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  1. Article: Szarvasmarhatartó telepen alkalmazott ivarzásindukáló hormonok megjelenése a hígtrágyában

    Gubó, Eduárd / Molnár, Tibor / Szakál, Pál / Pordán-Háber, Dóra / Bede-Fazekas, Ákos / Plutzer, Judit

    Agrokémia és talajtan. 2022 June 16,

    2022  

    Abstract: A review of the international literature also found that the amount and the presence in slurry of oestrus inducer hormone preparations used in intensive dairy cattle production has not been investigated. In our study, we followed the path of 5 different ... ...

    Title translation Appearance of on-farm bovine reproductive hormones in the resulting slurry
    Abstract A review of the international literature also found that the amount and the presence in slurry of oestrus inducer hormone preparations used in intensive dairy cattle production has not been investigated. In our study, we followed the path of 5 different sex-inducing drugs (alfaglandin, PGF, dinolytic, gonavet, ovarelin) including three active pharmaceutical ingredients (D-Phe6-Gonadorelin, Kloprostenol and Dinoprost-tromethamine) used in a cattle farm in Pest County from their use until their appearance in the slurry from 2017 to 2020. The study included a review of drug consumption and a seasonal analysis of the hormonal effects of slurry produced on the farm in quarterly cycles each year. We also tested separately the hormonal effects of the hormone preparations used on the farm. For the estrogenic effect tests, the yeast test with the human estrogenic receptor was used according to ISO 19040. Statistical evaluation of the results (Pearson correlation and Principal Component Analysis) was used to identify relationships between the use of sex inducers, the reproductive biology of the colony and the estrogenic effect of the slurry. We found that the estrogenic effects of slurry and sludge are strongly correlated. All three pharmaceuticals tested showed a strong correlation with the estrogenic effect of slurry/sludge. Our investigations confirm that slurry among other reasons due to its hormone and drug content shall be considered as a material that needs to be disposed of by new treatment methods before application to the field, because of its environmental and health risks.
    Keywords cattle production ; dairy cattle ; drugs ; estrogenic properties ; estrus ; farms ; humans ; pests ; principal component analysis ; sludge ; slurries ; yeasts
    Language English
    Dates of publication 2022-0616
    Publishing place Akadémiai Kiadó
    Document type Article
    ISSN 1588-2713
    DOI 10.1556/0088.2022.00116
    Database NAL-Catalogue (AGRICOLA)

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  2. Article ; Online: Correction to: A 4‑year study of bovine reproductive hormones that are induced by pharmaceuticals and appear as steroid estrogenic pollutants in the resulting slurry, using in vitro and instrumental analytical methods.

    Gubó, Eduárd / Plutzer, Judit / Molnár, Tibor / Pordán-Háber, Dóra / Szabó, Lili / Szalai, Zoltán / Gubó, Richard / Szakál, Pál / Szakál, Tamás / Környei, László / Bede-Fazekas, Ákos / Kalocsai, Renátó

    Environmental science and pollution research international

    2024  Volume 31, Issue 6, Page(s) 9868

    Language English
    Publishing date 2024-01-15
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-024-31992-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A 4-year study of bovine reproductive hormones that are induced by pharmaceuticals and appear as steroid estrogenic pollutants in the resulting slurry, using in vitro and instrumental analytical methods.

    Gubó, Eduárd / Plutzer, Judit / Molnár, Tibor / Pordán-Háber, Dóra / Szabó, Lili / Szalai, Zoltán / Gubó, Richard / Szakál, Pál / Szakál, Tamás / Környei, László / Bede-Fazekas, Ákos / Kalocsai, Renátó

    Environmental science and pollution research international

    2023  Volume 30, Issue 60, Page(s) 125596–125608

    Abstract: The main objective of the research was to study the environmental "price" of the large-scale, milk production from a rarely known perspective, from the mapping of the estrogenic footprint (the amount of oestrus-inducer hormonal products, and the ... ...

    Abstract The main objective of the research was to study the environmental "price" of the large-scale, milk production from a rarely known perspective, from the mapping of the estrogenic footprint (the amount of oestrus-inducer hormonal products, and the generated endoestrogens) in the resulting slurry in a dairy cow farm. These micropollutants are endocrine-disrupting chemicals (EDCs) and can be dangerous to the normal reproductive functions even at ng/kg concentration. One of them, 17ß-estradiol, has a 20,000 times stronger estrogenic effect than bisphenol-A, a widely known EDC of industrial origin. While most studies on EDCs are short-term and/or laboratory based, this study is longitudinal and field-based. We sampled the slurry pool on a quarterly basis between 2017 and 2020. Our purpose was testing the estrogenic effects using a dual approach. As an effect-based, holistic method, we developed and used the YES (yeast estrogen screen) test employing the genetically modified Saccharomyces cerevisiae BJ3505 strain which contains human estrogenic receptor. For testing exact molecules, UHPLC-FLD was used. Our study points out that slurry contains a growing amount of EDCs with the risk of penetrating into the soil, crops and the food chain. Considering the Green Chemistry concept, the most benign ways to prevent of the pollution of the slurry is choosing appropriate oestrus-inducing veterinary pharmaceuticals (OIVPs) and the separation of the solid and liquid parts with adequate treatment methods. To our knowledge, this is the first paper on the adaptation of the YES test for medicine and slurry samples, extending its applicability. The adapted YES test turned out to be a sensitive, robust and reliable method for testing samples with potential estrogenic effect. Our dual approach was successful in evaluating the estrogenic effect of the slurry samples.
    MeSH term(s) Cattle ; Animals ; Humans ; Environmental Pollutants/pharmacology ; Water Pollutants, Chemical/analysis ; Veterinary Drugs ; Estrogens/chemistry ; Estradiol/chemistry ; Saccharomyces cerevisiae ; Endocrine Disruptors/chemistry
    Chemical Substances Environmental Pollutants ; Water Pollutants, Chemical ; Veterinary Drugs ; Estrogens ; Estradiol (4TI98Z838E) ; Endocrine Disruptors
    Language English
    Publishing date 2023-11-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-31126-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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