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  1. Article ; Online: Right Upper Abdominal Resections in Advanced Stage Ovarian Cancer.

    Bacalbasa, Nicolae / Balescu, Irina / Diaconu, Camelia / Iliescu, Laura / Filipescu, Alexandru / Pop, Cora / Dima, Simona / Vilcu, Mihaela / Brezean, Iulian

    In vivo (Athens, Greece)

    2020  Volume 34, Issue 3, Page(s) 1487–1492

    Abstract: Background/aim: The right upper abdominal involvement is frequently encountered in patients with advanced stage ovarian cancer. The aim of this paper is to study the safety and efficacy of extended resections at this level as well as to determine the ... ...

    Abstract Background/aim: The right upper abdominal involvement is frequently encountered in patients with advanced stage ovarian cancer. The aim of this paper is to study the safety and efficacy of extended resections at this level as well as to determine the sites of residual disease.
    Patients and methods: Between January 2016 and December 2019, 26 patients submitted to right upper abdominal resections were identified.
    Results: Peritoneal stripping and full thickness resections were the most commonly performed resections (in 57% and 19% of cases, respectively), followed by capsular liver resection and atypical liver resection (in 30% and 23% of cases, respectively) while the most common sites where resection was incomplete were the liver pedicle and porta hepatis. Exceptionally, one case necessitated performing a pancreatoduodenectomy as part of debulking surgery. Postoperatively, two cases developed serious complications and required reintervention; however, the overall mortality was null.
    Conclusion: Right upper abdominal resections seem to be feasible and effective in order to maximize the debulking effort with acceptable risks arising from perioperative complications.
    MeSH term(s) Abdomen/surgery ; Adult ; Aged ; Blood Loss, Surgical ; Cytoreduction Surgical Procedures/adverse effects ; Cytoreduction Surgical Procedures/methods ; Female ; Humans ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Operative Time ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/surgery ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2020-04-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Debulking Surgery for Moderately Differentiated Neuroendocrine Gastric Carcinoma - A Case Report and Literature Review.

    Bacalbasa, Nicolae / Halmaciu, Iuliana / Bolca, Ciprian / Neacsu, Adrian / Cretoiu, Dragos / Balalau, Cristian / Diaconu, Camelia / Iliescu, Laura / Filipescu, Alexandru / Pop, Cora / Balescu, Irina

    In vivo (Athens, Greece)

    2020  Volume 34, Issue 3, Page(s) 1527–1531

    Abstract: Background/aim: Gastroenteropancreatic neuro-endocrine carcinomas represent poorly differentiated neoplasms with a high capacity of spreading inducing the development of distant metastases. In such cases debulking surgery seems to offer a good chance ... ...

    Abstract Background/aim: Gastroenteropancreatic neuro-endocrine carcinomas represent poorly differentiated neoplasms with a high capacity of spreading inducing the development of distant metastases. In such cases debulking surgery seems to offer a good chance for survival especially in well and moderately differentiated lesions. The aim of this study was to report the case of a 48-year-old patient submitted to surgery for moderately differentiated neuroendocrine gastric carcinoma with distant metastases.
    Case report: The patient was initially investigated for hematemesis and weight loss and was diagnosed with a lesser curvature gastric tumor in association with liver and peritoneal metastases. Due to the extent of the disease, the patient was initially submitted to neoadjuvant chemotherapy followed by surgery with radical intent. At the time of surgery subtotal gastrectomy en bloc with total omentectomy, peritonectomy, cholecystectomy and atypical liver resection were performed. Moreover, the two ovaries presented large tumoral masses so total hysterectomy with bilateral adnexectomy was performed. The histopathological studies confirmed the presence of a moderately differentiated neuroendocrine gastric carcinoma with negative resection margins.
    Conclusion: Multiple visceral resections might be needed in order to maximize the debulking effort in metastatic gastric neuroendocrine carcinomas.
    MeSH term(s) Carcinoma, Neuroendocrine/diagnosis ; Carcinoma, Neuroendocrine/surgery ; Combined Modality Therapy ; Cytoreduction Surgical Procedures/methods ; Humans ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Neoplasm Staging ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2020-04-29
    Publishing country Greece
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.11941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Securing wider EU commitment to the elimination of hepatitis C virus.

    Wedemeyer, Heiner / Tergast, Tammo L / Lazarus, Jeffrey V / Razavi, Homie / Bakoyannis, Kostas / Baptista-Leite, Ricardo / Bartoli, Marco / Bruggmann, Philip / Buşoi, Cristian-Silviu / Buti, Maria / Carballo, Manuel / Castera, Laurent / Colombo, Massimo / Coutinho, Rodrigo Sousa / Dadon, Yuval / Esmat, Gamal / Esteban, Rafael / Farran, Joan Colom / Gillyon-Powell, Mark /
    Goldberg, David / Hutchinson, Sharon / Janssen, Harry L A / Kalamitsis, George / Kondili, Loreta A / Lambert, John S / Marinho, Rui Tato / Maticic, Mojca / Patricello, Aldo / Peck-Radosavljevic, Markus / Pol, Stanislas / Poljak, Mario / Pop, Cora / Sokol, Tomislov / Sypsa, Vana / Tözün, Nurdan / Younossi, Zobair / Aghemo, Alessio / Papatheodoridis, George V / Hatzakis, Angelos

    Liver international : official journal of the International Association for the Study of the Liver

    2022  Volume 43, Issue 2, Page(s) 276–291

    Abstract: In 2016, the Hepatitis B and C Public Policy Association (HepBCPPA), gathered all the main stakeholders in the field of hepatitis C virus (HCV) to launch the now landmark HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. ... ...

    Abstract In 2016, the Hepatitis B and C Public Policy Association (HepBCPPA), gathered all the main stakeholders in the field of hepatitis C virus (HCV) to launch the now landmark HCV Elimination Manifesto, calling for the elimination of HCV in the EU by 2030. Since then, many European countries have made progress towards HCV elimination. Multiple programmes-from the municipality level to the EU level-were launched, resulting in an overall decrease in viremic HCV infections and liver-related mortality. However, as of 2021, most countries are not on track to reach the 2030 HCV elimination targets set by the WHO. Moreover, the COVID-19 pandemic has resulted in a decrease in HCV diagnoses and fewer direct-acting antiviral treatment initiations in 2020. Diagnostic and therapeutic tools to easily diagnose and treat chronic HCV infection are now well established. Treating all patients with chronic HCV infection is more cost-saving than treating and caring for patients with liver-related complications, decompensated cirrhosis or hepatocellular carcinoma. It is more important than ever to reinforce and scale-up action towards HCV elimination. Yet, efforts urgently need the dedicated commitment of policymakers at all governmental and policy levels. Therefore, the third EU Policy Summit, held in March 2021, featured EU parliamentarians and other key decision makers to promote dialogue and take strides towards securing wider EU commitment to advance and achieve HCV elimination by 2030. We have summarized the key action points and reported the 'Call-to-Action' statement supported by all the major relevant European associations in the field.
    MeSH term(s) Humans ; Hepacivirus ; Antiviral Agents/therapeutic use ; Pandemics ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/epidemiology ; Hepatitis C, Chronic/prevention & control ; COVID-19 ; Hepatitis C/diagnosis ; Hepatitis C/drug therapy ; Hepatitis C/epidemiology ; Liver Neoplasms/drug therapy
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15446
    Database MEDical Literature Analysis and Retrieval System OnLINE

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