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  1. AU="Polidoro, Silvia"
  2. AU="Dausset, J"
  3. AU=Eijkholt Marleen
  4. AU=Sousa Braian L A AU=Sousa Braian L A
  5. AU="Fresel, Marielle"
  6. AU="Ilana Babaev"
  7. AU="Tang, Hang"
  8. AU="McBride, Erin"

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  1. Artikel ; Online: Household pesticide exposure: an online survey and shelf research in the Metropolitan Region of Rio de Janeiro, Brazil.

    Galdiano, Leandro Lopes da Silva / Baltar, Valéria Troncoso / Polidoro, Silvia / Gallo, Valentina

    Cadernos de saude publica

    2021  Band 37, Heft 7, Seite(n) e00099420

    Abstract: This study aimed to estimate household pesticide exposure in adult individuals in the Metropolitan Region of Rio de Janeiro, Brazil, and to verify the accessibility of these products in local and online businesses. The data were collected by an online ... ...

    Abstract This study aimed to estimate household pesticide exposure in adult individuals in the Metropolitan Region of Rio de Janeiro, Brazil, and to verify the accessibility of these products in local and online businesses. The data were collected by an online questionnaire (1,015 responses) and a shelf survey in physical and online stores. Among the responses analyzed, 87.5% used pesticides in the previous year, most of which against mosquitoes (64.7%). The most common application method was aerosol spray (38.1%), and the most frequent places of use were bedrooms (29.7%) and living rooms (22.1%). About 30% of respondents reported invasion of pests, and the most common pests were ants (79.1%) and cockroaches (40.4%). Service area (71.6%) and kitchen (17.5%) were the most common storage locations. Approximately 91% of those who lived with children aged under 18 used pesticides. The use of chemical group of pyrethroids prevailed (81.6%), and 90.8% of the reportedly used products are class II [55.7% (highly toxic)] or class III [35.1% (medium toxic)]. The most significant amount of purchased products was in the pest category, followed by mosquitoes. More variety of products were available in online stores than in physical stores. The high exposure of the population to pesticides at household is a public health issue and confirms the need for studies that better assess the risks and consequences of chronic and low-dose exposure to these substances. It is essential to inform the population about the uncertainties and potential risks of indiscriminate use so that they can choose whether to use pesticides in their households.
    Mesh-Begriff(e) Adult ; Animals ; Brazil ; Child ; Family Characteristics ; Humans ; Pesticides ; Surveys and Questionnaires
    Chemische Substanzen Pesticides
    Sprache Englisch
    Erscheinungsdatum 2021-07-19
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 1115730-6
    ISSN 1678-4464 ; 0102-311X
    ISSN (online) 1678-4464
    ISSN 0102-311X
    DOI 10.1590/0102-311X00099420
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mind versus body: Perceived stress and biological stress are independently related to cognitive decline.

    De Looze, Céline / McCrory, Cathal / O'Halloran, Aisling / Polidoro, Silvia / Anne Kenny, Rose / Feeney, Joanne

    Brain, behavior, and immunity

    2023  Band 115, Seite(n) 696–704

    Abstract: Chronic stress may increase risk of age-related cognitive decline. 'Stress', however, is a multidimensional construct and few studies have investigated the inter-relationship of subjective stress and biological stress with cognitive decline. In this ... ...

    Abstract Chronic stress may increase risk of age-related cognitive decline. 'Stress', however, is a multidimensional construct and few studies have investigated the inter-relationship of subjective stress and biological stress with cognitive decline. In this study, we examine the relationship between perceived stress and two measures of biological stress - allostatic load, indexing stress at the physiological level and leukocyte telomere length, indexing stress at the cellular level - with cognitive decline over a 12-year period in adults aged 50 and older. 3,458 participants (aged ≥ 50) from The Irish Longitudinal study on Ageing with measurements of allostatic load, telomere length and perceived stress at baseline and repeated measures of cognitive function were included. Hierarchical linear regression models with adjustment for multiple potential confounders were applied, and repeated stratified by sex in sensitivity analyses. Higher perceived stress at baseline was associated with lower cognitive function (β = -0.10, 95 % CI -0.12, -0.07, p <.001), with similar strength of associations across waves. There were significant interactions between measures of biological stress and wave; higher allostatic load was associated (X
    Mesh-Begriff(e) Humans ; Female ; Middle Aged ; Aged ; Longitudinal Studies ; Aging/physiology ; Cognitive Dysfunction ; Cognition ; Stress, Psychological
    Sprache Englisch
    Erscheinungsdatum 2023-11-15
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639219-2
    ISSN 1090-2139 ; 0889-1591
    ISSN (online) 1090-2139
    ISSN 0889-1591
    DOI 10.1016/j.bbi.2023.10.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Associations between plasma levels of brominated flame retardants and methylation of DNA from peripheral blood: A cross-sectional study in a cohort of French women

    Omichessan, Hanane / Perduca, Vittorio / Polidoro, Silvia / Kvaskoff, Marina / Truong, Thérèse / Cano-Sancho, German / Antignac, Jean-Philippe / Baglietto, Laura / Mancini, Francesca Romana / Severi, Gianluca

    Environmental research. 2022 July, v. 210

    2022  

    Abstract: Brominated flame retardants (BFRs) are organic compounds that are widespread in the environment. Because of their persistence, they are able to bioaccumulate with major impacts on human health. It has been hypothesized that the effect of BFRs on human ... ...

    Abstract Brominated flame retardants (BFRs) are organic compounds that are widespread in the environment. Because of their persistence, they are able to bioaccumulate with major impacts on human health. It has been hypothesized that the effect of BFRs on human health is mediated by alterations of DNA methylation. The aim of this study was to examine the association between methylation of DNA extracted from peripheral blood and circulating levels of BFRs measured in plasma. We conducted a methylation wide association study on 336 blood samples from a study within the E3N (Etude Epidémiologique auprès de femmes de l'Education Nationale) cohort, a long-term longitudinal cohort of French women. DNA methylation at more than 850 000 cytosine-guanine dinucleotide (CpG) sites was measured with the Illumina Infinium HumanMethylation - EPIC BeadChip. Circulating levels of seven BFRs (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154 and PBB-153) were measured by gas chromatography coupled to high-resolution mass spectrometry in plasma samples. The association between DNA methylation and BFRs plasma levels was assessed through linear mixed-effects models followed by gene-set enrichment analyses (GSEA). We identified 253 CpG sites whose methylation levels were significantly associated with exposure to BFRs after Bonferroni correction. For 50 of these CpGs the p-values were less than 2.2x10⁻⁹ with the strongest association being between BDE-154 and cg23619365 (4.32x10⁻¹³). GSEA of CpG sites associated with exposure to BFRs identified significant enrichment of genes involved in hypoxia, glycolysis and adipogenesis. Exposure to BFRs appears to be related to numerous alterations in DNA methylation. These findings, if replicated in independent studies, provide insights into the biological and health effects of BFRs.
    Schlagwörter DNA ; DNA methylation ; adipogenesis ; bioaccumulation ; bromination ; cross-sectional studies ; gas chromatography ; glycolysis ; human health ; hypoxia ; mass spectrometry ; research
    Sprache Englisch
    Erscheinungsverlauf 2022-07
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.112788
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  4. Artikel: Role of Diacylglycerol Kinases in Acute Myeloid Leukemia.

    Gravina, Teresa / Boggio, Chiara Maria Teresa / Gorla, Elisa / Racca, Luisa / Polidoro, Silvia / Centonze, Sara / Ferrante, Daniela / Lunghi, Monia / Graziani, Andrea / Corà, Davide / Baldanzi, Gianluca

    Biomedicines

    2023  Band 11, Heft 7

    Abstract: Diacylglycerol kinases (DGKs) play dual roles in cell transformation and immunosurveillance. According to cancer expression databases, acute myeloid leukemia (AML) exhibits significant overexpression of multiple DGK isoforms, ... ...

    Abstract Diacylglycerol kinases (DGKs) play dual roles in cell transformation and immunosurveillance. According to cancer expression databases, acute myeloid leukemia (AML) exhibits significant overexpression of multiple DGK isoforms, including
    Sprache Englisch
    Erscheinungsdatum 2023-07-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11071877
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Birthweight DNA methylation signatures in infant saliva.

    Moccia, Chiara / Popovic, Maja / Isaevska, Elena / Fiano, Valentina / Trevisan, Morena / Rusconi, Franca / Polidoro, Silvia / Richiardi, Lorenzo

    Clinical epigenetics

    2021  Band 13, Heft 1, Seite(n) 57

    Abstract: Background: Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, ... ...

    Abstract Background: Low birthweight has been repeatedly associated with long-term adverse health outcomes and many non-communicable diseases. Our aim was to look-up cord blood birthweight-associated CpG sites identified by the PACE Consortium in infant saliva, and to explore saliva-specific DNA methylation signatures of birthweight.
    Methods: DNA methylation was assessed using Infinium HumanMethylation450K array in 135 saliva samples collected from children of the NINFEA birth cohort at an average age of 10.8 (range 7-17) months. The association analyses between birthweight and DNA methylation variations were carried out using robust linear regression models both in the exploratory EWAS analyses and in the look-up of the PACE findings in infant saliva.
    Results: None of the cord blood birthweight-associated CpGs identified by the PACE Consortium was associated with birthweight when analysed in infant saliva. In saliva EWAS analyses, considering a false discovery rate p-values < 0.05, birthweight as continuous variable was associated with DNA methylation in 44 CpG sites; being born small for gestational age (SGA, lower 10
    Conclusion: Our study provides an indication of the birthweight and SGA epigenetic salivary signatures in children around 10 months of age. DNA methylation signatures in cord blood may not be comparable with saliva DNA methylation signatures at about 10 months of age, suggesting that the birthweight epigenetic marks are likely time and tissue specific.
    Mesh-Begriff(e) Birth Weight/genetics ; CpG Islands/genetics ; DNA Methylation ; Female ; Fetal Blood/chemistry ; Humans ; Infant ; Infant, Newborn ; Italy ; Male ; Respiratory Sounds/genetics ; Saliva/chemistry
    Sprache Englisch
    Erscheinungsdatum 2021-03-19
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553921-8
    ISSN 1868-7083 ; 1868-7075
    ISSN (online) 1868-7083
    ISSN 1868-7075
    DOI 10.1186/s13148-021-01053-1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Early life adversity and age acceleration at mid-life and older ages indexed using the next-generation GrimAge and Pace of Aging epigenetic clocks.

    McCrory, Cathal / Fiorito, Giovanni / O'Halloran, Aisling M / Polidoro, Silvia / Vineis, Paolo / Kenny, Rose Anne

    Psychoneuroendocrinology

    2021  Band 137, Seite(n) 105643

    Abstract: Objective: This retrospective cross-sectional study was designed to explore whether the experience of childhood adversity was associated with epigenetic age acceleration in mid-life and older ages using the next generation GrimAge and Pace of Aging DNA ... ...

    Abstract Objective: This retrospective cross-sectional study was designed to explore whether the experience of childhood adversity was associated with epigenetic age acceleration in mid-life and older ages using the next generation GrimAge and Pace of Aging DNA methylation clocks.
    Method: The study involved a sub-sample of 490 individuals aged 50-87 years of age participating in the Irish Longitudinal Study on Aging (TILDA); a large nationally representative prospective cohort study of aging in Ireland. Childhood adversity was ascertained via self-report using 5-items that were deemed to indicate potentially nefarious childhood exposures, including growing up poor, death of a parent, parental substance abuse in the family, childhood physical abuse, and childhood sexual abuse.
    Results: Only childhood poverty was associated with significant epigenetic age acceleration according to the GrimAge and Pace of Aging clocks, hastening biological aging by 2.04 years [CI= 1.07, 3.00; p < 0.001] and 1.16 years [CI= 0.11, 2.21; p = 0.030] respectively. Analysis of the dose-response pattern revealed each additional adversity was associated with 0.69 years of age acceleration [CI= 0.23, 1.15; p = 0.004] according to the GrimAge clock. Mediation analysis suggested that lifetime smoking explains a substantial portion (>50%) of the excess risk of age acceleration amongst those who experienced childhood poverty.
    Conclusions: This study adds to the growing body of evidence which implicates early life adversity, particularly deprivation as a potential precipitant of earlier biological aging, and implicates smoking-related changes to DNA methylation processes as a candidate pathway and mechanism through which the social environment gets transduced at a biological level to hasten the aging process.
    Mesh-Begriff(e) Acceleration ; Adverse Childhood Experiences ; Aged ; Aged, 80 and over ; Aging/genetics ; Child, Preschool ; Cross-Sectional Studies ; DNA Methylation/genetics ; Epigenesis, Genetic ; Humans ; Longitudinal Studies ; Middle Aged ; Prospective Studies ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-12-23
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2021.105643
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  7. Artikel: Prenatal exposure to PM10 and changes in DNA methylation and telomere length in cord blood

    Isaevska, Elena / Fiano, Valentina / Asta, Federica / Stafoggia, Massimo / Moirano, Giovenale / Popovic, Maja / Pizzi, Costanza / Trevisan, Morena / De Marco, Laura / Polidoro, Silvia / Gagliardi, Luigi / Rusconi, Franca / Brescianini, Sonia / Nisticò, Lorenza / Stazi, Maria Antonietta / Ronfani, Luca / Porta, Daniela / Richiardi, Lorenzo

    Environmental research. 2022 June, v. 209

    2022  

    Abstract: Air pollution exposure in pregnancy can cause molecular level alterations that might influence later disease susceptibility. We investigated DNA methylation (DNAm) and telomere length (TL) in the cord blood in relation to gestational PM₁₀ exposure and ... ...

    Abstract Air pollution exposure in pregnancy can cause molecular level alterations that might influence later disease susceptibility. We investigated DNA methylation (DNAm) and telomere length (TL) in the cord blood in relation to gestational PM₁₀ exposure and explored potential gestational windows of susceptibility. Cord blood epigenome-wide DNAm (N = 384) and TL (N = 500) were measured in children of the Italian birth cohort Piccolipiù, using the Infinium Methylation EPIC BeadChip and qPCR, respectively. PM₁₀ daily exposure levels, based on maternal residential address, were estimated for different gestational periods using models based on satellite data. Epigenome-wide analysis to identify differentially methylated probes (DMPs) and regions (DMRs) was conducted, followed by a pathway analysis and replication analysis in an second Piccolipiù dataset. Distributed lag models (DLMs) using weekly exposures were used to study the association of PM₁₀ exposure across pregnancy with telomere length, as well as with the DMPs that showed robust associations. Gestational PM₁₀ exposure was associated with the DNA methylation of more than 250 unique DMPs, most of them identified in early gestation, and 1 DMR. Out of 151 DMPs available in the replication dataset, ten DMPs showed robust associations: eight were associated with exposure during early gestation and 2 with exposure during the whole pregnancy. These exposure windows were supported by the DLM analysis. The PM₁₀ exposure between 15th and 20th gestational week seem to be associated with shorter telomeres at birth, while exposure between 24th and 29th was associated with longer telomeres. The early pregnancy period is a potential critical window during which PM₁₀ exposure can influence cord blood DNA methylation. The results from the TL analysis were consistent with previous findings and merit further exploration in future studies. The study underlines the importance of considering gestational windows outside of the predefined trimesters that may not always overlap with biologically relevant windows of exposure.
    Schlagwörter DNA methylation ; air pollution ; blood ; data collection ; disease susceptibility ; maternal exposure ; pregnancy ; remote sensing ; research ; telomeres
    Sprache Englisch
    Erscheinungsverlauf 2022-06
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.112717
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  8. Artikel ; Online: Associations between plasma levels of brominated flame retardants and methylation of DNA from peripheral blood: A cross-sectional study in a cohort of French women.

    Omichessan, Hanane / Perduca, Vittorio / Polidoro, Silvia / Kvaskoff, Marina / Truong, Thérèse / Cano-Sancho, German / Antignac, Jean-Philippe / Baglietto, Laura / Mancini, Francesca Romana / Severi, Gianluca

    Environmental research

    2022  Band 210, Seite(n) 112788

    Abstract: Background: Brominated flame retardants (BFRs) are organic compounds that are widespread in the environment. Because of their persistence, they are able to bioaccumulate with major impacts on human health. It has been hypothesized that the effect of ... ...

    Abstract Background: Brominated flame retardants (BFRs) are organic compounds that are widespread in the environment. Because of their persistence, they are able to bioaccumulate with major impacts on human health. It has been hypothesized that the effect of BFRs on human health is mediated by alterations of DNA methylation.
    Objective: The aim of this study was to examine the association between methylation of DNA extracted from peripheral blood and circulating levels of BFRs measured in plasma.
    Methods: We conducted a methylation wide association study on 336 blood samples from a study within the E3N (Etude Epidémiologique auprès de femmes de l'Education Nationale) cohort, a long-term longitudinal cohort of French women. DNA methylation at more than 850 000 cytosine-guanine dinucleotide (CpG) sites was measured with the Illumina Infinium HumanMethylation - EPIC BeadChip. Circulating levels of seven BFRs (BDE-28, BDE-47, BDE-99, BDE-100, BDE-153, BDE-154 and PBB-153) were measured by gas chromatography coupled to high-resolution mass spectrometry in plasma samples. The association between DNA methylation and BFRs plasma levels was assessed through linear mixed-effects models followed by gene-set enrichment analyses (GSEA).
    Results: We identified 253 CpG sites whose methylation levels were significantly associated with exposure to BFRs after Bonferroni correction. For 50 of these CpGs the p-values were less than 2.2x10
    Conclusions: Exposure to BFRs appears to be related to numerous alterations in DNA methylation. These findings, if replicated in independent studies, provide insights into the biological and health effects of BFRs.
    Mesh-Begriff(e) Cross-Sectional Studies ; DNA ; DNA Methylation ; Female ; Flame Retardants/analysis ; Gas Chromatography-Mass Spectrometry ; Halogenated Diphenyl Ethers/analysis ; Humans ; Methylation
    Chemische Substanzen Flame Retardants ; Halogenated Diphenyl Ethers ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2022-02-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
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    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.112788
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  9. Artikel ; Online: Prenatal exposure to PM

    Isaevska, Elena / Fiano, Valentina / Asta, Federica / Stafoggia, Massimo / Moirano, Giovenale / Popovic, Maja / Pizzi, Costanza / Trevisan, Morena / De Marco, Laura / Polidoro, Silvia / Gagliardi, Luigi / Rusconi, Franca / Brescianini, Sonia / Nisticò, Lorenza / Stazi, Maria Antonietta / Ronfani, Luca / Porta, Daniela / Richiardi, Lorenzo

    Environmental research

    2022  Band 209, Seite(n) 112717

    Abstract: Background: Air pollution exposure in pregnancy can cause molecular level alterations that might influence later disease susceptibility.: Objectives: We investigated DNA methylation (DNAm) and telomere length (TL) in the cord blood in relation to ... ...

    Abstract Background: Air pollution exposure in pregnancy can cause molecular level alterations that might influence later disease susceptibility.
    Objectives: We investigated DNA methylation (DNAm) and telomere length (TL) in the cord blood in relation to gestational PM
    Methods: Cord blood epigenome-wide DNAm (N = 384) and TL (N = 500) were measured in children of the Italian birth cohort Piccolipiù, using the Infinium Methylation EPIC BeadChip and qPCR, respectively. PM
    Results: Gestational PM
    Discussion: The early pregnancy period is a potential critical window during which PM
    Mesh-Begriff(e) Child ; DNA Methylation ; Female ; Fetal Blood ; Humans ; Infant, Newborn ; Maternal Exposure/adverse effects ; Pregnancy ; Prenatal Exposure Delayed Effects/chemically induced ; Prenatal Exposure Delayed Effects/genetics ; Telomere
    Sprache Englisch
    Erscheinungsdatum 2022-01-19
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2022.112717
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  10. Artikel ; Online: Cys34 Adductomics Links Colorectal Cancer with the Gut Microbiota and Redox Biology.

    Grigoryan, Hasmik / Schiffman, Courtney / Gunter, Marc J / Naccarati, Alessio / Polidoro, Silvia / Dagnino, Sonia / Dudoit, Sandrine / Vineis, Paolo / Rappaport, Stephen M

    Cancer research

    2019  Band 79, Heft 23, Seite(n) 6024–6031

    Abstract: Chronic inflammation is an established risk factor for colorectal cancer. To study reactive products of gut inflammation and redox signaling on colorectal cancer development, we used untargeted adductomics to detect adduct features in prediagnostic serum ...

    Abstract Chronic inflammation is an established risk factor for colorectal cancer. To study reactive products of gut inflammation and redox signaling on colorectal cancer development, we used untargeted adductomics to detect adduct features in prediagnostic serum from the EPIC Italy cohort. We focused on modifications to Cys34 in human serum albumin, which is responsible for scavenging small reactive electrophiles that might initiate cancers. Employing a combination of statistical methods, we selected seven Cys34 adducts associated with colorectal cancer, as well as body mass index (BMI; a well-known risk factor). Five adducts were more abundant in colorectal cancer cases than controls and clustered with each other, suggesting a common pathway. Because two of these adducts were Cys34 modifications by methanethiol, a microbial-human cometabolite, and crotonaldehyde, a product of lipid peroxidation, these findings further implicate infiltration of gut microbes into the intestinal mucosa and the corresponding inflammatory response as causes of colorectal cancer. The other two associated adducts were Cys34 disulfides of homocysteine that were less abundant in colorectal cancer cases than controls and may implicate homocysteine metabolism as another causal pathway. The selected adducts and BMI ranked higher as potentially causal factors than variables previously associated with colorectal cancer (smoking, alcohol consumption, physical activity, and total meat consumption). Regressions of case-control differences in adduct levels on days to diagnosis showed no statistical evidence that disease progression, rather than causal factors at recruitment, contributed to the observed differences. These findings support the hypothesis that infiltration of gut microbes into the intestinal mucosa and the resulting inflammation are causal factors for colorectal cancer. SIGNIFICANCE: Infiltration of gut microbes into the intestinal mucosa and the resulting inflammation are causal factors for colorectal cancer.
    Mesh-Begriff(e) Adult ; Aldehydes/chemistry ; Aldehydes/metabolism ; Case-Control Studies ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/immunology ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/pathology ; Cysteine/chemistry ; Cysteine/metabolism ; Female ; Follow-Up Studies ; Gastrointestinal Microbiome/immunology ; Humans ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Intestinal Mucosa/pathology ; Male ; Middle Aged ; Oxidation-Reduction ; Serum Albumin, Human/chemistry ; Serum Albumin, Human/metabolism ; Sulfhydryl Compounds/chemistry ; Sulfhydryl Compounds/metabolism
    Chemische Substanzen Aldehydes ; Sulfhydryl Compounds ; methylmercaptan (2X8406WW9I) ; 2-butenal (9G72074TUW) ; Cysteine (K848JZ4886) ; Serum Albumin, Human (ZIF514RVZR)
    Sprache Englisch
    Erscheinungsdatum 2019-10-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-19-1529
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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