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  1. Article: Millennial-scale climate variability recorded in Late Pleistocene coastal deposits of Formentera Island (Balearic Archipelago, Western Mediterranean)

    del Valle, Laura / Timar-Gabor, Alida / Pomar, Francesc / Pons, Guillem X. / Fornós, Joan J.

    Quaternary international. 2022 Apr. 20, v. 617

    2022  

    Abstract: Pleistocene aeolian deposits interbedded with marine deposits, colluvial deposits and palaeosols are observed in area of Es Copinar, Caló d'es Mort and Es Ram-s’Estufadors in Formentera Island. The sedimentary succession outcropping along the south- ... ...

    Abstract Pleistocene aeolian deposits interbedded with marine deposits, colluvial deposits and palaeosols are observed in area of Es Copinar, Caló d'es Mort and Es Ram-s’Estufadors in Formentera Island. The sedimentary succession outcropping along the south-eastern coast of the island is characterized by a well-exposed high-resolution succession representing the main climate and geomorphological changes that occurred in this part of the western Mediterranean during the late Pleistocene. In this study we present the sedimentology and stratigraphy of carbonate sandstone, marine deposits, breccias and the aeolian-alluvial interaction deposits and silty facies, which allow describing ten major sedimentary units. Optically stimulated luminescence (OSL) dating and the biochronostratigraphic fauna from the marine deposits indicate that their deposition took place during the Last interglacial-glacial cycle, and their succession recorded Heinrich and Dansgaard-Oeschger events (DO). In this sense, dryer and cold Heinrich events led to the formation of extensive coastal dune fields when the sea level dropped. On the other hand, relatively warmer and wetter DO events drove the development of palaeosols and the aeolian-alluvial interaction deposits.
    Keywords Pleistocene epoch ; carbonates ; climate ; coasts ; cold ; fauna ; luminescence ; paleosolic soil types ; sandstone ; sea level ; stratigraphy
    Language English
    Dates of publication 2022-0420
    Size p. 112-128.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 1040-6182
    DOI 10.1016/j.quaint.2021.06.030
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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  2. Article: TRIB3 silencing promotes the downregulation of Akt pathway and PAX3-FOXO1 in high-risk rhabdomyosarcoma.

    Gallo-Oller, Gabriel / Pons, Guillem / Sansa-Girona, Júlia / Navarro, Natalia / Zarzosa, Patricia / García-Gilabert, Lia / Cabré-Fernandez, Paula / Guillén Burrieza, Gabriela / Valero-Arrese, Lorena / Segura, Miguel F / Lizcano, José M / Sánchez de Toledo, José / Moreno, Lucas / Gallego, Soledad / Roma, Josep

    Experimental hematology & oncology

    2024  Volume 13, Issue 1, Page(s) 38

    Abstract: Rhabdomyosarcoma (RMS), such as other childhood tumors, has witnessed treatment advancements in recent years. However, high-risk patients continue to face poor survival rates, often attributed to the presence of the PAX3/7-FOXO1 fusion proteins, which ... ...

    Abstract Rhabdomyosarcoma (RMS), such as other childhood tumors, has witnessed treatment advancements in recent years. However, high-risk patients continue to face poor survival rates, often attributed to the presence of the PAX3/7-FOXO1 fusion proteins, which has been associated with metastasis and treatment resistance. Despite efforts to directly target these chimeric proteins, clinical success remains elusive. In this study, the main aim was to address this challenge by investigating regulators of FOXO1. Specifically, we focused on TRIB3, a potential regulator of the fusion protein in RMS. Our findings revealed a prominent TRIB3 expression in RMS tumors, highlighting its correlation with the presence of fusion protein. By conducting TRIB3 genetic inhibition experiments, we observed an impairment on cell proliferation. Notably, the knockdown of TRIB3 led to a decrease in PAX3-FOXO1 and its target genes at protein level, accompanied by a reduction in the activity of the Akt signaling pathway. Additionally, inducible silencing of TRIB3 significantly delayed tumor growth and improved overall survival in vivo. Based on our analysis, we propose that TRIB3 holds therapeutic potential for treating the most aggressive subtype of RMS. The findings herein reported contribute to our understanding of the underlying molecular mechanisms driving RMS progression and provide novel insights into the potential use of TRIB3 as a therapeutic intervention for high-risk RMS patients.
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Letter
    ZDB-ID 2669066-4
    ISSN 2162-3619
    ISSN 2162-3619
    DOI 10.1186/s40164-024-00503-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Targeting the Hedgehog Pathway in Rhabdomyosarcoma.

    Zarzosa, Patricia / Garcia-Gilabert, Lia / Hladun, Raquel / Guillén, Gabriela / Gallo-Oller, Gabriel / Pons, Guillem / Sansa-Girona, Julia / Segura, Miguel F / Sánchez de Toledo, Josep / Moreno, Lucas / Gallego, Soledad / Roma, Josep

    Cancers

    2023  Volume 15, Issue 3

    Abstract: Aberrant activation of the Hedgehog (Hh) signalling pathway is known to play an oncogenic role in a wide range of cancers; in the particular case of rhabdomyosarcoma, this pathway has been demonstrated to be an important player for both oncogenesis and ... ...

    Abstract Aberrant activation of the Hedgehog (Hh) signalling pathway is known to play an oncogenic role in a wide range of cancers; in the particular case of rhabdomyosarcoma, this pathway has been demonstrated to be an important player for both oncogenesis and cancer progression. In this review, after a brief description of the pathway and the characteristics of its molecular components, we describe, in detail, the main activation mechanisms that have been found in cancer, including ligand-dependent, ligand-independent and non-canonical activation. In this context, the most studied inhibitors, i.e., SMO inhibitors, have shown encouraging results for the treatment of basal cell carcinoma and medulloblastoma, both tumour types often associated with mutations that lead to the activation of the pathway. Conversely, SMO inhibitors have not fulfilled expectations in tumours-among them sarcomas-mostly associated with ligand-dependent Hh pathway activation. Despite the controversy existing regarding the results obtained with SMO inhibitors in these types of tumours, several compounds have been (or are currently being) evaluated in sarcoma patients. Finally, we discuss some of the reasons that could explain why, in some cases, encouraging preclinical data turned into disappointing results in the clinical setting.
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15030727
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Analysis of Cancer Genomic Amplifications Identifies Druggable Collateral Dependencies within the Amplicon.

    Pons, Guillem / Gallo-Oller, Gabriel / Navarro, Natalia / Zarzosa, Patricia / Sansa-Girona, Júlia / García-Gilabert, Lia / Magdaleno, Ainara / Segura, Miguel F / Sánchez de Toledo, Josep / Gallego, Soledad / Moreno, Lucas / Roma, Josep

    Cancers

    2023  Volume 15, Issue 6

    Abstract: The identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last few years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets ... ...

    Abstract The identification of novel therapeutic targets for specific cancer molecular subtypes is crucial for the development of precision oncology. In the last few years, CRISPR/Cas9 screens have accelerated the discovery and validation of new targets associated with different tumor types, mutations, and fusions. However, there are still many cancer vulnerabilities associated with specific molecular features that remain to be explored. Here, we used data from CRISPR/Cas9 screens in 954 cancer cell lines to identify gene dependencies associated with 16 common cancer genomic amplifications. We found that high-copy-number genomic amplifications generate multiple collateral dependencies within the amplified region in most cases. Further, to prioritize candidate targets for each chromosomal region amplified, we integrated gene dependency parameters with both druggability data and subcellular location. Finally, analysis of the relationship between gene expression and gene dependency led to the identification of genes, the expression of which may constitute predictive biomarkers of dependency. In conclusion, our study provides a set of druggable targets specific for each amplification, opening the possibility to specifically target amplified tumors on this basis.
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15061636
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Insect trace fossils in Pleistocene deposits from the Pityusic Islands (Balearic Archipelago, Western Mediterranean): Ichnotaxonomy and palaeoenvironmental significance

    del Valle, Laura / Genise, Jorge F / Pons, Guillem X / Pomar, Francesc / Vicens, Damià / Fornós, Joan J

    Quaternary international. 2020 July 10, v. 553

    2020  

    Abstract: Insect trace fossils attributable to the Celliforma ichnofacies (Rebuffoichnus casamiquelai and Palmiraichnus castellanosi) are recorded from the Pleistocene deposits of nine sites from the Pityusic islands. These deposits, characterized by aeolian and ... ...

    Abstract Insect trace fossils attributable to the Celliforma ichnofacies (Rebuffoichnus casamiquelai and Palmiraichnus castellanosi) are recorded from the Pleistocene deposits of nine sites from the Pityusic islands. These deposits, characterized by aeolian and colluvial strata interbedded with two types of palaeosols with a high amount of trace fossils, show a strong relationship with environmental changes occurred during the Pleistocene. The Celliforma Ichnofacies is typical of well-drained palaeosols with low vegetation indicating semiarid to sub-humid conditions. According to the abundance of ichnospecies in each type of palaeosol, Palmiraichnus castellanosi indicates that bees preferred to nest in wetter conditions, whereas Rebuffoichnus casamiquelai, indicates that coleopterans could live under drier conditions, even in this case when its abundance is relatively high within periods with increased rainfall.
    Keywords Coleoptera ; Pleistocene epoch ; paleoecology ; paleosolic soil types ; rain ; vegetation
    Language English
    Dates of publication 2020-0710
    Size p. 83-93.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1040-6182
    DOI 10.1016/j.quaint.2020.05.042
    Database NAL-Catalogue (AGRICOLA)

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  6. Book ; Conference proceedings: V Jornades del Medi Ambient de les Illes Balears

    Pons, Guillem X

    Institut Menorquí d'Estudis (IME) Maó 23 - 24 de gener 2008, Centre Cultural SA NOSTRA (Palma), 6-7 de febrer 2008, Consell d'Eivissa, 14 - 15 de febrer 2008 ; [ponències i resums]

    2008  

    Title variant Cinquenes Jornades del Medi Ambient de les Illes Balears ; cinquenes
    Institution Jornades del Medi Ambient de les Illes Balears
    Societat d'Història Natural de les Balears
    Event/congress Jornades del Medi Ambient de les Illes Balears (5, 2008.01.23-24, MaóMenorca) ; Jornades del Medi Ambient de les Illes Balears (5, 2008.02.06-07, PalmaMallorca) ; Jornades del Medi Ambient de les Illes Balears (5, 2008.02.14-15, Eivissa)
    Author's details Societat d'Història Natural de les Balears. Ed. per Guillem X. Pons
    Language Spanish
    Size 467 S., Ill., graph. Darst., Kt.
    Publishing place Palma de Mallorca
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 9788496841574 ; 849684157X
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  7. Book ; Conference proceedings: V Jornades del Medi Ambient de les Illes Balears

    Pons, Guillem X

    Institut Menorquí d'Estudis (IME) Maó 23 - 24 de gener 2008, Centre Cultural SA NOSTRA (Palma), 6-7 de febrer 2008, Consell d'Eivissa, 14 - 15 de febrer 2008 ; [ponències i resums]

    2008  

    Title variant Cinquenes Jornades del Medi Ambient de les Illes Balears ; cinquenes
    Institution Jornades del Medi Ambient de les Illes Balears
    Societat d'Història Natural de les Balears
    Event/congress Jornades del Medi Ambient de les Illes Balears (5, 2008.01.23-24, MaóMenorca) ; Jornades del Medi Ambient de les Illes Balears (5, 2008.02.06-07, PalmaMallorca) ; Jornades del Medi Ambient de les Illes Balears (5, 2008.02.14-15, Eivissa)
    Author's details Societat d'Història Natural de les Balears. Ed. per Guillem X. Pons
    Language Spanish
    Size 467 S., Ill., graph. Darst., Kt.
    Publishing place Palma de Mallorca
    Document type Book ; Conference proceedings
    Note Literaturangaben
    ISBN 9788496841574 ; 849684157X
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article: Dickkopf Proteins and Their Role in Cancer: A Family of Wnt Antagonists with a Dual Role.

    Giralt, Irina / Gallo-Oller, Gabriel / Navarro, Natalia / Zarzosa, Patricia / Pons, Guillem / Magdaleno, Ainara / Segura, Miguel F / Sánchez de Toledo, José / Moreno, Lucas / Gallego, Soledad / Roma, Josep

    Pharmaceuticals (Basel, Switzerland)

    2021  Volume 14, Issue 8

    Abstract: The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has ... ...

    Abstract The Wnt signaling pathway regulates crucial aspects such as cell fate determination, cell polarity and organogenesis during embryonic development. Wnt pathway deregulation is a hallmark of several cancers such as lung, gastric and liver cancer, and has been reported to be altered in others. Despite the general agreement reached by the scientific community on the oncogenic potential of the central components of the pathway, the role of the antagonist proteins remains less clear. Deregulation of the pathway may be caused by overexpression or downregulation of a wide range of antagonist proteins. Although there is growing information related to function and regulation of Dickkopf (DKK) proteins, their pharmacological potential as cancer therapeutics still has not been fully developed. This review provides an update on the role of DKK proteins in cancer and possible potential as therapeutic targets for the treatment of cancer; available compounds in pre-clinical or clinical trials are also reviewed.
    Language English
    Publishing date 2021-08-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph14080810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Dickkopf-1 Inhibition Reactivates Wnt/β-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo.

    Giralt, Irina / Gallo-Oller, Gabriel / Navarro, Natalia / Zarzosa, Patricia / Pons, Guillem / Magdaleno, Ainara / Segura, Miguel F / Sábado, Constantino / Hladun, Raquel / Arango, Diego / Sánchez de Toledo, José / Moreno, Lucas / Gallego, Soledad / Roma, Josep

    International journal of molecular sciences

    2021  Volume 22, Issue 23

    Abstract: The Wnt/β-catenin signaling pathway plays a pivotal role during embryogenesis and its deregulation is a key mechanism in the origin and progression of several tumors. Wnt antagonists have been described as key modulators of Wnt/β-catenin signaling in ... ...

    Abstract The Wnt/β-catenin signaling pathway plays a pivotal role during embryogenesis and its deregulation is a key mechanism in the origin and progression of several tumors. Wnt antagonists have been described as key modulators of Wnt/β-catenin signaling in cancer, with Dickkopf-1 (DKK-1) being the most studied member of the DKK family. Although the therapeutic potential of DKK-1 inhibition has been evaluated in several diseases and malignancies, little is known in pediatric tumors. Only a few works have studied the genetic inhibition and function of DKK-1 in rhabdomyosarcoma. Here, for the first time, we report the analysis of the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, the most common soft tissue sarcoma in children. We performed DKK-1 inhibition via shRNA technology and via the chemical inhibitor WAY-2626211. Its inhibition led to β-catenin activation and the modulation of focal adhesion kinase (FAK), with positive effects on in vitro expression of myogenic markers and a reduction in proliferation and invasion. In addition, WAY-262611 was able to impair survival of tumor cells in vivo. Therefore, DKK-1 could constitute a molecular target, which could lead to novel therapeutic strategies in RMS, especially in those patients with high DKK-1 expression.
    MeSH term(s) Animals ; Case-Control Studies ; Cell Line, Tumor ; Focal Adhesion Protein-Tyrosine Kinases/metabolism ; Humans ; Intercellular Signaling Peptides and Proteins/metabolism ; Mice, SCID ; Molecular Targeted Therapy ; Muscles/metabolism ; MyoD Protein/metabolism ; Myogenin/metabolism ; Naphthalenes/pharmacology ; Naphthalenes/therapeutic use ; Piperidines/pharmacology ; Piperidines/therapeutic use ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; RNA, Small Interfering/therapeutic use ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/etiology ; Rhabdomyosarcoma/metabolism ; Wnt Signaling Pathway/drug effects ; Xenograft Model Antitumor Assays ; beta Catenin/metabolism ; Mice
    Chemical Substances DKK1 protein, human ; Dkk1 protein, mouse ; Intercellular Signaling Peptides and Proteins ; MyoD Protein ; MyoD1 myogenic differentiation protein ; Myogenin ; Naphthalenes ; Piperidines ; Pyrimidines ; RNA, Small Interfering ; WAY-262611 ; beta Catenin ; Focal Adhesion Protein-Tyrosine Kinases (EC 2.7.10.2)
    Language English
    Publishing date 2021-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms222312921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Conference proceedings: III Jornades del Medi Ambient de les Illes Balears

    Pons, Guillem X

    Can Tàpera (Palma), 14 - 16 de novembre 2001

    2001  

    Title variant tres
    Institution Jornades del Medi Ambient de les Illes Balears
    Societat d'Història Natural de les Balears
    Event/congress Jornades del Medi Ambient de les Illes Balears (3, 2001.11.14-16, PalmaMallorca)
    Author's details Societat d'Història Natural de les Balears. Ed. per Guillem X. Pons
    Language Spanish
    Size 313 S., Ill., graph. Darst., Kt.
    Publishing place Palma de Mallorca
    Document type Book ; Conference proceedings
    Note Bestand: nv
    ISBN 846073479X ; 9788460734796
    Database Former special subject collection: coastal and deep sea fishing

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