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  1. Article: Blood Donor Screening for Hepatitis E Virus in the European Union.

    Boland, Fiona / Martinez, Auxiliadora / Pomeroy, Louise / O'Flaherty, Niamh

    Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

    2019  Volume 46, Issue 2, Page(s) 95–103

    Abstract: This review article summarises hepatitis E virus (HEV) blood donation screening strategies in effect in the European Union (EU). Since 2012, eight EU countries have implemented HEV screening. Local rates of seroprevalence, RNA incidence, and molecular ... ...

    Abstract This review article summarises hepatitis E virus (HEV) blood donation screening strategies in effect in the European Union (EU). Since 2012, eight EU countries have implemented HEV screening. Local rates of seroprevalence, RNA incidence, and molecular epidemiology are variable and not usually directly comparable. We report a range of HEV-RNA reactivity rates from 1 in 744 donations (France) to 1 in 8,636 donations (Wales) with an overall EU rate of 1 in 3,109 donations (3.2 million donations screened). HEV genotypes 3c, 3e, and 3f are the most frequently reported subtypes. In these 8 countries, both universal (
    Language English
    Publishing date 2019-03-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000499121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Confirmed circulation of SARS-CoV-2 in Irish blood donors prior to first national notification of infection.

    Butler, Dearbhla / Coyne, Dermot / Pomeroy, Louise / Williams, Pádraig / Holder, Paul / Carterson, Alex / Field, Stephen / Waters, Allison / O'Flaherty, Niamh

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2021  Volume 146, Page(s) 105045

    Abstract: Introduction: Blood donor studies offer a unique opportunity to screen healthy populations for the presence of antibodies to emerging infections. We describe the use of blood donor specimens to track the 'first-wave' of the COVID-19 pandemic in Ireland.! ...

    Abstract Introduction: Blood donor studies offer a unique opportunity to screen healthy populations for the presence of antibodies to emerging infections. We describe the use of blood donor specimens to track the 'first-wave' of the COVID-19 pandemic in Ireland.
    Methodology: A random selection of donor samples received by the Irish Blood Transfusion Service (IBTS) between February and September 2020 (n = 8,509) were screened by multiple commercial SARs-CoV-2 antibody assays. The antibody detection rate was adjusted to the population to determine the SARS-CoV-2 seroprevalence in Ireland.
    Results: SARS-CoV-2 antibody detection rose significantly during the first peak of COVID-19 infection, increasing from 0.3% in March, to 2.9% in April (p < 0.0001, The first SARS-CoV-2 antibody positive donor samples were collected on the 17th February 2020, 2 weeks prior to the first official notification. This is the earliest serological evidence of SARS-CoV-2 circulating in the Irish population. Our results also show a significantly higher antibody prevalence in the Capital city and in donors less than 40 years of age.
    Conclusions: The present study demonstrates evidence of SARS-CoV-2 antibody reactivity across all age groups and counties. The critical value of blood donor seroprevalence studies is apparent in this report which identified the earliest serological evidence of SARS-CoV-2 infection in Ireland, as well as documenting the evolution of COVID-19 pandemic in Ireland over time.
    MeSH term(s) Antibodies, Viral ; Blood Donors ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-11-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2021.105045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Lessons learnt from syphilis-infected blood donors: a timely reminder of missed opportunities.

    Harvala, Heli / Reynolds, Claire / Fabiana, Alvin / Tossell, Joanne / Bulloch, Gillian / Brailsford, Susan / Blackmore, Stuart / Pomeroy, Louise

    Sexually transmitted infections

    2021  Volume 98, Issue 4, Page(s) 293–297

    Abstract: Objective: Due to the increased number of syphilis infections diagnosed in the UK and beyond, we reviewed our data on blood donors infected with syphilis in the UK and Ireland between 2016 and 2019.: Methods: Data were extracted from the surveillance ...

    Abstract Objective: Due to the increased number of syphilis infections diagnosed in the UK and beyond, we reviewed our data on blood donors infected with syphilis in the UK and Ireland between 2016 and 2019.
    Methods: Data were extracted from the surveillance database for all blood donors confirmed positive for syphilis in the UK and Ireland between 2016 and 2019, together with the total number of donations tested during that period. Data on positive cases included gender, age group, reported treatment, symptoms and confirmatory results. All cases were divided into recently acquired within 24 months and past syphilis infection. We also reviewed the information on symptoms characteristic of syphilis reported by blood donors with an untreated syphilis infection during the postdonation discussions.
    Results: Screening of 8 246 600 blood donations for treponemal antibodies identified 316 blood donors with confirmed syphilis infection in the UK and Ireland between 2016 and 2019 (1.6 per 100 000 donations). 42% of them (133 of 316) were classed as a recent infection based on their donation testing results, previous donation date and clinical history provided, and they were hence considered potentially infectious. Most of these blood donors (202 of 316, 64%) had not been previously diagnosed or treated for syphilis, although 50 of them reported symptoms consistent with syphilis infection and 19 had been misdiagnosed despite seeking medical help.
    Conclusions: This observational study shows that syphilis infection remains undiagnosed, especially among heterosexual men, and that infectious syphilis is often missed as a differential diagnosis even when donors have presented with genital or oral ulceration, rashes in the genital area and lymphadenopathy. Considering the recent resurgence of syphilis infections in the UK and beyond and our generally expanding sexual networks, it is important to consider syphilis in differential diagnosis even if specific risk factors have not been identified.
    MeSH term(s) Blood Donors ; HIV Infections/epidemiology ; Heterosexuality ; Humans ; Male ; Mass Screening ; Observational Studies as Topic ; Risk Factors ; Syphilis/diagnosis ; Syphilis/epidemiology
    Language English
    Publishing date 2021-08-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1420303-0
    ISSN 1472-3263 ; 1368-4973
    ISSN (online) 1472-3263
    ISSN 1368-4973
    DOI 10.1136/sextrans-2021-055034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Blood Donor Screening for Hepatitis E Virus in the European Union

    Boland, Fiona / Martinez, Auxiliadora / Pomeroy, Louise / O'Flaherty, Niamh

    Transfusion Medicine and Hemotherapy

    2019  Volume 46, Issue 2, Page(s) 95–103

    Abstract: This review article summarises hepatitis E virus (HEV) blood donation screening strategies in effect in the European Union (EU). Since 2012, eight EU countries have implemented HEV screening. Local rates of seroprevalence, RNA incidence, and molecular ... ...

    Institution Irish Blood Transfusion Service (IBTS), NAT Laboratory, Dublin, Ireland
    National Virus Reference Laboratory, University College Dublin (UCD), Dublin, Ireland
    Abstract This review article summarises hepatitis E virus (HEV) blood donation screening strategies in effect in the European Union (EU). Since 2012, eight EU countries have implemented HEV screening. Local rates of seroprevalence, RNA incidence, and molecular epidemiology are variable and not usually directly comparable. We report a range of HEV-RNA reactivity rates from 1 in 744 donations (France) to 1 in 8,636 donations (Wales) with an overall EU rate of 1 in 3,109 donations (3.2 million donations screened). HEV genotypes 3c, 3e, and 3f are the most frequently reported subtypes. In these 8 countries, both universal (>italic<n>/italic< = 5) and selective (>italic<n>/italic< = 3) screening policies have been introduced utilising either individual donation (ID; >italic<n>/italic< = 1) or mini-pool (MP; >italic<n>/italic< = 7; MP-6, -16, -24, and -96) testing. We also describe the Irish experience of HEV screening utilising an ID-NAT-based donor screening algorithm which intercepts donations even from those with low-level viraemia; 21 of 56 donors (37.5%) had a viral load (VL) < 100 IU/mL. We performed a MP-24 experiment which may prove useful to colleagues in relation to donor screening and associated blood component transmissibility. Irish results indicate that 59% of donors with a HEV-VL < 450 IU/mL may have screened negative in a MP-24.
    Keywords Hepatitis E virus ; Nucleic acid testing ; Viral load ; European Union
    Language English
    Publishing date 2019-03-14
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Review Article
    ZDB-ID 2100848-6
    ISSN 1660-3818 ; 1660-3796
    ISSN (online) 1660-3818
    ISSN 1660-3796
    DOI 10.1159/000499121
    Database Karger publisher's database

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  5. Article ; Online: International forum on Occult hepatitis B infection and transfusion safety.

    Seed, Clive R / Allain, Jean-Pierre / Lozano, Miquel / Laperche, Syria / Gallian, Pierre / Gross, Sylvie / Kwon, So-Yong / Oh, Eun Young / Kim, Jun Nyun / Chua, Sze Sze / Lam, Sally / Ang, Ai Leen / Tsoi, Wai-Chiu / Hewitt, Patricia E / Davison, Katy / Tettmar, Kate / O'Flaherty, Niamh / Boland, Fiona / Williams, Padraig /
    Pomeroy, Louise / Wendel, Silvano / Fachini, Roberta / Scuracchio, Patricia Santos Prado / Carminato, Patricia / Fearon, Margaret / O'Brien, Sheila F / Delages, Giles / Kiely, Philip / Hoad, Veronica C / Matsubayashi, Keiji / Satake, Masahiro / Taira, Rikizo / Stramer, Susan L / Sauleda, Silvia / Bes, Marta / Piron, Maria / Ekiaby, Magdy El / Vermeulen, Marion / Stezinar, Snežna Levičnik / Nograšek, Polona / Jarvis, Lisa M / Petrik, Juraj / Charlewood, Richard / Flanagan, Peter / Grabarczyk, Piotr / Kopacz, Aneta / Łętowska, Magdalena / Schmidt, Michael / Seifried, Erhard

    Vox sanguinis

    2019  Volume 114, Issue 4, Page(s) 397–406

    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: International Forum on Occult hepatitis B infection and transfusion safety.

    Seed, Clive R / Allain, Jean-Pierre / Lozano, Miquel / Laperche, Syria / Gallian, Pierre / Gross, Sylvie / Kwon, So-Yong / Oh, E Y / Kim, J N / Chua, Sze Sze / Lam, Sally / Ang, Ai Leen / Tsoi, Wai-Chiu / Hewitt, Patricia E / Davison, Katy L / Tettmar, Kate / O'Flaherty, Niamh / Boland, Fiona / Williams, Padraig /
    Pomeroy, Louise / Wendel, Silvano / Fachini, Roberta / Scuracchio, Patrícia / Carminato, Patricia / Fearon, Margaret / O'Brien, Sheila F / Delage, Gilles / Kiely, Philip / Hoad, Veronica / Matsubayashi, Keiji / Satake, Masahiro / Taira, Rikizo / Stramer, Susan L / Sauleda, Silvia / Bes, Marta / Piron, Maria / El Ekiaby, Magdy / Vermeulen, Marion / Levičnik Stezinar, Snežna / Nograšek, Polona / Jarvis, Lisa M / Petrik, Juraj / Charlewood, Richard / Flanagan, Peter / Grabarczyk, Piotr / Kopacz, Aneta / Łętowska, Magdalena / Seifried, Erhard / Schmidt, Michael

    Vox sanguinis

    2019  Volume 114, Issue 4, Page(s) e1–e35

    Language English
    Publishing date 2019-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 80313-3
    ISSN 1423-0410 ; 0042-9007
    ISSN (online) 1423-0410
    ISSN 0042-9007
    DOI 10.1111/vox.12743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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