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Article ; Online: Harnessing the post-vaccination era: Do emerging HPV types represent a new threat?

Ponce-de-Leon, Sergio / Lizano, Marcela

2023 Volume 31, Issue 11, Page(s) 1774–1775

Abstract: While the HPV vaccine is highly effective, it is unknown whether other, untargeted viral types could occupy empty niches to become an emerging threat. In this issue of Cell Host & Microbe, Pimenoff and colleagues present a community-level epidemiological ...

Abstract	While the HPV vaccine is highly effective, it is unknown whether other, untargeted viral types could occupy empty niches to become an emerging threat. In this issue of Cell Host & Microbe, Pimenoff and colleagues present a community-level epidemiological analysis of HPV types up to 8 years after different vaccination policies.
MeSH term(s)	Humans ; Papillomavirus Infections/prevention & control ; Papillomavirus Vaccines ; Vaccination
Chemical Substances	Papillomavirus Vaccines
Language	English
Publishing date	2023-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2278004-X
ISSN	1934-6069 ; 1931-3128
ISSN (online)	1934-6069
ISSN	1931-3128
DOI	10.1016/j.chom.2023.10.013
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Article: Wave energy in the Balearic Sea. Evolution from a 29 year spectral wave hindcast

Ponce de León, S / A. Orfila / G. Simarro

Renewable energy. 2016 Jan., v. 85

2016

Abstract: This work studies the wave energy availability in the Western Mediterranean Sea using wave simulation from January 1983 to December 2011. The model implemented is the WAM, forced by the ECMWF ERA-Interim wind fields. The Advanced Scatterometer (ASCAT) ... ...

Abstract	This work studies the wave energy availability in the Western Mediterranean Sea using wave simulation from January 1983 to December 2011. The model implemented is the WAM, forced by the ECMWF ERA-Interim wind fields. The Advanced Scatterometer (ASCAT) data from MetOp satellite and the TOPEX-Poseidon altimetry data are used to assess the quality of the wind fields and WAM results respectively. Results from the hindcast are the starting point to analyse the potentiality of obtaining wave energy around the Balearic Islands Archipelago. The comparison of the 29 year hindcast against wave buoys located in Western, Central and Eastern basins shows a high correlation between the hindcasted and the measured significant wave height (Hs), indicating a proper representation of spatial and temporal variability of Hs. It is found that the energy flux at the Balearic coasts range from 9.1 kW/m, in the north of Menorca Island, to 2.5 kW/m in the vicinity of the Bay of Palma. The energy flux is around 5 and 6 times lower in summer as compared to winter.
Keywords	basins ; coasts ; energy flow ; models ; satellites ; summer ; temporal variation ; water power ; wind ; winter ; Balearic Islands ; Mediterranean Sea
Language	English
Dates of publication	2016-01
Size	p. 1192-1200.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	2001449-1
ISSN	0960-1481
ISSN	0960-1481
DOI	10.1016/j.renene.2015.07.076
Database	NAL-Catalogue (AGRICOLA)

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Conference proceedings ; Online: EOatSEE - Earth observation advanced science tools for sea level extreme events

Jose da Costa Ribeiro, P. / Almeida, P. / Bonanad, C. / Cecilio, C. / Dufau, C. / Fauny, O. / Voirand, T. / Federico, I. / Coppini, G. / Gawehn, M. / Eleveld, M. / Benveniste, J. / Restano, M. / Ponce De Léon, S.

XXVIII General Assembly of the International Union of Geodesy and Geophysics (IUGG)

scientific challenges, technical requirements and proposed approach

2023

Abstract: Extreme sea level (ESL) events are the phenomena that result in exceptional water level at the coast, which can cause flooding, inundation, and erosion. Recent global scale studies show that relative sea level rise will increase the recurrence of ESL ... ...

Abstract	Extreme sea level (ESL) events are the phenomena that result in exceptional water level at the coast, which can cause flooding, inundation, and erosion. Recent global scale studies show that relative sea level rise will increase the recurrence of ESL events, by reducing their return period. Also, the compound nature of these events, including the contribution from pluvial, fluvial, and ocean processes, is now understood to affect key processes in estuarine and delta environments. The EOatSEE project (https://eoatsee.eu/), funded by ESA under the Earth Observation Science for Society programmatic line, aims to provide a data-driven description of ESL events as a mean to advance scientific knowledge on this subject matter. It shall foster a community effort, bringing together the EO data provider and the numerical modelling communities, to fully exploit the novel capabilities and synergies offered by the latest advances in EO technology. In this work, a literature review and a collection of needs from the scientific community enabled the identification of current scientific challenges and technical requirements associated with process understanding, predictability and vulnerability & risk assessment of ESL events. Increasing the understanding of the non-linear interactions between oceanic and fluvial processes, and considering coastal morphology response within long-term flooding risk assessments are some examples of the scientific challenges identified, which are to be studied within 9 scientific demonstrators over 6 different coastal regions. Within IUGG2023, a set of preliminary results shall also be presented, as innovative solutions are developed and produced along EOatSEE to address those challenges.
Subject code	910
Language	English
Publishing date	2023-07-11
Publishing country	de
Document type	Conference proceedings ; Online
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Article ; Online: Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemic.

Jácome, Rodrigo / Campillo-Balderas, José Alberto / Ponce de León, Samuel / Becerra, Arturo / Lazcano, Antonio

Scientific reports

2020 Volume 10, Issue 1, Page(s) 9294

Abstract: As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. The structural superposition of the hepatitis C virus polymerase bound to sofosbuvir, a nucleoside ...

Abstract	As of today, there is no antiviral for the treatment of the SARS-CoV-2 infection, and the development of a vaccine might take several months or even years. The structural superposition of the hepatitis C virus polymerase bound to sofosbuvir, a nucleoside analog antiviral approved for hepatitis C virus infections, with the SARS-CoV polymerase shows that the residues that bind to the drug are present in the latter. Moreover, a multiple alignment of several SARS-CoV-2, SARS and MERS-related coronaviruses polymerases shows that these residues are conserved in all these viruses, opening the possibility to use sofosbuvir against these highly infectious pathogens.
MeSH term(s)	Antiviral Agents/chemistry ; Antiviral Agents/therapeutic use ; Base Sequence ; Betacoronavirus/enzymology ; COVID-19 ; Catalytic Domain ; Computer Simulation ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Coronavirus RNA-Dependent RNA Polymerase ; Humans ; Middle East Respiratory Syndrome Coronavirus/enzymology ; Pandemics/prevention & control ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; Protein Binding ; Protein Structure, Tertiary ; RNA-Dependent RNA Polymerase/chemistry ; RNA-Dependent RNA Polymerase/genetics ; SARS Virus/enzymology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/drug therapy ; Severe Acute Respiratory Syndrome/virology ; Sofosbuvir/chemistry ; Sofosbuvir/therapeutic use ; Viral Nonstructural Proteins/chemistry ; Viral Nonstructural Proteins/genetics
Chemical Substances	Antiviral Agents ; Viral Nonstructural Proteins ; Coronavirus RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; NS-5 protein, hepatitis C virus (EC 2.7.7.48) ; NSP12 protein, SARS-CoV-2 (EC 2.7.7.48) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Sofosbuvir (WJ6CA3ZU8B)
Keywords	covid19
Language	English
Publishing date	2020-06-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-66440-9
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Article: Ciencia y confianza: la necesidad de ser claros

Ponce de León, Samuel

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2014 Volume 66, Issue 1, Page(s) 93–94

Title translation	Science and confidence: the need to be clear.
MeSH term(s)	Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/therapy ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/therapy ; Lymphoma, Non-Hodgkin/diagnosis ; Lymphoma, Non-Hodgkin/therapy
Language	Spanish
Publishing date	2014-01
Publishing country	Mexico
Document type	Comment ; Letter
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
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Article ; Online: Redox Dysregulation of Vascular Smooth Muscle Sirtuin-1 in Thoracic Aortic Aneurysm in Marfan Syndrome.

Budbazar, Enkhjargal / Sulser Ponce De Leon, Sandra / Tsukahara, Yuko / Liu, Hanxiao / Huangfu, Yuhao / Wang, Yu / Seabra, Pedro Maria / Yang, Xiaoqiu / Goodman, Jena Brooke / Wan, Xueping / Chitalia, Vipul / Han, Jingyan / Seta, Francesca

Arteriosclerosis, thrombosis, and vascular biology

2023 Volume 43, Issue 8, Page(s) e339–e357

Abstract: Background: Thoracic aortic aneurysms (TAAs) are abnormal aortic dilatations and a major cardiovascular complication of Marfan syndrome. We previously demonstrated a critical role for vascular smooth muscle (VSM) SirT1 (sirtuin-1), a lysine deacetylase, ...

Abstract	Background: Thoracic aortic aneurysms (TAAs) are abnormal aortic dilatations and a major cardiovascular complication of Marfan syndrome. We previously demonstrated a critical role for vascular smooth muscle (VSM) SirT1 (sirtuin-1), a lysine deacetylase, against maladaptive aortic remodeling associated with chronic oxidative stress and aberrant activation of MMPs (matrix metalloproteinases). Methods: In this study, we investigated whether redox dysregulation of SirT1 contributed to the pathogenesis of TAA using fibrillin-1 hypomorphic mice (Fbn1 Results: Oxidative stress markers 3-nitrotyrosine and 4-hydroxynonenal were significantly elevated in aortas of patients with Marfan syndrome. Moreover, reversible oxidative post-translational modifications (rOPTM) of protein cysteines, particularly S-glutathionylation, were dramatically increased in aortas of Fbn1 Conclusions: Our novel findings strongly suggest a causal role of S-glutathionylation of SirT1 in the pathogenesis of TAA. Prevention or reversal of SirT1 rOPTM may be a novel therapeutic strategy to prevent TAA and TAA dissection/ruptures in individuals with Marfan syndrome, for which, thus far, no targeted therapy has been developed.
MeSH term(s)	Mice ; Animals ; Marfan Syndrome/complications ; Marfan Syndrome/genetics ; Marfan Syndrome/metabolism ; Matrix Metalloproteinase 2/metabolism ; Fibrillins/metabolism ; Muscle, Smooth, Vascular/metabolism ; Sirtuin 1/genetics ; Sirtuin 1/metabolism ; Microfilament Proteins/metabolism ; Aortic Aneurysm, Thoracic/genetics ; Aortic Aneurysm, Thoracic/prevention & control ; Fibrillin-1/genetics ; Fibrillin-1/metabolism ; Aortic Rupture/prevention & control ; Transforming Growth Factor beta/metabolism ; Oxidation-Reduction ; Disease Models, Animal ; Glutaredoxins/metabolism ; Glutaredoxins/therapeutic use
Chemical Substances	Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Fibrillins ; Sirtuin 1 (EC 3.5.1.-) ; Microfilament Proteins ; Fibrillin-1 ; Transforming Growth Factor beta ; Glrx protein, mouse ; Glutaredoxins
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1221433-4
ISSN	1524-4636 ; 1079-5642
ISSN (online)	1524-4636
ISSN	1079-5642
DOI	10.1161/ATVBAHA.123.319145
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Book ; Article ; Online: Dispersion of a new coronavirus SARS-CoV-2 by airlines in 2020

Cruz-Pacheco, Gustavo / Bustamante-Castañeda, J.F. / Caputo, Jean-Guy / Jiménez-Corona, M.E. / Ponce-de-León, S.

https://hal.archives-ouvertes.fr/hal-02507142 ; 2020

Temporal estimates of the outbreak in Mexico

2020

Abstract: On January 23, 2020, China imposed a quarantine on the city of Wuhan to contain the Covid-19 outbreak. In this work we show an analysis of the dispersion of this infection to other cities by airlines based on the classic model the Kermack and McKendrick ... ...

Abstract	On January 23, 2020, China imposed a quarantine on the city of Wuhan to contain the Covid-19 outbreak. In this work we show an analysis of the dispersion of this infection to other cities by airlines based on the classic model the Kermack and McKendrick complemented with diffusion on a graph. The main purpose is to give estimates of the arrival virus and times of the outbreak to other locations. We use Mexico City as an example. In this case, our estimate of the arrival time is around March 20, 2020. This analysis is limited to the analysis of dispersion by airlines, so this estimate should be takenAs an overestimate since the infection can arrive by other means. Last, we show that these estimates are robust to small variations of epidemiological parameters.
Keywords	outbreak ; COVID-19 ; coronavirus ; SARS-CoV-2 ; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ; [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS] ; covid19
Language	English
Publishing date	2020-03-12
Publisher	HAL CCSD
Publishing country	fr
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Article ; Online: Dispersion of a new coronavirus SARS-CoV-2 by airlines in 2020

Cruz-Pacheco, Gustavo / Bustamante-Castañeda, J.F. / Caputo, Jean-Guy / Jiménez-Corona, M.E. / Ponce-de-León, S.

https://hal.archives-ouvertes.fr/hal-02507142 ; 2020

Temporal estimates of the outbreak in Mexico

2020

Abstract	On January 23, 2020, China imposed a quarantine on the city of Wuhan to contain the Covid-19 outbreak. In this work we show an analysis of the dispersion of this infection to other cities by airlines based on the classic model the Kermack and McKendrick complemented with diffusion on a graph. The main purpose is to give estimates of the arrival virus and times of the outbreak to other locations. We use Mexico City as an example. In this case, our estimate of the arrival time is around March 20, 2020. This analysis is limited to the analysis of dispersion by airlines, so this estimate should be takenAs an overestimate since the infection can arrive by other means. Last, we show that these estimates are robust to small variations of epidemiological parameters.
Keywords	outbreak ; COVID-19 ; coronavirus ; SARS-CoV-2 ; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ; [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS] ; covid19
Language	English
Publishing date	2020-03-12
Publisher	HAL CCSD
Publishing country	fr
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Article ; Online: Dispersion of a new coronavirus SARS-CoV-2 by airlines in 2020

Cruz-Pacheco, Gustavo / Bustamante-Castañeda, J.F. / Caputo, Jean-Guy / Jiménez-Corona, M.E. / Ponce-de-León, S.

https://hal.archives-ouvertes.fr/hal-02507142 ; 2020

Temporal estimates of the outbreak in Mexico

2020

Abstract	On January 23, 2020, China imposed a quarantine on the city of Wuhan to contain the Covid-19 outbreak. In this work we show an analysis of the dispersion of this infection to other cities by airlines based on the classic model the Kermack and McKendrick complemented with diffusion on a graph. The main purpose is to give estimates of the arrival virus and times of the outbreak to other locations. We use Mexico City as an example. In this case, our estimate of the arrival time is around March 20, 2020. This analysis is limited to the analysis of dispersion by airlines, so this estimate should be takenAs an overestimate since the infection can arrive by other means. Last, we show that these estimates are robust to small variations of epidemiological parameters.
Keywords	outbreak ; COVID-19 ; coronavirus ; SARS-CoV-2 ; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ; [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS] ; covid19
Language	English
Publishing date	2020-03-12
Publisher	HAL CCSD
Publishing country	fr
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Article ; Online: Dispersion of a new coronavirus SARS-CoV-2 by airlines in 2020

Cruz-Pacheco, Gustavo / Bustamante-Castañeda, J.F. / Caputo, Jean-Guy / Jiménez-Corona, M.E. / Ponce-de-León, S.

https://hal.archives-ouvertes.fr/hal-02507142 ; 2020

Temporal estimates of the outbreak in Mexico

2020

Abstract	On January 23, 2020, China imposed a quarantine on the city of Wuhan to contain the Covid-19 outbreak. In this work we show an analysis of the dispersion of this infection to other cities by airlines based on the classic model the Kermack and McKendrick complemented with diffusion on a graph. The main purpose is to give estimates of the arrival virus and times of the outbreak to other locations. We use Mexico City as an example. In this case, our estimate of the arrival time is around March 20, 2020. This analysis is limited to the analysis of dispersion by airlines, so this estimate should be takenAs an overestimate since the infection can arrive by other means. Last, we show that these estimates are robust to small variations of epidemiological parameters.
Keywords	outbreak ; COVID-19 ; coronavirus ; SARS-CoV-2 ; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ; [MATH.MATH-DS]Mathematics [math]/Dynamical Systems [math.DS] ; covid19
Language	English
Publishing date	2020-03-12
Publisher	HAL CCSD
Publishing country	fr
Document type	Book ; Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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