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  1. Article ; Online: Aging hallmarks, biomarkers, and clocks for personalized medicine: (re)positioning the limelight.

    Polidori, M Cristina

    Free radical biology & medicine

    2024  Volume 215, Page(s) 48–55

    Abstract: The rapidly increasing aging prevalence, complexity, and heterogeneity pose the scientific and medical communities in front of challenges. These are delivered by gaps between basic and translational research, as well as between clinical practice ... ...

    Abstract The rapidly increasing aging prevalence, complexity, and heterogeneity pose the scientific and medical communities in front of challenges. These are delivered by gaps between basic and translational research, as well as between clinical practice guidelines to improve survival and absence of evidence on personalized strategies to improve functions, wellbeing and quality of life. The triumphs of aging science sheding more and more light on mechanisms of aging as well as those of medical and technological progress to prolong life expectancy are clear. Currently, and in the next two to three decades, all efforts must be put in a closer interdisciplinary dialogue between biogerontologists and geriatricians to enable real-life measures of aging phenotypes to be used to uncover the physiological - and therefore translational - relevance of newly discovered aging clocks, biomarkers, and hallmarks.
    MeSH term(s) Quality of Life ; Precision Medicine ; Life Expectancy ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2024.02.012
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  2. Article ; Online: Frailty from conceptualization to action: the biopsychosocial model of frailty and resilience.

    Polidori, M Cristina / Ferrucci, Luigi

    Aging clinical and experimental research

    2023  Volume 35, Issue 4, Page(s) 725–727

    MeSH term(s) Humans ; Aged ; Frailty/psychology ; Concept Formation ; Models, Biopsychosocial ; Frail Elderly/psychology ; Aging
    Language English
    Publishing date 2023-03-22
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02337-z
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  3. Article ; Online: On frailty and accelerated aging during SARS-Cov-2: senescence.

    Müller-Werdan, Ursula / Polidori, M Cristina / Simm, Andreas

    Aging clinical and experimental research

    2023  Volume 35, Issue 4, Page(s) 907–912

    Abstract: The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially multimorbid and frail persons are at an increased risk. As bio-functional rather than calendrical age is in the ... ...

    Abstract The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially multimorbid and frail persons are at an increased risk. As bio-functional rather than calendrical age is in the meanwhile known to play a crucial role for COVID-19-related outcomes, aging-associated risk factors, overall prognosis and physiological age-related changes should be systematically considered for clinical decision-making. In this overview, we focus on cellular senescence as a major factor of biological aging, associated with organ dysfunction and increased inflammation (inflammaging).
    MeSH term(s) Humans ; SARS-CoV-2 ; Frailty/complications ; COVID-19/complications ; Pandemics ; Aging ; Cellular Senescence
    Language English
    Publishing date 2023-03-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-023-02364-4
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  4. Article ; Online: [No title information]

    Polidori, M Cristina

    Zeitschrift fur Gerontologie und Geriatrie

    2018  Volume 51, Issue 1, Page(s) 80

    Title translation Correction: Ziel- und patientenorientierte Versorgung mithilfe des Comprehensive Geriatric Assessment : Prognoseberechnung für klinische Entscheidungen bei älteren Patienten.
    Language German
    Publishing date 2018
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-017-1364-6
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    Zs.A 497: Show issues Location:
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  5. Article ; Online: Focus on senescence: Clinical significance and practical applications.

    Boccardi, Virginia / Orr, Miranda Ethel / Polidori, M Cristina / Ruggiero, Carmelinda / Mecocci, Patrizia

    Journal of internal medicine

    2024  Volume 295, Issue 5, Page(s) 599–619

    Abstract: The older population is increasing worldwide, and life expectancy is continuously rising, predominantly thanks to medical and technological progress. Healthspan refers to the number of years an individual can live in good health. From a gerontological ... ...

    Abstract The older population is increasing worldwide, and life expectancy is continuously rising, predominantly thanks to medical and technological progress. Healthspan refers to the number of years an individual can live in good health. From a gerontological viewpoint, the mission is to extend the life spent in good health, promoting well-being and minimizing the impact of aging-related diseases to slow the aging process. Biologically, aging is a malleable process characterized by an intra- and inter-individual heterogeneous and dynamic balance between accumulating damage and repair mechanisms. Cellular senescence is a key component of this process, with senescent cells accumulating in different tissues and organs, leading to aging and age-related disease susceptibility over time. Removing senescent cells from the body or slowing down the burden rate has been proposed as an efficient way to reduce age-dependent deterioration. In animal models, senotherapeutic molecules can extend life expectancy and lifespan by either senolytic or senomorphic activity. Much research shows that dietary and physical activity-driven lifestyle interventions protect against senescence. This narrative review aims to summarize the current knowledge on targeting senescent cells to reduce the risk of age-related disease in animal models and their translational potential for humans. We focused on studies that have examined the potential role of senotherapeutics in slowing the aging process and modifying age-related disease burdens. The review concludes with a general discussion of the mechanisms underlying this unique trajectory and its implications for future research.
    MeSH term(s) Animals ; Humans ; Clinical Relevance ; Aging ; Longevity ; Life Expectancy ; Cellular Senescence
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13775
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  6. Article ; Online: Ziel- und patientenorientierte Versorgung mithilfe des Comprehensive Geriatric Assessment : Prognoseberechnung für klinische Entscheidungen bei älteren Patienten.

    Polidori, M Cristina

    Zeitschrift fur Gerontologie und Geriatrie

    2017  Volume 50, Issue 8, Page(s) 706–709

    Title translation Target and patient-oriented care using the comprehensive geriatric assessment : Prognosis estimation for clinical decisions with elderly patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Comprehensive Health Care/methods ; Decision Support Techniques ; Geriatric Assessment/methods ; Germany ; Health Status Indicators ; Humans ; Life Expectancy ; Patient Care Planning ; Patient-Centered Care/methods ; Prognosis
    Language German
    Publishing date 2017-11-21
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1227032-5
    ISSN 1435-1269 ; 0044-281X ; 0948-6704
    ISSN (online) 1435-1269
    ISSN 0044-281X ; 0948-6704
    DOI 10.1007/s00391-017-1332-1
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  7. Article ; Online: The multidimensional prognostic index in hospitalized older adults: practicability with regard to time needs.

    Bonnekoh, Selma Irmgard / Meyer, Anna Maria / Pickert, Lena / Schulz, Ralf-Joachim / Becker, Ingrid / Polidori, M Cristina

    Aging clinical and experimental research

    2023  Volume 35, Issue 3, Page(s) 711–716

    Abstract: Background: Comprehensive Geriatric Assessment (CGA) is decisive in patient-centered medicine of the aged individual, yet it is not systematically used.: Aim: The aim of this study was to provide precise practice-relevant time expenditure data for ... ...

    Abstract Background: Comprehensive Geriatric Assessment (CGA) is decisive in patient-centered medicine of the aged individual, yet it is not systematically used.
    Aim: The aim of this study was to provide precise practice-relevant time expenditure data for the Multidimensional Prognostic Index (MPI), a questionnaire-based frailty assessment tool.
    Methods: MPI was determined in ninety older multimorbid adults in three geriatric departments (cohorts 1, 2 and 3). The time needed to perform the MPI (tnpMPI) was recorded in minutes. Follow-up data were collected after 6 months.
    Results: The median tnpMPI was 15.0 min (IQR 7.0) in the total collective. In the last visited cohort 3, the median was 10.0 min and differed significantly from cohorts 1 and 2 with medians of 15.5 and 15.0 (p < 0.001).
    Conclusion: These findings indicate, that MPI, as a highly informative frailty tool of individualized medicine, can be performed in an adequately practicable time frame.
    MeSH term(s) Aged ; Humans ; Prognosis ; Frailty/diagnosis ; Multimorbidity ; Geriatric Assessment/methods
    Language English
    Publishing date 2023-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2104785-6
    ISSN 1720-8319 ; 1594-0667
    ISSN (online) 1720-8319
    ISSN 1594-0667
    DOI 10.1007/s40520-022-02311-9
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  8. Article ; Online: Nutritional cognitive neuroscience of aging: Focus on carotenoids and cognitive frailty.

    Polidori, M Cristina / Stahl, Wilhelm / Griffiths, Helen R

    Redox biology

    2021  Volume 44, Page(s) 101996

    Abstract: The term "nutritional cognitive neuroscience" was recently established to define a research field focusing on the impact of nutrition on cognition and brain health across the life span. In this overview, we summarize the robust evidence on the role of ... ...

    Abstract The term "nutritional cognitive neuroscience" was recently established to define a research field focusing on the impact of nutrition on cognition and brain health across the life span. In this overview, we summarize the robust evidence on the role of carotenoids as micronutrients with different biological properties in persons with cognitive (pre)frailty. As neurodegenerative processes during aging occur in a continuum from brain aging to dementia, we propose the name "nutritional cognitive neuroscience of aging" to define research on the role of nutrition and micronutrients in cognitive frailty. Further studies are warranted which integrate carotenoid interventions in multidomain, personalized lifestyle strategies.
    MeSH term(s) Aging ; Carotenoids ; Cognition ; Cognitive Neuroscience ; Frailty ; Humans
    Chemical Substances Carotenoids (36-88-4)
    Language English
    Publishing date 2021-05-08
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2021.101996
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  9. Article: Ziel- und patientenorientierte Versorgung mithilfe des Comprehensive Geriatric Assessment : Prognoseberechnung für klinische Entscheidungen bei älteren Patienten

    Polidori, M. Cristina

    Zeitschrift für Gerontologie und Geriatrie

    2017  Volume 50, Issue 8, Page(s) 706

    Keywords Alter. ; Versorgung ; Entscheidung ; Prognose ; Patient ; Individualisierte Medizin ; Beurteilung
    Language German
    Document type Article
    ZDB-ID 1227032-5
    ISSN 0948-6704
    ISSN 0948-6704
    Database bibnet.org

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  10. Article ; Online: COVID-19 mortality as a fingerprint of biological age.

    Polidori, M Cristina / Sies, Helmut / Ferrucci, Luigi / Benzing, Thomas

    Ageing research reviews

    2021  Volume 67, Page(s) 101308

    Abstract: Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it ... ...

    Abstract Corona virus disease 2019 (COVID-19) is a global emergency able to overwhelm the healthcare capacities worldwide and to affect the older generation especially. When addressing the pathophysiological mechanisms and clinical manifestations of COVID-19, it becomes evident that the disease targets pathways and domains affected by the main aging- and frailty-related pathophysiological changes. A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. There is a need for systematic, consequent action of identifying frail (not only older, not only multimorbid, not only symptomatic) persons at risk of poor outcomes.
    MeSH term(s) Aging ; COVID-19 ; Frailty/diagnosis ; Humans ; Multimorbidity ; SARS-CoV-2
    Language English
    Publishing date 2021-02-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2021.101308
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