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  1. Article ; Online: Do anti-Aβ monoclonal antibodies lower brain plaques in Alzheimer patients through microglia activation?

    Pomara, Nunzio / Imbimbo, Bruno Pietro

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  Volume 20, Issue 3, Page(s) 2289–2290

    MeSH term(s) Humans ; Animals ; Mice ; Alzheimer Disease ; Microglia/metabolism ; Brain/metabolism ; Amyloid beta-Peptides/metabolism ; Antibodies, Monoclonal/therapeutic use ; Mice, Transgenic ; Disease Models, Animal ; Plaque, Amyloid
    Chemical Substances Amyloid beta-Peptides ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Letter
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6316: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

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  2. Article ; Online: Lecanemab in Early Alzheimer's Disease.

    Pomara, Nunzio / Imbimbo, Bruno P

    The New England journal of medicine

    2023  Volume 388, Issue 17, Page(s) 1630–1631

    MeSH term(s) Humans ; Alzheimer Disease ; Positron-Emission Tomography
    Chemical Substances lecanemab (12PYH0FTU9)
    Language English
    Publishing date 2023-04-25
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2301380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  3. Article ; Online: Use of Donanemab in Early Symptomatic Alzheimer Disease.

    Pomara, Nunzio / Imbimbo, Bruno Pietro

    JAMA

    2023  Volume 330, Issue 23, Page(s) 2304

    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Alzheimer Disease/drug therapy ; Amyloid beta-Peptides ; Cognition Disorders/diagnosis ; Cognition Disorders/drug therapy ; Neuropsychological Tests ; Antibodies, Monoclonal, Humanized/therapeutic use
    Chemical Substances Amyloid beta-Peptides ; donanemab ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.21106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.88: Show issues Location:
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  4. Article ; Online: Brain Amyloid Deposition in Late-Life Depression.

    Pomara, Nunzio / Imbimbo, Bruno Pietro

    Biological psychiatry

    2020  Volume 89, Issue 8, Page(s) e41–e42

    MeSH term(s) Alzheimer Disease ; Amyloid/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Depression ; Humans ; Neuroimaging
    Chemical Substances Amyloid
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2020.07.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 720: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19.

    Pomara, Nunzio / Imbimbo, Bruno P

    Medical hypotheses

    2020  Volume 144, Page(s) 110274

    MeSH term(s) Acetylcholinesterase/metabolism ; Aged ; Aging ; Alzheimer Disease/complications ; Alzheimer Disease/immunology ; Brain/immunology ; Brain/metabolism ; Butyrylcholinesterase/metabolism ; COVID-19/complications ; COVID-19/immunology ; Cholinergic Agents/metabolism ; Cytokines/blood ; Cytokines/metabolism ; Dementia/complications ; Dementia/immunology ; Humans ; Immunity, Innate ; Inflammation/virology ; Neuroimmunomodulation ; T-Lymphocytes/immunology
    Chemical Substances Cholinergic Agents ; Cytokines ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8)
    Language English
    Publishing date 2020-09-16
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1132: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Drug-induced reductions in brain amyloid-β levels may adversely affect cognition and behavior by a disruption of functional connectivity homeostasis.

    Imbimbo, Bruno P / Pomara, Nunzio

    Neurodegenerative disease management

    2019  Volume 9, Issue 4, Page(s) 189–191

    MeSH term(s) Brain ; Cognition ; Homeostasis ; Humans
    Language English
    Publishing date 2019-07-24
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 1758-2032
    ISSN (online) 1758-2032
    DOI 10.2217/nmt-2019-0013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: APOE-based psychopharmacogenetics and delirium.

    Pomara, Nunzio

    Critical care medicine

    2013  Volume 41, Issue 6, Page(s) e101

    MeSH term(s) Coronary Care Units ; Delirium/epidemiology ; Female ; Humans ; Intensive Care Units ; Male
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0b013e318287bc0f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1261: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Semagacestat for treatment of Alzheimer's disease.

    Pomara, Nunzio

    The New England journal of medicine

    2013  Volume 369, Issue 17, Page(s) 1661

    MeSH term(s) Alanine/analogs & derivatives ; Alzheimer Disease/drug therapy ; Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Azepines/therapeutic use ; Female ; Humans ; Male
    Chemical Substances Azepines ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Alanine (OF5P57N2ZX)
    Language English
    Publishing date 2013-10-24
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1310845#SA2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  9. Article ; Online: Basal Forebrain Resting Functional Activity Associated with Brain Amyloid-β Burden in ε4 Carriers and Older Women: Possible Implications for Baseline Cognition and Response to Amyloid-β-based Preventive Trials.

    Pomara, Nunzio / Bruno, Davide

    Radiology

    2019  Volume 290, Issue 3, Page(s) 850–851

    MeSH term(s) Aged ; Basal Forebrain ; Brain ; Cognition ; Female ; Humans ; Memory ; Rest ; Women
    Language English
    Publishing date 2019-02-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2018182659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.106: Show issues Location:
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  10. Article ; Online: Pathological Increases in Neuronal Hyperactivity in Selective Cholinergic and Noradrenergic Pathways May Limit the Efficacy of Amyloid-β-Based Interventions in Mild Cognitive Impairment and Alzheimer's Disease.

    Pomara, Nunzio / Bruno, Davide

    Journal of Alzheimer's disease reports

    2018  Volume 2, Issue 1, Page(s) 165–167

    Abstract: In spite of compelling evidence linking amyloid-β (Aβ) disturbances to the pathophysiology of Alzheimer's disease (AD), Aβ-based treatments have consistently failed to produce any beneficial effects both in mild cognitive impairment (MCI) and AD, even ... ...

    Abstract In spite of compelling evidence linking amyloid-β (Aβ) disturbances to the pathophysiology of Alzheimer's disease (AD), Aβ-based treatments have consistently failed to produce any beneficial effects both in mild cognitive impairment (MCI) and AD, even with successful reductions of toxic aggregated and soluble Aβ species. Before abandoning both the hypothesis and approach, there is a need to examine some overlooked factors that may have contributed to the lack of efficacy, such as the potential drug-induced increases in neuronal hyperactivity leading to adverse cognitive effects. In particular, we posit that selective cholinergic and noradrenergic pathways will be especially vulnerable to this adverse effect. If confirmed, this idea could help identify a potentially preventable and treatable obstacle for enhancing the efficacy of therapeutic agents in MCI and AD.
    Language English
    Publishing date 2018-10-03
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-180077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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