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  1. AU="Polishchuk, Ilya"
  2. AU=Jalali Rostam
  3. AU="Baek, Kyoung Eun"
  4. AU="Gordon, Jay E"
  5. AU="Huang, Mingsheng"
  6. AU="Karkowski, L"
  7. AU="Rana, Punam"
  8. AU=Kawasaki Shunsuke
  9. AU="Oliveira-Júnior, Gersiel"
  10. AU="Alvarado-Aguilar, Pablo"
  11. AU="Kyrin R. Hanning" AU="Kyrin R. Hanning"
  12. AU="Teixidor, Francesc"
  13. AU=Minhas Jasmit
  14. AU="Poe, Alyssa"
  15. AU="Ni, Bo"
  16. AU="Vemuri, Kiranmayi"
  17. AU="Hernández-Wolters, Benjamin"
  18. AU="Chobanova, Veronika"
  19. AU="Otten, Gisela"
  20. AU="Elhence, Anshuman"
  21. AU="Tinneberg, H-R"
  22. AU="Puro, Neeraj"
  23. AU=Yang Chi-Fu Jeffrey
  24. AU="Oliveira, Giuliana S"
  25. AU="Maria Cecilia Jocson"
  26. AU="Tollman, Stephen"
  27. AU="Cherry, Katie E."
  28. AU="Nazet, Ute"
  29. AU="Kranzer, K"
  30. AU="Avelino, Samuel"
  31. AU="Sun, Xiang-Dong"
  32. AU="Vogl, Thomas J."
  33. AU="Johnson, C R"
  34. AU="Gil-Pérez, Pablo"
  35. AU="Donno, Federica"
  36. AU="Vom Saal, Frederick S."
  37. AU="Gazzana, S"
  38. AU="Viswanadha, Vijaya P"
  39. AU="Anastasi, G A"
  40. AU="Romerosa, Antonio"
  41. AU=Gupta Gaorav P
  42. AU="Fernández-Susavila, Héctor"

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  1. Artikel: Epidemiology of Acute Pancreatitis in Southern Israel: A Retrospective Study.

    Polishchuk, Ilya / Halperin, Demian / Algedafy, Ahmed / Delgado, Jorge-Shmuel / Zamir, Mariana / Zamir, Doron

    The Israel Medical Association journal : IMAJ

    2020  Band 22, Heft 5, Seite(n) 310–314

    Abstract: Background: There is a lack of information regarding acute pancreatitis in Israel. However, the most prevalent worldwide etiologic causes of acute pancreatitis are biliary stones and alcohol abuse.: Objectives: To delineate the prevalence, main ... ...

    Abstract Background: There is a lack of information regarding acute pancreatitis in Israel. However, the most prevalent worldwide etiologic causes of acute pancreatitis are biliary stones and alcohol abuse.
    Objectives: To delineate the prevalence, main causes, rate of recurrence, mortality, and complications of acute pancreatitis in southern Israel.
    Methods: In this retrospective study medical files of all hospitalized patients diagnosed with acute pancreatitis during a 13-year period were reviewed.
    Results: The study comprised 602 patients with acute pancreatitis (120/100,000 patients or 1.2/1000 admissions). The main causes were: biliary stones (41.5%), alcohol (8.8%), and drugs (8.3%). Disothiazide was the most common drug associated with acute pancreatitis followed by sitagliptin, angiotensin converting enzyme (ACE) inhibitors, and simvastatin. Undetermined etiology made up 33.6% of the cases. Recurrence rate was 33.8% (alcohol 3.7%, hypertriglyceridemia 1.8%). This finding had no implications on mortality rate, which was stable at 4.3%. Bilateral pleural effusion, advanced computed tomography severity index (CTSI) grading, older age, and being single were found to be poor prognostic predictive factors.
    Conclusions: Biliary pancreatitis is the main cause of acute pancreatitis in southern Israel, similar to the rest of the world, and constitutes a much more common etiology than alcohol. Furthermore, drug-induced pancreatitis is a common etiology, with disothiazide being the most common drug associated with pancreatitis followed by ACE-Inhibitors, sitagliptin, and simvastatin. Recurrence of pancreatitis is common in this geographic area, and older age, advanced CTSI grading, bilateral pleural effusion, and being single are all poor prognostic predictive factors.
    Mesh-Begriff(e) Acute Disease ; Adult ; Aged ; Female ; Humans ; Israel/epidemiology ; Male ; Middle Aged ; Pancreatitis/complications ; Pancreatitis/epidemiology ; Pancreatitis/etiology ; Prevalence ; Recurrence ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2020-05-07
    Erscheinungsland Israel
    Dokumenttyp Journal Article
    ZDB-ID 2008291-5
    ISSN 1565-1088 ; 0021-2180
    ISSN 1565-1088 ; 0021-2180
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Safety and rapid response of dabrafenib and trametinib therapy during hyperbilirubinemia in metastatic melanoma.

    Shalata, Walid / Steckbeck, Rachel / Polishchuk, Ilya / Cohen, Ahron Yehonatan / Rouvinov, Keren / Tokar, Margarita / Abu Jama, Ashraf / Abu Saleh, Omar / Sheva, Kim / Yakobson, Alexander

    Frontiers in oncology

    2023  Band 13, Seite(n) 1102330

    Abstract: This case report describes the occurrence of hyperbilirubinemia as a complication of metastatic melanoma. A 72-year-old male patient was diagnosed with BRAF V600E-mutated melanoma with metastases in the liver, lymph nodes, lungs, pancreas, and stomach. ... ...

    Abstract This case report describes the occurrence of hyperbilirubinemia as a complication of metastatic melanoma. A 72-year-old male patient was diagnosed with BRAF V600E-mutated melanoma with metastases in the liver, lymph nodes, lungs, pancreas, and stomach. Due to a lack of clinical data and specific guidelines for the treatment of mutated metastatic melanoma patients with hyperbilirubinemia, a conference of specialists debated between initiating treatment or providing supportive care. Ultimately, the patient was started on the combination therapy of dabrafenib and trametinib. This treatment resulted in a significant therapeutic response
    Sprache Englisch
    Erscheinungsdatum 2023-02-14
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1102330
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Chaotic Dynamics in a Quantum Fermi-Pasta-Ulam Problem.

    Burin, Alexander L / Maksymov, Andrii O / Schmidt, Ma'ayan / Polishchuk, Il'ya Ya

    Entropy (Basel, Switzerland)

    2019  Band 21, Heft 1

    Abstract: We investigate the emergence of chaotic dynamics in a quantum Fermi-Pasta-Ulam problem for anharmonic vibrations in atomic chains applying semi-quantitative analysis of resonant interactions complemented by exact diagonalization numerical studies. The ... ...

    Abstract We investigate the emergence of chaotic dynamics in a quantum Fermi-Pasta-Ulam problem for anharmonic vibrations in atomic chains applying semi-quantitative analysis of resonant interactions complemented by exact diagonalization numerical studies. The crossover energy separating chaotic high energy phase and localized (integrable) low energy phase is estimated. It decreases inversely proportionally to the number of atoms until approaching the quantum regime where this dependence saturates. The chaotic behavior appears at lower energies in systems with free or fixed ends boundary conditions compared to periodic systems. The applications of the theory to realistic molecules are discussed.
    Sprache Englisch
    Erscheinungsdatum 2019-01-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2014734-X
    ISSN 1099-4300 ; 1099-4300
    ISSN (online) 1099-4300
    ISSN 1099-4300
    DOI 10.3390/e21010051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Sex Differences in Infective Endocarditis.

    Polishchuk, Ilya / Stavi, Vered / Awesat, Jenan / Ben Baruch Golan, Yael / Bartal, Carmi / Sagy, Iftach / Jotkowitz, Alan / Barski, Leonid

    The American journal of the medical sciences

    2020  Band 361, Heft 1, Seite(n) 83–89

    Abstract: Background: The impact of sex on the presentation, etiology, and outcomes of infective endocarditis (IE) has not been adequately studied. The aim of the present research was to analyze the impact of sex on the presentation, etiology, and outcomes of IE.! ...

    Abstract Background: The impact of sex on the presentation, etiology, and outcomes of infective endocarditis (IE) has not been adequately studied. The aim of the present research was to analyze the impact of sex on the presentation, etiology, and outcomes of IE.
    Methods: We performed a retrospective study of 214 adult patients (131 male and 83 female) with IE. All cases of IE were reviewed by two investigators- both senior physicians in internal medicine. Two groups of patients were compared: male and female patients with IE. The primary outcome was in-hospital mortality.
    Results: We found significant differences in etiologic factors of IE in male and female patients. Microbiologic etiology differences between male and female groups of patients were in coagulase negative staphylococcus (15.0% in male vs 3.8% in female groups, P = 0.011), and culture negative endocarditis (8.7% in male vs 23.8% in female groups, P = 0.004). We did not find a difference in the primary outcome between the two groups; however, all-cause mortality was significantly higher in the female group as compared to the male group (26 [31.3] vs 22 [16.8], P = 0.018).
    Conclusions: We found that sex may have important role in both the microbial profile and the patient's outcome with IE.
    Mesh-Begriff(e) Adult ; Aged ; Aged, 80 and over ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/microbiology ; Female ; Gram-Negative Bacteria/physiology ; Humans ; Incidence ; Israel/epidemiology ; Male ; Middle Aged ; Retrospective Studies ; Sex Factors ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2020-08-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2020.08.021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Nivolumab-induced systemic capillary leak syndrome as an ultra rare life-threatening phenomenon of late toxicity and intravenous immunoglobulin efficacy.

    Polishchuk, Ilya / Yakobson, Alexander / Zemel, Melanie / A Sharb, Adam / Shalata, Walid / Rosenberg, Eli / A Kian, Tawfeek / Alguayn, Farouq / Peled, Nir / Rouvinov, Keren / Alguayn, Wafeek / Kian, Waleed

    Immunotherapy

    2021  Band 13, Heft 10, Seite(n) 807–811

    Abstract: Systemic capillary leak syndrome (SCLS) is a life-threatening disease. It is characterized by severe capillary hyperpermeability to proteins resulting in hemoconcentration, hypoalbuminemia and hypovolemic shock. Its treatment remains supportive, and the ... ...

    Abstract Systemic capillary leak syndrome (SCLS) is a life-threatening disease. It is characterized by severe capillary hyperpermeability to proteins resulting in hemoconcentration, hypoalbuminemia and hypovolemic shock. Its treatment remains supportive, and the prognosis is generally poor. We report on a 51-year old male with melanoma treated with nivolumab for 1 year. 1 month following the completion of the treatment, the patient presented with signs of hypovolemic shock, anasarca, hemoconcentration and hypoalbuminemia. After excluding other diseases, a diagnosis of nivolumab-induced systemic capillary leak syndrome was made. A high dose of intravenous steroid therapy was promptly initiated without any significant clinical improvement. Intravenous immunoglobulin therapy was then administered with normalization of blood pressure, hemoconcentration and complete resolution of anasarca. Intravenous immunoglobulin should be considered a first-line treatment option for this rare phenomenon.
    Mesh-Begriff(e) Adrenal Cortex Hormones/therapeutic use ; Capillary Leak Syndrome/chemically induced ; Capillary Leak Syndrome/immunology ; Capillary Leak Syndrome/therapy ; Fluid Therapy/methods ; Humans ; Immune Checkpoint Inhibitors/adverse effects ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Middle Aged ; Nivolumab/adverse effects ; Treatment Outcome
    Chemische Substanzen Adrenal Cortex Hormones ; Immune Checkpoint Inhibitors ; Immunoglobulins, Intravenous ; Nivolumab (31YO63LBSN)
    Sprache Englisch
    Erscheinungsdatum 2021-05-09
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2020-0335
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Factors associated with drug survival of methotrexate and acitretin in patients with psoriasis.

    Shalom, Guy / Zisman, Devy / Harman-Boehm, Ilana / Biterman, Haim / Greenberg-Dotan, Sari / Polishchuk, Ilya / Moser, Hadas / Freud, Tamar / Feldhamer, Ilan / Cohen, Arnon D

    Acta dermato-venereologica

    2015  Band 95, Heft 8, Seite(n) 973–977

    Abstract: Drug survival has recently become an important clinical issue in psoriasis. However, there has been little research into factors associated with drug survival of methotrexate and acitretin. The aim of this study was to investigate factors associated with ...

    Abstract Drug survival has recently become an important clinical issue in psoriasis. However, there has been little research into factors associated with drug survival of methotrexate and acitretin. The aim of this study was to investigate factors associated with drug survival of methotrexate and acitretin treatment for psoriasis. Survival analysis was performed in patients who received methotrexate or acitretin for the treatment of psoriasis, drawn from the Clalit Health Services database. Investigated factors included demographic variables, obesity, metabolic syndrome, psoriatic arthritis, administration route and folic acid supplementation. Among 6,256 patients, factors associated with treatment drop-out were: younger age (p <0.001) and psoriatic arthritis (acitretin p < 0.001). For methotrexate, metabolic syndrome (p = 0.033), intramuscular administration route of injection (p <0.001) and lack of folic acid supplementation (p <0.001) were associated with treatment drop-out. In patients with psoriasis, some ancillary factors may modify the drug survival of acitretin and methotrexate.
    Mesh-Begriff(e) Acitretin/administration & dosage ; Acitretin/therapeutic use ; Administration, Oral ; Adult ; Age Factors ; Aged ; Arthritis, Psoriatic/complications ; Databases, Factual ; Dermatologic Agents/adverse effects ; Dermatologic Agents/therapeutic use ; Drug Prescriptions/statistics & numerical data ; Female ; Folic Acid/therapeutic use ; Humans ; Israel ; Kaplan-Meier Estimate ; Keratolytic Agents/administration & dosage ; Keratolytic Agents/therapeutic use ; Male ; Medication Adherence ; Metabolic Syndrome/complications ; Methotrexate/administration & dosage ; Methotrexate/therapeutic use ; Middle Aged ; Psoriasis/complications ; Psoriasis/drug therapy
    Chemische Substanzen Dermatologic Agents ; Keratolytic Agents ; Folic Acid (935E97BOY8) ; Acitretin (LCH760E9T7) ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2015-11
    Erscheinungsland Sweden
    Dokumenttyp Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-2130
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Ui VI Zs.101: Hefte anzeigen Standort:
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