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Article ; Online: Testing the Reference of Biological Kind Terms.

Devitt, Michael / Porter, Brian C

2021 Volume 45, Issue 5, Page(s) e12979

Abstract: Recent experimental work on "natural" kind terms has shown evidence of both descriptive and nondescriptive reference determination. This has led some to propose ambiguity or hybrid theories, as opposed to traditional description and causal-historical ... ...

Abstract	Recent experimental work on "natural" kind terms has shown evidence of both descriptive and nondescriptive reference determination. This has led some to propose ambiguity or hybrid theories, as opposed to traditional description and causal-historical theories of reference. Many of those experiments tested theories against referential intuitions. We reject this method, urging that reference should be tested against usage, preferably by elicited production. Our tests of the usage of a biological kind term confirm that there are indeed both descriptive and causal-historical elements to the reference determination of some natural kind terms. We argue that to accommodate our results and earlier ones, we should abandon the common assumption that any one theory of reference fits all natural kind terms. Rather, it is likely that some terms are descriptive, some causal-historical, some ambiguous, and some hybrid. This substantive conclusion is accompanied by a methodological one. Our experiments, like some earlier ones, found participants contradicting both each other and themselves. We argue that these contradictions indicate a lack of linguistic competence with the term. We conclude that these experiments have been faulty, because they test terms that are novel to participants and/or use fantastical vignettes. We provide some suggestions for future research.
MeSH term(s)	Causality ; Humans ; Intuition ; Research Design
Language	English
Publishing date	2021-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2002940-8
ISSN	1551-6709 ; 0364-0213
ISSN (online)	1551-6709
ISSN	0364-0213
DOI	10.1111/cogs.12979
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Article ; Online: What is your diagnosis? Large perianal mass in a dog.

Chu, Candice P / Nabity, Mary B / Porter, Brian F / Aceino, Alexander

Veterinary clinical pathology

2023

Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2114702-4
ISSN	1939-165X ; 0275-6382
ISSN (online)	1939-165X
ISSN	0275-6382
DOI	10.1111/vcp.13231
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Article ; Online: Automation and artificial intelligence in radiation therapy treatment planning.

Jones, Scott / Thompson, Kenton / Porter, Brian / Shepherd, Meegan / Sapkaroski, Daniel / Grimshaw, Alexandra / Hargrave, Catriona

Journal of medical radiation sciences

2023

Abstract: Automation and artificial intelligence (AI) is already possible for many radiation therapy planning and treatment processes with the aim of improving workflows and increasing efficiency in radiation oncology departments. Currently, AI technology is ... ...

Abstract	Automation and artificial intelligence (AI) is already possible for many radiation therapy planning and treatment processes with the aim of improving workflows and increasing efficiency in radiation oncology departments. Currently, AI technology is advancing at an exponential rate, as are its applications in radiation oncology. This commentary highlights the way AI has begun to impact radiation therapy treatment planning and looks ahead to potential future developments in this space. Historically, radiation therapist's (RT's) role has evolved alongside the adoption of new technology. In Australia, RTs have key clinical roles in both planning and treatment delivery and have been integral in the implementation of automated solutions for both areas. They will need to continue to be informed, to adapt and to transform with AI technologies implemented into clinical practice in radiation oncology departments. RTs will play an important role in how AI-based automation is implemented into practice in Australia, ensuring its application can truly enable personalised and higher-quality treatment for patients. To inform and optimise utilisation of AI, research should not only focus on clinical outcomes but also AI's impact on professional roles, responsibilities and service delivery. Increased efficiencies in the radiation therapy workflow and workforce need to maintain safe improvements in practice and should not come at the cost of creativity, innovation, oversight and safety.
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2734841-6
ISSN	2051-3909 ; 2051-3909
ISSN (online)	2051-3909
ISSN	2051-3909
DOI	10.1002/jmrs.729
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Article ; Online: Meningoencephalitis caused by concurrent infection with canine distemper virus and a unique

Neupane, Sarita / Wellehan, James F X / Childress, April L / Snook, Eric R / Porter, Brian F

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

2023 Volume 35, Issue 4, Page(s) 443–447

Abstract: A deceased 9-wk-old male gray fox ( ...

Abstract	A deceased 9-wk-old male gray fox (
MeSH term(s)	Male ; Animals ; Dogs ; Sarcocystis ; Foxes ; Distemper Virus, Canine ; Bayes Theorem ; Meningoencephalitis/veterinary ; Meningoencephalitis/pathology ; Sarcocystosis/diagnosis ; Sarcocystosis/veterinary ; Sarcocystosis/pathology ; Distemper ; Dog Diseases
Language	English
Publishing date	2023-04-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387231169768
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Article ; Online: Subcutaneous Implantation of Hepatocellular Carcinoma in a Dog.

Peterson, Marisa R / Porter, Brian F / Edwards, Erin E / Piccione, Julie

Journal of comparative pathology

2022 Volume 199, Page(s) 51–54

Abstract: A 13-year-old male neutered Cocker Spaniel mixed-breed dog developed a subcutaneous mass 2 years after undergoing surgery to remove a hepatocellular carcinoma. An approximately 4 × 3 cm subcutaneous mass was found on the ventral abdomen at the cranial ... ...

Abstract	A 13-year-old male neutered Cocker Spaniel mixed-breed dog developed a subcutaneous mass 2 years after undergoing surgery to remove a hepatocellular carcinoma. An approximately 4 × 3 cm subcutaneous mass was found on the ventral abdomen at the cranial end of the abdominal incision from the previous surgery. The subcutaneous mass was surgically removed and histopathological examination determined that it was an implantation of the previously excised hepatocellular carcinoma. The diagnosis was confirmed by immunohistochemical labelling with hepatocyte paraffin 1 antibody and pancytokeratin. Based on the location of the subcutaneous mass at the cranial end of the abdominal incision associated with the previous hepatocellular carcinoma resection, it is likely there was iatrogenic metastasis from the primary tumour excision. Subcutaneous iatrogenic metastasis of hepatocellular carcinoma is well recognized in humans but has apparently never been reported in dogs. Clinicians should be aware of this potential surgical complication.
MeSH term(s)	Humans ; Male ; Dogs ; Animals ; Carcinoma, Hepatocellular/veterinary ; Liver Neoplasms/surgery ; Liver Neoplasms/veterinary ; Iatrogenic Disease/veterinary ; Dog Diseases/surgery ; Dog Diseases/pathology
Language	English
Publishing date	2022-10-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2022.09.009
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Article ; Online: A de novo mutation in CACNA1A is associated with autosomal dominant bovine familial convulsions and ataxia in Angus cattle.

Reith, Rachel R / Beever, Jonathan E / Paschal, Joe C / Banta, Jason / Porter, Brian F / Steffen, David J / Hairgrove, Thomas B / Petersen, Jessica L

Animal genetics

2024 Volume 55, Issue 3, Page(s) 344–351

Abstract: Bovine familial convulsions and ataxia (BFCA) is considered an autosomal dominant syndrome with incomplete penetrance. Nine Angus calves from the same herd were diagnosed with BFCA within days of birth. Necropsy revealed cerebellar and spinal cord ... ...

Abstract	Bovine familial convulsions and ataxia (BFCA) is considered an autosomal dominant syndrome with incomplete penetrance. Nine Angus calves from the same herd were diagnosed with BFCA within days of birth. Necropsy revealed cerebellar and spinal cord lesions associated with the condition. Parentage testing confirmed that all affected calves had a common sire. The sire was then bred to 36 cows across two herds using artificial insemination, producing an additional 14 affected calves. The objective of this investigation was to identify hypothesized dominant genetic variation underlying the condition. Whole-genome sequencing was performed on the sire, six affected and seven unaffected paternal half-sibling calves and combined with data from 135 unrelated controls. The sire and five of the six affected calves were heterozygous for a nonsense variant (Chr7 g.12367906C>T, c.5073C>T, p.Arg1681*) in CACNA1A. The other affected calves (N = 8) were heterozygous for the variant but it was absent in the other unaffected calves (N = 7) and parents of the sire. This variant was also absent in sequence data from over 6500 other cattle obtained via public repositories and collaborator projects. The variant in CACNA1A is expressed in the cerebellum of the ataxic calves as detected in the transcriptome and was not differentially expressed compared with controls. The CACNA1A protein is part of a highly expressed cerebellar calcium voltage gated channel. The nonsense variant is proposed to cause haploinsufficiency, preventing proper transmission of neuronal signals through the channel and resulting in BFCA.
MeSH term(s)	Animals ; Cattle/genetics ; Calcium Channels/genetics ; Ataxia/veterinary ; Ataxia/genetics ; Cattle Diseases/genetics ; Seizures/veterinary ; Seizures/genetics ; Male ; Female ; Whole Genome Sequencing/veterinary ; Genes, Dominant ; Mutation
Chemical Substances	Calcium Channels
Language	English
Publishing date	2024-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	632766-7
ISSN	1365-2052 ; 0268-9146 ; 0268-9154
ISSN (online)	1365-2052
ISSN	0268-9146 ; 0268-9154
DOI	10.1111/age.13409
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Article ; Online: Deer mastadenovirus B pneumonia in a white-tailed deer fawn

Hoskins, Emily / Hoffman, Jay / Ferro, Pamela J. / Diaz-Delgado, Josué / Porter, Brian F. / Gómez, Gabriel / Cliften, Paul

Journal of Veterinary Diagnostic Investigation. 2023 Sept., v. 35, no. 5 p.543-546

2023

Abstract: A 7-mo-old farmed white-tailed deer fawn (Odocoileus virginianus) died after several weeks of progressive deterioration associated with endoparasitism and respiratory signs. A field autopsy was performed, and lung tissue was submitted for histologic ... ...

Abstract	A 7-mo-old farmed white-tailed deer fawn (Odocoileus virginianus) died after several weeks of progressive deterioration associated with endoparasitism and respiratory signs. A field autopsy was performed, and lung tissue was submitted for histologic examination. The findings were consistent with necrosuppurative bronchointerstitial pneumonia with intranuclear viral inclusions. Immunofluorescence using fluorescently labeled polyclonal antibodies to bovine adenovirus 3 and 5 was positive. To rule out cross-reactivity with other adenoviruses, formalin-fixed, paraffin-embedded tissue sections were submitted for genome sequence analysis, which revealed a 99.6% match to Deer mastadenovirus B (formerly Odocoileus adenovirus 2, OdAdV2). To our knowledge, natural clinical disease associated with OdAdV2 has not been reported previously.
Keywords	Bovine mastadenovirus B ; Odocoileus virginianus ; cross reaction ; fawns ; fluorescent antibody technique ; histology ; lungs ; necropsy ; nucleotide sequences ; pneumonia ; sequence analysis ; Adenoviridae ; Deer mastadenovirus B ; bovine adenovirus 3 ; bronchointerstitial pneumonia ; Cervidae ; immunofluorescence ; white-tailed deer
Language	English
Dates of publication	2023-09
Size	p. 543-546.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387231179140
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Article ; Online: Meningoencephalitis caused by concurrent infection with canine distemper virus and a unique Sarcocystis sp. in a gray fox

Neupane, Sarita / Wellehan, James F. X. / Childress, April L. / Snook, Eric R. / Porter, Brian F.

Journal of Veterinary Diagnostic Investigation. 2023 July, v. 35, no. 4 p.443-447

2023

Abstract: A deceased 9-wk-old male gray fox (Urocyon cinereoargenteus) with a history of decreased ambulation and diarrhea was submitted to the Texas A&M Veterinary Medical Diagnostic Laboratory. No significant gross findings were evident on postmortem examination. ...

Abstract	A deceased 9-wk-old male gray fox (Urocyon cinereoargenteus) with a history of decreased ambulation and diarrhea was submitted to the Texas A&M Veterinary Medical Diagnostic Laboratory. No significant gross findings were evident on postmortem examination. Histologically, the cerebrum and brainstem had mild necrotizing meningoencephalitis with protozoal schizonts and merozoites. Additionally, glial cells contained intracytoplasmic and intranuclear viral inclusion bodies. Sections of the cerebrum were positive for canine distemper virus (CDV) and negative for Sarcocystis neurona on immunohistochemistry. Bayesian analysis revealed that this Sarcocystis sp. clustered most closely with a clade of unnamed Sarcocystis sp. found in viperid snakes, with a posterior probability of 99%. CDV likely played a significant role in the expression of clinical sarcocystosis in this gray fox.
Keywords	Bayesian theory ; Canine morbillivirus ; Sarcocystis neurona ; Urocyon cinereoargenteus ; brain stem ; cerebrum ; diarrhea ; immunohistochemistry ; males ; meningoencephalitis ; merozoites ; mixed infection ; necropsy ; probability ; sarcocystosis ; schizonts ; Texas ; brain ; canine distemper ; gray foxes ; Sarcocystis sp. ; viperid snakes
Language	English
Dates of publication	2023-07
Size	p. 443-447.
Publishing place	SAGE Publications
Document type	Article ; Online
ZDB-ID	287603-6
ISSN	1943-4936 ; 1040-6387
ISSN (online)	1943-4936
ISSN	1040-6387
DOI	10.1177/10406387231169768
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Article: Subcutaneous Implantation of Hepatocellular Carcinoma in a Dog

Peterson, Marisa R. / Porter, Brian F. / Edwards, Erin E. / Piccione, Julie

Journal of comparative pathology. 2022 Sept. 20,

2022

Abstract: A 13-year-old male neutered Cocker Spaniel mixed breed dog developed a subcutaneous mass 2 years after undergoing surgery to remove a hepatocellular carcinoma. An approximately 4 × 3 cm subcutaneous mass was found on the ventral abdomen at the cranial ... ...

Abstract	A 13-year-old male neutered Cocker Spaniel mixed breed dog developed a subcutaneous mass 2 years after undergoing surgery to remove a hepatocellular carcinoma. An approximately 4 × 3 cm subcutaneous mass was found on the ventral abdomen at the cranial end of the abdominal incision from the previous surgery. The subcutaneous mass was surgically removed and histopathological examination determined that it was an implantation of the previously excised hepatocellular carcinoma. The diagnosis was confirmed by immunohistochemical labelling with hepatocyte paraffin 1 antibody and of pancytokeratin. Based on the location of the subcutaneous mass at the cranial end of the abdominal incision associated with the previous hepatocellular carcinoma resection, it is likely there was iatrogenic metastasis from the primary tumour excision. Subcutaneous iatrogenic metastasis of hepatocellular carcinoma is well recognized in humans but has apparently never been reported in dogs. Clinicians should be aware of this potential surgical complication.
Keywords	Cocker Spaniel ; abdomen ; antibodies ; dogs ; excision ; hepatoma ; histopathology ; immunohistochemistry ; males ; metastasis ; resection
Language	English
Dates of publication	2022-0920
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	390920-7
ISSN	1532-3129 ; 0021-9975
ISSN (online)	1532-3129
ISSN	0021-9975
DOI	10.1016/j.jcpa.2022.09.009
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Article ; Online: Treatment of Platypnea-Orthodeoxia Syndrome in a Patient with Normal Cardiac Hemodynamics: A Review of Mechanisms with Implications for Management.

Porter, Brian S / Hettleman, Bruce

Methodist DeBakey cardiovascular journal

2018 Volume 14, Issue 2, Page(s) 141–146

Abstract: Platypnea-orthodeoxia syndrome is a rare entity characterized by dyspnea and hypoxemia in the sitting position and usually resolved by lying down. Although it is not well understood, it is thought to be associated with either intracardiac or extracardiac ...

Abstract	Platypnea-orthodeoxia syndrome is a rare entity characterized by dyspnea and hypoxemia in the sitting position and usually resolved by lying down. Although it is not well understood, it is thought to be associated with either intracardiac or extracardiac factors. Within the group of intracardiac etiologies, it typically occurs in the presence of right heart failure or elevated right-sided filling pressures. When right heart failure is absent, platypnea-orthodeoxia is thought to be due to either anatomic changes that produce a baffle-directing flow across an atrial defect or to posture-dependent right-to-left pressure gradients. We report this case of a patient with no prior diagnosis of heart failure who presented to our hospital with 6 months of New York Heart Association class IV dyspnea and recent paradoxical embolus across a patent foramen ovale (PFO). Platypnea-orthodeoxia syndrome was diagnosed clinically. Transesophageal echocardiography revealed bidirectional shunting across the PFO. In the catheterization laboratory, invasive hemodynamics showed normal right and left atrial pressures and normal pulmonary arterial pressures. An Amplatzer Cribiform occluder device (AGA Medical Corp.) was used to close the PFO, completely curing the patient's symptoms. This is a novel case of subacute-onset severe platypnea-orthodeoxia associated with paradoxical embolus occurring while seated in the upright position. The cause of the patient's symptoms may have been progressive kyphosis or to increased pulmonary tidal volumes. Evaluation for platypnea-orthodeoxia is important in cases of occult dyspnea because the condition may be cured by closing the anatomic defect, as it was in this case.
MeSH term(s)	Aged ; Cardiac Catheterization/instrumentation ; Dyspnea/diagnosis ; Dyspnea/etiology ; Dyspnea/physiopathology ; Echocardiography, Doppler, Color ; Echocardiography, Transesophageal ; Embolism, Paradoxical/diagnosis ; Embolism, Paradoxical/etiology ; Embolism, Paradoxical/physiopathology ; Foramen Ovale, Patent/complications ; Foramen Ovale, Patent/diagnostic imaging ; Foramen Ovale, Patent/physiopathology ; Foramen Ovale, Patent/therapy ; Hemodynamics ; Humans ; Hypoxia/diagnosis ; Hypoxia/etiology ; Hypoxia/physiopathology ; Male ; Posture ; Septal Occluder Device ; Severity of Illness Index ; Syndrome ; Treatment Outcome
Language	English
Publishing date	2018-06-07
Publishing country	United States
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	2544079-2
ISSN	1947-6108 ; 1947-6094
ISSN (online)	1947-6108
ISSN	1947-6094
DOI	10.14797/mdcj-14-2-141
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