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  1. Article: Epidemiology of panic disorder and subthreshold panic symptoms in the Greek general population.

    Politis, S / Bellos, St / Hadjulis, M / Gournellis, R / Petrikis, P / Ploumpidis, D / Skapinakis, P

    Psychiatrike = Psychiatriki

    2020  Volume 31, Issue 3, Page(s) 201–215

    Abstract: Panic disorder (PD) is a common anxiety disorder with severe social and health consequences in the lives of individuals who suffer from it. General population studies that attempt to measure the prevalence of this disorder across the world suggest that a ...

    Abstract Panic disorder (PD) is a common anxiety disorder with severe social and health consequences in the lives of individuals who suffer from it. General population studies that attempt to measure the prevalence of this disorder across the world suggest that a 1.7% to 4.7 % of adults and adolescents suffer from Panic Disorder. In Greece, research analyzing the abovementioned matters is limited, and previous studies were put forward in small samples. The aim of the present study was to describe the prevalence and sociodemographic associations of panic disorder (PD) and related subthreshold panic symptoms in the general population of Greece and to appraise the comorbidity, use of services and impact on quality of life of these syndromes. This was a secondary analysis of the 2009-2010 psychiatric morbidity survey carried out in a representative sample of the Greek general population (4894 participants living in private households, 18-70 years, response rate 54%). Psychiatric disorders were assessed with the computerized version of the revised Clinical Interview Schedule (CIS-R). Quality of life was assessed with the EuroQoL EQ-5D generic instrument. The utilization of health services was examined by making relevant questions. Finally, direct questions were used to assess sociodemographic and socioeconomic factors According to our findings, 1.87% of the participants (95% confidence interval [CI]: 1.50-2.26%) met criteria for PD and 1.61% met criteria for subclinical PD (95% CI: 1.26-1.96%). There was a clear female preponderance for both PD (p=0.001) and Sub-PD (p=0.01). In addition, 3.48% of the participants reported having experienced panic attacks during the past week (95% confidence interval [CI]: 2.98-4.01%). PD or subclinical PD was independently associated with a limited number of sociodemographic and socioeconomic variables especially after the adjusted analysis. Both panic related conditions involved significant reductions in quality of life and elevated utilization of health services for both medical and psychological reasons in comparison to healthy participants. In conclusion, PD and subclinical panic symptoms were common in the general Greek population with substantial comorbidity and impaired quality of life. The observed use of the general and psychological health services among adults with panic symptoms and its temporal and economic consequences calls for more efficient diagnostic and treatment policies.
    MeSH term(s) Comorbidity ; Female ; Greece/epidemiology ; Humans ; Male ; Mental Health Services/statistics & numerical data ; Middle Aged ; Panic Disorder/diagnosis ; Panic Disorder/epidemiology ; Panic Disorder/psychology ; Panic Disorder/therapy ; Patient Acceptance of Health Care ; Prevalence ; Quality of Life ; Risk Factors ; Socioeconomic Factors ; Symptom Assessment/methods ; Symptom Assessment/statistics & numerical data
    Language English
    Publishing date 2020-10-21
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2653266-9
    ISSN 1105-2333
    ISSN 1105-2333
    DOI 10.22365/jpsych.2020.313.201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Type of hormonal treatment administered to induce vitellogenesis in European eel influences biochemical composition of eggs and yolk-sac larvae

    Benini, E. / Politis, S.N. / Nielsen, A. / Sørensen, S. R. / Tomkiewicz, J. / Engrola, S.

    Fish physiology and biochemistry. 2022 Feb., v. 48, no. 1

    2022  

    Abstract: Egg biochemical composition is among the main factors affecting offspring quality and survival during the yolk-sac stage, when larvae depend exclusively on yolk nutrients. These nutrients are primarily embedded in the developing oocytes during ... ...

    Abstract Egg biochemical composition is among the main factors affecting offspring quality and survival during the yolk-sac stage, when larvae depend exclusively on yolk nutrients. These nutrients are primarily embedded in the developing oocytes during vitellogenesis. In aquaculture, assisted reproduction procedures may be applied enabling gamete production. For the European eel (Anguilla anguilla), reproductive treatment involves administration of pituitary extracts from carp (CPE) or salmon (SPE) to induce and sustain vitellogenesis. In the present study, we compared the influence of CPE and SPE treatments on offspring quality and composition as well as nutrient utilization during the yolk-sac stage. Thus, dry weight, proximal composition (total lipid, total protein), free amino acids, and fatty acids were assessed in eggs and larvae throughout the yolk-sac stage, where body and oil-droplet area were measured to estimate growth rate, oil-droplet utilization, and oil-droplet utilization efficiency. The results showed that CPE females spawned eggs with higher lipid and free amino acid contents. However, SPE females produced more buoyant eggs with higher fertilization rate as well as larger larvae with more energy reserves (estimated as oil-droplet area). Overall, general patterns of nutrient utilization were detected, such as the amount of total lipid and monounsaturated fatty acids decreasing from the egg stage and throughout the yolk-sac larval stage. On the contrary, essential fatty acids and free amino acids were retained. Notably, towards the end of the yolk-sac stage, the proximal composition and biometry of surviving larvae, from both treatments, were similar.
    Keywords Anguilla anguilla ; aquaculture ; biometry ; carp ; eggs ; energy ; free amino acids ; larvae ; nutrient utilization ; oocytes ; progeny ; protein content ; salmon ; vitellogenesis ; yolk sac
    Language English
    Dates of publication 2022-02
    Size p. 185-200.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 292907-7
    ISSN 1573-5168 ; 0920-1742
    ISSN (online) 1573-5168
    ISSN 0920-1742
    DOI 10.1007/s10695-021-01042-4
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Early and abrupt salinity reduction impacts European eel larval culture.

    Syropoulou, E / Benini, E / Sørensen, S R / Butts, I A E / Tomkiewicz, J / Politis, S N

    Fish physiology and biochemistry

    2022  Volume 48, Issue 2, Page(s) 355–366

    Abstract: Reducing water salinity towards iso-osmotic conditions is a common practice applied in euryhaline fish farming to limit osmoregulation costs and enhance growth. In this respect, the present study investigated the timing of salinity reduction in an abrupt ...

    Abstract Reducing water salinity towards iso-osmotic conditions is a common practice applied in euryhaline fish farming to limit osmoregulation costs and enhance growth. In this respect, the present study investigated the timing of salinity reduction in an abrupt manner during European eel (Anguilla anguilla) larval culture by examining associated impacts on morphological and molecular levels. Larvae from 3 different parental combinations (families) were reared at constant 36 psu for 6 days (control) or subjected to a direct reduction to 18 psu on 1, 2, or 3 days post-hatch. Overall, salinity reduction enhanced growth and survival, resulting from more efficient energy resource utilization. In the control group, expression of growth-related igf2 remained constant, demonstrating a steady growth progression, while igf1 expression increased over time only for the salinity reduced treatments, potentially qualifying as a useful biomarker for growth performance. Even though each parental combination seems to have a different capacity to cope with salinity alterations, as observed by family-driven water-transport-related aquaporin (aqp1, aqp3) gene expression, it could be inferred that the abrupt salinity change is generally not stressful, based on non-upregulated heat shock proteins (hsp70, hsp90). However, the applied salinity reduction (irrespective of timing) induced the development of pericardial edema. As such, we conclude that despite the positive effect of salinity reduction on early growth and survival, the long-term benefit for eel larval culture lies in establishing a protocol for salinity reduction, at a precise developmental time point, without causing pericardial malformations.
    MeSH term(s) Anguilla/genetics ; Animals ; Humans ; Larva ; Osmoregulation ; Salinity ; Water/metabolism
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 292907-7
    ISSN 1573-5168 ; 0920-1742
    ISSN (online) 1573-5168
    ISSN 0920-1742
    DOI 10.1007/s10695-022-01056-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Type of hormonal treatment administered to induce vitellogenesis in European eel influences biochemical composition of eggs and yolk-sac larvae.

    Benini, E / Politis, S N / Nielsen, A / Sørensen, S R / Tomkiewicz, J / Engrola, S

    Fish physiology and biochemistry

    2022  Volume 48, Issue 1, Page(s) 185–200

    Abstract: Egg biochemical composition is among the main factors affecting offspring quality and survival during the yolk-sac stage, when larvae depend exclusively on yolk nutrients. These nutrients are primarily embedded in the developing oocytes during ... ...

    Abstract Egg biochemical composition is among the main factors affecting offspring quality and survival during the yolk-sac stage, when larvae depend exclusively on yolk nutrients. These nutrients are primarily embedded in the developing oocytes during vitellogenesis. In aquaculture, assisted reproduction procedures may be applied enabling gamete production. For the European eel (Anguilla anguilla), reproductive treatment involves administration of pituitary extracts from carp (CPE) or salmon (SPE) to induce and sustain vitellogenesis. In the present study, we compared the influence of CPE and SPE treatments on offspring quality and composition as well as nutrient utilization during the yolk-sac stage. Thus, dry weight, proximal composition (total lipid, total protein), free amino acids, and fatty acids were assessed in eggs and larvae throughout the yolk-sac stage, where body and oil-droplet area were measured to estimate growth rate, oil-droplet utilization, and oil-droplet utilization efficiency. The results showed that CPE females spawned eggs with higher lipid and free amino acid contents. However, SPE females produced more buoyant eggs with higher fertilization rate as well as larger larvae with more energy reserves (estimated as oil-droplet area). Overall, general patterns of nutrient utilization were detected, such as the amount of total lipid and monounsaturated fatty acids decreasing from the egg stage and throughout the yolk-sac larval stage. On the contrary, essential fatty acids and free amino acids were retained. Notably, towards the end of the yolk-sac stage, the proximal composition and biometry of surviving larvae, from both treatments, were similar.
    MeSH term(s) Amino Acids/chemistry ; Anguilla ; Animals ; Cell Extracts ; Fatty Acids/chemistry ; Female ; Hormones/pharmacology ; Larva ; Ovum/chemistry ; Pituitary Gland ; Vitellogenesis/drug effects ; Yolk Sac/chemistry
    Chemical Substances Amino Acids ; Cell Extracts ; Fatty Acids ; Hormones
    Language English
    Publishing date 2022-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 292907-7
    ISSN 1573-5168 ; 0920-1742
    ISSN (online) 1573-5168
    ISSN 0920-1742
    DOI 10.1007/s10695-021-01042-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Early and abrupt salinity reduction impacts European eel larval culture

    Syropoulou, E. / Benini, E. / Sørensen, S. R. / Butts, I. A. E. / Tomkiewicz, J. / Politis, S. N.

    Fish physiology and biochemistry. 2022 Apr., v. 48, no. 2

    2022  

    Abstract: Reducing water salinity towards iso-osmotic conditions is a common practice applied in euryhaline fish farming to limit osmoregulation costs and enhance growth. In this respect, the present study investigated the timing of salinity reduction in an abrupt ...

    Abstract Reducing water salinity towards iso-osmotic conditions is a common practice applied in euryhaline fish farming to limit osmoregulation costs and enhance growth. In this respect, the present study investigated the timing of salinity reduction in an abrupt manner during European eel (Anguilla anguilla) larval culture by examining associated impacts on morphological and molecular levels. Larvae from 3 different parental combinations (families) were reared at constant 36 psu for 6 days (control) or subjected to a direct reduction to 18 psu on 1, 2, or 3 days post-hatch. Overall, salinity reduction enhanced growth and survival, resulting from more efficient energy resource utilization. In the control group, expression of growth-related igf2 remained constant, demonstrating a steady growth progression, while igf1 expression increased over time only for the salinity reduced treatments, potentially qualifying as a useful biomarker for growth performance. Even though each parental combination seems to have a different capacity to cope with salinity alterations, as observed by family-driven water-transport-related aquaporin (aqp1, aqp3) gene expression, it could be inferred that the abrupt salinity change is generally not stressful, based on non-upregulated heat shock proteins (hsp70, hsp90). However, the applied salinity reduction (irrespective of timing) induced the development of pericardial edema. As such, we conclude that despite the positive effect of salinity reduction on early growth and survival, the long-term benefit for eel larval culture lies in establishing a protocol for salinity reduction, at a precise developmental time point, without causing pericardial malformations.
    Keywords Anguilla anguilla ; aquaporins ; biomarkers ; edema ; eel ; energy ; euryhaline species ; gene expression ; growth performance ; heat stress ; osmoregulation ; pericardium ; water salinity
    Language English
    Dates of publication 2022-04
    Size p. 355-366.
    Publishing place Springer Netherlands
    Document type Article
    ZDB-ID 292907-7
    ISSN 1573-5168 ; 0920-1742
    ISSN (online) 1573-5168
    ISSN 0920-1742
    DOI 10.1007/s10695-022-01056-6
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Prevalence, comorbidity, quality of life and use of services of obsessive-compulsive disorder and subthreshold obsessive-compulsive symptoms in the general adult population of Greece.

    Skapinakis, Petros / Politis, Spyridon / Karampas, Andreas / Petrikis, Petros / Mavreas, Venetsanos

    International journal of psychiatry in clinical practice

    2019  Volume 23, Issue 3, Page(s) 215–224

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Adolescent ; Adult ; Aged ; Anxiety Disorders/epidemiology ; Case-Control Studies ; Comorbidity ; Cross-Sectional Studies ; Depressive Disorder/epidemiology ; Female ; Greece/epidemiology ; Humans ; Male ; Middle Aged ; Obsessive-Compulsive Disorder/epidemiology ; Obsessive-Compulsive Disorder/psychology ; Patient Acceptance of Health Care/statistics & numerical data ; Prevalence ; Prodromal Symptoms ; Quality of Life ; Sex Characteristics ; Young Adult
    Language English
    Publishing date 2019-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1465531-7
    ISSN 1471-1788 ; 1365-1501
    ISSN (online) 1471-1788
    ISSN 1365-1501
    DOI 10.1080/13651501.2019.1588327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Early and abrupt salinity reduction impacts European eel larval culture

    Syropoulou, E. / Benini, E. / Sørensen, S.R. / Butts, I.A.E. / Tomkiewicz, J. / Politis, S.N.

    Fish Physiology and Biochemistry

    2022  Volume 48, Issue 2

    Abstract: Reducing water salinity towards iso-osmotic conditions is a common practice applied in euryhaline fish farming to limit osmoregulation costs and enhance growth. In this respect, the present study investigated the timing of salinity reduction in an abrupt ...

    Abstract Reducing water salinity towards iso-osmotic conditions is a common practice applied in euryhaline fish farming to limit osmoregulation costs and enhance growth. In this respect, the present study investigated the timing of salinity reduction in an abrupt manner during European eel (Anguilla anguilla) larval culture by examining associated impacts on morphological and molecular levels. Larvae from 3 different parental combinations (families) were reared at constant 36 psu for 6 days (control) or subjected to a direct reduction to 18 psu on 1, 2, or 3 days post-hatch. Overall, salinity reduction enhanced growth and survival, resulting from more efficient energy resource utilization. In the control group, expression of growth-related igf2 remained constant, demonstrating a steady growth progression, while igf1 expression increased over time only for the salinity reduced treatments, potentially qualifying as a useful biomarker for growth performance. Even though each parental combination seems to have a different capacity to cope with salinity alterations, as observed by family-driven water-transport-related aquaporin (aqp1, aqp3) gene expression, it could be inferred that the abrupt salinity change is generally not stressful, based on non-upregulated heat shock proteins (hsp70, hsp90). However, the applied salinity reduction (irrespective of timing) induced the development of pericardial edema. As such, we conclude that despite the positive effect of salinity reduction on early growth and survival, the long-term benefit for eel larval culture lies in establishing a protocol for salinity reduction, at a precise developmental time point, without causing pericardial malformations.
    Keywords Anguilla anguilla ; Early life history ; Osmoregulation ; Pericardial edema ; Physiology
    Subject code 710
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 292907-7
    ISSN 1573-5168 ; 0920-1742
    ISSN (online) 1573-5168
    ISSN 0920-1742
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Development of rapidly dissolving pellets within the Quality by Design approach.

    Karatzas, A A / Politis, S N / Rekkas, D M

    Drug development and industrial pharmacy

    2017  Volume 43, Issue 5, Page(s) 770–779

    Abstract: The purpose of this study was the development of novel, fast disintegrating, effervescent pellets by employing the direct pelletization technique as a single step process. In line with the Quality by Design (QbD) regulatory framework, statistical ... ...

    Abstract The purpose of this study was the development of novel, fast disintegrating, effervescent pellets by employing the direct pelletization technique as a single step process. In line with the Quality by Design (QbD) regulatory framework, statistical experimental design was extensively applied to correlate significant formulation and process variables with the critical quality attributes of the product. Pellets were studied with regards to sphericity, size and size distribution. In contrast to the existing multiparticulate platforms, this development integrated only water-soluble excipients to facilitate the multifunctional use of the final dosage form. The application of a screening fractional factorial design augmented to a full factorial design set the roadmap for the rational selection of the composition and process parameters, revealing in parallel the positive contribution of the powder feeder on the CQAs, when the critical process and formulation factors were properly adjusted. The response surface methodology was exploited for the final process optimization phase, which allowed the construction of appropriate mathematical models connecting the input variables and the CQAs under study. The implementation of the desirability function, lead to the optimum formulation and process settings for the production of pellets with narrow size distribution and geometric mean diameter of approximately 800 μm. In conclusion, using a lean approach supported by design of experiments (DoE) techniques within the QbD framework, a novel multifunctional formulation platform has been developed.
    MeSH term(s) Chemistry, Pharmaceutical/methods ; Drug Implants/chemistry ; Excipients/chemistry ; Models, Theoretical ; Particle Size ; Powders/chemistry ; Solubility ; Technology, Pharmaceutical/methods ; Water/chemistry
    Chemical Substances Drug Implants ; Excipients ; Powders ; Water (059QF0KO0R)
    Language English
    Publishing date 2017-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 751874-2
    ISSN 1520-5762 ; 0363-9045
    ISSN (online) 1520-5762
    ISSN 0363-9045
    DOI 10.1080/03639045.2016.1220576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book: Risikomanagement in der Lieferantenbewertung

    Politis, Sotiris

    (Dienstleistungsmanagement in Theorie und Praxis ; 3)

    2010  

    Author's details Sotiris Politis
    Series title Dienstleistungsmanagement in Theorie und Praxis ; 3
    Keywords Risikomanagement ; Lieferantenbeurteilung ; Lieferantenmanagement
    Language German
    Size VIII, 115 S., graph. Darst., 24 cm
    Document type Book
    Note Literaturverz. S. [105] - 115
    ISBN 9783832523220 ; 9783832523022 ; 3832523227 ; 3832523022
    Database ECONomics Information System

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  10. Article: Epidemiology of Alcohol Use in Late Adolescence in Greece and Comorbidity with Depression and Other Common Mental Disorders.

    Michalis, Grigorios / Bellos, Stefanos / Politis, Spyridon / Magklara, Konstantina / Petrikis, Petros / Skapinakis, Petros

    Depression research and treatment

    2019  Volume 2019, Page(s) 5871857

    Abstract: Background: The aim of the current study was to examine the prevalence and associations of hazardous alcohol use with sociodemographic variables and its comorbidity with depression and other common mental disorders in a sample of Greek adolescents ... ...

    Abstract Background: The aim of the current study was to examine the prevalence and associations of hazardous alcohol use with sociodemographic variables and its comorbidity with depression and other common mental disorders in a sample of Greek adolescents between 16 and 18 year old.
    Methods: We recruited 2431 adolescents attending 25 senior high schools in Greece. We assessed depressive and anxiety disorders using the computerized version of a fully-structured psychiatric interview (the revised Clinical Interview Schedule / CIS-R). Alcohol use was assessed using questions taken from a previous WHO school survey.
    Results: Approximately one-third of adolescents (overall: 30.7%, boys: 39.2%, girls: 21.9%, p < 0.001) consumed alcohol on a weekly basis. The experience of excessive consumption, leading to drunkenness at least two or more times in their lifetime, was reported by 15.39% of the adolescents (19.42% for the boys and 11.24% for the girls, p < 0.001). Frequent alcohol consumption and drunkenness were strongly associated with the presence of depression, all other anxiety disorders except panic disorder, current smoking, and lifetime cannabis use, lower school performance, bad or fair relationship with parents, and increased health services use.
    Conclusion: Alcohol use is highly prevalent among Greek adolescents. Special attention for the development of more focused preventive strategies should be paid to adolescents suffering from depression or other common mental disorders.
    Language English
    Publishing date 2019-09-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573947-5
    ISSN 2090-133X ; 2090-1321
    ISSN (online) 2090-133X
    ISSN 2090-1321
    DOI 10.1155/2019/5871857
    Database MEDical Literature Analysis and Retrieval System OnLINE

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