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  1. Article ; Online: Developing quantitative assays for six urinary glycoproteins using parallel reaction monitoring, data-independent acquisition, and TMT-based data-dependent acquisition.

    Ponce, Sean / Zhang, Hui

    Proteomics

    2023  Volume 23, Issue 7-8, Page(s) e2200072

    Abstract: Quantitative approaches encompassing parallel reaction monitoring (PRM), data-independent acquisition (DIA), and data-dependent acquisition (DDA) are commonly used to investigate protein expression profiles. However, analytical performances of assays ... ...

    Abstract Quantitative approaches encompassing parallel reaction monitoring (PRM), data-independent acquisition (DIA), and data-dependent acquisition (DDA) are commonly used to investigate protein expression profiles. However, analytical performances of assays developed using PRM, DIA, and Tandem Mass Tag (TMT)-based DDA for quantitative proteomics have yet not been investigated. Here, we developed assays for glycopeptides identified from six glycoproteins, including Leucine-rich alpha-2-glycoprotein (LRG1), Prostaglandin-H2 D-isomerase (PTGDS), Aminopeptidase N (ANPEP), CD63 antigen (CD63), Clusterin (CLU), and Prostatic acid phosphatase (ACPP), using PRM, DDA, and DIA and evaluated the analytical performances of each assay using the different acquisition modes. We also compared assays in each acquisition mode on three different orbitrap instruments: Thermo Fisher Q Exactive, Exploris 480, and Lumos. We found that DIA showed the largest linear range, highest sensitivity, and most reproducibility. We then applied our developed DIA assays to urine samples from non-aggressive (n = 48) and aggressive (n = 35) prostate cancer patients. In conclusion, we developed assays for the six glycoproteins, evaluated the analytical performances of each assay in DIA, PRM, and PRM acquisition modes on three types of mass spectrometry instruments, and chose the DIA assays for the quantitative analysis of urine samples from patients with aggressive and non-aggressive prostate cancer.
    MeSH term(s) Male ; Humans ; Reproducibility of Results ; Mass Spectrometry/methods ; Proteomics/methods ; Glycoproteins
    Chemical Substances Glycoproteins
    Language English
    Publishing date 2023-01-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2032093-0
    ISSN 1615-9861 ; 1615-9853
    ISSN (online) 1615-9861
    ISSN 1615-9853
    DOI 10.1002/pmic.202200072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5386: Show issues Location:
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  2. Article ; Online: Reversal of Band-Ordering Leads to High Hole Mobility in Strained

    Rudra, Sourav / Rao, Dheemahi / Poncé, Samuel / Saha, Bivas

    Nano letters

    2023  Volume 23, Issue 17, Page(s) 8211–8217

    Abstract: Low hole mobility of nitride semiconductors is a significant impediment to realizing their high-efficiency device applications. Scandium nitride (ScN), an emerging rocksalt indirect band gap semiconductor, suffers from low hole mobility. Utilizing ... ...

    Abstract Low hole mobility of nitride semiconductors is a significant impediment to realizing their high-efficiency device applications. Scandium nitride (ScN), an emerging rocksalt indirect band gap semiconductor, suffers from low hole mobility. Utilizing the
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ISSN 1530-6992
    ISSN (online) 1530-6992
    DOI 10.1021/acs.nanolett.3c02350
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  3. Article ; Online: Achieving the Unachievable: Work-Life Balance in Radiation Oncology.

    Beltrán Ponce, Sara / Katz, Leah M / Seldon, Crystal

    Practical radiation oncology

    2023  Volume 13, Issue 6, Page(s) 486–487

    Abstract: As radiation oncologists, we often participate in discussions on work-life balance, are offered lectures and free meals, and complete hospital-mandated modules, all under the guise of physician wellness. But how often are these measures efficacious? How ... ...

    Abstract As radiation oncologists, we often participate in discussions on work-life balance, are offered lectures and free meals, and complete hospital-mandated modules, all under the guise of physician wellness. But how often are these measures efficacious? How do we define being well in our demanding and fast-paced careers? What does it actually look like on a day-to-day basis to achieve work-life balance? Furthermore, is it even possible?
    MeSH term(s) Humans ; Radiation Oncology ; Work-Life Balance ; Physicians ; Radiation Oncologists
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2023.06.010
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  4. Article ; Online: Predictive Model for Allergic Contact Dermatitis in Patients With Hand Eczema.

    Ponce, S / Borrego, L / Saavedra, P

    Actas dermo-sifiliograficas

    2020  Volume 111, Issue 4, Page(s) 300–305

    Abstract: Introduction: Patch tests are only indicated for hand eczema when it is diagnosed as chronic. A positive reaction of current relevance requires a change in treatment strategy. Knowing which clinical factors are associated with current relevance would ... ...

    Title translation Modelo predictivo de dermatitis alérgica de contacto en pacientes con eccema de manos.
    Abstract Introduction: Patch tests are only indicated for hand eczema when it is diagnosed as chronic. A positive reaction of current relevance requires a change in treatment strategy. Knowing which clinical factors are associated with current relevance would allow tests to be performed sooner.
    Objective: To develop a model for predicting currently relevant patch test positivity in patients with hand eczema only.
    Material and methods: Retrospective study of patients with hand eczema only. We collected data on age, sex, time since onset, occupation, and history of atopic dermatitis. We built a predictive logistic regression model and assessed discrimination by computing the area under the receiver operating characteristic curve.
    Results: We included 262 patients; 66.03% had positive patch tests (28.6% of current relevance). Univariate analysis detected significant associations between positivity of current relevance and employment as a hairdresser-aesthetician, a personal history of atopy, male sex, and a time since onset of over 6 months. Multivariate analysis confirmed employment as a hairdresser-aesthetician as an independent risk factor and male sex and a personal history of atopy as protective factors. The score suggested by the predictive model was 2.316(hairdresser-aesthetician)-1.792(atopic dermatitis)-0.601(male sex).
    Conclusions: Occupation, sex, and a history of atopy influence the likelihood of patch test positivity of current relevance in patients with hand eczema in Spain. Our model suggests that a diagnosis of chronic eczema is not necessarily an indication for patch testing. Future studies with larger samples are needed to determine the true usefulness of predictive models in this setting.
    MeSH term(s) Dermatitis, Allergic Contact/diagnosis ; Eczema/diagnosis ; Hand Dermatoses/diagnosis ; Humans ; Male ; Retrospective Studies ; Spain
    Language Spanish
    Publishing date 2020-04-16
    Document type Journal Article
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2019.10.001
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  5. Article ; Online: Cystic Vulvar Lesion.

    Ponce, S / Montenegro, T / Cameselle, D

    Actas dermo-sifiliograficas

    2020  Volume 111, Issue 9, Page(s) 769–770

    Title translation Lesión quística vulvar.
    MeSH term(s) Female ; Humans ; Vulvar Diseases/diagnosis
    Language Spanish
    Publishing date 2020-08-25
    Document type Case Reports
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2019.02.029
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  6. Article ; Online: Coincident Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder in Two Sisters.

    Ponce, S / Peñate, Y / Montenegro, T

    Actas dermo-sifiliograficas

    2020  Volume 111, Issue 3, Page(s) 271–273

    Title translation Trastorno linfoproliferativo primario de células T pleomórficas pequeñas/medianas CD4+ coincidente en dos hermanas.
    MeSH term(s) CD4-Positive T-Lymphocytes ; Humans ; Lymphoma, T-Cell, Cutaneous/diagnosis ; Lymphoproliferative Disorders ; Skin Diseases ; Skin Neoplasms
    Language Spanish
    Publishing date 2020-01-21
    Document type Case Reports
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2018.09.020
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  7. Article: Challenges and Solutions for Establishing Robust Diversity, Equity, and Inclusion Efforts in US Academic Radiation Oncology Departments.

    Beltrán Ponce, Sara / Franco, Idalid / Paradis, Kelly C / Mattes, Malcolm D

    Advances in radiation oncology

    2023  Volume 8, Issue 4, Page(s) 101182

    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ISSN 2452-1094
    ISSN 2452-1094
    DOI 10.1016/j.adro.2023.101182
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  8. Article ; Online: Accurate Prediction of Hall Mobilities in Two-Dimensional Materials through Gauge-Covariant Quadrupolar Contributions.

    Poncé, Samuel / Royo, Miquel / Gibertini, Marco / Marzari, Nicola / Stengel, Massimiliano

    Physical review letters

    2023  Volume 130, Issue 16, Page(s) 166301

    Abstract: Despite considerable efforts, accurate computations of electron-phonon and carrier transport properties of low-dimensional materials from first principles have remained elusive. By building on recent advances in the description of long-range ... ...

    Abstract Despite considerable efforts, accurate computations of electron-phonon and carrier transport properties of low-dimensional materials from first principles have remained elusive. By building on recent advances in the description of long-range electrostatics, we develop a general approach to the calculation of electron-phonon couplings in two-dimensional materials. We show that the nonanalytic behavior of the electron-phonon matrix elements depends on the Wannier gauge, but that a missing Berry connection restores invariance to quadrupolar order. We showcase these contributions in a MoS_{2} monolayer, calculating intrinsic drift and Hall mobilities with precise Wannier interpolations. We also find that the contributions of dynamical quadrupoles to the scattering potential are essential, and that their neglect leads to errors of 23% and 76% in the room-temperature electron and hole Hall mobilities, respectively.
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.130.166301
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    In stock of ZB MED Bonn / Germany

    Z 4' 58/153: Show issues

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  9. Article ; Online: Behaviors, Attitudes, and Knowledge Related to Sun Exposure Among Medical Students at the Universidad de Las Palmas de Gran Canaria.

    Ponce, S / Jódar, A / Borrego, L / Saavedra, P

    Actas dermo-sifiliograficas

    2018  Volume 110, Issue 5, Page(s) 372–384

    Abstract: Introduction: The incidence of skin cancer, for which the main risk factor is exposure to ultraviolet radiation, has risen worldwide. Sunburn is one of the simplest ways to assess sun exposure habits. To date, few studies have evaluated sun exposure in ... ...

    Title translation Comportamientos, actitudes y conocimientos relacionados con la exposición solar en estudiantes de medicina de la Universidad de Las Palmas de Gran Canaria.
    Abstract Introduction: The incidence of skin cancer, for which the main risk factor is exposure to ultraviolet radiation, has risen worldwide. Sunburn is one of the simplest ways to assess sun exposure habits. To date, few studies have evaluated sun exposure in university students.
    Objectives: To determine behaviors, attitudes, and knowledge related to sun exposure and sun protection measures among medical students at the Universidad de Las Palmas de Gran Canaria; and to assess their relation to sunburn frequency.
    Material and methods: The voluntary participants in this cross-sectional survey were first-, second- and sixth-year university students enrolled during the 2016-2017 academic year. The students responded to a validated questionnaire about their habits, attitudes, and knowledge in relation to sun exposure. Respondents were grouped according to the number of sunburns they had experienced during the previous summer.
    Results: A total of 286 students responded. The students demonstrated a high level of knowledge, but the percentage who experienced a sunburn was high. Multivariate analysis showed independent correlations between experiencing a sunburn and age, male sex, academic year of enrollment at the time of the survey, phototype, and negative attitudes toward the use of sun protection measures.
    Conclusions: Our medical students' level of knowledge about sun exposure and sun protection is high and scarcely varies with time spent at the university. However, their knowledge is not reflected in their behavior and attitudes or in the frequency of sunburns.
    MeSH term(s) Attitude to Health ; Cross-Sectional Studies ; Female ; Health Behavior ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Spain ; Students, Medical/psychology ; Sunburn/epidemiology ; Sunlight ; Universities ; Young Adult
    Language Spanish
    Publishing date 2018-12-26
    Document type Journal Article
    ZDB-ID 2541876-2
    ISSN 2173-5778 ; 2173-5778
    ISSN (online) 2173-5778
    ISSN 2173-5778
    DOI 10.1016/j.ad.2018.10.002
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  10. Article ; Online: Challenges of Reaching Patients With Cancer on Social Media: Lessons From the Failed #CancerRealTalk Experience.

    Beltrán Ponce, Sara / McAlarnen, Lindsey A / Teplinsky, Eleonora

    JCO oncology practice

    2022  Volume 19, Issue 2, Page(s) 63–65

    MeSH term(s) Humans ; Social Media ; Neoplasms/complications ; Neoplasms/epidemiology ; Neoplasms/therapy
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.22.00515
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