH term(s) Child ; Diabetes Mellitus/drug therapy ; Humans
    Language French
    Publishing date 2013-12
    Publishing country France
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1181947-9
    ISSN 1769-664X ; 0929-693X
    ISSN (online) 1769-664X
    ISSN 0929-693X
    DOI 10.1016/S0929-693X(13)71423-4
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