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  1. Article ; Online: Alcohol withdrawal and pain: Peripheral mechanisms join central circuits.

    Neugebauer, Volker / Ponomarev, Igor

    Neuron

    2024  Volume 112, Issue 1, Page(s) 1–3

    Abstract: Negative affective aspects of alcohol withdrawal and pain involve converging brain circuits. In this issue of Neuron, Son et al. ...

    Abstract Negative affective aspects of alcohol withdrawal and pain involve converging brain circuits. In this issue of Neuron, Son et al.
    MeSH term(s) Humans ; Substance Withdrawal Syndrome/psychology ; Receptors, Corticotropin-Releasing Hormone/physiology ; Alcoholism ; Corticotropin-Releasing Hormone ; Pain
    Chemical Substances Receptors, Corticotropin-Releasing Hormone ; Corticotropin-Releasing Hormone (9015-71-8)
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.12.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2496: Show issues Location:
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  2. Article ; Online: Biphasic parameter identification of 3D scaffold-free cartilage transplants (SFCT) from stress relaxation compression tests using an optimized 3D FE-based method with tension-compression nonlinearity

    Reuter Thomas / Ponomarev Igor

    Current Directions in Biomedical Engineering, Vol 7, Iss 2, Pp 355-

    2021  Volume 358

    Abstract: Cartilage constructs produced by SFCTtechnology provide promising opportunities to restore cartilage defects. Mechanical parameters of soft tissues are explicit markers for quantitative tissue characterization. In this study, we present a biphasic 3D-FE- ... ...

    Abstract Cartilage constructs produced by SFCTtechnology provide promising opportunities to restore cartilage defects. Mechanical parameters of soft tissues are explicit markers for quantitative tissue characterization. In this study, we present a biphasic 3D-FE-based method to determine the biomechanical properties of SFCT from stress relaxation compression tests (ε = 20 %, t = 3400 s) whereby cartilaginous tissue is modeled as a biphasic material with tension-compression nonlinearity (BMTCN). The FE-model computation was optimized by exploiting the axial symmetry and mesh resolution. The R² of the fit results varies between 0.970 and 0.983. The Young’s and fiber modulus determined from SFCT are 37-times and 5-times lower than from native articular cartilage, respectively. Permeability, on the other hand, is 11-times higher than from native articular cartilage.
    Keywords cartilage ; scaffold-free cartilage transplants (sfct) ; stress relaxation ; fe-modelling ; parameter identification ; biphasic theory ; tension-compression- nonlinearity (tcn) ; Medicine ; R
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Successful treatment of xanthelasma palpebrarum grade III with copper vapour laser radiation (578 nm).

    Ponomarev, Igor V / Topchiy, Sergey B / Shakina, Lyudmila D

    Indian journal of dermatology, venereology and leprology

    2023  , Page(s) 1–2

    Language English
    Publishing date 2023-07-17
    Publishing country United States
    Document type Letter
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.25259/IJDVL_339_2023
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 85: Show issues Location:
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  4. Article ; Online: Successful treatment of Xanthelasma palpebrarum with copper vapor laser radiation at 578 nm.

    Ponomarev, Igor V / Topchiy, Sergey B / Shakina, Lyudmila D

    Journal of cosmetic dermatology

    2023  Volume 22, Issue 12, Page(s) 3522–3523

    MeSH term(s) Humans ; Lasers, Gas ; Eyelid Diseases/etiology ; Eyelid Diseases/radiotherapy ; Xanthomatosis/etiology ; Xanthomatosis/radiotherapy ; Skin Neoplasms
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Letter
    ZDB-ID 2280551-5
    ISSN 1473-2165 ; 1473-2130
    ISSN (online) 1473-2165
    ISSN 1473-2130
    DOI 10.1111/jocd.15880
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    Zs.A 6539: Show issues Location:
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  5. Article: Development of High-Performance Hydrogen-Air Fuel Cell with Flourine-Free Sulfonated Co-Polynaphthoyleneimide Membrane.

    Zavorotnaya, Ulyana M / Ponomarev, Igor I / Volkova, Yulia A / Sinitsyn, Vitaly V

    Membranes

    2023  Volume 13, Issue 5

    Abstract: This paper presents research on the technological development of hydrogen-air fuel cells with high output power characteristics using fluorine-free co-polynaphtoyleneimide (co-PNIS) membranes. It is found that the optimal operating temperature of a fuel ... ...

    Abstract This paper presents research on the technological development of hydrogen-air fuel cells with high output power characteristics using fluorine-free co-polynaphtoyleneimide (co-PNIS) membranes. It is found that the optimal operating temperature of a fuel cell based on a co-PNIS membrane with the hydrophilic/hydrophobic blocks = 70/30 composition is in the range of 60-65 °C. The maximum output power of a membrane-electrode assembly (MEA), created according to the developed technology, is 535 mW/cm
    Language English
    Publishing date 2023-04-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes13050485
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  6. Article ; Online: Hmgb1 Silencing in the Amygdala Inhibits Pain-Related Behaviors in a Rat Model of Neuropathic Pain.

    Presto, Peyton / Ji, Guangchen / Ponomareva, Olga / Ponomarev, Igor / Neugebauer, Volker

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Chronic pain presents a therapeutic challenge due to the highly complex interplay of sensory, emotional-affective and cognitive factors. The mechanisms of the transition from acute to chronic pain are not well understood. We hypothesized that neuroimmune ...

    Abstract Chronic pain presents a therapeutic challenge due to the highly complex interplay of sensory, emotional-affective and cognitive factors. The mechanisms of the transition from acute to chronic pain are not well understood. We hypothesized that neuroimmune mechanisms in the amygdala, a brain region involved in the emotional-affective component of pain and pain modulation, play an important role through high motility group box 1 (Hmgb1), a pro-inflammatory molecule that has been linked to neuroimmune signaling in spinal nociception. Transcriptomic analysis revealed an upregulation of Hmgb1 mRNA in the right but not left central nucleus of the amygdala (CeA) at the chronic stage of a spinal nerve ligation (SNL) rat model of neuropathic pain. Hmgb1 silencing with a stereotaxic injection of siRNA for Hmgb1 into the right CeA of adult male and female rats 1 week after (post-treatment), but not 2 weeks before (pre-treatment) SNL induction decreased mechanical hypersensitivity and emotional-affective responses, but not anxiety-like behaviors, measured 4 weeks after SNL. Immunohistochemical data suggest that neurons are a major source of Hmgb1 in the CeA. Therefore, Hmgb1 in the amygdala may contribute to the transition from acute to chronic neuropathic pain, and the inhibition of Hmgb1 at a subacute time point can mitigate neuropathic pain.
    MeSH term(s) Animals ; Female ; Male ; Rats ; Amygdala ; Chronic Pain ; Neuralgia/genetics ; Neuralgia/therapy ; Neurons/physiology ; Rats, Sprague-Dawley
    Chemical Substances Hbp1 protein, rat
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241511944
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  7. Article: Successful Treatment of Sebaceous Nevus With Copper Vapor Laser.

    Ponomarev, Igor V / Topchiy, Sergey B / Andrusenko, Yuri N / Shakina, Lyudmila D

    Journal of lasers in medical sciences

    2023  Volume 14, Page(s) e20

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-06-23
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2023.20
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  8. Article ; Online: Water Sorption by Polyheteroarylenes.

    Chalykh, Anatoly E / Petrova, Tatiana F / Ponomarev, Igor I

    Polymers

    2022  Volume 14, Issue 11

    Abstract: The sorption-diffusion characteristics of rigid-chain glassy polymers based on polyheteroarylenes (PHAs) have been studied in a wide interval of relative humidity and temperatures of thermal treatment of the polymer sorbents. Experimental data on water ... ...

    Abstract The sorption-diffusion characteristics of rigid-chain glassy polymers based on polyheteroarylenes (PHAs) have been studied in a wide interval of relative humidity and temperatures of thermal treatment of the polymer sorbents. Experimental data on water vapor sorption for polynaphthoyleneimidobenzimidazole (PNIB) and its copolymers with different chemical nature have been obtained. Water diffusion coefficients have been calculated, and parameters of their concentration and temperature dependences have been determined. It was found that water molecules sorbed by PNIB and its copolymers are strongly bounded. Water mobile and cluster states depend on the structure of macromolecules and thermal prehistory of polymer sorbents. It is shown that the translational coefficients of water diffusion for all PHAs are in the range from 10
    Language English
    Publishing date 2022-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14112255
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  9. Article: Numerical Modeling of The Dysplastic Vessel Heating in PWS by Yellow 578 nm Copper Vapor Laser Radiation for Different Skin Phototypes.

    Ponomarev, Igor V / Topchiy, Sergey B / Pushkareva, Alexandra E

    Journal of lasers in medical sciences

    2022  Volume 13, Page(s) e11

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2022-03-11
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2658681-2
    ISSN 2228-6721 ; 2008-9783
    ISSN (online) 2228-6721
    ISSN 2008-9783
    DOI 10.34172/jlms.2022.11
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  10. Article: Epigenetic control of gene expression in the alcoholic brain.

    Ponomarev, Igor

    Alcohol research : current reviews

    2013  Volume 35, Issue 1, Page(s) 69–76

    Abstract: Chronic alcohol exposure causes widespread changes in brain gene expression in humans and animal models. Many of these contribute to cellular adaptations that ultimately lead to behavioral tolerance and alcohol dependence. There is an emerging ... ...

    Abstract Chronic alcohol exposure causes widespread changes in brain gene expression in humans and animal models. Many of these contribute to cellular adaptations that ultimately lead to behavioral tolerance and alcohol dependence. There is an emerging appreciation for the role of epigenetic processes in alcohol-induced changes in brain gene expression and behavior. For example, chronic alcohol exposure produces changes in DNA and histone methylation, histone acetylation, and microRNA expression that affect expression of multiple genes in various types of brain cells (i.e., neurons and glia) and contribute to brain pathology and brain plasticity associated with alcohol abuse and dependence. Drugs targeting the epigenetic "master regulators" are emerging as potential therapeutics for neurodegenerative disorders and drug addiction.
    MeSH term(s) Alcoholism/genetics ; Animals ; Behavior/drug effects ; Brain/drug effects ; Brain/metabolism ; Central Nervous System Depressants/adverse effects ; Epigenesis, Genetic/drug effects ; Ethanol/adverse effects ; Humans
    Chemical Substances Central Nervous System Depressants ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2013-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ISSN 2168-3492
    ISSN 2168-3492
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