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  1. Article ; Online: Whipworm Infection in Mice Increases Coinfection of Enteric Pathogens but Promotes Clearance of Ascaris Larvae From the Lungs.

    Polakovicova, Nina / Adji, Antonia Vania / Myhill, Laura J / Williams, Andrew R

    The Journal of infectious diseases

    2023  Volume 227, Issue 12, Page(s) 1428–1432

    Abstract: Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent ...

    Abstract Infection with intestinal whipworms (Trichuris spp.) causes widespread morbidity and may alter responses to enteric and extraintestinal coinfections. Here, we show that Trichuris muris infection in mice increases coinfection with 2 evolutionary divergent enteric pathogens, the bacterium Citrobacter rodentium and the helminth Heligmosomoides polygyrus. Coinfection caused reduced weight gain and promoted type 1-biased inflammation. In contrast, T. muris-infected mice were more resistant to migrating Ascaris suum larvae in the lungs. Our results highlight the divergent nature of pathogen interactions and suggest that whipworm infection is a risk factor for coinfections with other pathogens within the gastrointestinal tract.
    MeSH term(s) Animals ; Mice ; Trichuriasis ; Coinfection ; Ascaris ; Intestines ; Trichuris ; Lung
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiad063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Diet composition drives tissue-specific intensity of murine enteric infections.

    Israelson, Helene / Vedsted-Jakobsen, Amalie / Zhu, Ling / Gagnaire, Aurelie / von Münchow, Alexandra / Polakovicova, Nina / Valente, Angela H / Raza, Ali / Andersen-Civil, Audrey I S / Olsen, John E / Myhill, Laura J / Geldhof, Peter / Williams, Andrew R

    mBio

    2024  Volume 15, Issue 2, Page(s) e0260323

    Abstract: Diet composition plays a large role in regulating gut health and enteric infection. In particular, synthetic "Western-style" diets may predispose to disease, while whole-grain diets containing high levels of crude fiber are thought to promote gut health. ...

    Abstract Diet composition plays a large role in regulating gut health and enteric infection. In particular, synthetic "Western-style" diets may predispose to disease, while whole-grain diets containing high levels of crude fiber are thought to promote gut health. Here, we show that, in contrast to this paradigm, mice fed with unrefined chow are significantly more susceptible to infection with
    MeSH term(s) Mice ; Animals ; Inulin ; Intestine, Small ; Diet/methods ; Inflammation ; Mucous Membrane ; Dietary Fiber
    Chemical Substances Inulin (9005-80-5) ; Dietary Fiber
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.02603-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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