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  1. Article ; Online: Longitudinal analysis of neuropsychiatric symptoms in a large cohort of early-moderate manifest Huntington's disease patients.

    Ruiz-Idiago, Jesús / Pomarol-Clotet, Edith / Salvador, Raymond

    Parkinsonism & related disorders

    2022  Volume 106, Page(s) 105228

    Abstract: Background: The relationship between neuropsychiatric symptoms (NPS) and other clinical dimensions in Huntington's disease (HD) is controversial. This longitudinal study analyzed the association between NPS and motor, cognitive and functional aspects of ...

    Abstract Background: The relationship between neuropsychiatric symptoms (NPS) and other clinical dimensions in Huntington's disease (HD) is controversial. This longitudinal study analyzed the association between NPS and motor, cognitive and functional aspects of the disease along with other variables related to its clinical onset and progression.
    Methods: 639 early-moderate HD patients were assessed longitudinally (mean: 4.95 visits/5 years). Generalized linear mixed models were used to explore associations between NPS and the aforementioned aspects. Other variables previously reported as significant in smaller or cross-sectional studies were included in the models.
    Results: Significant associations found included a negative linear relationship between presence of depressed mood and illness duration (7.2% odds reduction of being depressed per year), a 7.6% increase in the odds of having irritability with increased chorea scores, a negative association (4.3% reduction in odds) between age at onset and aggression (i.e. earlier onset was related to a higher probability of having aggressive behaviors) and a negative association between irritability and the interference component of the Stroop test (3% odds change). Total functional capacity (TFC) was the most frequently associated factor with NPS, with apathy and perseverative behavior having the strongest relations with TFC (22% and 18% increases in odds per unit reduction in TFC respectively).
    Conclusions: With the exception of irritability, NPS are not related to motor or cognitive variables in early-moderate HD. Total functional capacity (TFC) is the most frequently associated factor with NPS, with apathy and perseverative behavior having the strongest relations with TFC.
    MeSH term(s) Humans ; Huntington Disease/complications ; Huntington Disease/epidemiology ; Longitudinal Studies ; Cross-Sectional Studies ; Chorea/complications ; Apathy
    Language English
    Publishing date 2022-11-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1311489-x
    ISSN 1873-5126 ; 1353-8020
    ISSN (online) 1873-5126
    ISSN 1353-8020
    DOI 10.1016/j.parkreldis.2022.11.020
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  2. Book ; Thesis: Ausarbeitung und Erprobung einer spanischen Version der ICD-10-Merkmalsliste für die psychiatrische Diagnostik

    Pomarol Clotet, Edith

    2000  

    Author's details vorgelegt von Edith Pomarol Clotet
    Language German
    Size 131 S., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Lübeck, Med. Univ., Diss., 2001
    HBZ-ID HT013385124
    Database Catalogue ZB MED Medicine, Health

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    2002 D 2397 order for loan Magazin

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  3. Article ; Online: Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic.

    Radua, Joaquim / Fortea, Lydia / Pomarol-Clotet, Edith / Vieta, Eduard / Fullana, Miquel Àngel / Solanes, Aleix

    Revista de psiquiatria y salud mental

    2022  Volume 15, Issue 2, Page(s) 147–149

    MeSH term(s) Anxiety/etiology ; COVID-19 ; Depression/etiology ; Diet ; Humans ; Pandemics
    Language English
    Publishing date 2022-07-12
    Publishing country Spain
    Document type Case Reports
    ISSN 2173-5050
    ISSN (online) 2173-5050
    DOI 10.1016/j.rpsmen.2022.07.003
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  4. Article ; Online: Brain Functional Correlates of Recall of Life Events in Medication-Naïve Adolescents with Borderline Personality Disorder.

    Salgado-Pineda, Pilar / Ferrer, Marc / Calvo, Natàlia / Costa, Xavier / Pozuelo-López, María Ángeles / Ramos-Quiroga, Josep Antoni / Tarragona, Brenda / Fuentes-Claramonte, Paola / Salvador, Raymond / Pomarol-Clotet, Edith

    Neuropsychobiology

    2024  Volume 83, Issue 1, Page(s) 49–60

    Abstract: Introduction: Recall of autobiographical events has been found to be impaired in borderline personality disorder (BPD), but few studies have examined if this impairment has brain functional correlates. This study evaluated brain functional alterations ... ...

    Abstract Introduction: Recall of autobiographical events has been found to be impaired in borderline personality disorder (BPD), but few studies have examined if this impairment has brain functional correlates. This study evaluated brain functional alterations during autobiographical recall using medication-naive adolescent patients to avoid potential confounding effects of treatment.
    Methods: Thirty-two adolescent female patients with BPD who were never-medicated and without psychiatric comorbidity and 33 matched healthy females underwent fMRI while they viewed individualized cue words that evoked autobiographical memories. Control conditions included viewing non-memory-evoking cues and a low-level baseline (cross-fixation).
    Results: During autobiographical recall, in comparison to the low-level baseline, the BPD patients showed increased brain activity in regions including the posterior hippocampus, the lingual and calcarine cortex, and the precuneus compared to the healthy controls. The BPD patients also showed a failure to deactivate the right dorsolateral prefrontal cortex during autobiographical recall. No patient-control differences were found when memory-evoking words were compared to non-memory-evoking words.
    Discussion/conclusions: This study finds evidence of hippocampal/lingual/calcarine/precuneus hyperactivation to stimuli that evoke autobiographical memories in patients with BPD. As the changes were seen in never-treated patients without other comorbidities, they could be considered intrinsic to the disorder. Our study also adds to existing evidence for failure of deactivation in BPD, this time outside the default mode network.
    MeSH term(s) Humans ; Female ; Adolescent ; Borderline Personality Disorder ; Brain/diagnostic imaging ; Mental Recall/physiology ; Brain Mapping ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-01-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 442239-9
    ISSN 1423-0224 ; 0302-282X
    ISSN (online) 1423-0224
    ISSN 0302-282X
    DOI 10.1159/000535409
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  5. Article ; Online: Alterations in the volume and shape of the basal ganglia and thalamus in schizophrenia with auditory hallucinations.

    Perez-Rando, Marta / García-Martí, Gracián / Escarti, Maria J / Salgado-Pineda, Pilar / McKenna, Peter J / Pomarol-Clotet, Edith / Grasa, Eva / Postiguillo, Alba / Corripio, Iluminada / Nacher, Juan

    Progress in neuro-psychopharmacology & biological psychiatry

    2024  Volume 131, Page(s) 110960

    Abstract: Different lines of evidence indicate that the structure and physiology of the basal ganglia and the thalamus is disturbed in schizophrenia. However, it is unknown whether the volume and shape of these subcortical structures are affected in schizophrenia ... ...

    Abstract Different lines of evidence indicate that the structure and physiology of the basal ganglia and the thalamus is disturbed in schizophrenia. However, it is unknown whether the volume and shape of these subcortical structures are affected in schizophrenia with auditory hallucinations (AH), a core positive symptom of the disorder. We took structural MRI from 63 patients with schizophrenia, including 36 patients with AH and 27 patients who had never experienced AH (NAH), and 51 matched healthy controls. We extracted volumes for the left and right thalamus, globus pallidus, putamen, caudate and nucleus accumbens. Shape analysis was also carried out. When comparing to controls, the volume of the right globus pallidus, thalamus, and putamen, was only affected in AH patients. The volume of the left putamen was also increased in individuals with AH, whereas the left globus pallidus was affected in both groups of patients. The shapes of right and left putamen and thalamus were also affected in both groups. The shape of the left globus pallidus was only altered in patients lacking AH, both in comparison to controls and to cases with AH. Lastly, the general PANSS subscale was correlated with the volume of the right thalamus, and the right and left putamen, in patients with AH. We have found volume and shape alterations of many basal ganglia and thalamus in patients with and without AH, suggesting in some cases a possible relationship between this positive symptom and these morphometric alterations.
    MeSH term(s) Humans ; Schizophrenia/complications ; Schizophrenia/diagnostic imaging ; Basal Ganglia/diagnostic imaging ; Thalamus/diagnostic imaging ; Putamen/diagnostic imaging ; Hallucinations/diagnostic imaging ; Magnetic Resonance Imaging
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 781181-0
    ISSN 1878-4216 ; 0278-5846
    ISSN (online) 1878-4216
    ISSN 0278-5846
    DOI 10.1016/j.pnpbp.2024.110960
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  6. Article ; Online: Corrigendum to 'Voxel-based meta-analysis via permutation of subject images (PSI): Theory and implementation for SDM' [Neuroimage 186 (2019) 174-184/YNIMG_15396].

    Albajes-Eizagirre, Anton / Solanes, Aleix / Vieta, Eduard / Salvador, Raymond / Pomarol-Clotet, Edith / Radua, Joaquim

    NeuroImage

    2021  Volume 231, Page(s) 117859

    Language English
    Publishing date 2021-02-17
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2021.117859
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  7. Article ; Online: Following a healthy/balanced diet predicts lower anxiety and depression during the COVID-19 pandemic.

    Radua, Joaquim / Fortea, Lydia / Pomarol-Clotet, Edith / Vieta, Eduard / Fullana, Miquel Àngel / Solanes, Aleix

    Revista de psiquiatria y salud mental

    2021  Volume 15, Issue 2, Page(s) 147–149

    Language English
    Publishing date 2021-12-17
    Publishing country Spain
    Document type Case Reports
    ISSN 1989-4600
    ISSN (online) 1989-4600
    DOI 10.1016/j.rpsm.2021.12.004
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  8. Article ; Online: Longer illness duration is associated with greater individual variability in functional brain activity in Schizophrenia, but not bipolar disorder.

    Gallucci, Julia / Pomarol-Clotet, Edith / Voineskos, Aristotle N / Guerrero-Pedraza, Amalia / Alonso-Lana, Silvia / Vieta, Eduard / Salvador, Raymond / Hawco, Colin

    NeuroImage. Clinical

    2022  Volume 36, Page(s) 103269

    Abstract: Background: Individuals with schizophrenia exhibit greater inter-patient variability in functional brain activity during neurocognitive task performance. Some studies have shown associations of age and illness duration with brain function; however, the ... ...

    Abstract Background: Individuals with schizophrenia exhibit greater inter-patient variability in functional brain activity during neurocognitive task performance. Some studies have shown associations of age and illness duration with brain function; however, the association of these variables with variability in brain function activity is not known. In order to better understand the progressive effects of age and illness duration across disorders, we examined the relationship with individual variability in brain activity.
    Methods: Neuroimaging and behavioural data were extracted from harmonized datasets collectively including 212 control participants, 107 individuals with bipolar disorder, and 232 individuals with schizophrenia (total n = 551). Functional activity in response to an N-back working memory task (2-back vs 1-back) was examined. Individual variability was quantified via the correlational distance of fMRI activity between participants; mean correlational distance of one participant in relation to all others was defined as a 'variability score'.
    Results: Greater individual variability was found in the schizophrenia group compared to the bipolar disorder and control groups (p = 1.52e-09). Individual variability was significantly associated with aging (p = 0.027), however, this relationship was not different across diagnostic groups. In contrast, in the schizophrenia sample only, a longer illness duration was associated with increased variability (p = 0.027).
    Conclusion: An increase in variability was observed in the schizophrenia group related to illness duration, beyond the effects of normal aging, implying illness-related deterioration of cognitive networks. This has clinical implications for considering long-term trajectories in schizophrenia and progressive neural and cognitive decline which may be amiable to novel treatments.
    Language English
    Publishing date 2022-11-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2022.103269
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  9. Article ; Online: Psychometric properties of the Spanish version of the Health of Nation Outcome Scales for schizophrenia patients.

    Feria-Raposo, Isabel / García-León, María Ángeles / Rodríguez-Cano, Elena / Blanco-Blanco, Joan / Moreno-Casbas, María Teresa / Gonzalez-Castro, Ana Isabel / Gómez-Lozano, María José / Guerrero-Pedraza, Amalia / Sarri, Carmen / Portillo, Francisco / Sarró, Salvador / McKenna, Peter J / Salvador, Raymond / Pomarol-Clotet, Edith

    Journal of psychiatric and mental health nursing

    2024  

    Abstract: Accessible Summary What is known on the subject? Functioning is one of the most affected areas in schizophrenia. Social, occupational and personal domains are affected, and these deficits are responsible for a major part of the disability associated with ...

    Abstract Accessible Summary What is known on the subject? Functioning is one of the most affected areas in schizophrenia. Social, occupational and personal domains are affected, and these deficits are responsible for a major part of the disability associated with the disorder. There are several instruments to measure functioning, but the HoNOS provides a wide assessment of impairment in 12 areas of functioning. What does the paper add to existing knowledge? The Spanish version of the HoNOS shows good properties in terms of reliability and validity for use in schizophrenia patients. Although some authors divide the scale according to proposed underlying dimensions, in schizophrenia this division may not be appropriate. What are the implications for practice? A reliable and easy-to-use measure of impairment in different areas of functioning is useful for optimizing the treatment and rehabilitation of patients with schizophrenia.
    Abstract: INTRODUCTION: The HoNOS scale was designed for the assessment of psychosocial impairment in various domains. While it is widely used in psychiatric settings, it has not been validated in Spanish for use in patients with schizophrenia.
    Aim: To examine the psychometric properties of the Spanish version of the HoNOS scale in a sample of schizophrenia patients.
    Method: A total of 194 individuals aged 18 to 65 with schizophrenia spectrum diagnoses were evaluated using the HoNOS. Illness severity and level of functioning were also assessed.
    Results: The HoNOS showed moderate internal consistency, good inter-observer reliability and good test-retest reliability. Factor analysis revealed an internal structure consisting of four factors, with item distribution differing from the theoretical dimensions proposed for the original scale.
    Discussion: The Spanish version of the HoNOS scale is a reliable and valid instrument for assessing psychosocial impairment in individuals diagnosed with schizophrenia spectrum disorders. However, further research is needed to determine its internal structure more accurately.
    Implications for practice: The HoNOS scale provides researchers and clinicians with a valid measure of impairment in twelve different domains, which can facilitate and guide the treatment of schizophrenia patients.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328479-4
    ISSN 1365-2850 ; 1351-0126
    ISSN (online) 1365-2850
    ISSN 1351-0126
    DOI 10.1111/jpm.13046
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    Zs.A 4466: Show issues Location:
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  10. Article ; Online: Associations of altered leukocyte DDR1 promoter methylation and childhood trauma with bipolar disorder and suicidal behavior in euthymic patients.

    Garcia-Ruiz, Beatriz / Jiménez, Esther / Aranda, Selena / Verdolini, Norma / Gutiérrez-Zotes, Alfonso / Sáez, Cristina / Losantos, Elisa / Alonso-Lana, Silvia / Fatjó-Vilas, Mar / Sarró, Salvador / Torres, Llanos / Panicalli, Francesco / Bonnin, Caterina Del Mar / Pomarol-Clotet, Edith / Vieta, Eduard / Vilella, Elisabet

    Molecular psychiatry

    2024  

    Abstract: Altered DNA methylation (DNAm) patterns of discoidin domain receptor 1 (DDR1) have been found in the blood and brain of patients with schizophrenia (SCZ) and the brain of patients with bipolar disorder (BD). Childhood trauma (CT) is associated with ... ...

    Abstract Altered DNA methylation (DNAm) patterns of discoidin domain receptor 1 (DDR1) have been found in the blood and brain of patients with schizophrenia (SCZ) and the brain of patients with bipolar disorder (BD). Childhood trauma (CT) is associated with changes in DNAm that in turn are related to suicidal behavior (SB) in patients with several psychiatric disorders. Here, using MassARRAY® technology, we studied 128 patients diagnosed with BD in remission and 141 healthy controls (HCs) to compare leukocyte DDR1 promoter DNAm patterns between patients and HCs and between patients with and without SB. Additionally, we investigated whether CT was associated with DDR1 DNAm and mediated SB. We found hypermethylation at DDR1 cg19215110 and cg23953820 sites and hypomethylation at cg14279856 and cg03270204 sites in patients with BD compared to HCs. Logistic regression models showed that hypermethylation of DDR1 cg23953820 but not cg19215110 and CT were risk factors for BD, while cg14279856 and cg03270204 hypomethylation were protective factors. In patients, CT was a risk factor for SB, but DDR1 DNAm, although associated with CT, did not mediate the association of CT with SB. This is the first study demonstrating altered leukocyte DDR1 promoter DNAm in euthymic patients with BD. We conclude that altered DDR1 DNAm may be related to immune and inflammatory mechanisms and could be a potential blood biomarker for the diagnosis and stratification of psychiatric patients.
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02522-8
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