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  1. Article ; Online: Hypothermic Machine Perfusion in Liver Transplantation-A Randomised Trial and Beyond.

    Friend, Peter / Pollok, Joerg-Matthias

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10257

    MeSH term(s) Humans ; Liver ; Liver Transplantation ; Organ Preservation ; Perfusion ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2022-03-24
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10257
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  2. Article: The Current Role and Future Applications of Machine Perfusion in Liver Transplantation.

    Staubli, Sebastian M / Ceresa, Carlo D L / Pollok, Joerg M

    Bioengineering (Basel, Switzerland)

    2023  Volume 10, Issue 5

    Abstract: The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs. Currently, machine perfusion techniques have led to the improvement of the quality ... ...

    Abstract The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs. Currently, machine perfusion techniques have led to the improvement of the quality of marginal livers and to prolonged cold ischemia time and have allowed for the prediction of graft function through the analysis of the organ during perfusion, improving the rate of organ use. In the future, the implementation of organ modulation might expand the scope of machine perfusion beyond its current usage. The aim of this review was to provide an overview of the current clinical use of machine perfusion devices in liver transplantation and to provide a perspective for future clinical use, including therapeutic interventions in perfused donor liver grafts.
    Language English
    Publishing date 2023-05-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2746191-9
    ISSN 2306-5354
    ISSN 2306-5354
    DOI 10.3390/bioengineering10050593
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  3. Article ; Online: Machine perfusion of the liver: applications in transplantation and beyond.

    Ceresa, Carlo D L / Nasralla, David / Pollok, Joerg-Matthias / Friend, Peter J

    Nature reviews. Gastroenterology & hepatology

    2022  Volume 19, Issue 3, Page(s) 199–209

    Abstract: The shortage of donor livers considered suitable for transplantation has driven the development of novel methods for organ preservation and reconditioning. Machine perfusion techniques can improve the quality of marginal livers, extend the time for which ...

    Abstract The shortage of donor livers considered suitable for transplantation has driven the development of novel methods for organ preservation and reconditioning. Machine perfusion techniques can improve the quality of marginal livers, extend the time for which they can be preserved and enable an objective assessment of their quality and viability. These benefits can help avoid the needless wastage of organs based on hypothetical concerns regarding quality. As machine perfusion techniques are gaining traction in clinical practice, attention has now shifted to their potential applications beyond transplantation. As well as providing an update on the current status of machine perfusion in clinical practice, this Perspective discusses how this technology is being used as a tool for therapeutic interventions including defatting of steatotic livers, immunomodulation and gene therapies.
    MeSH term(s) Humans ; Liver ; Liver Transplantation/methods ; Organ Preservation/methods ; Perfusion/methods ; Tissue Donors
    Language English
    Publishing date 2022-01-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-021-00557-8
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  4. Article ; Online: COVID-19 infection in patients following hepato-pancreatico-biliary intervention: An early experience

    Doran, S.L.F. / Patel, P.H. / Chaudry, A. / Pollok, J.M. / Pollok, J.M. / Kumar, S. / Bhogal, R.H.

    European Journal of Surgical Oncology

    Keywords covid19
    Publisher Elsevier
    Document type Article ; Online
    DOI 10.1016/j.ejso.2020.04.045
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  5. Article ; Online: Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference.

    Pollok, Joerg M / Tinguely, Pascale / Berenguer, Marina / Niemann, Claus U / Raptis, Dimitri A / Spiro, Michael

    The lancet. Gastroenterology & hepatology

    2022  Volume 8, Issue 1, Page(s) 81–94

    Abstract: There is much controversy regarding enhanced recovery for recipients of liver transplants from deceased and living donors. The objectives of this Review were to summarise current knowledge on individual enhanced recovery elements on short-term outcomes, ... ...

    Abstract There is much controversy regarding enhanced recovery for recipients of liver transplants from deceased and living donors. The objectives of this Review were to summarise current knowledge on individual enhanced recovery elements on short-term outcomes, identify key components for comprehensive pathways, and create internationally accepted guidelines on enhanced recovery for liver-transplant recipients. The ERAS4OLT.org collaborative partnered by the International Liver Transplantation Society performed systematic literature reviews on the effect of 32 relevant enhanced perioperative recovery elements on short-term outcomes, and global specialists prepared expert statements on deceased and living donor liver transplantation. The Grading Recommendations, Assessment, Development and Evaluations approach was used for rating of quality of evidence and grading of recommendations. A virtual international consensus conference was held in January, 2022, in which results were presented, voted on by the audience, and discussed by an independent international jury of eight members, applying the Danish model of consensus. 273 liver transplantation specialists from 30 countries prepared expert statements on elements of enhanced recovery for liver transplantation based on the systematic literature reviews. The consensus conference yielded 80 final recommendations, covering aspects of enhanced recovery for preoperative assessment and optimisation, intraoperative surgical and anaesthetic conduct, and postoperative management for the recipients of liver transplants from both deceased and living donors, and for the living donor. The recommendations represent a comprehensive overview of the relevant elements and areas of enhanced recovery for liver transplantation. These internationally established guidelines could direct the development of enhanced recovery programmes worldwide, allowing adjustments according to local resources and practices.
    MeSH term(s) Humans ; Liver Transplantation/methods ; Living Donors ; Consensus
    Language English
    Publishing date 2022-12-09
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(22)00268-0
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  6. Article ; Online: Liver transplant outcomes after ex vivo machine perfusion: a meta-analysis.

    Liew, Belle / Nasralla, David / Iype, Satheesh / Pollok, Joerg-Matthias / Davidson, Brian / Raptis, Dimitri A

    The British journal of surgery

    2021  Volume 108, Issue 12, Page(s) 1409–1416

    Abstract: Background: The pressure on liver-transplant programmes has expanded the usage of extended-criteria allografts. Machine perfusion may be better than conventional static cold storage (SCS) in alleviating ischaemia-reperfusion injury in this setting. ... ...

    Abstract Background: The pressure on liver-transplant programmes has expanded the usage of extended-criteria allografts. Machine perfusion may be better than conventional static cold storage (SCS) in alleviating ischaemia-reperfusion injury in this setting. Recipient outcomes with hypothermic or normothermic machine perfusion were assessed against SCS here.
    Methods: A search in MEDLINE, EMBASE and Scopus was conducted in February 2021. Primary studies investigating ex vivo machine perfusion were assessed for the following outcomes: morbidity, ICU and hospital stay, graft and patient survival rates and relative costs. Meta-analysis was performed to obtain pooled summary measures.
    Results: Thirty-four articles involving 1742 patients were included, of which 20 were used for quantitative synthesis. Odds ratios favoured hypothermic machine perfusion (over SCS) with less early allograft dysfunction, ischaemic cholangiopathy, non-anastomotic strictures and graft loss. Hypothermic machine perfusion was associated with a shorter hospital stay and normothermic machine perfusion with reduced graft injury. Two randomized clinical trials found normothermic machine perfusion reduced major complication risks.
    Conclusion: Machine perfusion assists some outcomes with potential cost savings.
    MeSH term(s) Cryopreservation ; Graft Survival ; Humans ; Length of Stay ; Liver Transplantation ; Organ Preservation/methods ; Perfusion ; Reperfusion Injury/prevention & control
    Language English
    Publishing date 2021-11-08
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2985-3
    ISSN 1365-2168 ; 0263-1202 ; 0007-1323 ; 1355-7688
    ISSN (online) 1365-2168
    ISSN 0263-1202 ; 0007-1323 ; 1355-7688
    DOI 10.1093/bjs/znab364
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  7. Article ; Online: Salvage of a Right-extended Split Liver Graft Using Ex Situ Normothermic Machine Perfusion-A New Therapeutic Horizon.

    Kathirvel, Manikandan / Nasralla, David / Iype, Satheesh / Tzerbinis, Helen / Crick, Keziah / Cortes Cerisuelo, Miriam / Pollok, Joerg-Matthias

    Transplantation

    2022  Volume 106, Issue 6, Page(s) e320–e321

    MeSH term(s) Liver/surgery ; Liver Transplantation/adverse effects ; Organ Preservation ; Perfusion
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Letter
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004067
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  8. Article ; Online: Donor-Recipient Body Surface Area Mismatch and the Outcome of Liver Transplantation in the UK.

    Kostakis, Ioannis D / Raptis, Dimitri Aristotle / Davidson, Brian R / Iype, Satheesh / Nasralla, David / Imber, Charles / Sharma, Dinesh / Pissanou, Theodora / Pollok, Joerg Matthias

    Progress in transplantation (Aliso Viejo, Calif.)

    2022  Volume 33, Issue 1, Page(s) 61–68

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Adult ; Humans ; Liver Transplantation ; Living Donors ; Body Surface Area ; Liver ; United Kingdom ; Graft Survival ; Retrospective Studies
    Language English
    Publishing date 2022-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2864264-8
    ISSN 2164-6708 ; 1526-9248
    ISSN (online) 2164-6708
    ISSN 1526-9248
    DOI 10.1177/15269248221145035
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  9. Article ; Online: Enhanced recovery after surgery programs improve short-term outcomes after liver transplantation-A systematic review and meta-analysis.

    Tinguely, Pascale / Morare, Nolitha / Ramirez-Del Val, Alejandro / Berenguer, Marina / Niemann, Claus U / Pollok, Joerg M / Raptis, Dimitri A / Spiro, Michael

    Clinical transplantation

    2021  Volume 35, Issue 11, Page(s) e14453

    Abstract: This systematic review aimed to investigate the available quality of evidence (QOE) of enhanced recovery after surgery (ERAS) for liver transplantation (LT) on short-term outcomes, grade recommendations, and identify relevant components for ERAS ... ...

    Abstract This systematic review aimed to investigate the available quality of evidence (QOE) of enhanced recovery after surgery (ERAS) for liver transplantation (LT) on short-term outcomes, grade recommendations, and identify relevant components for ERAS protocols. A systematic review and meta-analysis were conducted on short-term outcomes after LT when applying comprehensive ERAS protocols (> 1 ERAS component) versus control groups (CRD42021210374), following the GRADE approach for grading QOE and strength of recommendations. Endpoints were morbidity, mortality, length of stay, and readmission rates after ERAS for LT. Of 858 screened articles, two randomized controlled trials, two prospective, and one retrospective cohort studies were included (2002-2020). Frequent ERAS components were early extubation and postoperative antibiotic, fluid, and nutrition management. Overall complications were reduced in ERAS versus control cohorts (OR .4 (CI .2, .7), with no significant differences in mortality and hospital readmission rates. Intensive care unit and hospital length of stay were shorter in ERAS groups (percentage decrease, 55% and 29%, respectively). QOE for individual outcomes was rated moderate to low. ERAS protocols in LT are related to improved short-term outcomes after LT (QOE; Moderate to low | Grade of Recommendation; Strong), but currently lack standardization.
    MeSH term(s) Enhanced Recovery After Surgery ; Humans ; Length of Stay ; Liver Transplantation ; Postoperative Complications ; Prospective Studies ; Retrospective Studies
    Language English
    Publishing date 2021-09-16
    Publishing country Denmark
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14453
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  10. Article ; Online: Combining Donor and Recipient Age With Preoperative MELD and UKELD Scores for Predicting Survival After Liver Transplantation.

    Kostakis, Ioannis D / Iype, Satheesh / Nasralla, David / Davidson, Brian R / Imber, Charles / Sharma, Dinesh / Pollok, Joerg Matthias

    Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

    2021  Volume 19, Issue 6, Page(s) 570–579

    Abstract: Objectives: The end-stage liver disease scoring systems MELD, UKELD, and D-MELD (donor age × MELD) have had mediocre results for survival assessment after orthotopic liver transplant. Here, we introduced new indices based on preoperative MELD and ... ...

    Abstract Objectives: The end-stage liver disease scoring systems MELD, UKELD, and D-MELD (donor age × MELD) have had mediocre results for survival assessment after orthotopic liver transplant. Here, we introduced new indices based on preoperative MELD and UKELDscores and assessed their predictive ability on survival posttransplant.
    Materials and methods: We included 1017 deceased donor orthotopic liver transplants that were performed between 2008 (the year UKELD was introduced) and 2019. Donor and recipient characteristics, liver disease scores, transplant characteristics, and outcomes were collected for analyses. D-MELD, D-UKELD (donor age × UKELD),DR-MELD[(donor age + recipient age) × MELD], and DR-UKELD [(donor age + recipient age) × UKELD] were calculated.
    Results: No score had predictive value for graft survival. For patient survival,DR-MELD and DR-UKELD provided the best results but with low accuracy. The highest accuracy was observed at 1 year posttransplant (areas under the curve of 0.598 [95% CI, 0.529-0.667] and 0.609 [95% CI, 0.549-0.67]forDR-MELDandDR-UKELD). Addition of donor and recipient age significantly improved the predictive abilities of MELD and UKELD for patient survival, but addition of donor age alone did not. For 1-year mortality (using receiver operating characteristic curves), optimal cut-off points were DR-MELD>2345 and DR-UKELD>5908. Recipients with DR-MELD >2345 (P < .001) and DR-UKELD >5908 (P = .002) had worse patient survival within the first year, but only DR-MELD >2345 remained significant after multivariable analysis (P = .007).
    Conclusions: DR-MELD and DR-UKELD scores provided the best, albeit mediocre, predictive ability among the 6 tested models, especially at 1 year after posttransplant, although only for patient but not for graft survival. A DR-MELD >2345 was considered to be an additional independent risk factor for worse recipient survival within the first postoperative year.
    MeSH term(s) End Stage Liver Disease/diagnosis ; End Stage Liver Disease/surgery ; Graft Survival ; Humans ; Liver Transplantation/adverse effects ; Retrospective Studies ; Severity of Illness Index ; Tissue Donors ; Treatment Outcome
    Language English
    Publishing date 2021-01-11
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2396778-X
    ISSN 2146-8427 ; 1304-0855
    ISSN (online) 2146-8427
    ISSN 1304-0855
    DOI 10.6002/ect.2020.0513
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