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Article ; Online: Pituitary apoplexy associated with COVID-19 infection: review and a case report

Popov, Deyan / Hadzhiyanev, Asen

Biotechnology & Biotechnological Equipment. 2022 Dec. 31, v. 36, no. 1, p. 75-81

2022 , Page(s) 75–81

Abstract: Pituitary apoplexy (PA) is a clinical syndrome caused by a hemorrhage and/or infarction in a pituitary adenoma due to a diverse group of pathophysiological mechanisms. The clinical spectrum consists of severe headaches, visual disturbances, cranial nerve ...

Abstract	Pituitary apoplexy (PA) is a clinical syndrome caused by a hemorrhage and/or infarction in a pituitary adenoma due to a diverse group of pathophysiological mechanisms. The clinical spectrum consists of severe headaches, visual disturbances, cranial nerve involvement and hormonal deficiencies. There have been a growing number of case reports of pituitary apoplexy with a possible association with Coronavirus disease 2019 (COVID-19) recently. The aim of this paper is to review and analyze the possible connection between pituitary apoplexy and the novel coronavirus SARS-CoV-2. The literature review was conducted by searching the term ‘COVID-19 pituitary apoplexy’ in the PubMed database. Seventeen results were screened. We identified 12 cases of patients with pituitary apoplexy with a possible connection to COVID-19. The pathophysiological mechanisms include infarction and acute hemorrhage. COVID-19 could contribute to pituitary apoplexy due to a series of predisposing factors, like hemodynamic instability, increase in intracranial pressure, coagulopathy, endothelial dysfunction and hypercoagulative state. The possible association between COVID-19 and pituitary apoplexy is still debatable. Finally, we report a case of a 63-year-old female presenting with pituitary apoplexy with an onset of symptoms 15 days after initial positive polymerase chain reaction (PCR) testing for SARS-CoV-2. The patient was hospitalized for COVID-19 due to associated pneumonia for 12 days. Three days after discharge from the hospital, the patient developed a severe onset headache. Magnetic resonance imaging revealed a pituitary macroadenoma with pituitary apoplexy. In the presented case, the most probable reason for the pituitary apoplexy is infarction and not acute hemorrhage.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; adenoma ; biotechnology ; case studies ; databases ; equipment ; females ; headache ; hemodynamics ; hemorrhage ; hospitals ; infarction ; magnetism ; nerve tissue ; patients ; pneumonia ; polymerase chain reaction ; Pituitary apoplexy ; pituitary adenoma ; COVID-19 ; SARS-CoV-2
Language	English
Dates of publication	2022-1231
Size	p. 75-81
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1214963-9
ISSN	1314-3530 ; 0205-2067 ; 1310-2818
ISSN (online)	1314-3530
ISSN	0205-2067 ; 1310-2818
DOI	10.1080/13102818.2022.2051738
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Article ; Online: Adaptation of Skeletal Muscles to Contractile Activity of Varying Duration and Intensity: The Role of PGC-1α.

Popov, D V

Biochemistry. Biokhimiia

2018 Volume 83, Issue 6, Page(s) 613–628

Abstract: A large body of experimental data have shown that aerobic exercise of different duration, intensity, and pattern affect molecular mechanisms regulating mitochondrial biogenesis in skeletal muscles. This review focuses on the effects of exercise duration ... ...

Abstract	A large body of experimental data have shown that aerobic exercise of different duration, intensity, and pattern affect molecular mechanisms regulating mitochondrial biogenesis in skeletal muscles. This review focuses on the effects of exercise duration and intensity on the molecular mechanisms of mitochondrial biogenesis regulation in skeletal muscles, namely PGC-1α-dependent signaling. Studies of the effects of acute exercise and exercise training showed that an increase in the duration of aerobic exercise from 30 to 90 min does not provide additional stimuli to activate signaling pathways regulating post-translational modification of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and expression of the PGC-1α gene (PPARGC1A). Conversely, exercise intensity substantially affects mitochondrial biogenesis due to the increase in the recruitment of type II muscle fibers with accompanying pronounced metabolic shift leading to the activation of signaling cascades and expression of genes regulating mitochondrial biogenesis. Therefore, intermittent exercise, which recruits type II muscle fibers, is more efficient in the activation of mitochondrial biogenesis than work-matched continuous exercise. In skeletal muscle adapted to aerobic training, intensity-dependent activation of mitochondrial biogenesis after acute exercise is associated primarily with the AMP-activated protein kinase/PGC-1α pathway, expression of PGC-1α-regulated genes, and expression of PPARGC1A from the alternative (distal) inducible promoter regulated by the cAMP response element-binding protein 1-related transcription factors and their coactivators. Elucidation of the effects of duration and intensity of aerobic exercise on the PGC-1α-dependent and -independent mechanisms of mitochondrial biogenesis is important for treatment of patients with various metabolic disorders, as well as for optimization of training in athletes.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Cyclic AMP Response Element-Binding Protein/metabolism ; Exercise ; Humans ; Muscle Contraction/physiology ; Muscle, Skeletal/metabolism ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/genetics ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism
Chemical Substances	Cyclic AMP Response Element-Binding Protein ; PPARGC1A protein, human ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17) ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2018-05-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1109-5
ISSN	1608-3040 ; 0006-2979 ; 0320-9717
ISSN (online)	1608-3040
ISSN	0006-2979 ; 0320-9717
DOI	10.1134/S0006297918060019
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Article ; Online: Acute mesenteric ischemia secondary to superior mesenteric vein thrombosis in a patient with liver cirrhosis: A case report.

Mitev, Stefan / Topalova-Dimitrova, Antoniya / Varlyakov, Anton / Popov, Dimitar

Medicine

2023 Volume 102, Issue 32, Page(s) e34549

Abstract: Rationale: Acute mesenteric ischemia due to superior mesenteric vein (SMV) thrombosis is a rare yet potentially life-threatening emergency. Our case report explores this condition in the context of a patient with liver cirrhosis due to Wilson disease. ... ...

Abstract	Rationale: Acute mesenteric ischemia due to superior mesenteric vein (SMV) thrombosis is a rare yet potentially life-threatening emergency. Our case report explores this condition in the context of a patient with liver cirrhosis due to Wilson disease. We specifically highlight the complex derangement of the coagulative balance in liver cirrhosis. Patient concerns: A 34-year-old female with Wilson disease-related cirrhosis presented with intractable abdominal pain, nausea, and vomiting that showed no response to antispasmodic medication. Diagnoses: A contrast-enhanced abdominal computed tomography scan and Doppler ultrasound confirmed an intraluminal filling defect in the SMV, leading to the diagnosis of SMV thrombosis. Interventions: Prompt anticoagulation, intravenous fluids, and an antibiotic were initiated. Surgical consultation recommended conservative therapy with close monitoring. Outcomes: Over the following 2 days, the patient's condition improved considerably, with almost complete resolution of her symptoms. Genetic testing identified a 4G/4G homozygous genotype of the plasminogen activator inhibitor 1 gene, associated with a higher risk of thrombosis in the vessels of internal organs. After 2 months of sustained anticoagulant therapy, a follow-up contrast-enhanced computed tomography scan revealed near-complete recanalization of the SMV, and the patient remained symptom-free. Lessons: This case underscores the importance of early detection and treatment of acute mesenteric ischemia in patients with liver cirrhosis, as well as the potential role of genetic factors in thrombosis.
MeSH term(s)	Humans ; Female ; Adult ; Mesenteric Ischemia/complications ; Mesenteric Ischemia/drug therapy ; Venous Thrombosis/complications ; Venous Thrombosis/diagnosis ; Hepatolenticular Degeneration/complications ; Mesenteric Veins/diagnostic imaging ; Treatment Outcome ; Thrombosis/complications ; Liver Cirrhosis/complications
Language	English
Publishing date	2023-07-29
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000034549
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Article ; Online: White Laue and powder diffraction studies to reveal mechanisms of HCP-to-BCC phase transformation in single crystals of Mg under high pressure.

Vasilev, Evgenii / Popov, Dmitry / Somayazulu, Maddury / Velisavljevic, Nenad / Knezevic, Marko

Scientific reports

2023 Volume 13, Issue 1, Page(s) 2173

Abstract: Mechanisms of hexagonal close-packed (HCP) to body-centered cubic (BCC) phase transformation in Mg single crystals are observed using a combination of polychromatic beam Laue diffraction and monochromatic beam powder diffraction techniques under quasi- ... ...

Abstract	Mechanisms of hexagonal close-packed (HCP) to body-centered cubic (BCC) phase transformation in Mg single crystals are observed using a combination of polychromatic beam Laue diffraction and monochromatic beam powder diffraction techniques under quasi-hydrostatic pressures of up to 58 ± 2 GPa at ambient temperature. Although experiments were performed with both He and Ne pressure media, crystals inevitably undergo plastic deformation upon loading to 40-44 GPa. The plasticity is accommodated by dislocation glide causing local misorientations of up to 1°-2°. The selected crystals are tracked by mapping Laue diffraction spots up to the onset of the HCP to BCC transformation, which is determined to be at a pressure of 56.6 ± 2 GPa. Intensity of the Laue reflections from HCP crystals rapidly decrease but no reflections from crystalline BCC phase are observed with a further increase of pressure. Nevertheless, the powder diffraction shows the formation of 110 BCC peak at 56.6 GPa. The peak intensity increases at 59.7 GPa. Upon the full transformation, a powder-like BCC aggregate is formed revealing the destructive nature of the HCP to BCC transformation in single crystals of Mg.
Language	English
Publishing date	2023-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-29424-z
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Article: Phase Transitions of Cu and Fe at Multiscales in an Additively Manufactured Cu-Fe Alloy under High-Pressure.

Chatterjee, Arya / Popov, Dmitry / Velisavljevic, Nenad / Misra, Amit

Nanomaterials (Basel, Switzerland)

2022 Volume 12, Issue 9

Abstract: A state of the art, custom-built direct-metal deposition (DMD)-based additive manufacturing (AM) system at the University of Michigan was used to manufacture 50Cu-50Fe alloy with tailored properties for use in high strain/deformation environments. ... ...

Abstract	A state of the art, custom-built direct-metal deposition (DMD)-based additive manufacturing (AM) system at the University of Michigan was used to manufacture 50Cu-50Fe alloy with tailored properties for use in high strain/deformation environments. Subsequently, we performed preliminary high-pressure compression experiments to investigate the structural stability and deformation of this material. Our work shows that the alpha (BCC) phase of Fe is stable up to ~16 GPa before reversibly transforming to HCP, which is at least a few GPa higher than pure bulk Fe material. Furthermore, we observed evidence of a transition of Cu nano-precipitates in Fe from the well-known FCC structure to a metastable BCC phase, which has only been predicted via density functional calculations. Finally, the metastable FCC Fe nano-precipitates within the Cu grains show a modulated nano-twinned structure induced by high-pressure deformation. The results from this work demonstrate the opportunity in AM application for tailored functional materials and extreme stress/deformation applications.
Language	English
Publishing date	2022-04-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano12091514
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Article ; Online: Protein S-glutathionylation: from current basics to targeted modifications.

Popov, Doina

Archives of physiology and biochemistry

2014 Volume 120, Issue 4, Page(s) 123–130

Abstract: The interaction between antioxidant glutathione and the free thiol in susceptible cysteine residues of proteins leads to reversible protein S-glutathionylation. This reaction ensures cellular homeostasis control (as a common redox-dependent post- ... ...

Abstract	The interaction between antioxidant glutathione and the free thiol in susceptible cysteine residues of proteins leads to reversible protein S-glutathionylation. This reaction ensures cellular homeostasis control (as a common redox-dependent post-translational modification associated with signal transduction) and intervenes in oxidative stress-related cardiovascular pathology (as initiated by redox imbalance). The purpose of this review is to evaluate the recent knowledge on protein S-glutathionylation in terms of chemistry, broad cellular intervention, specific quantification, and potential for therapeutic exploitation. The data bases searched were Medline and PubMed, from 2009 to 2014 (term: glutathionylation). Protein S-glutathionylation ensures protection of protein thiols against irreversible over-oxidation, operates as a biological redox switch in both cell survival (influencing kinases and protein phosphatases pathways) and cell death (by potentiation of apoptosis), and cross-talks with phosphorylation and with S-nitrosylation. Collectively, protein S-glutathionylation appears as a valuable biomarker for oxidative stress, with potential for translation into novel therapeutic strategies.
MeSH term(s)	Animals ; Glutathione/metabolism ; Humans ; Oxidative Stress ; Protein Processing, Post-Translational ; Proteins/metabolism ; Sulfhydryl Compounds/chemistry
Chemical Substances	Proteins ; Sulfhydryl Compounds ; Glutathione (GAN16C9B8O)
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1238320-x
ISSN	1744-4160 ; 1381-3455
ISSN (online)	1744-4160
ISSN	1381-3455
DOI	10.3109/13813455.2014.944544
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Article ; Online: Metabolic determinants of NAFLD in adults with type 1 diabetes.

Serdarova, M / Dimova, R / Chakarova, N / Grozeva, G / Todorova, A / Tsarkova, P / Marinova, C / Popov, D / Mateva, L / Tankova, T

Diabetes research and clinical practice

2022 Volume 186, Page(s) 109819

Abstract: Aim: To assess the main metabolic determinants of non-alcoholic fatty liver disease (NAFLD) in adult patients with type 1 diabetes (T1D).: Methods: 115 patients with T1D were divided into 4 groups according to NAFLD grade. NAFLD was diagnosed via ... ...

Abstract	Aim: To assess the main metabolic determinants of non-alcoholic fatty liver disease (NAFLD) in adult patients with type 1 diabetes (T1D). Methods: 115 patients with T1D were divided into 4 groups according to NAFLD grade. NAFLD was diagnosed via transient elastography when CAP > 233 dB/m. Body composition was evaluated by Inbody720, Biospace. Serum lipids, liver enzymes, uric acid, creatinine, hsCRP and HbA1c were evaluated at fasting. Results: The overall prevalence of NAFLD was 47% (n = 54). In the subgroup with BMI > 25 kg/m Conclusions: NAFLD is highly prevalent in adults with T1D and obesity or other metabolic derangements and might be independently related to poor long-term glycemic control and waist circumference in females.
MeSH term(s)	Adult ; Body Mass Index ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Glycated Hemoglobin A ; Humans ; Metabolic Syndrome/diagnosis ; Non-alcoholic Fatty Liver Disease/complications ; Non-alcoholic Fatty Liver Disease/epidemiology ; Prevalence ; Risk Factors ; Waist Circumference
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2022-03-03
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632523-3
ISSN	1872-8227 ; 0168-8227
ISSN (online)	1872-8227
ISSN	0168-8227
DOI	10.1016/j.diabres.2022.109819
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Article ; Online: Nontrivial nanostructure, stress relaxation mechanisms, and crystallography for pressure-induced Si-I → Si-II phase transformation.

Chen, Hao / Levitas, Valery I / Popov, Dmitry / Velisavljevic, Nenad

Nature communications

2022 Volume 13, Issue 1, Page(s) 982

Abstract: Crystallographic theory based on energy minimization suggests austenite-twinned martensite interfaces with specific orientation, which are confirmed experimentally for various materials. Pressure-induced phase transformation (PT) from semiconducting Si-I ...

Abstract	Crystallographic theory based on energy minimization suggests austenite-twinned martensite interfaces with specific orientation, which are confirmed experimentally for various materials. Pressure-induced phase transformation (PT) from semiconducting Si-I to metallic Si-II, due to very large and anisotropic transformation strain, may challenge this theory. Here, unexpected nanostructure evolution during Si-I → Si-II PT is revealed by combining molecular dynamics (MD), crystallographic theory, generalized for strained crystals, and in situ real-time Laue X-ray diffraction (XRD). Twinned Si-II, consisting of two martensitic variants, and unexpected nanobands, consisting of alternating strongly deformed and rotated residual Si-I and third variant of Si-II, form [Formula: see text] interface with Si-I and produce almost self-accommodated nanostructure despite the large transformation volumetric strain of [Formula: see text]. The interfacial bands arrest the [Formula: see text] interfaces, leading to repeating nucleation-growth-arrest process and to growth by propagating [Formula: see text] interface, which (as well as [Formula: see text] interface) do not appear in traditional crystallographic theory.
Language	English
Publishing date	2022-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28604-1
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Article ; Online: Mid-regional pro-adrenomedullin as a predictor of in-hospital mortality in adult patients with COVID-19: a single-centre prospective study.

Popov, Dmitry / Borovkova, Ulyana / Rybka, Mikhail / Ramnyonok, Tatiana / Golukhova, Elena

Anaesthesiology intensive therapy

2022 Volume 54, Issue 3, Page(s) 242–246

Abstract: Background: To determine the predictive value of mid-regional pro-adrenomedullin (MR-proADM) compared to routine clinical and laboratory parameters in patients with COVID-19.: Methods: A total of 135 adult patients hospitalized with COVID-19 were ... ...

Abstract	Background: To determine the predictive value of mid-regional pro-adrenomedullin (MR-proADM) compared to routine clinical and laboratory parameters in patients with COVID-19. Methods: A total of 135 adult patients hospitalized with COVID-19 were included in a prospective single-centre study. In addition to routine parameters, the levels of MR-proADM in blood plasma were measured on the day of hospitalization. The patients were divided into 2 groups: those who survived and were discharged (n = 115, 85%) and those who did not survive (n = 20, 15%). Data are presented as median and interquartile range. Results: The non-survivors had a statistically significantly greater age (73.4 [63.5-84.8] vs. 62.2 [50.3-71.4] years, P = 0.001), a lower level of haemoglobin oxygen saturation (91 [87-92] vs. 92 [92-93]%, P < 0.001), lower lymphocyte level (13 [7-30] vs. 21 [15-27]%, P = 0.03), higher lactate dehydrogenase (338 [273-480] vs. 280 [233-383] EU L-1, P = 0.04) and aspartate aminotransferase levels (49 [28-72] vs. 33 [23-47] EU L-1, P = 0.03), a higher National Early Warning (NEWS) score (7 [7- 8] vs. 6 [5-7] points, P < 0.001), and higher procalcitonin (0.16 [0.11-0.32] vs. 0.1 [0.07-0.18] ng mL-1, P = 0.006) and MR-proADM levels (1.288 [0.886-1.847] vs. 0.769 [0.6-0.955] nmol L-1, P < 0.001). MR-proADM had the highest predictive value for death during hospital stay (cut-off: 0.895 nmol L-1, AUC ROC 0.78 [95% CI: 0.66-0.90], sensitivity 75%, specificity 69%, OR 6.58 [95% CI: 2.22-19.51]). Conclusions: Compared with other indicators, MR-proADM has the highest predictive value for in-hospital mortality in patients with COVID-19.
MeSH term(s)	Adrenomedullin ; Adult ; Aspartate Aminotransferases ; Biomarkers ; COVID-19 ; Hemoglobins ; Hospital Mortality ; Humans ; Lactate Dehydrogenases ; Procalcitonin ; Prognosis ; Prospective Studies ; Protein Precursors
Chemical Substances	Biomarkers ; Hemoglobins ; Procalcitonin ; Protein Precursors ; Adrenomedullin (148498-78-6) ; Lactate Dehydrogenases (EC 1.1.-) ; Aspartate Aminotransferases (EC 2.6.1.1)
Language	English
Publishing date	2022-10-12
Publishing country	Poland
Document type	Journal Article
ISSN	1731-2531
ISSN (online)	1731-2531
DOI	10.5114/ait.2022.115367
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Article ; Online: An outlook on vascular hydrogen sulphide effects, signalling, and therapeutic potential.

Popov, Doina

Archives of physiology and biochemistry

2013 Volume 119, Issue 5, Page(s) 189–194

Abstract: Hydrogen sulphide (H(2)S) is the most recently discovered gasotransmitter. It is endogenously generated in mammalian vascular cells and attracts substantial interest by its function as physiological relevant signalling mediator, and by its dysfunction in ...

Abstract	Hydrogen sulphide (H(2)S) is the most recently discovered gasotransmitter. It is endogenously generated in mammalian vascular cells and attracts substantial interest by its function as physiological relevant signalling mediator, and by its dysfunction in metabolic diseases like obesity, type 2 diabetes and their associated complications. The purpose of this review is to highlight the novel findings on vascular H(2)S homeostasis, pathology-associated dysregulation, cell signalling, and therapeutic potential. The data bases searched were Medline and PubMed, from 2008 to 2012 (terms: hydrogen sulphide, sulfhydration). The new reports definitely assess the vasculoprotectant role of H(2)S in health, and its reduced biosynthesis/systemic levels in obesity, diabetes, atherosclerosis and hypertension. One of the mechanisms of H(2)S signalling discussed here is S-sulfhydration of catalytic cysteine residue of PTP1B, a negative regulator of insulin and leptin signalling. Finally, the review critically evaluates the compounds able to regulate vascular H(2)S bioavailability, and with potential in therapeutic exploitation.
MeSH term(s)	Blood Vessels/metabolism ; Humans ; Hydrogen Sulfide/metabolism ; Metabolic Diseases/complications ; Metabolic Diseases/metabolism ; Metabolic Diseases/pathology ; Metabolic Diseases/therapy ; Oxidative Stress ; Signal Transduction ; Therapeutics/methods
Chemical Substances	Hydrogen Sulfide (YY9FVM7NSN)
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1238320-x
ISSN	1744-4160 ; 1381-3455
ISSN (online)	1744-4160
ISSN	1381-3455
DOI	10.3109/13813455.2013.803578
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