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  1. Article ; Online: Telehealth in the Military Health System: Impact, Obstacles, and Opportunities.

    Madsen, Cathaleen / Poropatich, Ronald / Koehlmoos, Tracey Pérez

    Military medicine

    2023  Volume 188, Issue Suppl 1, Page(s) 15–23

    Abstract: Background: The U.S. Military Health System (MHS) pioneered the use of telehealth in deployed environments in the early 1990s. However, its use in non-deployed environments historically lagged behind that of the Veterans Health Administration (VHA) and ... ...

    Abstract Background: The U.S. Military Health System (MHS) pioneered the use of telehealth in deployed environments in the early 1990s. However, its use in non-deployed environments historically lagged behind that of the Veterans Health Administration (VHA) and comparable large civilian health systems, due to administrative, policy, and other obstacles that slowed or blocked its expansion in the MHS. A report was prepared in December 2016, which summarized past and then-present telehealth initiatives in the MHS; described the obstacles, opportunities, and policy environment; and provided three possible courses of action for expansion of telehealth in deployed and non-deployed settings.
    Methods: Gray literature, peer-reviewed literature, presentations, and direct input were aggregated under the guidance of subject matter experts.
    Results: Past and then-current efforts demonstrated significant telehealth capability in use and in development for the MHS, mainly in deployed or operational settings. Policy from 2011 to 2017 demonstrated an environment favorable for MHS expansion, while the review of comparable civilian and veterans' healthcare systems showed significant benefits including increased access and lower cost from use of telehealth in non-deployed settings. The 2017 National Defense Authorization Act charged the Secretary of Defense with promoting telehealth usage for the Department of Defense, including provisions for removing obstacles and reporting progress within 3 years. The MHS has the ability to reduce burdensome interstate licensing and privileging requirements, but still requires an increased level of cybersecurity, compared to civilian systems.
    Discussion: The benefits of telehealth fit with the MHS Quadruple Aim of improving cost, quality, access, and readiness. Readiness is particularly served by the use of "physician extenders," which allows nurses, physician assistants, medics, and corpsmen to provide hands-on care under remote oversight and to practice at the top of their licenses. Based on this review, three courses of action were recommended: to focus largely on developing telehealth in deployed environments; to maintain focus in deployed environments and increase telehealth development in non-deployed environments to keep pace with the VHA and private sector; or to use lessons learned from military and civilian telehealth initiatives to leapfrog the private sector.
    Conclusion: This review serves as a snapshot in time of the steps leading to telehealth expansion before 2017, which helped to set the stage for later use of telehealth in behavioral health initiatives and as a response to coronavirus disease 2019. The lessons learned are ongoing and further research is expected to inform additional development of telehealth capability for the MHS.
    MeSH term(s) United States ; Humans ; COVID-19 ; Military Health Services ; Telemedicine ; Hand ; Military Personnel
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 391061-1
    ISSN 1930-613X ; 0026-4075
    ISSN (online) 1930-613X
    ISSN 0026-4075
    DOI 10.1093/milmed/usac207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Telemedicine for trauma, emergencies, and disaster management

    Latifi, Rifat / Poropatich, Ronald K. / Hadeed, George J.

    2011  

    Author's details Rifat Latifi, ed. Ronald K. Poropatich ; George J. Hadeed contributing eds
    Keywords Telemedicine / methods ; Wounds and Injuries ; Disasters ; Disaster Medicine / methods ; Telemedicine--methods ; Disaster Medicine--methods ; Telecommunication in medicine ; Wounds and injuries ; Emergency management
    Subject code 610.285
    Language English
    Size XXV, 411 S. : Ill., graph. Darst., Kt.
    Publisher Artech House
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016925131
    ISBN 978-1-60783-997-2 ; 1-60783-997-0
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: Artificial Intelligence in Health: Enhancing a Return to Patient-Centered Communication.

    Holtz, Bree / Nelson, Victoria / Poropatich, Ronald K

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2022  Volume 29, Issue 6, Page(s) 795–797

    Abstract: The medical environment is on the verge of a dramatic transformation as artificial intelligence (AI) evolves. With the inevitable shift toward AI in health care delivery, there are concerns around its implementation, including ethics, privacy, data ... ...

    Abstract The medical environment is on the verge of a dramatic transformation as artificial intelligence (AI) evolves. With the inevitable shift toward AI in health care delivery, there are concerns around its implementation, including ethics, privacy, data representation, and the potential for eliminating physicians. However, AI cannot replicate a physician's knowledge and understanding of the patient as a person and the conditions in which he or she lives. Therefore, provider-patient communication will be paramount in providing safe and effective health care. This piece describes the importance of patient-centered communication and the unintentional move away from this in recent times. We argue that patient-provider communication is vital in the age of AI as it will integrate into the way medicine is practiced, thus leading to more time with the patient to build rapport, trust, and empathy. This will ultimately lead to optimal health-related outcomes.
    MeSH term(s) Female ; Humans ; Artificial Intelligence ; Communication ; Delivery of Health Care ; Physicians ; Patient-Centered Care
    Language English
    Publishing date 2022-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2022.0413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Act now! Critical care roles and obligations during an urban war.

    Bielka, Kateryna / Kotfis, Katarzyna / Poropatich, Ronald / Pinsky, Michael R

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 65

    MeSH term(s) Critical Care ; Humans
    Language English
    Publishing date 2022-03-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-03951-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Adopting and expanding ethical principles for generative artificial intelligence from military to healthcare.

    Oniani, David / Hilsman, Jordan / Peng, Yifan / Poropatich, Ronald K / Pamplin, Jeremy C / Legault, Gary L / Wang, Yanshan

    NPJ digital medicine

    2023  Volume 6, Issue 1, Page(s) 225

    Abstract: In 2020, the U.S. Department of Defense officially disclosed a set of ethical principles to guide the use of Artificial Intelligence (AI) technologies on future battlefields. Despite stark differences, there are core similarities between the military and ...

    Abstract In 2020, the U.S. Department of Defense officially disclosed a set of ethical principles to guide the use of Artificial Intelligence (AI) technologies on future battlefields. Despite stark differences, there are core similarities between the military and medical service. Warriors on battlefields often face life-altering circumstances that require quick decision-making. Medical providers experience similar challenges in a rapidly changing healthcare environment, such as in the emergency department or during surgery treating a life-threatening condition. Generative AI, an emerging technology designed to efficiently generate valuable information, holds great promise. As computing power becomes more accessible and the abundance of health data, such as electronic health records, electrocardiograms, and medical images, increases, it is inevitable that healthcare will be revolutionized by this technology. Recently, generative AI has garnered a lot of attention in the medical research community, leading to debates about its application in the healthcare sector, mainly due to concerns about transparency and related issues. Meanwhile, questions around the potential exacerbation of health disparities due to modeling biases have raised notable ethical concerns regarding the use of this technology in healthcare. However, the ethical principles for generative AI in healthcare have been understudied. As a result, there are no clear solutions to address ethical concerns, and decision-makers often neglect to consider the significance of ethical principles before implementing generative AI in clinical practice. In an attempt to address these issues, we explore ethical principles from the military perspective and propose the "GREAT PLEA" ethical principles, namely Governability, Reliability, Equity, Accountability, Traceability, Privacy, Lawfulness, Empathy, and Eutonomy, for generative AI in healthcare. Furthermore, we introduce a framework for adopting and expanding these ethical principles in a practical way that has been useful in the military and can be applied to healthcare for generative AI, based on contrasting their ethical concerns and risks. Ultimately, we aim to proactively address the ethical dilemmas and challenges posed by the integration of generative AI into healthcare practice.
    Language English
    Publishing date 2023-12-02
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-023-00965-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rectal administration of tacrolimus protects against post-ERCP pancreatitis in mice.

    Lin, Yu-Chu / Ni, Jianbo / Swaminathan, Gayathri / Khalid, Asna / Barakat, Monique T / Frymoyer, Adam R / Tsai, Cheng-Yu / Ding, Ying / Murayi, Judy-April / Jayaraman, Thottala / Poropatich, Ronald / Bottino, Rita / Wen, Li / Papachristou, Georgios I / Sheth, Sunil G / Yu, Mang / Husain, Sohail Z

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2023  Volume 23, Issue 7, Page(s) 777–783

    Abstract: Objective: There is an unmet clinical need for effective, targeted interventions to prevent post-ERCP pancreatitis (PEP). We previously demonstrated that the serine-threonine phosphatase, calcineurin (Cn) is a critical mediator of PEP and that the FDA- ... ...

    Abstract Objective: There is an unmet clinical need for effective, targeted interventions to prevent post-ERCP pancreatitis (PEP). We previously demonstrated that the serine-threonine phosphatase, calcineurin (Cn) is a critical mediator of PEP and that the FDA-approved calcineurin inhibitors, tacrolimus (Tac) or cyclosporine A, prevented PEP. Our recent observations in preclinical PEP models demonstrating that Cn deletion in both pancreatic and hematopoietic compartments is required for maximal pancreas protection, highlighted the need to target both systemic and pancreas-specific Cn signaling. We hypothesized that rectal administration of Tac would effectively mitigate PEP by ensuring systemic and pancreatic bioavailability of Tac. We have tested the efficacy of rectal Tac in a preclinical PEP model and in cerulein-induced experimental pancreatitis.
    Methods: C57BL/6 mice underwent ductal cannulation with saline infusion to simulate pressure-induced PEP or were given seven, hourly, cerulein injections to induce pancreatitis. To test the efficacy of rectal Tac in pancreatitis prevention, a rectal Tac suppository (1 mg/kg) was administered 10 min prior to cannulation or first cerulein injection. Histological and biochemical indicators of pancreatitis were evaluated post-treatment. Pharmacokinetic parameters of Tac in the blood after rectal delivery compared to intravenous and intragastric administration was evaluated.
    Results: Rectal Tac was effective in reducing pancreatic injury and inflammation in both PEP and cerulein models. Pharmacokinetic studies revealed that the rectal administration of Tac helped achieve optimal blood levels of Tac over an extended time compared to intravenous or intragastric delivery.
    Conclusion: Our results underscore the effectiveness and clinical utility of rectal Tac for PEP prophylaxis.
    MeSH term(s) Animals ; Mice ; Administration, Rectal ; Anti-Inflammatory Agents, Non-Steroidal ; Ceruletide ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Mice, Inbred C57BL ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Tacrolimus/administration & dosage ; Tacrolimus/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Ceruletide (888Y08971B) ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2023-09-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2023.09.080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Preclinical safety evaluation of calcineurin inhibitors delivered through an intraductal route to prevent post-ERCP pancreatitis demonstrates endocrine and systemic safety.

    Ni, Jianbo / Khalid, Asna / Lin, Yu-Chu / Barakat, Monique T / Wang, Jing / Tsai, Cheng-Yu / Azar, Pasha Reza Shams / Ding, Ying / Murayi, Judy-April / Jayaraman, Thottala / Poropatich, Ronald / Bottino, Rita / Wen, Li / Papachristou, Georgios I / Swaminathan, Gayathri / Yu, Mang / Husain, Sohail Z

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2023  Volume 23, Issue 4, Page(s) 333–340

    Abstract: Objective: There is an urgent need for safe and targeted interventions to mitigate post-ERCP pancreatitis (PEP). Calcineurin inhibitors (CnIs) offer therapeutic promise as calcineurin signaling within acinar cells is a key initiating event in PEP. In ... ...

    Abstract Objective: There is an urgent need for safe and targeted interventions to mitigate post-ERCP pancreatitis (PEP). Calcineurin inhibitors (CnIs) offer therapeutic promise as calcineurin signaling within acinar cells is a key initiating event in PEP. In previous proof-of-concept studies using experimental models, we showed that concurrent intra-pancreatic ductal administration of the CnIs, tacrolimus (Tac) or cyclosporine A (CsA) with the ERCP radiocontrast agent (RC) prevented PEP. To translate this finding clinically, we investigated potential toxic effects of intraductal delivery of a single-dose RC-CnI formulation on endocrine pancreas function and systemic toxicities in a preclinical PEP model.
    Methods: C57BL/6J mice underwent ductal cannulation and received a single, intra-pancreatic ductal infusion of RC or RC with Tac or CsA (treatment groups) or underwent ductal cannulation without infusion ('sham' group). To assess endocrine function, intraperitoneal glucose tolerance test (IPGTT) was performed at two days before infusion and on day 2 and 14 post-surgery. To evaluate off-target tissue toxicities, renal and hepatic function-related parameters including blood urea nitrogen, plasma creatinine, potassium, aspartate aminotransferase, alanine aminotransferase, and total bilirubin were measured at the same time-points as IPGTT. Histological and biochemical indicators of pancreas injury and inflammation were also evaluated.
    Results: No abnormalities in glucose metabolism, hepatic or renal function were observed on day 2 or 14 in mice administered with intraductal RC or RC with Tac or CsA.
    Conclusion: Intraductal delivery of RC-CnI formulation was safe and well-tolerated with no significant acute or subacute endocrine or systemic toxicities, underscoring its clinical utility to prevent PEP.
    MeSH term(s) Mice ; Animals ; Calcineurin Inhibitors/therapeutic use ; Calcineurin Inhibitors/pharmacology ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Mice, Inbred C57BL ; Tacrolimus/therapeutic use ; Tacrolimus/pharmacology ; Cyclosporine/therapeutic use ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Pancreatitis/pathology ; Contrast Media
    Chemical Substances Calcineurin Inhibitors ; Tacrolimus (WM0HAQ4WNM) ; Cyclosporine (83HN0GTJ6D) ; Contrast Media
    Language English
    Publishing date 2023-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2023.03.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A review of the rationale for the testing of the calcineurin inhibitor tacrolimus for post-ERCP pancreatitis prevention.

    Barakat, Monique T / Khalid, Asna / Yu, Mang / Ding, Ying / Murayi, Judy-April / Jayaraman, Thottala / Poropatich, Ronald / Akshintala, Venkat / Juakiem, Wassem / Wen, Li / Papachristou, Georgios I / Husain, Sohail Z

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2022  Volume 22, Issue 6, Page(s) 678–682

    Abstract: Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for the management of pancreaticobiliary disorders. The most troublesome ERCP-associated adverse event is post-ERCP pancreatitis (PEP), which occurs in up to 15% of all patients ... ...

    Abstract Endoscopic retrograde cholangiopancreatography (ERCP) is commonly performed for the management of pancreaticobiliary disorders. The most troublesome ERCP-associated adverse event is post-ERCP pancreatitis (PEP), which occurs in up to 15% of all patients undergoing ERCP. A substantial body of preclinical data support a mechanistic rationale for calcineurin inhibitors in preventing PEP. The findings are coupled with recent clinical data suggesting lower rates of PEP in patients who concurrently use the calcineurin inhibitor tacrolimus (e.g., solid organ transplant recipients). In this review, we will firstly summarize data in support of testing the use of tacrolimus for PEP prophylaxis, either in combination with rectal indomethacin or by itself. Secondly, we propose that administering tacrolimus through the rectal route could be favorable for PEP prophylaxis over other routes of administration.
    MeSH term(s) Administration, Rectal ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Calcineurin Inhibitors/therapeutic use ; Cholangiopancreatography, Endoscopic Retrograde/adverse effects ; Humans ; Pancreatitis/drug therapy ; Pancreatitis/etiology ; Pancreatitis/prevention & control ; Risk Factors ; Tacrolimus/therapeutic use
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Calcineurin Inhibitors ; Tacrolimus (WM0HAQ4WNM)
    Language English
    Publishing date 2022-07-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2022.07.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Conference proceedings: Remote cardiology consultations using advanced medical technology

    Klapan, Ivica / Poropatich, Ronald

    applications for NATO operations

    (NATO science series. Series I, Life and behavioural sciences, ; v. 372)

    2006  

    Institution North Atlantic Treaty Organization. / Public Diplomacy Division
    Event/congress NATO Advanced Research Workshop on Remote Cardiology Consultations Using Advanced Medical Technology--Applications for NATO Operations (2005, ZagrebCroatia)
    Author's details edited by Ivica Klapan and Ronald Poropatich
    Series title NATO science series. Series I, Life and behavioural sciences, ; v. 372
    MeSH term(s) Cardiology ; Telemedicine/methods
    Language English
    Size xxiv, 163 p. :, ill. ;, 25 cm.
    Publisher IOS Press
    Publishing place Amsterdam ; Washington, DC
    Document type Book ; Conference proceedings
    Note "Published in cooperation with NATO Public Diplomacy Division." ; "Proceedings of the NATO Advanced Research Workshop on Remote Cardiology Consultations Using Advanced Medical Technology--Applications for NATO Operations, Zagreb, Croatia, 13-16 September 2005"--T.p. verso.
    ISBN 9781586036577 ; 1586036572
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Book: Telemedicine for trauma, emergencies, and disaster management

    Latifi, Rifat / Poropatich, Ronald / Hadeed, George J

    2011  

    Author's details Rifat Latifi, editor ; Ronald K. Poropatich, George J. Hadeed, contributing editors
    MeSH term(s) Telemedicine/methods ; Wounds and Injuries ; Disasters ; Disaster Medicine/methods
    Language English
    Size xxv, 411 p. :, ill.
    Publisher Artech House
    Publishing place Boston
    Document type Book
    ISBN 9781607839972 ; 1607839970
    Database Catalogue of the US National Library of Medicine (NLM)

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