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  1. Article ; Online: IL-6: Relevance for immunopathology of SARS-CoV-2.

    Gubernatorova, E O / Gorshkova, E A / Polinova, A I / Drutskaya, M S

    Cytokine & growth factor reviews

    2020  Volume 53, Page(s) 13–24

    Abstract: COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to ... ...

    Abstract COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics.
    MeSH term(s) Antibodies, Monoclonal, Humanized/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/immunology ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/mortality ; Coronavirus Infections/pathology ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/pathology ; Cytokine Release Syndrome/virology ; Humans ; Interleukin-6/antagonists & inhibitors ; Interleukin-6/blood ; Interleukin-6/immunology ; Lung Diseases/immunology ; Lung Diseases/pathology ; Lung Diseases/virology ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/mortality ; Pneumonia, Viral/pathology ; SARS-CoV-2
    Chemical Substances Antibodies, Monoclonal, Humanized ; IL6 protein, human ; Interleukin-6 ; sarilumab (NU90V55F8I)
    Keywords covid19
    Language English
    Publishing date 2020-05-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1330534-7
    ISSN 1879-0305 ; 1359-6101
    ISSN (online) 1879-0305
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2020.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: IL-6: Relevance for immunopathology of SARS-CoV-2

    Gubernatorova, E O / Gorshkova, E A / Polinova, A I / Drutskaya, M S

    Cytokine Growth Factor Rev

    Abstract: COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to ... ...

    Abstract COVID-19 mortality is strongly associated with the development of severe pneumonia and acute respiratory distress syndrome with the worst outcome resulting in cytokine release syndrome and multiorgan failure. It is becoming critically important to identify at the early stage of the infection those patients who are prone to develop the most adverse effects. Elevated systemic interleukin-6 levels in patients with COVID-19 are considered as a relevant parameter in predicting most severe course of disease and the need for intensive care. This review discusses the mechanisms by which IL-6 may possibly contribute to disease exacerbation and the potential of therapeutic approaches based on anti-IL-6 biologics.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #324437
    Database COVID19

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  3. Article ; Online: IL-6

    Gubernatorova, E.O. / Gorshkova, E.A. / Polinova, A.I. / Drutskaya, M.S.

    Cytokine & Growth Factor Reviews

    Relevance for immunopathology of SARS-CoV-2

    2020  Volume 53, Page(s) 13–24

    Keywords Immunology ; General Biochemistry, Genetics and Molecular Biology ; Immunology and Allergy ; Endocrinology, Diabetes and Metabolism ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1330534-7
    ISSN 1359-6101
    ISSN 1359-6101
    DOI 10.1016/j.cytogfr.2020.05.009
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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