Article: Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Cell. 2021 Nov. 11, v. 184, no. 23
2021
Abstract: Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United ... ...
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| Abstract | Extension of the interval between vaccine doses for the BNT162b2 mRNA vaccine was introduced in the United Kingdom to accelerate population coverage with a single dose. At this time, trial data were lacking, and we addressed this in a study of United Kingdom healthcare workers. The first vaccine dose induced protection from infection from the circulating alpha (B.1.1.7) variant over several weeks. In a substudy of 589 individuals, we show that this single dose induces severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibody (NAb) responses and a sustained B and T cell response to the spike protein. NAb levels were higher after the extended dosing interval (6–14 weeks) compared with the conventional 3- to 4-week regimen, accompanied by enrichment of CD4⁺ T cells expressing interleukin-2 (IL-2). Prior SARS-CoV-2 infection amplified and accelerated the response. These data on dynamic cellular and humoral responses indicate that extension of the dosing interval is an effective immunogenic protocol. |
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| Keywords | Severe acute respiratory syndrome coronavirus 2 ; health services ; immunogenicity ; interleukin-2 ; vaccines ; United Kingdom | ||||||||||
| Language | English | ||||||||||
| Dates of publication | 2021-1111 | ||||||||||
| Size | p. 5699-5714.e11. | ||||||||||
| Publishing place | Elsevier Inc. | ||||||||||
| Document type | Article | ||||||||||
| ZDB-ID | 187009-9 | ||||||||||
| ISSN | 1097-4172 ; 0092-8674 | ||||||||||
| ISSN (online) | 1097-4172 | ||||||||||
| ISSN | 0092-8674 | ||||||||||
| DOI | 10.1016/j.cell.2021.10.011 | ||||||||||
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| Database | NAL-Catalogue (AGRICOLA) |
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