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  1. Article ; Online: Dual effect of anandamide on spinal nociceptive transmission in control and inflammatory conditions.

    Pontearso, Monica / Slepicka, Jakub / Bhattacharyya, Anirban / Spicarova, Diana / Palecek, Jiri

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 173, Page(s) 116369

    Abstract: Anandamide (AEA) is an important modulator of nociception in the spinal dorsal horn, acting presynaptically through Cannabinoid ( ... ...

    Abstract Anandamide (AEA) is an important modulator of nociception in the spinal dorsal horn, acting presynaptically through Cannabinoid (CB
    MeSH term(s) Humans ; Endocannabinoids/pharmacology ; Nociception ; Polyunsaturated Alkamides/pharmacology ; Spinal Cord Dorsal Horn ; Analgesics/pharmacology ; Inflammation/drug therapy ; Amidohydrolases ; Arachidonic Acids ; Benzamides ; Carbamates
    Chemical Substances anandamide (UR5G69TJKH) ; Endocannabinoids ; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester ; Polyunsaturated Alkamides ; Analgesics ; Amidohydrolases (EC 3.5.-) ; Arachidonic Acids ; Benzamides ; Carbamates
    Language English
    Publishing date 2024-03-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Inhibition of synaptic transmission by anandamide precursor 20:4-NAPE is mediated by TRPV1 receptors under inflammatory conditions.

    Spicarova, Diana / Nerandzic, Vladimir / Muzik, David / Pontearso, Monica / Bhattacharyya, Anirban / Nagy, Istvan / Palecek, Jiri

    Frontiers in molecular neuroscience

    2023  Volume 16, Page(s) 1188503

    Abstract: Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel, and cannabinoid receptor 1 ( ... ...

    Abstract Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel, and cannabinoid receptor 1 (CB
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2023.1188503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dual PI3Kδ/γ Inhibitor Duvelisib Prevents Development of Neuropathic Pain in Model of Paclitaxel-Induced Peripheral Neuropathy.

    Adamek, Pavel / Heles, Mario / Bhattacharyya, Anirban / Pontearso, Monica / Slepicka, Jakub / Palecek, Jiri

    The Journal of neuroscience : the official journal of the Society for Neuroscience

    2022  Volume 42, Issue 9, Page(s) 1864–1881

    Abstract: The development of painful paclitaxel-induced peripheral neuropathy (PIPN) represents a major dose-limiting side effect of paclitaxel chemotherapy. Here we report a promising effect of duvelisib (Copiktra), a novel FDA-approved PI3Kδ/γ isoform-specific ... ...

    Abstract The development of painful paclitaxel-induced peripheral neuropathy (PIPN) represents a major dose-limiting side effect of paclitaxel chemotherapy. Here we report a promising effect of duvelisib (Copiktra), a novel FDA-approved PI3Kδ/γ isoform-specific inhibitor, in preventing paclitaxel-induced pain-like behavior and pronociceptive signaling in DRGs and spinal cord dorsal horn (SCDH) in rat and mouse model of PIPN. Duvelisib blocked the development of mechanical hyperalgesia in both males and females. Moreover, duvelisib prevented paclitaxel-induced sensitization of TRPV1 receptors, and increased PI3K/Akt signaling in small-diameter DRG neurons and an increase of CD68
    MeSH term(s) Animals ; Antineoplastic Agents, Phytogenic/pharmacology ; Female ; Hyperalgesia/chemically induced ; Hyperalgesia/drug therapy ; Hyperalgesia/prevention & control ; Isoquinolines ; Male ; Mice ; Neuralgia/chemically induced ; Neuralgia/drug therapy ; Neuralgia/prevention & control ; Paclitaxel/adverse effects ; Pain ; Peripheral Nervous System Diseases ; Phosphatidylinositol 3-Kinases ; Purines ; Rats
    Chemical Substances Antineoplastic Agents, Phytogenic ; Isoquinolines ; Purines ; duvelisib (610V23S0JI) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604637-x
    ISSN 1529-2401 ; 0270-6474
    ISSN (online) 1529-2401
    ISSN 0270-6474
    DOI 10.1523/JNEUROSCI.1324-21.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1668: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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