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Article ; Online: Mycobacterium ulcerans not detected by PCR on human skin in Buruli ulcer endemic areas of south eastern Australia.

Velink, Anita / Porter, Jessica L / Stinear, Timothy P / Johnson, Paul D R

2023 Volume 17, Issue 10, Page(s) e0011272

Abstract: Introduction: Mycobacterium ulcerans (MU) causes Buruli ulcer (Buruli), a geographically restricted infection that can result in skin loss, contracture and permanent scarring. Lesion-location maps compiled from more than 640 cases in south eastern ... ...

Abstract	Introduction: Mycobacterium ulcerans (MU) causes Buruli ulcer (Buruli), a geographically restricted infection that can result in skin loss, contracture and permanent scarring. Lesion-location maps compiled from more than 640 cases in south eastern Australia suggest biting insects are likely involved in transmission, but it is unclear whether MU is brought by insects to humans or if MU is already on the skin and inoculation is an opportunistic event that need not be insect dependent. Methods: We validated a PCR swab detection assay and defined its dynamic range using laboratory cultured M. ulcerans and fresh pigskin. We invited volunteers in Buruli-endemic and non-endemic areas to sample their skin surfaces with self-collected skin swabs tested by IS2404 quantitative PCR. Results: Pigskin validation experiments established a limit-of-detection of 0.06 CFU/cm2 at a qPCR cycle threshold (Ct) of 35. Fifty-seven volunteers returned their self-collected kits of 4 swabs (bilateral ankles, calves, wrists, forearms), 10 from control areas and 47 from endemic areas. Collection was timed to coincide with the known peak-transmission period of Buruli. All swabs from human volunteers tested negative (Ct ≥35). Conclusions: M. ulcerans was not detected on the skin of humans from highly Buruli endemic areas.
MeSH term(s)	Humans ; Animals ; Cattle ; Buruli Ulcer/diagnosis ; Buruli Ulcer/epidemiology ; Buruli Ulcer/microbiology ; Mycobacterium ulcerans/genetics ; DNA, Bacterial ; Polymerase Chain Reaction ; Insecta ; Australia/epidemiology
Chemical Substances	DNA, Bacterial
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011272
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In vitro activity of SPR719 against Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera.

Pidot, Sacha J / Porter, Jessica L / Lister, Troy / Stinear, Timothy P

PLoS neglected tropical diseases

2021 Volume 15, Issue 7, Page(s) e0009636

Abstract: Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial ... ...

Abstract	Nontuberculosis mycobacterial (NTM) infections are increasing in prevalence across the world. In many cases, treatment options for these infections are limited. However, there has been progress in recent years in the development of new antimycobacterial drugs. Here, we investigate the in vitro activity of SPR719, a novel aminobenzimidazole antibiotic and the active form of the clinical-stage compound, SPR720, against several isolates of Mycobacterium ulcerans, Mycobacterium marinum and Mycobacterium chimaera. We show that SPR719 is active against these NTM species with a MIC range of 0.125-4 μg/ml and that this compares favorably with the commonly utilized antimycobacterial antibiotics, rifampicin and clarithromycin. Our findings suggest that SPR720 should be further evaluated for the treatment of NTM infections.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; DNA Gyrase/genetics ; DNA Gyrase/metabolism ; Drug Resistance, Bacterial ; Gene Expression Regulation, Bacterial ; Mutation ; Mycobacterium/drug effects ; Mycobacterium marinum/drug effects ; Mycobacterium ulcerans/drug effects
Chemical Substances	Anti-Bacterial Agents ; DNA Gyrase (EC 5.99.1.3)
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0009636
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mycobacterium ulcerans challenge strain selection for a Buruli ulcer controlled human infection model.

Muhi, Stephen / Buultjens, Andrew H / Porter, Jessica L / Marshall, Julia L / Doerflinger, Marcel / Pidot, Sacha J / O'Brien, Daniel P / Johnson, Paul D R / Lavender, Caroline J / Globan, Maria / McCarthy, James / Osowicki, Joshua / Stinear, Timothy P

PLoS neglected tropical diseases

2024 Volume 18, Issue 5, Page(s) e0011979

Abstract: Critical scientific questions remain regarding infection with Mycobacterium ulcerans, the organism responsible for the neglected tropical disease, Buruli ulcer (BU). A controlled human infection model has the potential to accelerate our knowledge of the ... ...

Abstract	Critical scientific questions remain regarding infection with Mycobacterium ulcerans, the organism responsible for the neglected tropical disease, Buruli ulcer (BU). A controlled human infection model has the potential to accelerate our knowledge of the immunological correlates of disease, to test prophylactic interventions and novel therapeutics. Here we present microbiological evidence supporting M. ulcerans JKD8049 as a suitable human challenge strain. This non-genetically modified Australian isolate is susceptible to clinically relevant antibiotics, can be cultured in animal-free and surfactant-free media, can be enumerated for precise dosing, and has stable viability following cryopreservation. Infectious challenge of humans with JKD8049 is anticipated to imitate natural infection, as M. ulcerans JKD8049 is genetically stable following in vitro passage and produces the key virulence factor, mycolactone. Also reported are considerations for the manufacture, storage, and administration of M. ulcerans JKD8049 for controlled human infection.
Language	English
Publishing date	2024-05-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2735
ISSN (online)	1935-2735
ISSN	1935-2735
DOI	10.1371/journal.pntd.0011979
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Statistical modeling based on structured surveys of Australian native possum excreta harboring

Vandelannoote, Koen / Buultjens, Andrew H / Porter, Jessica L / Velink, Anita / Wallace, John R / Blasdell, Kim R / Dunn, Michael / Boyd, Victoria / Fyfe, Janet A M / Tay, Ee Laine / Johnson, Paul D R / Windecker, Saras M / Golding, Nick / Stinear, Timothy P

eLife

2023 Volume 12

Abstract: Background: Buruli ulcer (BU) is a neglected tropical disease caused by infection of subcutaneous tissue with : Methods: We thus established a highly structured 12 month possum excreta surveillance program across an area of 350 km: Results: Over ... ...

Abstract	Background: Buruli ulcer (BU) is a neglected tropical disease caused by infection of subcutaneous tissue with Methods: We thus established a highly structured 12 month possum excreta surveillance program across an area of 350 km Results: Over two sampling campaigns in summer and winter, we collected 2,282 possum excreta specimens of which 11% were PCR positive for Conclusions: This study highlights the Funding: This research was supported by the National Health and Medical Research Council of Australia and the Victorian Government Department of Health (GNT1152807 and GNT1196396).
MeSH term(s)	Humans ; Australia/epidemiology ; Bacterial Shedding ; Bacterial Zoonoses/microbiology ; Bacterial Zoonoses/transmission ; Buruli Ulcer/epidemiology ; Buruli Ulcer/microbiology ; Disease Reservoirs/microbiology ; Disease Reservoirs/statistics & numerical data ; Feces/microbiology ; Models, Statistical ; Mycobacterium ulcerans/genetics ; Mycobacterium ulcerans/isolation & purification ; Phalangeridae/microbiology
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.84983
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book: Negotiating at work

Kolb, Deborah M / Porter, Jessica L

turn small wins into big gains

2015

Abstract: Understand the context of negotiations to achieve better resultsNegotiation has always been at the heart of solving problems at work. Yet today, when people in organizations are asked to do more with less, be responsive 24/7, and manage in rapidly ... ...

Author's details	Deborah M. Kolb with Jessica L. Porter
Abstract	Understand the context of negotiations to achieve better resultsNegotiation has always been at the heart of solving problems at work. Yet today, when people in organizations are asked to do more with less, be responsive 24/7, and manage in rapidly changing environments, negotiation is more essential than ever. What has been missed in much of the literature of the past 30 years is that negotiations in organizations always take place within a context--of organizational culture, of prior negotiations, of power relationships--that dictates which issues are negotiable and by whom. When we negotiate for new opportunities or increased flexibility, we never do it in a vacuum. We challenge the status quo and we build out the path for others to negotiate those issues after us. In this way, negotiating for ourselves at work can create small wins that can grow into something bigger, for ourselves and our organizations. Seen in this way, negotiation becomes a tool for addressing ineffective practices and outdated assumptions, and for creating change.Small Wins, Big Gains offers practical advice for managing your own workplace negotiations: how to get opportunities, promotions, flexibility, buy-in, support, and credit for your work. It does so within the context of organizational dynamics, recognizing that to negotiate with someone who has more power adds a level of complexity. This is true when we negotiate with our managers, and it's also true for women and people of color who are even more likely to meet with resistance. Small Wins, Big Gains is rooted in real-life cases of professionals from a wide range of industries and organizations, both national and international. Strategies to get the other person to the table and engage in creative problem solving, even when they are reluctant to do so Tips on how to recognize opportunities to negotiate, bolster your confidence prior to the negotiation, turn 'asks' into a negotiation, and advance negotiations that get "stuck" A rich examination of research on negotiation, conflict management, and gender Videos that walk you through difficult negotiation scenarios step-by-step By using these strategies, you can negotiate successfully for your job and your career; in a larger field, you can also alter organizational practices and policies that impact others.
Keywords	Negotiation ; Negotiation in business ; Verhandlungstechnik ; Verhalten in Organisationen
Language	English
Size	XL, 243 S.
Edition	1. ed.
Document type	Book
ISBN	9781118352410 ; 1118352416
Database	ECONomics Information System

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Book: Negotiating at work

Kolb, Deborah M / Porter, Jessica L

turn small wins into big gains

2015

Author's details	Deborah M. Kolb. With Jessica L. Porter
Abstract	Understand the context of negotiations to achieve better resultsNegotiation has always been at the heart of solving problems at work. Yet today, when people in organizations are asked to do more with less, be responsive 24/7, and manage in rapidly changing environments, negotiation is more essential than ever. What has been missed in much of the literature of the past 30 years is that negotiations in organizations always take place within a context--of organizational culture, of prior negotiations, of power relationships--that dictates which issues are negotiable and by whom. When we negotiate for new opportunities or increased flexibility, we never do it in a vacuum. We challenge the status quo and we build out the path for others to negotiate those issues after us. In this way, negotiating for ourselves at work can create small wins that can grow into something bigger, for ourselves and our organizations. Seen in this way, negotiation becomes a tool for addressing ineffective practices and outdated assumptions, and for creating change.Small Wins, Big Gains offers practical advice for managing your own workplace negotiations: how to get opportunities, promotions, flexibility, buy-in, support, and credit for your work. It does so within the context of organizational dynamics, recognizing that to negotiate with someone who has more power adds a level of complexity. This is true when we negotiate with our managers, and it's also true for women and people of color who are even more likely to meet with resistance. Small Wins, Big Gains is rooted in real-life cases of professionals from a wide range of industries and organizations, both national and international. Strategies to get the other person to the table and engage in creative problem solving, even when they are reluctant to do so Tips on how to recognize opportunities to negotiate, bolster your confidence prior to the negotiation, turn 'asks' into a negotiation, and advance negotiations that get "stuck" A rich examination of research on negotiation, conflict management, and gender Videos that walk you through difficult negotiation scenarios step-by-step By using these strategies, you can negotiate successfully for your job and your career; in a larger field, you can also alter organizational practices and policies that impact others.
Keywords	Negotiation ; Negotiation in business ; Verhandlungstechnik ; Verhalten in Organisationen
Language	English
Size	XL, 243 S.
Edition	1. ed.
Publisher	Jossey-Bass
Publishing place	San Francisco, Calif
Document type	Book
ISBN	9781118352410 ; 9781118420478 ; 1118352416 ; 1118420470
Database	Former special subject collection: coastal and deep sea fishing

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Book: Weniger arbeiten - mehr leisten

Perlow, Leslie A / Porter, Jessica L

das Harvard Konzept für eine gelungene Work-Life-Balance

(HBM Audio ; Harvard business manager ; [33.2011,1],CD)

2011

Author's details	von Leslie A. Perlow und Jessica L. Porter
Series title	HBM Audio Harvard business manager ; [33.2011,1],CD
Keywords	Stress ; Zeiteinteilung ; Berufstätigkeit ; Arbeitsorganisation
Language	German
Size	1 CD, 12 cm
Publisher	Manager-Magazin-Verl.-Ges.
Publishing place	Hamburg
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: Making time off predictable--and required.

Perlow, Leslie A / Porter, Jessica L

Harvard business review

2009 Volume 87, Issue 10, Page(s) 102–9, 142

Abstract: People in professional services believe a 24/7 work ethic is essential for getting ahead--and so they work 60-plus hours a week and stay tethered to their Black-Berrys. This perpetuates a vicious cycle: Responsiveness breeds the need for more ... ...

Abstract	People in professional services believe a 24/7 work ethic is essential for getting ahead--and so they work 60-plus hours a week and stay tethered to their Black-Berrys. This perpetuates a vicious cycle: Responsiveness breeds the need for more responsiveness. When people are always "on," responsiveness becomes ingrained in the way they work, expected by clients and partners, and even institutionalized in performance metrics. There is no impetus to question whether the work actually requires 24/7 responsiveness; on the contrary, people work harder and longer, without stopping to explore how they could work better. But four years of research conducted by the authors in several North American offices of the Boston Consulting Group suggests that consultants and other professionals can provide the highest standards of service and still have planned, uninterrupted time off. They can do this even in times of recession. In this article, Perlow and Porter outline the lessons from BCG's implementation of predictable time off--namely, impose a strict mechanism for taking days and nights off, encourage lots of talk about what's working and what isn't, promote experimentation with different ways of working, and insist on top-level support.
MeSH term(s)	Commerce ; Fatigue/prevention & control ; Humans ; Leisure Activities ; Organizational Policy
Language	English
Publishing date	2009-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2066391-2
ISSN	0017-8012
ISSN	0017-8012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Identification and Mobilization of a Cryptic Antibiotic Biosynthesis Gene Locus from a Human-Pathogenic

Herisse, Marion / Ishida, Keishi / Porter, Jessica L / Howden, Ben / Hertweck, Christian / Stinear, Timothy P / Pidot, Sacha J

ACS chemical biology

2019 Volume 15, Issue 5, Page(s) 1161–1168

Abstract: ... The ... ...

Abstract	The genus
MeSH term(s)	Actinobacteria/genetics ; Actinobacteria/metabolism ; Amino Acid Sequence ; Anthraquinones/chemistry ; Anthraquinones/metabolism ; Anti-Bacterial Agents/biosynthesis ; Anti-Bacterial Agents/metabolism ; Base Sequence ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Genome, Bacterial ; Humans ; Infections/metabolism ; Multigene Family ; Nocardia/genetics ; Nocardia/metabolism ; Secondary Metabolism ; Streptomyces/genetics ; Streptomyces/metabolism
Chemical Substances	Anthraquinones ; Anti-Bacterial Agents
Language	English
Publishing date	2019-11-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1554-8937
ISSN (online)	1554-8937
DOI	10.1021/acschembio.9b00763
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mosquitoes provide a transmission route between possums and humans for Buruli ulcer in southeastern Australia.

Mee, Peter T / Buultjens, Andrew H / Oliver, Jane / Brown, Karen / Crowder, Jodie C / Porter, Jessica L / Hobbs, Emma C / Judd, Louise M / Taiaroa, George / Puttharak, Natsuda / Williamson, Deborah A / Blasdell, Kim R / Tay, Ee Laine / Feldman, Rebecca / Muzari, Mutizwa Odwell / Sanders, Chris / Larsen, Stuart / Crouch, Simon R / Johnson, Paul D R /

Wallace, John R / Price, David J / Hoffmann, Ary A / Gibney, Katherine B / Stinear, Timothy P / Lynch, Stacey E

Nature microbiology

2024 Volume 9, Issue 2, Page(s) 377–389

Abstract: Buruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in transmission, ... ...

Abstract	Buruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in transmission, it remains unclear how humans acquire infection. We conducted extensive field survey analyses of M. ulcerans prevalence among mosquitoes in the Mornington Peninsula region of southeastern Australia. PCR screening of trapped mosquitoes revealed a significant association between M. ulcerans and Aedes notoscriptus. Spatial scanning statistics revealed overlap between clusters of M. ulcerans-positive Ae. notoscriptus, M. ulcerans-positive possum excreta and Buruli ulcer cases, and metabarcoding analyses showed individual mosquitoes had fed on humans and possums. Bacterial genomic analysis confirmed shared single-nucleotide-polymorphism profiles for M. ulcerans detected in mosquitoes, possum excreta and humans. These findings indicate Ae. notoscriptus probably transmit M. ulcerans in southeastern Australia and highlight mosquito control as a Buruli ulcer prevention measure.
MeSH term(s)	Animals ; Humans ; Buruli Ulcer/epidemiology ; Buruli Ulcer/genetics ; Buruli Ulcer/microbiology ; Mycobacterium ulcerans/genetics ; Australia ; Genome, Bacterial ; Aedes/genetics
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ISSN	2058-5276
ISSN (online)	2058-5276
DOI	10.1038/s41564-023-01553-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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