LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Book ; Thesis: Ergebnisse nach Früh- und Spätsynovektomie des Kniegelenks bei chronischen Polyarthritiden

    Pommer, Stefan

    1997  

    Author's details vorgelegt von Stefan Pommer
    Language German
    Size 87 S. : graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Regensburg, Univ., Diss., 1997
    HBZ-ID HT008353813
    Database Catalogue ZB MED Medicine, Health

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    98 D 1495 order for loan Magazin

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: The Effect of Serotonin Receptor 5-HT1B on Lateral Inhibition between Spiny Projection Neurons in the Mouse Striatum.

    Pommer, Stefan / Akamine, Yumiko / Schiffmann, Serge N / de Kerchove d'Exaerde, Alban / Wickens, Jeffery R

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2021  Volume 41, Issue 37, Page(s) 7831–7847

    Abstract: The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main axon, forming a local lateral inhibition network. Serotonin, acting via the 5-HT1B receptor, ... ...

    Abstract The principal neurons of the striatum, the spiny projection neurons (SPNs), make inhibitory synaptic connections with each other via collaterals of their main axon, forming a local lateral inhibition network. Serotonin, acting via the 5-HT1B receptor, modulates neurotransmitter release from SPN terminals in striatal output nuclei, but the role of 5-HT1B receptors in lateral inhibition among SPNs in the striatum is unknown. Here, we report the effects of 5-HT1B receptor activation on lateral inhibition in the mouse striatum. Whole-cell recordings were made from SPNs in acute brain slices of either sex, while optogenetically activating presynaptic SPNs or fast-spiking interneurons (FSIs). Activation of 5-HT1B receptors significantly reduced the amplitude of IPSCs evoked by optical stimulation of both direct and indirect pathway SPNs. This reduction was blocked by application of a 5-HT1B receptor antagonist. Activation of 5-HT1B receptors did not reduce the amplitude of IPSCs evoked from FSIs. These results suggest a new role for serotonin as a modulator of lateral inhibition among striatal SPNs. The 5-HT1B receptor may, therefore, be a suitable target for future behavioral experiments investigating the currently unknown role of lateral inhibition in the function of the striatum.
    MeSH term(s) Action Potentials/drug effects ; Animals ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Interneurons/drug effects ; Interneurons/metabolism ; Mice ; Neural Inhibition/drug effects ; Neurons/drug effects ; Neurons/metabolism ; Patch-Clamp Techniques ; Receptor, Serotonin, 5-HT1B/metabolism ; Serotonin/metabolism ; Serotonin 5-HT1 Receptor Agonists/pharmacology ; Synaptic Transmission/drug effects ; gamma-Aminobutyric Acid/metabolism
    Chemical Substances Receptor, Serotonin, 5-HT1B ; Serotonin 5-HT1 Receptor Agonists ; Serotonin (333DO1RDJY) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1037-20.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity.

    Carrasco, Andres / Tamura, Atsushi / Pommer, Stefan / Chouinard, Julie A / Kurima, Kiyoto / Barzaghi, Paolo / Wickens, Jeffery R

    The Journal of comparative neurology

    2019  Volume 528, Issue 5, Page(s) 787–804

    Abstract: Recent developments in genetic engineering have established murine models that permit the selective control of cholinergic neurons via optical stimulation. Despite copious benefits granted by these experimental advances, the sensory physiognomy of these ... ...

    Abstract Recent developments in genetic engineering have established murine models that permit the selective control of cholinergic neurons via optical stimulation. Despite copious benefits granted by these experimental advances, the sensory physiognomy of these organisms has remained poorly understood. Therefore, the present study evaluates sensory and neuronal response properties of animal models developed for the study of optically induced acetylcholine release regulation. Auditory brainstem responses, fluorescence imaging, and patch clamp recording techniques were used to assess the impact of viral infection, sex, age, and anesthetic agents across the ascending auditory pathway of ChAT-Cre and ChAT-ChR2(Ai32) mice. Data analyses revealed that neither genetic configuration nor adeno-associated viral infection alters the early stages of auditory processing or the cellular response properties of cholinergic neurons. However, anesthetic agent and dosage amount profoundly modulate the response properties of brainstem neurons. Last, analyses of age-related hearing loss in virally infected ChAT-Cre mice did not differ from those reported in wild type animals. This investigation demonstrates that ChAT-Cre and ChAT-ChR2(Ai32) mice are viable models for the study of cholinergic modulation in auditory processing, and it emphasizes the need for prudence in the selection of anesthetic procedures.
    MeSH term(s) Anesthetics/pharmacology ; Animals ; Cholinergic Neurons/drug effects ; Cholinergic Neurons/metabolism ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Evoked Potentials, Auditory, Brain Stem/drug effects ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Models, Animal ; Opsins/metabolism
    Chemical Substances Anesthetics ; Opsins
    Language English
    Publishing date 2019-11-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3086-7
    ISSN 1096-9861 ; 0021-9967 ; 0092-7317
    ISSN (online) 1096-9861
    ISSN 0021-9967 ; 0092-7317
    DOI 10.1002/cne.24795
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ub I Zs.66: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Book ; Thesis: Ergebnisse nach Früh- und Spätsynovektomie des Kniegelenks bei chronischen Polyarthritiden

    Pommer, Stefan

    1997  

    Author's details vorgelegt von Stefan Pommer
    Language German
    Size 87 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Regensburg, 1997
    Database Former special subject collection: coastal and deep sea fishing

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Book ; Thesis: Ergebnisse nach Früh- und Spätsynovektomie des Kniegelenks bei chronischen Polyarthritiden

    Pommer, Stefan

    1997  

    Author's details vorgelegt von Stefan Pommer
    Language German
    Size 87 S, Ill., graph. Darst, 21 cm
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Regensburg, 1997
    Database Special collection on veterinary medicine and general parasitology

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top