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  1. Book ; Online: Natural Language to Code Generation in Interactive Data Science Notebooks

    Yin, Pengcheng / Li, Wen-Ding / Xiao, Kefan / Rao, Abhishek / Wen, Yeming / Shi, Kensen / Howland, Joshua / Bailey, Paige / Catasta, Michele / Michalewski, Henryk / Polozov, Alex / Sutton, Charles

    2022  

    Abstract: Computational notebooks, such as Jupyter notebooks, are interactive computing environments that are ubiquitous among data scientists to perform data wrangling and analytic tasks. To measure the performance of AI pair programmers that automatically ... ...

    Abstract Computational notebooks, such as Jupyter notebooks, are interactive computing environments that are ubiquitous among data scientists to perform data wrangling and analytic tasks. To measure the performance of AI pair programmers that automatically synthesize programs for those tasks given natural language (NL) intents from users, we build ARCADE, a benchmark of 1082 code generation problems using the pandas data analysis framework in data science notebooks. ARCADE features multiple rounds of NL-to-code problems from the same notebook. It requires a model to understand rich multi-modal contexts, such as existing notebook cells and their execution states as well as previous turns of interaction. To establish a strong baseline on this challenging task, we develop PaChiNCo, a 62B code language model (LM) for Python computational notebooks, which significantly outperforms public code LMs. Finally, we explore few-shot prompting strategies to elicit better code with step-by-step decomposition and NL explanation, showing the potential to improve the diversity and explainability of model predictions.

    Comment: 46 pages. 32 figures
    Keywords Computer Science - Computation and Language ; Computer Science - Software Engineering
    Subject code 004
    Publishing date 2022-12-19
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Structure-activity relationship studies leading to the identification of (2E)-3-[l-[(2,4-dichlorophenyl)methyl]-5-fluoro-3-methyl-lH-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a potent and selective prostanoid EP3 receptor antagonist, as a novel antiplatelet agent that does not prolong bleeding.

    Singh, Jasbir / Zeller, Wayne / Zhou, Nian / Hategan, Georgeta / Mishra, Rama K / Polozov, Alex / Yu, Peng / Onua, Emmanuel / Zhang, Jun / Ramírez, José L / Sigthorsson, Gudmundur / Thorsteinnsdottir, Margret / Kiselyov, Alex S / Zembower, David E / Andrésson, Thorkell / Gurney, Mark E

    Journal of medicinal chemistry

    2010  Volume 53, Issue 1, Page(s) 18–36

    Abstract: The EP(3) receptor on the platelet mediates prostaglandin E(2) potentiation of thrombogenic coagonists including collagen and adenosine diphosphate (ADP). A pharmacophore driven approach led to the identification of diverse peri-substituted heterocycles ... ...

    Abstract The EP(3) receptor on the platelet mediates prostaglandin E(2) potentiation of thrombogenic coagonists including collagen and adenosine diphosphate (ADP). A pharmacophore driven approach led to the identification of diverse peri-substituted heterocycles as potent and selective EP(3) receptor antagonists. A simultaneous chemical optimization and druglike assessment of prioritized molecules converged on a lead compound 50 (DG-041) that displayed favorable in vitro and functional activities as an inhibitor of human platelet aggregation. This agent is currently in human clinical trials for the treatment of atherothrombosis.
    MeSH term(s) Acrylamides/chemical synthesis ; Acrylamides/chemistry ; Acrylamides/pharmacology ; Blood Coagulation/drug effects ; Drug Discovery ; Hemorrhage ; Humans ; Ligands ; Molecular Structure ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/chemical synthesis ; Platelet Aggregation Inhibitors/chemistry ; Platelet Aggregation Inhibitors/pharmacology ; Receptors, Prostaglandin E/antagonists & inhibitors ; Receptors, Prostaglandin E, EP3 Subtype ; Stereoisomerism ; Structure-Activity Relationship ; Sulfones/chemical synthesis ; Sulfones/chemistry ; Sulfones/pharmacology
    Chemical Substances 3-(1-((2,4-dichlorophenyl)methyl)-5-fluoro-3-methyl-1H-indol-7-yl)-N-((4,5-dichloro-2-thienyl)sulfonyl)-2-propenamide ; Acrylamides ; Ligands ; PTGER3 protein, human ; Platelet Aggregation Inhibitors ; Receptors, Prostaglandin E ; Receptors, Prostaglandin E, EP3 Subtype ; Sulfones
    Language English
    Publishing date 2010-01-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/jm9005912
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: PaLM 2 Technical Report

    Anil, Rohan / Dai, Andrew M. / Firat, Orhan / Johnson, Melvin / Lepikhin, Dmitry / Passos, Alexandre / Shakeri, Siamak / Taropa, Emanuel / Bailey, Paige / Chen, Zhifeng / Chu, Eric / Clark, Jonathan H. / Shafey, Laurent El / Huang, Yanping / Meier-Hellstern, Kathy / Mishra, Gaurav / Moreira, Erica / Omernick, Mark / Robinson, Kevin /
    Ruder, Sebastian / Tay, Yi / Xiao, Kefan / Xu, Yuanzhong / Zhang, Yujing / Abrego, Gustavo Hernandez / Ahn, Junwhan / Austin, Jacob / Barham, Paul / Botha, Jan / Bradbury, James / Brahma, Siddhartha / Brooks, Kevin / Catasta, Michele / Cheng, Yong / Cherry, Colin / Choquette-Choo, Christopher A. / Chowdhery, Aakanksha / Crepy, Clément / Dave, Shachi / Dehghani, Mostafa / Dev, Sunipa / Devlin, Jacob / Díaz, Mark / Du, Nan / Dyer, Ethan / Feinberg, Vlad / Feng, Fangxiaoyu / Fienber, Vlad / Freitag, Markus / Garcia, Xavier / Gehrmann, Sebastian / Gonzalez, Lucas / Gur-Ari, Guy / Hand, Steven / Hashemi, Hadi / Hou, Le / Howland, Joshua / Hu, Andrea / Hui, Jeffrey / Hurwitz, Jeremy / Isard, Michael / Ittycheriah, Abe / Jagielski, Matthew / Jia, Wenhao / Kenealy, Kathleen / Krikun, Maxim / Kudugunta, Sneha / Lan, Chang / Lee, Katherine / Lee, Benjamin / Li, Eric / Li, Music / Li, Wei / Li, YaGuang / Li, Jian / Lim, Hyeontaek / Lin, Hanzhao / Liu, Zhongtao / Liu, Frederick / Maggioni, Marcello / Mahendru, Aroma / Maynez, Joshua / Misra, Vedant / Moussalem, Maysam / Nado, Zachary / Nham, John / Ni, Eric / Nystrom, Andrew / Parrish, Alicia / Pellat, Marie / Polacek, Martin / Polozov, Alex / Pope, Reiner / Qiao, Siyuan / Reif, Emily / Richter, Bryan / Riley, Parker / Ros, Alex Castro / Roy, Aurko / Saeta, Brennan / Samuel, Rajkumar / Shelby, Renee / Slone, Ambrose / Smilkov, Daniel / So, David R. / Sohn, Daniel / Tokumine, Simon / Valter, Dasha / Vasudevan, Vijay / Vodrahalli, Kiran / Wang, Xuezhi / Wang, Pidong / Wang, Zirui / Wang, Tao / Wieting, John / Wu, Yuhuai / Xu, Kelvin / Xu, Yunhan / Xue, Linting / Yin, Pengcheng / Yu, Jiahui / Zhang, Qiao / Zheng, Steven / Zheng, Ce / Zhou, Weikang / Zhou, Denny / Petrov, Slav / Wu, Yonghui

    2023  

    Abstract: We introduce PaLM 2, a new state-of-the-art language model that has better multilingual and reasoning capabilities and is more compute-efficient than its predecessor PaLM. PaLM 2 is a Transformer-based model trained using a mixture of objectives. Through ...

    Abstract We introduce PaLM 2, a new state-of-the-art language model that has better multilingual and reasoning capabilities and is more compute-efficient than its predecessor PaLM. PaLM 2 is a Transformer-based model trained using a mixture of objectives. Through extensive evaluations on English and multilingual language, and reasoning tasks, we demonstrate that PaLM 2 has significantly improved quality on downstream tasks across different model sizes, while simultaneously exhibiting faster and more efficient inference compared to PaLM. This improved efficiency enables broader deployment while also allowing the model to respond faster, for a more natural pace of interaction. PaLM 2 demonstrates robust reasoning capabilities exemplified by large improvements over PaLM on BIG-Bench and other reasoning tasks. PaLM 2 exhibits stable performance on a suite of responsible AI evaluations, and enables inference-time control over toxicity without additional overhead or impact on other capabilities. Overall, PaLM 2 achieves state-of-the-art performance across a diverse set of tasks and capabilities. When discussing the PaLM 2 family, it is important to distinguish between pre-trained models (of various sizes), fine-tuned variants of these models, and the user-facing products that use these models. In particular, user-facing products typically include additional pre- and post-processing steps. Additionally, the underlying models may evolve over time. Therefore, one should not expect the performance of user-facing products to exactly match the results reported in this report.
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
    Subject code 571
    Publishing date 2023-05-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding.

    Singh, Jasbir / Zeller, Wayne / Zhou, Nian / Hategen, Georgeta / Mishra, Rama / Polozov, Alex / Yu, Peng / Onua, Emmanuel / Zhang, Jun / Zembower, David / Kiselyov, Alex / Ramírez, José L / Sigthorsson, Gudmundur / Bjornsson, Jon Mar / Thorsteinsdottir, Margret / Andrésson, Thorkell / Bjarnadottir, Maria / Magnusson, Olafur / Fabre, Jean-Etienne /
    Stefansson, Kari / Gurney, Mark E

    ACS chemical biology

    2009  Volume 4, Issue 2, Page(s) 115–126

    Abstract: Myocardial infarction and stroke are caused by blood clots forming over a ruptured or denuded atherosclerotic plaque (atherothrombosis). Production of prostaglandin E(2) (PGE(2)) by an inflamed plaque exacerbates atherothrombosis and may limit the ... ...

    Abstract Myocardial infarction and stroke are caused by blood clots forming over a ruptured or denuded atherosclerotic plaque (atherothrombosis). Production of prostaglandin E(2) (PGE(2)) by an inflamed plaque exacerbates atherothrombosis and may limit the effectiveness of current therapeutics. Platelets express multiple G-protein coupled receptors, including receptors for ADP and PGE(2). ADP can mobilize Ca(2+) and through the P(2)Y(12) receptor can inhibit cAMP production, causing platelet activation and aggregation. Clopidogrel (Plavix), a selective P(2)Y(12) antagonist, prevents platelets from clotting but thereby increases the risk of severe or fatal bleeding. The platelet EP(3) receptor for PGE(2), like the P(2)Y(12) receptor, also inhibits cAMP synthesis. However, unlike ADP, facilitation of platelet aggregation via the PGE(2)/EP(3) pathway is dependent on co-agonists that can mobilize Ca(2+). We used a ligand-based design strategy to develop peri-substituted bicylic acylsulfonamides as potent and selective EP(3) antagonists. We show that DG-041, a selective EP(3) antagonist, inhibits PGE(2) facilitation of platelet aggregation in vitro and ex vivo. PGE(2) can resensitize platelets to agonist even when the P(2)Y(12) receptor has been blocked by clopidogrel, and this can be inhibited by DG-041. Unlike clopidogrel, DG-041 does not affect bleeding time in rats, nor is bleeding time further increased when DG-041 is co-administered with clopidogrel. This indicates that EP(3) antagonists potentially have a superior safety profile compared to P(2)Y(12) antagonists and represent a novel class of antiplatelet agents.
    MeSH term(s) Acrylamides/pharmacology ; Animals ; Dinoprostone/antagonists & inhibitors ; Dinoprostone/metabolism ; Female ; Hemorrhage/prevention & control ; Humans ; Male ; Platelet Aggregation/drug effects ; Platelet Aggregation Inhibitors/chemistry ; Platelet Aggregation Inhibitors/pharmacology ; Prostaglandin Antagonists/pharmacology ; Purinergic P2 Receptor Antagonists ; Rats ; Receptors, Prostaglandin E/antagonists & inhibitors ; Receptors, Prostaglandin E, EP3 Subtype ; Receptors, Purinergic P2Y12 ; Sulfones/pharmacology ; Thrombosis/drug therapy ; Thrombosis/metabolism ; Ticlopidine/analogs & derivatives ; Ticlopidine/pharmacology
    Chemical Substances 3-(1-((2,4-dichlorophenyl)methyl)-5-fluoro-3-methyl-1H-indol-7-yl)-N-((4,5-dichloro-2-thienyl)sulfonyl)-2-propenamide ; Acrylamides ; P2RY12 protein, human ; PTGER3 protein, human ; Platelet Aggregation Inhibitors ; Prostaglandin Antagonists ; Purinergic P2 Receptor Antagonists ; Receptors, Prostaglandin E ; Receptors, Prostaglandin E, EP3 Subtype ; Receptors, Purinergic P2Y12 ; Sulfones ; clopidogrel (A74586SNO7) ; Dinoprostone (K7Q1JQR04M) ; Ticlopidine (OM90ZUW7M1)
    Language English
    Publishing date 2009-02-20
    Publishing country United States
    Document type Journal Article
    ISSN 1554-8937
    ISSN (online) 1554-8937
    DOI 10.1021/cb8002094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online: Gemini

    Gemini Team / Anil, Rohan / Borgeaud, Sebastian / Wu, Yonghui / Alayrac, Jean-Baptiste / Yu, Jiahui / Soricut, Radu / Schalkwyk, Johan / Dai, Andrew M. / Hauth, Anja / Millican, Katie / Silver, David / Petrov, Slav / Johnson, Melvin / Antonoglou, Ioannis / Schrittwieser, Julian / Glaese, Amelia / Chen, Jilin / Pitler, Emily /
    Lillicrap, Timothy / Lazaridou, Angeliki / Firat, Orhan / Molloy, James / Isard, Michael / Barham, Paul R. / Hennigan, Tom / Lee, Benjamin / Viola, Fabio / Reynolds, Malcolm / Xu, Yuanzhong / Doherty, Ryan / Collins, Eli / Meyer, Clemens / Rutherford, Eliza / Moreira, Erica / Ayoub, Kareem / Goel, Megha / Tucker, George / Piqueras, Enrique / Krikun, Maxim / Barr, Iain / Savinov, Nikolay / Danihelka, Ivo / Roelofs, Becca / White, Anaïs / Andreassen, Anders / von Glehn, Tamara / Yagati, Lakshman / Kazemi, Mehran / Gonzalez, Lucas / Khalman, Misha / Sygnowski, Jakub / Frechette, Alexandre / Smith, Charlotte / Culp, Laura / Proleev, Lev / Luan, Yi / Chen, Xi / Lottes, James / Schucher, Nathan / Lebron, Federico / Rrustemi, Alban / Clay, Natalie / Crone, Phil / Kocisky, Tomas / Zhao, Jeffrey / Perz, Bartek / Yu, Dian / Howard, Heidi / Bloniarz, Adam / Rae, Jack W. / Lu, Han / Sifre, Laurent / Maggioni, Marcello / Alcober, Fred / Garrette, Dan / Barnes, Megan / Thakoor, Shantanu / Austin, Jacob / Barth-Maron, Gabriel / Wong, William / Joshi, Rishabh / Chaabouni, Rahma / Fatiha, Deeni / Ahuja, Arun / Liu, Ruibo / Li, Yunxuan / Cogan, Sarah / Chen, Jeremy / Jia, Chao / Gu, Chenjie / Zhang, Qiao / Grimstad, Jordan / Hartman, Ale Jakse / Chadwick, Martin / Tomar, Gaurav Singh / Garcia, Xavier / Senter, Evan / Taropa, Emanuel / Pillai, Thanumalayan Sankaranarayana / Devlin, Jacob / Laskin, Michael / Casas, Diego de Las / Valter, Dasha / Tao, Connie / Blanco, Lorenzo / Badia, Adrià Puigdomènech / Reitter, David / Chen, Mianna / Brennan, Jenny / Rivera, Clara / Brin, Sergey / Iqbal, Shariq / Surita, Gabriela / Labanowski, Jane / Rao, Abhi / Winkler, Stephanie / Parisotto, Emilio / Gu, Yiming / Olszewska, Kate / Zhang, Yujing / Addanki, Ravi / Miech, Antoine / Louis, Annie / Shafey, Laurent El / Teplyashin, Denis / Brown, Geoff / Catt, Elliot / Attaluri, Nithya / Balaguer, Jan / Xiang, Jackie / Wang, Pidong / Ashwood, Zoe / Briukhov, Anton / Webson, Albert / Ganapathy, Sanjay / Sanghavi, Smit / Kannan, Ajay / Chang, Ming-Wei / Stjerngren, Axel / Djolonga, Josip / Sun, Yuting / Bapna, Ankur / Aitchison, Matthew / Pejman, Pedram / Michalewski, Henryk / Yu, Tianhe / Wang, Cindy / Love, Juliette / Ahn, Junwhan / Bloxwich, Dawn / Han, Kehang / Humphreys, Peter / Sellam, Thibault / Bradbury, James / Godbole, Varun / Samangooei, Sina / Damoc, Bogdan / Kaskasoli, Alex / Arnold, Sébastien M. R. / Vasudevan, Vijay / Agrawal, Shubham / Riesa, Jason / Lepikhin, Dmitry / Tanburn, Richard / Srinivasan, Srivatsan / Lim, Hyeontaek / Hodkinson, Sarah / Shyam, Pranav / Ferret, Johan / Hand, Steven / Garg, Ankush / Paine, Tom Le / Li, Jian / Li, Yujia / Giang, Minh / Neitz, Alexander / Abbas, Zaheer / York, Sarah / Reid, Machel / Cole, Elizabeth / Chowdhery, Aakanksha / Das, Dipanjan / Rogozińska, Dominika / Nikolaev, Vitaly / Sprechmann, Pablo / Nado, Zachary / Zilka, Lukas / Prost, Flavien / He, Luheng / Monteiro, Marianne / Mishra, Gaurav / Welty, Chris / Newlan, Josh / Jia, Dawei / Allamanis, Miltiadis / Hu, Clara Huiyi / de Liedekerke, Raoul / Gilmer, Justin / Saroufim, Carl / Rijhwani, Shruti / Hou, Shaobo / Shrivastava, Disha / Baddepudi, Anirudh / Goldin, Alex / Ozturel, Adnan / Cassirer, Albin / Xu, Yunhan / Sohn, Daniel / Sachan, Devendra / Amplayo, Reinald Kim / Swanson, Craig / Petrova, Dessie / Narayan, Shashi / Guez, Arthur / Brahma, Siddhartha / Landon, Jessica / Patel, Miteyan / Zhao, Ruizhe / Villela, Kevin / Wang, Luyu / Jia, Wenhao / Rahtz, Matthew / Giménez, Mai / Yeung, Legg / Lin, Hanzhao / Keeling, James / Georgiev, Petko / Mincu, Diana / Wu, Boxi / Haykal, Salem / Saputro, Rachel / Vodrahalli, Kiran / Qin, James / Cankara, Zeynep / Sharma, Abhanshu / Fernando, Nick / Hawkins, Will / Neyshabur, Behnam / Kim, Solomon / Hutter, Adrian / Agrawal, Priyanka / Castro-Ros, Alex / Driessche, George van den / Wang, Tao / Yang, Fan / Chang, Shuo-yiin / Komarek, Paul / McIlroy, Ross / Lučić, Mario / Zhang, Guodong / Farhan, Wael / Sharman, Michael / Natsev, Paul / Michel, Paul / Cheng, Yong / Bansal, Yamini / Qiao, Siyuan / Cao, Kris / Shakeri, Siamak / Butterfield, Christina / Chung, Justin / Rubenstein, Paul Kishan / Agrawal, Shivani / Mensch, Arthur / Soparkar, Kedar / Lenc, Karel / Chung, Timothy / Pope, Aedan / Maggiore, Loren / Kay, Jackie / Jhakra, Priya / Wang, Shibo / Maynez, Joshua / Phuong, Mary / Tobin, Taylor / Tacchetti, Andrea / Trebacz, Maja / Robinson, Kevin / Katariya, Yash / Riedel, Sebastian / Bailey, Paige / Xiao, Kefan / Ghelani, Nimesh / Aroyo, Lora / Slone, Ambrose / Houlsby, Neil / Xiong, Xuehan / Yang, Zhen / Gribovskaya, Elena / Adler, Jonas / Wirth, Mateo / Lee, Lisa / Li, Music / Kagohara, Thais / Pavagadhi, Jay / Bridgers, Sophie / Bortsova, Anna / Ghemawat, Sanjay / Ahmed, Zafarali / Liu, Tianqi / Powell, Richard / Bolina, Vijay / Iinuma, Mariko / Zablotskaia, Polina / Besley, James / Chung, Da-Woon / Dozat, Timothy / Comanescu, Ramona / Si, Xiance / Greer, Jeremy / Su, Guolong / Polacek, Martin / Kaufman, Raphaël Lopez / Tokumine, Simon / Hu, Hexiang / Buchatskaya, Elena / Miao, Yingjie / Elhawaty, Mohamed / Siddhant, Aditya / Tomasev, Nenad / Xing, Jinwei / Greer, Christina / Miller, Helen / Ashraf, Shereen / Roy, Aurko / Zhang, Zizhao / Ma, Ada / Filos, Angelos / Besta, Milos / Blevins, Rory / Klimenko, Ted / Yeh, Chih-Kuan / Changpinyo, Soravit / Mu, Jiaqi / Chang, Oscar / Pajarskas, Mantas / Muir, Carrie / Cohen, Vered / Lan, Charline Le / Haridasan, Krishna / Marathe, Amit / Hansen, Steven / Douglas, Sholto / Samuel, Rajkumar / Wang, Mingqiu / Austin, Sophia / Lan, Chang / Jiang, Jiepu / Chiu, Justin / Lorenzo, Jaime Alonso / Sjösund, Lars Lowe / Cevey, Sébastien / Gleicher, Zach / Avrahami, Thi / Boral, Anudhyan / Srinivasan, Hansa / Selo, Vittorio / May, Rhys / Aisopos, Konstantinos / Hussenot, Léonard / Soares, Livio Baldini / Baumli, Kate / Chang, Michael B. / Recasens, Adrià / Caine, Ben / Pritzel, Alexander / Pavetic, Filip / Pardo, Fabio / Gergely, Anita / Frye, Justin / Ramasesh, Vinay / Horgan, Dan / Badola, Kartikeya / Kassner, Nora / Roy, Subhrajit / Dyer, Ethan / Campos, Víctor / Tomala, Alex / Tang, Yunhao / Badawy, Dalia El / White, Elspeth / Mustafa, Basil / Lang, Oran / Jindal, Abhishek / Vikram, Sharad / Gong, Zhitao / Caelles, Sergi / Hemsley, Ross / Thornton, Gregory / Feng, Fangxiaoyu / Stokowiec, Wojciech / Zheng, Ce / Thacker, Phoebe / Ünlü, Çağlar / Zhang, Zhishuai / Saleh, Mohammad / Svensson, James / Bileschi, Max / Patil, Piyush / Anand, Ankesh / Ring, Roman / Tsihlas, Katerina / Vezer, Arpi / Selvi, Marco / Shevlane, Toby / Rodriguez, Mikel / Kwiatkowski, Tom / Daruki, Samira / Rong, Keran / Dafoe, Allan / FitzGerald, Nicholas / Gu-Lemberg, Keren / Khan, Mina / Hendricks, Lisa Anne / Pellat, Marie / Feinberg, Vladimir / Cobon-Kerr, James / Sainath, Tara / Rauh, Maribeth / Hashemi, Sayed Hadi / Ives, Richard / Hasson, Yana / Li, YaGuang / Noland, Eric / Cao, Yuan / Byrd, Nathan / Hou, Le / Wang, Qingze / Sottiaux, Thibault / Paganini, Michela / Lespiau, Jean-Baptiste / Moufarek, Alexandre / Hassan, Samer / Shivakumar, Kaushik / van Amersfoort, Joost / Mandhane, Amol / Joshi, Pratik / Goyal, Anirudh / Tung, Matthew / Brock, Andrew / Sheahan, Hannah / Misra, Vedant / Li, Cheng / Rakićević, Nemanja / Dehghani, Mostafa / Liu, Fangyu / Mittal, Sid / Oh, Junhyuk / Noury, Seb / Sezener, Eren / Huot, Fantine / Lamm, Matthew / De Cao, Nicola / Chen, Charlie / Elsayed, Gamaleldin / Chi, Ed / Mahdieh, Mahdis / Tenney, Ian / Hua, Nan / Petrychenko, Ivan / Kane, Patrick / Scandinaro, Dylan / Jain, Rishub / Uesato, Jonathan / Datta, Romina / Sadovsky, Adam / Bunyan, Oskar / Rabiej, Dominik / Wu, Shimu / Zhang, John / Vasudevan, Gautam / Leurent, Edouard / Alnahlawi, Mahmoud / Georgescu, Ionut / Wei, Nan / Zheng, Ivy / Chan, Betty / Rabinovitch, Pam G / Stanczyk, Piotr / Zhang, Ye / Steiner, David / Naskar, Subhajit / Azzam, Michael / Johnson, Matthew / Paszke, Adam / Chiu, Chung-Cheng / Elias, Jaume Sanchez / Mohiuddin, Afroz / Muhammad, Faizan / Miao, Jin / Lee, Andrew / Vieillard, Nino / Potluri, Sahitya / Park, Jane / Davoodi, Elnaz / Zhang, Jiageng / Stanway, Jeff / Garmon, Drew / Karmarkar, Abhijit / Dong, Zhe / Lee, Jong / Kumar, Aviral / Zhou, Luowei / Evens, Jonathan / Isaac, William / Chen, Zhe / Jia, Johnson / Levskaya, Anselm / Zhu, Zhenkai / Gorgolewski, Chris / Grabowski, Peter / Mao, Yu / Magni, Alberto / Yao, Kaisheng / Snaider, Javier / Casagrande, Norman / Suganthan, Paul / Palmer, Evan / Irving, Geoffrey / Loper, Edward / Faruqui, Manaal / Arkatkar, Isha / Chen, Nanxin / Shafran, Izhak / Fink, Michael / Castaño, Alfonso / Giannoumis, Irene / Kim, Wooyeol / Rybiński, Mikołaj / Sreevatsa, Ashwin / Prendki, Jennifer / Soergel, David / Goedeckemeyer, Adrian / Gierke, Willi / Jafari, Mohsen / Gaba, Meenu / Wiesner, Jeremy / Wright, Diana Gage / Wei, Yawen / Vashisht, Harsha / Kulizhskaya, Yana / Hoover, Jay / Le, Maigo / Li, Lu / Iwuanyanwu, Chimezie / Liu, Lu / Ramirez, Kevin / Khorlin, Andrey / Cui, Albert / LIN, Tian / Georgiev, Marin / Wu, Marcus / Aguilar, Ricardo / Pallo, Keith / Chakladar, Abhishek / Repina, Alena / Wu, Xihui / van der Weide, Tom / Ponnapalli, Priya / Kaplan, Caroline / Simsa, Jiri / Li, Shuangfeng / Dousse, Olivier / Piper, Jeff / Ie, Nathan / Lui, Minnie / Pasumarthi, Rama / Lintz, Nathan / Vijayakumar, Anitha / Thiet, Lam Nguyen / Andor, Daniel / Valenzuela, Pedro / Paduraru, Cosmin / Peng, Daiyi / Lee, Katherine / Zhang, Shuyuan / Greene, Somer / Nguyen, Duc Dung / Kurylowicz, Paula / Velury, Sarmishta / Krause, Sebastian / Hardin, Cassidy / Dixon, Lucas / Janzer, Lili / Choo, Kiam / Feng, Ziqiang / Zhang, Biao / Singhal, Achintya / Latkar, Tejasi / Zhang, Mingyang / Le, Quoc / Abellan, Elena Allica / Du, Dayou / McKinnon, Dan / Antropova, Natasha / Bolukbasi, Tolga / Keller, Orgad / Reid, David / Finchelstein, Daniel / Raad, Maria Abi / Crocker, Remi / Hawkins, Peter / Dadashi, Robert / Gaffney, Colin / Lall, Sid / Franko, Ken / Filonov, Egor / Bulanova, Anna / Leblond, Rémi / Yadav, Vikas / Chung, Shirley / Askham, Harry / Cobo, Luis C. / Xu, Kelvin / Fischer, Felix / Xu, Jun / Sorokin, Christina / Alberti, Chris / Lin, Chu-Cheng / Evans, Colin / Zhou, Hao / Dimitriev, Alek / Forbes, Hannah / Banarse, Dylan / Tung, Zora / Liu, Jeremiah / Omernick, Mark / Bishop, Colton / Kumar, Chintu / Sterneck, Rachel / Foley, Ryan / Jain, Rohan / Mishra, Swaroop / Xia, Jiawei / Bos, Taylor / Cideron, Geoffrey / Amid, Ehsan / Piccinno, Francesco / Wang, Xingyu / Banzal, Praseem / Gurita, Petru / Noga, Hila / Shah, Premal / Mankowitz, Daniel J. / Polozov, Alex / Kushman, Nate / Krakovna, Victoria / Brown, Sasha / Bateni, MohammadHossein / Duan, Dennis / Firoiu, Vlad / Thotakuri, Meghana / Natan, Tom / Mohananey, Anhad / Geist, Matthieu / Mudgal, Sidharth / Girgin, Sertan / Li, Hui / Ye, Jiayu / Roval, Ofir / Tojo, Reiko / Kwong, Michael / Lee-Thorp, James / Yew, Christopher / Yuan, Quan / Bagri, Sumit / Sinopalnikov, Danila / Ramos, Sabela / Mellor, John / Sharma, Abhishek / Severyn, Aliaksei / Lai, Jonathan / Wu, Kathy / Cheng, Heng-Tze / Miller, David / Sonnerat, Nicolas / Vnukov, Denis / Greig, Rory / Beattie, Jennifer / Caveness, Emily / Bai, Libin / Eisenschlos, Julian / Korchemniy, Alex / Tsai, Tomy / Jasarevic, Mimi / Kong, Weize / Dao, Phuong / Zheng, Zeyu / Liu, Frederick / Zhu, Rui / Geller, Mark / Teh, Tian Huey / 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    A Family of Highly Capable Multimodal Models

    2023  

    Abstract: This report introduces a new family of multimodal models, Gemini, that exhibit remarkable capabilities across image, audio, video, and text understanding. The Gemini family consists of Ultra, Pro, and Nano sizes, suitable for applications ranging from ... ...

    Abstract This report introduces a new family of multimodal models, Gemini, that exhibit remarkable capabilities across image, audio, video, and text understanding. The Gemini family consists of Ultra, Pro, and Nano sizes, suitable for applications ranging from complex reasoning tasks to on-device memory-constrained use-cases. Evaluation on a broad range of benchmarks shows that our most-capable Gemini Ultra model advances the state of the art in 30 of 32 of these benchmarks - notably being the first model to achieve human-expert performance on the well-studied exam benchmark MMLU, and improving the state of the art in every one of the 20 multimodal benchmarks we examined. We believe that the new capabilities of Gemini models in cross-modal reasoning and language understanding will enable a wide variety of use cases and we discuss our approach toward deploying them responsibly to users.
    Keywords Computer Science - Computation and Language ; Computer Science - Artificial Intelligence ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 004
    Publishing date 2023-12-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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