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Book ; Online: Beyond Energy Efficiency in Architecture. New Challenges and Research Trajectories for Buildings and the Built Environment

Poli, Tiziana / Mainini, Andrea Giovanni / Lobaccaro, Gabriele / Košir, Mitja / Cadena, Juan Diego Blanco

2023

Keywords	Technology: general issues ; History of engineering & technology ; bidirectional gated recurrent unit ; convolutional neural networks ; electricity consumption prediction ; hybrid deep learning model ; residential load prediction ; solar energy ; building energy performance ; energy saving ; passive solar design ; synergistic design ; risk assessment ; climate change ; health ; heat stress ; AQI ; solar reflective coatings ; heat transfer ; daily heat gains ; cool roofs ; residential energy modeling ; COVID-19 ; coronavirus pandemic ; temperature sensitivity ; energy security ; phase change material ; thermal energy storage ; energy efficiency ; passive strategies ; active strategies ; adaptive envelopes ; Vertical Greenery Systems (VGS) ; classification ; comparison of different types of VGS ; mathematical modeling and thermohygrometric analysis ; EnergyPlus ; public school buildings ; optimal cost ; energy renovation ; public buildings ; solar cadaster ; solar potential modeling ; numerical validation ; heritage values ; user ; sustainability ; thermal comfort ; heritage buildings ; decision-making ; preservation ; Mexico City ; urban planning ; active solar systems ; passive solar strategies ; Italian case studies ; agrivoltaics ; visual comfort ; lighting ; daylight ; user centred design ; modeling ; monitoring ; indoor air quality (IAQ) ; smart building ; sustainable development goals (SDGs) ; CO2 ; refurbishment
Language	English
Size	1 electronic resource (284 pages)
Publisher	MDPI - Multidisciplinary Digital Publishing Institute
Publishing place	Basel
Document type	Book ; Online
Note	English
HBZ-ID	HT030376867
ISBN	9783036571379 ; 303657137X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Perioperative pain management after scapular tip free flap harvesting for head and neck reconstruction using mini-catheters to inject the local anesthetic.

Ferri, A / Varazzani, A / Tognin, L / Bellanti, L / Pedrazzi, G / Bianchi, B / Arcuri, F / Ferrari, S / Poli, T

Oral and maxillofacial surgery

2024

Abstract: Purpose: Although functional and esthetic results after the use of a scapular tip free flap (STFF) in head and neck reconstruction, and the related donor-site morbidity, have been extensively described, data regarding acute postoperative donor-site pain ...

Abstract	Purpose: Although functional and esthetic results after the use of a scapular tip free flap (STFF) in head and neck reconstruction, and the related donor-site morbidity, have been extensively described, data regarding acute postoperative donor-site pain management are lacking. Purpose of this study is to explore the use of mini-catheters to administer local anesthetics for donor-site pain management after reconstruction using STFF. Methods: Patients who underwent head and neck reconstruction using a STFF were prospectively enrolled and, through a perineural catheter placed in the donor site during the surgical procedure, a bolus of chirochaine was injected before the patient regained consciousness and at 8, 16, and 24 h postoperatively. Before and 40 min after each dose administration, donor-site pain on a numerical rating scale (NRS; 0-10) was evaluated. Results: Study population consisted of 20 patients (40-88 years). At 8 h, the pain scores before and after the injection were 0-10 (mean 3.35) and 0-5 (mean 1.25), respectively. At 16 h, the pain scores before and after the injection were 0-8 (mean 2.55) and 0-4 (mean 0.55), respectively. At 24 h, the pain scores before and after the injection were 0-8 (mean 1.30) and 0-4 (mean 0.30), respectively. Conclusion: Statistical analysis confirmed a significant difference between the pain scores before and after administration at 8, 16, and 24 h (p < 0.001, p < 0.001, and p = 0.003, respectively). Mini-catheters for local anesthetic administration represent an effective strategy for pain control after STFF harvesting for head and neck reconstruction.
Language	English
Publishing date	2024-01-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2406731-3
ISSN	1865-1569 ; 1865-1550
ISSN (online)	1865-1569
ISSN	1865-1550
DOI	10.1007/s10006-024-01212-7
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Article ; Online: Technical refinements of the scapular tip-free flap for mandibular reconstruction.

Ferri, Andrea / Perlangeli, Giuseppe / Zito, Francesca / Ferrari, Silvano / Bianchi, Bernardo / Arcuri, Francesco / Poli, Tito

Microsurgery

2024 Volume 44, Issue 4, Page(s) e31176

Abstract: Background: The use of scapular tip chimeric free flaps (STFFs) for reconstructing mandibular defects has recently become popular, but its utility relative to other bone-containing free flaps remains debatable. The aim of the report is to describe how ... ...

Abstract	Background: The use of scapular tip chimeric free flaps (STFFs) for reconstructing mandibular defects has recently become popular, but its utility relative to other bone-containing free flaps remains debatable. The aim of the report is to describe how technical modification of STFF impacted in its use for mandibular reconstruction also commenting results obtained in a unicentric series of patients. Patients and methods: Patients undergoing mandibular reconstruction using an STFF from January 1, 2014 to June 1, 2022 were retrospectively enrolled in this report. We collected data on chimeric flap type, bone management, vascular pedicles, and the final outcomes. In total, 31 patients (13 men and 18 women) with a mean age of 68 years were enrolled. According to the classification system of Urken, 15 patients had body defects, while 7 had ramus defects, another 7 had symphysis defects, and 2 had both ramus and bodily defects. STFF was always harvested working in two equips simultaneously, in supine position. Dissection included preparation of chimeric components of the flap as latissimus dorsi, serratus and scapular tip. After pedicle dissection scapular bone was cut basing on reconstructive needing with a rectangular (stick) shape including the border of the scapula. In cases of longer bone harvesting, circumflex pedicle was also included to perfuse the upper portion of the scapular border. In five cases, the STFF was harvested with only the scapular angle component, and was thus a composite osteomuscular flap; for the remaining 26 cases, a chimeric STFF was used. Circumflex pedicle was included for eight patients. Six of the seven patients with symphyseal defects underwent a single osteotomy. Results: The average length of the harvested was 69.92 mm (maximum length = 104 mm). The average height of transplanted bone was 26.78 mm (maximum height = 44.2 mm). Mouth-opening was normal in 25 patients, limited in 6 patients, and severely impaired in no patients. The cosmetic results were rated as excellent by 20 patients, good by 8 patients, and poor by 3 patients. Conclusion: The STFF is an excellent option for mandibular reconstruction when other flaps are not available and for patients in poor general condition. Technical innovations here presented made possible to harvest long bone segments with accurate shape thanks to osteotomies if needed and with adequate soft tissues components of the chimeric flap, ensuring satisfactory functional and cosmetic results.
MeSH term(s)	Male ; Humans ; Female ; Aged ; Free Tissue Flaps/transplantation ; Mandibular Reconstruction/methods ; Retrospective Studies ; Plastic Surgery Procedures ; Scapula/transplantation
Language	English
Publishing date	2024-03-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	605524-2
ISSN	1098-2752 ; 0738-1085
ISSN (online)	1098-2752
ISSN	0738-1085
DOI	10.1002/micr.31176
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Zs.A 1570: Show issues

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Article ; Online: Intratumor genetic heterogeneity and head and neck cancer relapse.

Pierik, A S / Poell, J B / Brink, A / Stigter-van Walsum, M / de Roest, R H / Poli, T / Yaromin, A / Lambin, P / Leemans, C R / Brakenhoff, R H

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2024 Volume 191, Page(s) 110087

Abstract: Background: Head and neck squamous cell carcinomas are treated by surgery, radiotherapy (RT), chemoradiotherapy (CRT) or combinations thereof, but locoregional recurrences (LRs) occur in 30-40% of treated patients. We have previously shown that in ... ...

Abstract	Background: Head and neck squamous cell carcinomas are treated by surgery, radiotherapy (RT), chemoradiotherapy (CRT) or combinations thereof, but locoregional recurrences (LRs) occur in 30-40% of treated patients. We have previously shown that in approximately half of the LRs after CRT, cancer driver mutations are not shared with the index tumor. Aim: To investigate two possible explanations for these genetically unrelated relapses, treatment-induced genetic changes and intratumor genetic heterogeneity. Methods: To investigate treatment-induced clonal DNA changes, we compared copy number alterations (CNAs) and mutations between primary and recurrent xenografted tumors after treatment with (C)RT. Intratumor genetic heterogeneity was studied by multi-region sequencing on DNA from 31 biopsies of 11 surgically treated tumors. Results: Induction of clonal DNA changes by (C)RT was not observed in the xenograft models. Multi-region sequencing demonstrated variations in CNA profiles between paired biopsies of individual tumors, with copy number heterogeneity scores varying from 0.027 to 0.333. In total, 32 cancer driver mutations could be identified and were shared in all biopsies of each tumor. Remarkably, multi-clonal mutations in these same cancer driver genes were observed in 6 of 11 tumors. Genetically distinct heterogeneous cell cultures could also be established from single tumors, with different biomarker profiles and drug sensitivities. Conclusion: Intratumor genetic heterogeneity at the level of the cancer driver mutations might explain the discordant mutational profiles in LRs after CRT, while there are no indications in xenograft models that these changes are induced by CRT.
MeSH term(s)	Humans ; Genetic Heterogeneity ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/therapy ; Mutation ; Recurrence ; DNA
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2024-01-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2024.110087
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Article ; Online: The ability of the eighth edition of the TNM staging system plus minor invasion criteria to predict the biological behaviour of oral cavity carcinomas.

Perlangeli, Giuseppe / Lilloni, Giovanni / Salti, Giulia / Ferri, Andrea / Ferrari, Silvano / Poli, Tito

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology

2023 Volume 52, Issue 8, Page(s) 746–750

Abstract: Background: Oral squamous cell carcinoma (OSCC) treatment is based largely on the TNM stage. The eighth edition includes important new prognostic parameters (extranodal extension and depth of invasion), while it does not consider tumour molecular ... ...

Abstract	Background: Oral squamous cell carcinoma (OSCC) treatment is based largely on the TNM stage. The eighth edition includes important new prognostic parameters (extranodal extension and depth of invasion), while it does not consider tumour molecular characteristics or minor invasion criteria (perineural and lymphovascular invasion, grading and resection margins). This study evaluated how well the TNM eighth edition predicts the biological behaviour of OSCC, considering survival and risk of locoregional recurrence. Materials and methods: Data from 217 patients treated for OSCC were analysed, including epidemiologic characteristics, histological features and treatment. Results: No significant correlations with overall survival or tumour recurrence were found for pT stages and the type of treatment, while different pN stages had significant differences in recurrence, but not in overall survival. We found significant correlations between overall survival and tumour grade and lymphovascular and perineural invasion and a significant correlation between tumour resection margins and the risk of recurrence. Conclusions: The current TNM staging system is a necessary but not sufficient tool for predicting the overall survival and risk of recurrence of OSCC. It could be improved by considering other factors, such as minor invasion criteria and biological markers.
MeSH term(s)	Humans ; Neoplasm Staging ; Mouth Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Margins of Excision ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/pathology ; Head and Neck Neoplasms/pathology ; Retrospective Studies
Language	English
Publishing date	2023-08-01
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1021270-x
ISSN	1600-0714 ; 0904-2512
ISSN (online)	1600-0714
ISSN	0904-2512
DOI	10.1111/jop.13469
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Zs.A 825: Show issues

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Article: Diagnosis and Management of Parotid Gland Cancer with Focus on the Role of Preoperative Fine-Needle Aspiration Cytology: A 10-Year-Long Retrospective Study with 5-Year Follow-Up.

Varazzani, Andrea / Tognin, Laura / Bergonzani, Michela / Ferri, Andrea / Ferrari, Silvano / Poli, Tito

Journal of maxillofacial and oral surgery

2023 Volume 22, Issue 2, Page(s) 373–380

Abstract: Introduction: Salivary gland cancers represent a rare heterogeneous group of neoplasms with complex clinicopathological characteristics and distinct biological behaviour. The appropriate diagnosis and management of parotid gland cancer are challenging ... ...

Abstract	Introduction: Salivary gland cancers represent a rare heterogeneous group of neoplasms with complex clinicopathological characteristics and distinct biological behaviour. The appropriate diagnosis and management of parotid gland cancer are challenging and should be based on the clinical, imaging, cytological, and histological features. The present study analysed the use of preoperative fine-needle aspiration cytology (FNAC) and intraoperative frozen section (FS) to guide the appropriate surgical and postoperative treatment of parotid gland cancers. Materials and methods: We selected 48 patients with primary malignancy of the parotid gland surgically treated between 1 January 2008 and 30 June 2017 at the Maxillo-Facial Surgery Division, University Hospital of Parma, Italy. The patients had postoperative histological diagnosis of malignant parotid cancer and were followed up for longer than 5 years. Results: The 48 patients included in this study had a mean age of 56.7 years. The most frequent type of parotid gland cancer was carcinoma ex pleomorphic adenoma (22.9%), followed by mucoepidermoid carcinoma (16.7%) and acinic cell carcinoma (14.6%). All 48 patients underwent preoperative FNAC: 29 (60.4%) and 19 (39.6%) were suggestive of malignant and benign lesions, respectively. In 31 patients, intraoperative FS was performed. Discussion: Compared to previous studies, the present study showed significantly lower diagnostic sensitivity of FNAC for parotid gland cancers. The preoperative diagnostic accuracy for suspected malignant cases may be improved by repeat analysis of the cytological specimen by experts, preoperative core needle biopsy, and/or intraoperative FS analysis of the suspected mass.
Language	English
Publishing date	2023-01-18
Publishing country	India
Document type	Journal Article
ZDB-ID	2502352-4
ISSN	0974-942X ; 0972-8279
ISSN (online)	0974-942X
ISSN	0972-8279
DOI	10.1007/s12663-023-01849-z
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Article ; Online: MRI radiomics in head and neck cancer from reproducibility to combined approaches.

Corti, Anna / Cavalieri, Stefano / Calareso, Giuseppina / Mattavelli, Davide / Ravanelli, Marco / Poli, Tito / Licitra, Lisa / Corino, Valentina D A / Mainardi, Luca

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9451

Abstract: The clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the ... ...

Abstract	The clinical applicability of radiomics in oncology depends on its transferability to real-world settings. However, the absence of standardized radiomics pipelines combined with methodological variability and insufficient reporting may hamper the reproducibility of radiomic analyses, impeding its translation to clinics. This study aimed to identify and replicate published, reproducible radiomic signatures based on magnetic resonance imaging (MRI), for prognosis of overall survival in head and neck squamous cell carcinoma (HNSCC) patients. Seven signatures were identified and reproduced on 58 HNSCC patients from the DB2Decide Project. The analysis focused on: assessing the signatures' reproducibility and replicating them by addressing the insufficient reporting; evaluating their relationship and performances; and proposing a cluster-based approach to combine radiomic signatures, enhancing the prognostic performance. The analysis revealed key insights: (1) despite the signatures were based on different features, high correlations among signatures and features suggested consistency in the description of lesion properties; (2) although the uncertainties in reproducing the signatures, they exhibited a moderate prognostic capability on an external dataset; (3) clustering approaches improved prognostic performance compared to individual signatures. Thus, transparent methodology not only facilitates replication on external datasets but also advances the field, refining prognostic models for potential personalized medicine applications.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Head and Neck Neoplasms/diagnostic imaging ; Head and Neck Neoplasms/pathology ; Female ; Male ; Reproducibility of Results ; Middle Aged ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/diagnostic imaging ; Squamous Cell Carcinoma of Head and Neck/pathology ; Aged ; Adult ; Radiomics
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60009-6
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Article: A multi-analytical approach for precise identification of alkyd spray paints and for a better understanding of their ageing behaviour in graffiti and urban artworks

Pellis, G. / Bertasa, M. / Ricci, C. / Scarcella, A. / Croveri, P. / Poli, T. / Scalarone, D.

Journal of analytical and applied pyrolysis. 2022 Aug., v. 165

2022

Abstract: Contemporary graffiti and murals became an artistic expression worthy of attention worldwide as well as their conservation. The application of spray paints with increasing technical performance mirrors the variety of the chemical composition of these ... ...

Abstract	Contemporary graffiti and murals became an artistic expression worthy of attention worldwide as well as their conservation. The application of spray paints with increasing technical performance mirrors the variety of the chemical composition of these increasingly common painting materials. An insight into the formulation and the ageing process is extremely important to predict and prevent the possible decay phenomena observed on outdoor urban artworks. This paper aims to investigate the relationship between the macroscopic outcomes and the chemical changes occurring on spray paints after the ageing by a multi-analytical approach. A systematic artificial ageing procedure was performed on multiple sets of concrete mock-ups painted with three different alkyd-based spray paints and in three different light-sensitive colours. The colour variation was assessed by colorimetric measurements, the changes in the paint cross section were observed by scanning electron microscopy, Fourier transform infrared spectroscopy (FTIR) was applied both to characterize the spray paints and to detect the chemical changes of the organic compounds during the ageing. A significant and innovative contribution to this research is the application of the evolved gas analysis-mass spectrometry (EGA-MS) and pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS) with tetramethylammonium hydroxide in double-shot mode. These two analytical methodologies allowed an accurate classification of the different alkyd-based binders, the identification of plasticizers, organic pigments and other components often hard to spot in complex formulations, and an analysis of their fate following ageing.
Keywords	Fourier transform infrared spectroscopy ; chemical composition ; color ; colorimetry ; pyrolysis ; pyrolysis gas chromatography ; tetramethylammonium compounds
Language	English
Dates of publication	2022-08
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0165-2370
DOI	10.1016/j.jaap.2022.105576
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Prognostic radiomic signature for head and neck cancer: Development and validation on a multi-centric MRI dataset.

Bologna, Marco / Corino, Valentina / Cavalieri, Stefano / Calareso, Giuseppina / Gazzani, Silvia Eleonora / Poli, Tito / Ravanelli, Marco / Mattavelli, Davide / de Graaf, Pim / Nauta, Irene / Scheckenbach, Kathrin / Licitra, Lisa / Mainardi, Luca

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 183, Page(s) 109638

Abstract: Background and purpose: Prognosis in locally advanced head and neck cancer (HNC) is currently based on TNM staging system and tumor subsite. However, quantitative imaging features (i.e., radiomic features) from magnetic resonance imaging (MRI) may ... ...

Abstract	Background and purpose: Prognosis in locally advanced head and neck cancer (HNC) is currently based on TNM staging system and tumor subsite. However, quantitative imaging features (i.e., radiomic features) from magnetic resonance imaging (MRI) may provide additional prognostic info. The aim of this work is to develop and validate an MRI-based prognostic radiomic signature for locally advanced HNC. Materials and methods: Radiomic features were extracted from T1- and T2-weighted MRI (T1w and T2w) using the segmentation of the primary tumor as mask. In total 1072 features (536 per image type) were extracted for each tumor. A retrospective multi-centric dataset (n = 285) was used for features selection and model training. The selected features were used to fit a Cox proportional hazard regression model for overall survival (OS) that outputs the radiomic signature. The signature was then validated on a prospective multi-centric dataset (n = 234). Prognostic performance for OS and disease-free survival (DFS) was evaluated using C-index. Additional prognostic value of the radiomic signature was explored. Results: The radiomic signature had C-index = 0.64 for OS and C-index = 0.60 for DFS in the validation set. The addition of the radiomic signature to other clinical features (TNM staging and tumor subsite) increased prognostic ability for both OS (HPV- C-index 0.63 to 0.65; HPV+ C-index 0.75 to 0.80) and DFS (HPV- C-index 0.58 to 0.61; HPV+ C-index 0.64 to 0.65). Conclusion: An MRI-based prognostic radiomic signature was developed and prospectively validated. Such signature can successfully integrate clinical factors in both HPV+ and HPV- tumors.
MeSH term(s)	Humans ; Prognosis ; Retrospective Studies ; Papillomavirus Infections ; Prospective Studies ; Head and Neck Neoplasms/diagnostic imaging ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2023-03-31
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.109638
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Article ; Online: Interactions of natural resins and pigments in works of art.

Poli, Tommaso / Piccirillo, Anna / Nervo, Marco / Chiantore, Oscar

Journal of colloid and interface science

2017 Volume 503, Page(s) 1–9

Abstract: The degradation process involving the formation of metal soaps in drying oils is a well-known problem due to cations from pigments reacting with free fatty acids from the oil. The aggregation of these carboxylates in semi-crystalline structures can lead ... ...

Abstract	The degradation process involving the formation of metal soaps in drying oils is a well-known problem due to cations from pigments reacting with free fatty acids from the oil. The aggregation of these carboxylates in semi-crystalline structures can lead to eruptions through the paint layers and 'blooming' on the surface. In this work, the metal soaps formation in presence of natural resins has been assessed and studied by means of Fourier transform infrared spectroscopy with experiments concerning the ageing of drying oil and different natural resins (shellac, dammar and colophony) in the presence of common historic pigments (smalt, ochre, umber, azurite, lead white, zinc white and titanium white). Mixtures of resins and pigments have been exposed to photo-ageing in solar box up to 1000h, thermal ageing at 50°C up to 1100h and 6month of room conditions exposure as reference. The decrease in the intensity of the carbonyl band in the spectra, as well as the contemporary increase of the metal carboxylates (in the range from 1500 to 1650cm
Language	English
Publishing date	2017-10-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2017.04.094
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