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Article ; Online: One-year survival of aneurysmal subarachnoid hemorrhage after airplane transatlantic transfer - a monocenter retrospective study.

Martino, Frédéric / Fleuri, Antoine / Engrand, Nicolas / Rolle, Amélie / Piotin, Michel / Carles, Michel / Delta, Delphine / Do, Laurent / Pons, Adrien / Portecop, Patrick / Sitcharn, Mathys / Valette, Marc / Camous, Laurent / Pommier, Jean-David / Demoule, Alexandre

BMC anesthesiology

2024 Volume 24, Issue 1, Page(s) 140

Abstract: Background: Aneurysmal subarachnoid hemorrhage (aSAH) is preferentially treated by prompt endovascular coiling, which is not available in Guadeloupe. Subsequently, patients are transferred to Paris, France mainland, by commercial airplane (6751 km ... ...

Abstract	Background: Aneurysmal subarachnoid hemorrhage (aSAH) is preferentially treated by prompt endovascular coiling, which is not available in Guadeloupe. Subsequently, patients are transferred to Paris, France mainland, by commercial airplane (6751 km flight) after being managed according to guidelines. This study describes the characteristics, management and outcomes related to these patients. Methods: Retrospective observational cohort study of 148 patients admitted in intensive care unit for a suspected aSAH and transferred by airplane over a 10-year period (2010-2019). Results: The median [interquartile range] age was 53 [45-64] years and 61% were female. On admission, Glasgow coma scale was 15 [13-15], World Federation of Neurological Surgeons (WFNS) grading scale was 1 [1-3] and Fisher scale was 4 [2-4]. External ventricular drainage and mechanical ventilation were performed prior to the flight respectively in 42% and 47% of patients. One-year mortality was 16% over the study period. By COX logistic regression analysis, acute hydrocephalus (hazard ratio [HR] 2.34, 95% confidence interval [CI] 0.98-5.58) prior to airplane transfer, WFNS grading scale on admission (HR 1.53, 95% CI 1.16-2.02) and age (OR 1.03, 95% 1.00-1.07) were associated with one-year mortality. Conclusion: When necessary, transatlantic air transfer of patients with suspected aSAH after management according to local guidelines seems feasible and safe.
MeSH term(s)	Humans ; Female ; Middle Aged ; Male ; Retrospective Studies ; Subarachnoid Hemorrhage/surgery ; Aircraft ; Drainage ; France
Language	English
Publishing date	2024-04-12
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2091252-3
ISSN	1471-2253 ; 1471-2253
ISSN (online)	1471-2253
ISSN	1471-2253
DOI	10.1186/s12871-024-02532-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: COVID-19 Outbreak: Burnout and Posttraumatic Stress Disorder, a Harmful Chronology for Health Caregivers in Emergency Departments and Intensive Care Units.

Pujo, Jean Marc / Fitriani, Dewi Yunia / Adi, Nuri Purwito / Portecop, Patrick / Resiere, Dabor / Mansyur, Muchtaruddin / Kallel, Hatem

Disaster medicine and public health preparedness

2022 , Page(s) 1–2

Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2375268-3
ISSN	1938-744X ; 1935-7893
ISSN (online)	1938-744X
ISSN	1935-7893
DOI	10.1017/dmp.2022.24
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Article ; Online: Dedicated team to ambulatory care for patients with COVID-19 requiring oxygen: Low rate of hospital readmission.

Viel, Sophie / Markowicz, Samuel / Ait-Medjber, Larbi / Ouissa, Rachida / Delta, Delphine / Portecop, Patrick / Foucan, Tania / Roger, Pierre-Marie

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 123, Page(s) 92–96

Abstract: Objectives: We aimed to determine the impact of a dedicated medical team (DMT) on ambulatory care for patients requiring oxygen.: Methods: The DMT selected patients requiring oxygen for less than 5 l/min in the emergency department (ED). The rate of ... ...

Abstract	Objectives: We aimed to determine the impact of a dedicated medical team (DMT) on ambulatory care for patients requiring oxygen. Methods: The DMT selected patients requiring oxygen for less than 5 l/min in the emergency department (ED). The rate of ED readmission was compared in patients managed by the DMT and those managed by the ED physicians (EDPs). Consensual treatment for COVID-19 pneumonia with oxygen requirement was steroids + preventive anticoagulation. Results: A total of 1397 patients with COVID-19 came to our ED from the first to the 31 Conclusion: A DMT for ambulatory care of patients with COVID-19 requiring oxygen was associated with less return to the ED than usual practices.
MeSH term(s)	Ambulatory Care ; Anticoagulants ; COVID-19/therapy ; Emergency Service, Hospital ; Humans ; Oxygen ; Patient Readmission ; Retrospective Studies
Chemical Substances	Anticoagulants ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-08-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.07.057
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Article: Bradycardie sinusale par ingestion de fruits de mancenillier.

Dupuy, Caroline / Guerin, Côme / Portecop, Patrick / Boucaud-Maitre, Denis

La Revue du praticien

2019 Volume 68, Issue 4, Page(s) 407

Title translation	Sinus bradycardia by the ingestion of Mancenillier fruits.
MeSH term(s)	Arrhythmias, Cardiac ; Bradycardia/etiology ; Electrocardiography ; Fruit/adverse effects ; Humans
Language	French
Publishing date	2019-04-03
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Monitoring the post-containment COVID-19 crisis in Guadeloupe: Early-warning signals of destabilisation through bootstrapped probability density functions

ALLALI, Meriem / Portecop, Patrick / Carles, Michel / Gibert, Dominique

medRxiv

Abstract: We propose a method to detect early-warning information in relation with subtle changes occurring in the trend of evolution in data time series of the COVID-19 epidemic spread (e.g. daily new cases). The method is simple and easy to implement on laptop ... ...

Abstract	We propose a method to detect early-warning information in relation with subtle changes occurring in the trend of evolution in data time series of the COVID-19 epidemic spread (e.g. daily new cases). The method is simple and easy to implement on laptop computers. It is designed to be able to provide reliable results even with very small amounts of data (i.e. ≈ 10 − 20). The results are given as compact graphics easy to interpret. The data are separated into two subsets: the old data used as control points to statistically define a "trend" and the recent data that are tested to evaluate their conformity with this trend. The trend is characterised by bootstrapping in order to obtain probability density functions of the expected misfit of each data point. The probability densities are used to compute distance matrices where data clusters and outliers are easily visually recognised. In addition to be able to detect very subtle changes in trend, the method is also able to detect outliers. A simulated case is analysed where R<sub>0</sub> is slowly augmented (i.e. from 1.5 to 2.0 in 20 days) to pass from a stable damped control of the epidemic spread to an exponentially diverging situation. The method is able to give an early warning signal as soon as the very beginning of the R<sub>0</sub> variation. Application to the data of Guadeloupe shows that a small destabilising event occurred in the data near April 30, 2020. This may be due to an increase of R<sub>0</sub> ≈ 0.7 around April 13-15, 2020.
Keywords	covid19
Language	English
Publishing date	2020-05-30
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.05.29.20117333
Database	COVID19

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Article ; Online: Prediction of the time evolution of the COVID-19 disease in Guadeloupe with a stochastic evolutionary model

ALLALI, MERIEM / PORTECOP, PATRICK / CARLES, MICHEL / GIBERT, DOMINIQUE

Abstract: Predictions on the time-evolution of the number of severe and critical cases of COVID-19 patients in Guadeloupe are presented. A stochastic model is purposely developed to explicitly account for the entire population (≈ 400000 inhabitants) of Guadeloupe. ...

Abstract	Predictions on the time-evolution of the number of severe and critical cases of COVID-19 patients in Guadeloupe are presented. A stochastic model is purposely developed to explicitly account for the entire population (≈ 400000 inhabitants) of Guadeloupe. The available data for Guadeloupe are analysed and combined with general characteristics of the COVID-19 to constrain the parameters of the model. The time-evolution of the number of cases follows the well-known exponential-like model observed at the very beginning of a pandemic outbreak. The exponential growth of the number of infected individuals is controlled by the so-called basic reproductive number, R0, defined as the likely number of additional cases generated by a single infectious case during its infectious period TI. Because of the rather long duration of infectious period (≈ 14 days) a high rate of contamination is sustained during several weeks after the beginning of the containment period. This may constitute a source of discouragement for people restrained to respect strict containment rules. It is then unlikely that, during the containment period, R0 falls to zero. Fortunately, our models shows that the containment effects are not much sensitive to the exact value of R0 provided we have R0 < 0.6. For such conditions, we show that the number of severe and critical cases is highly tempered about 4 to 6 weeks after the beginning of the containment. Also, the maximum number of critical cases (i.e. the cases that may exceed the hospital intensive care capacity) remains near 30 when R0 < 0.6. For a larger R0 = 0.8 a slower decrease of the number of critical cases occurs, leading to a larger number of deceased patients. This last example illustrates the great importance to maintain an as low as possible R0 during and after the containment period. The rather long delay between the beginning of the containment and the appearance of the slowing-down of the rate of contamination puts a particular strength on the communication and sanitary education of people. To be mostly efficient, this communication must be done by a locally recognised medical staff. We believe that this point is a crucial matter of success.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.04.12.20063008
Database	COVID19

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Article ; Online: Model of a Testing-and-Quarantine Strategy to Slow-Down the COVID-19 Outbreak in Guadeloupe

ALLALI, Meriem / PORTECOP, Patrick / CARLES, Michel / GIBERT, Dominique

medRxiv

Abstract: Using a stochastic epidemic model explicitly considering the entire population of Guadeloupe (1), we explore the domain of solutions presenting an efficient slowing down of the COVID-19 epidemic spread during the post-containment period. The considered ... ...

Abstract	Using a stochastic epidemic model explicitly considering the entire population of Guadeloupe (1), we explore the domain of solutions presenting an efficient slowing down of the COVID-19 epidemic spread during the post-containment period. The considered model parameters are the basic reproduction number R0 to simulate the effects of social distancing, the time delay δTQ elapsed between the detection of a symptomatic person and her/his placement in quarantine to suppress her/his contagiousness, and the number Na of asymptomatic people tested positively and isolated. We show that acceptable solutions are obtained for a wide range of parameter values. Thanks to a good control of the initial epidemic spread resulting from an early containment and efficient communication by the sanitary and administrative authorities, the present situation corresponds to a pre-epidemic state. The most safe solutions are a combinations of social distancing, numerous testing to perform a systematic isolation of symptomatic patients and guided detection of asymptomatic people in the entourage of localised symptomatic patients.
Keywords	covid19
Language	English
Publishing date	2020-05-06
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.05.01.20088138
Database	COVID19

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Article ; Online: Prediction of the time evolution of the COVID-19 disease in Guadeloupe with a stochastic evolutionary model

ALLALI, MERIEM / PORTECOP, PATRICK / CARLES, MICHEL / GIBERT, DOMINIQUE

medRxiv

Abstract	Predictions on the time-evolution of the number of severe and critical cases of COVID-19 patients in Guadeloupe are presented. A stochastic model is purposely developed to explicitly account for the entire population (≈ 400000 inhabitants) of Guadeloupe. The available data for Guadeloupe are analysed and combined with general characteristics of the COVID-19 to constrain the parameters of the model. The time-evolution of the number of cases follows the well-known exponential-like model observed at the very beginning of a pandemic outbreak. The exponential growth of the number of infected individuals is controlled by the so-called basic reproductive number, R0, defined as the likely number of additional cases generated by a single infectious case during its infectious period T<sub>I</sub>. Because of the rather long duration of infectious period (≈ 14 days) a high rate of contamination is sustained during several weeks after the beginning of the containment period. This may constitute a source of discouragement for people restrained to respect strict containment rules. It is then unlikely that, during the containment period, R0 falls to zero. Fortunately, our models shows that the containment effects are not much sensitive to the exact value of R0 provided we have R0 < 0.6. For such conditions, we show that the number of severe and critical cases is highly tempered about 4 to 6 weeks after the beginning of the containment. Also, the maximum number of critical cases (i.e. the cases that may exceed the hospital intensive care capacity) remains near 30 when R0 < 0.6. For a larger R0 = 0.8 a slower decrease of the number of critical cases occurs, leading to a larger number of deceased patients. This last example illustrates the great importance to maintain an as low as possible R0 during and after the containment period. The rather long delay between the beginning of the containment and the appearance of the slowing-down of the rate of contamination puts a particular strength on the communication and sanitary education of people. To be mostly efficient, this communication must be done by a locally recognised medical staff. We believe that this point is a crucial matter of success.
Keywords	covid19
Language	English
Publishing date	2020-04-16
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.04.12.20063008
Database	COVID19

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Article ; Online: Antimicrobial Susceptibility of Community-Acquired Urine Bacterial Isolates in French Amazonia.

NkontCho, Flaubert / Sainte-Rose, Vincent / Abboud, Philippe / Portecop, Patrick / Pujo, Jean Marc / Cook, Fabrice / Walter, Gaelle / Mounier, Roman / Resiere, Dabor / Houcke, Stephanie / Demar, Magalie / Kallel, Hatem / Djossou, Felix

The American journal of tropical medicine and hygiene

2023 Volume 108, Issue 5, Page(s) 927–935

Abstract: Bacterial resistance in community-acquired urinary tract infections (UTIs) is increasing worldwide. Our study aimed to assess the microbiological epidemiology and antimicrobial susceptibility patterns of community-acquired urine bacterial isolates in ... ...

Abstract	Bacterial resistance in community-acquired urinary tract infections (UTIs) is increasing worldwide. Our study aimed to assess the microbiological epidemiology and antimicrobial susceptibility patterns of community-acquired urine bacterial isolates in French Amazonia. Our study is retrospective. It was conducted from January 2015 to December 2019 in the microbiology laboratory of the Cayenne General Hospital (French Guiana). It includes all positive urine samples from adult (> 18 years) outpatients (N = 2,533). Isolated microorganisms were Gram-negative rods in 83.9%, mainly Enterobacterales (98.4%). The main isolated bacteria were Escherichia coli (58.7%) and Klebsiella pneumoniae (13.3%). Among the isolated E. coli, 37.2% were susceptible to amoxicillin, 77.9% to amoxicillin/clavulanic acid, 94.9% to cefotaxime, 78.9% to ofloxacin, and 98.9% to nitrofurantoin. In 106 cases (5.1%), isolated Enterobacterales were extended-spectrum β-lactamase producers (5% of E. coli and 8.9% of K. pneumoniae). Overall, high levels of cross- and co-resistance were registered. The main isolated Gram-positive bacteria was Staphylococcus saprophyticus (28.9%). It was resistant to oxacillin in 52.5% of cases and susceptible to nitrofurantoin in 99.1% of cases. Patients with S. saprophyticus were young women in almost all cases. In conclusion, the most isolated microorganisms from outpatient urinalyses were E. coli and K. pneumoniae. They showed a high resistance rate to amoxicillin, but they were susceptible to the most remaining antibiotics. S. saprophyticus was isolated mainly in young women and was resistant to oxacillin in half of the cases. Interestingly, nitrofurantoin was active against most isolated organisms and can be considered as empirical treatment in uncomplicated UTIs.
MeSH term(s)	Adult ; Humans ; Female ; Nitrofurantoin ; Escherichia coli ; Retrospective Studies ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/microbiology ; Community-Acquired Infections/epidemiology ; Amoxicillin-Potassium Clavulanate Combination ; Oxacillin
Chemical Substances	Nitrofurantoin (927AH8112L) ; Anti-Bacterial Agents ; Amoxicillin-Potassium Clavulanate Combination (74469-00-4) ; Oxacillin (UH95VD7V76)
Language	English
Publishing date	2023-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.22-0242
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Article ; Online: Pain Control for Sickle Cell Crisis, a Novel Approach? A Retrospective Study.

Rollé, Amélie / Vidal, Elsa / Laguette, Pierre / Garnier, Yohann / Delta, Delphine / Martino, Frédéric / Portecop, Patrick / Etienne-Julan, Maryse / Piednoir, Pascale / De Jong, Audrey / Romana, Marc / Bernit, Emmanuelle

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 12

Abstract: Background and ... ...

Abstract	Background and Objectives
MeSH term(s)	Adult ; Female ; Humans ; Pain Management/methods ; Retrospective Studies ; Analgesics, Opioid/therapeutic use ; Volatile Organic Compounds ; Pain/drug therapy ; Pain/etiology ; Analgesics/therapeutic use ; Anemia, Sickle Cell/complications
Chemical Substances	Analgesics, Opioid ; Volatile Organic Compounds ; Analgesics
Language	English
Publishing date	2023-12-18
Publishing country	Switzerland
Document type	Systematic Review ; Journal Article
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59122196
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