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  1. Article: Anesthetic Agents in Operations for Gunshot Wounds.

    Porter, John B

    Western journal of medicine and surgery

    2024  Volume 10, Issue 3, Page(s) 251–252

    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings: Iron toxicity

    Porter, John B.

    optimizing chelation therapy across transfusion-dependent anaemias ; proceedings of a satellite symposium at the 14th congress of the European Hematology Association (EHA), held in June 2009 in Berlin

    (Blood reviews ; 23, Suppl. 1)

    2009  

    Author's details guest ed.: John B. Porter
    Series title Blood reviews ; 23, Suppl. 1
    Collection
    Language English
    Size S25 S. : graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT016266518
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: A role for fiction in science.

    Porter, John D

    EMBO reports

    2021  Volume 22, Issue 4, Page(s) e52614

    MeSH term(s) Science
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202152614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: 'Integrative approaches to health': A long way to go.

    Porter, John / Mathpati, Mahesh

    Journal of Ayurveda and integrative medicine

    2023  Volume 14, Issue 1, Page(s) 100705

    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Editorial
    ISSN 0975-9476
    ISSN 0975-9476
    DOI 10.1016/j.jaim.2023.100705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: What is the Role of Whole Blood Transfusions on Trauma Patients?

    Porter, John M / Hazelton, Joshua P

    Advances in surgery

    2023  Volume 57, Issue 1, Page(s) 257–266

    Abstract: Whole blood use in trauma has historically been limited to military use, but in recent years, there has been increasing data for use in civilian trauma. Emerging clinical data demonstrate an associated survival benefit, while some authors have also ... ...

    Abstract Whole blood use in trauma has historically been limited to military use, but in recent years, there has been increasing data for use in civilian trauma. Emerging clinical data demonstrate an associated survival benefit, while some authors have also identified decreased use of an overall number of blood products and decreased complications. Use of whole blood is gradually moving toward becoming the standard of care in the hemorrhaging trauma patient.
    MeSH term(s) Humans ; Resuscitation/adverse effects ; Blood Transfusion ; Shock, Hemorrhagic/etiology ; Wounds and Injuries/complications ; Wounds and Injuries/therapy
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 411889-3
    ISSN 1878-0555 ; 0065-3411
    ISSN (online) 1878-0555
    ISSN 0065-3411
    DOI 10.1016/j.yasu.2023.04.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Iron Through the Prism of Haematology.

    Porter, John B

    British journal of haematology

    2020  Volume 191, Issue 4, Page(s) 587–592

    Abstract: Since the inception of the British Society for Haematology (BSH) 60 years ago, our increased scientific understanding of iron metabolism, together with clinical developments, have changed the way we diagnose and treat its disorders. In the UK, perhaps ... ...

    Abstract Since the inception of the British Society for Haematology (BSH) 60 years ago, our increased scientific understanding of iron metabolism, together with clinical developments, have changed the way we diagnose and treat its disorders. In the UK, perhaps the most notable contributions relate to iron overload, some of which I will outline from personal experience. Diagnostically, this began with the identification of serum ferritin as a marker of iron overload and continued later with the application of MRI-based imaging techniques for iron and its distribution. Therapeutically, the first trials of both parenteral and oral chelation, which have radically changed the outcomes of transfusional iron-overloaded patients, took place in the UK and are now part of standard clinical practice. During this time, our scientific understanding of iron metabolism at a cellular and systemic level have advanced the diagnosis and treatment of inherited disorders of iron metabolism. There are potential novel applications related to our recent understanding of hepcidin metabolism and manipulation.
    MeSH term(s) Biomarkers ; Disease Management ; Disease Susceptibility ; Hematologic Diseases/complications ; Hematologic Diseases/etiology ; Hematologic Diseases/therapy ; Hemochromatosis/diagnosis ; Hemochromatosis/etiology ; Hemochromatosis/metabolism ; Hemochromatosis/therapy ; Humans ; Iron/metabolism ; Iron Chelating Agents/therapeutic use ; Iron Overload/diagnosis ; Iron Overload/etiology ; Iron Overload/metabolism ; Iron Overload/therapy
    Chemical Substances Biomarkers ; Iron Chelating Agents ; Iron (E1UOL152H7)
    Language English
    Publishing date 2020-11-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.17164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Beyond transfusion therapy: new therapies in thalassemia including drugs, alternate donor transplant, and gene therapy.

    Porter, John

    Hematology. American Society of Hematology. Education Program

    2018  Volume 2018, Issue 1, Page(s) 361–370

    Abstract: Transfusion combined with chelation therapy for severe β thalassemia syndromes (transfusion-dependent thalassemia [TDT]) has been successful in extending life expectancy, decreasing comorbidities and improving quality of life. However, this puts lifelong ...

    Abstract Transfusion combined with chelation therapy for severe β thalassemia syndromes (transfusion-dependent thalassemia [TDT]) has been successful in extending life expectancy, decreasing comorbidities and improving quality of life. However, this puts lifelong demands not only on the patients but also on the health care systems that are tasked with delivering long-term treatment and comprehensive support. Prevention programs and curative approaches are therefore an important part of overall strategy. Curative treatments alter the dynamic of a patient's health care costs, from financial commitment over 50 years, into a potential "one-off" investment. Since the 1980s, this has usually been available only to the 30% or so of young children with matched sibling donors. By improving the safety of matched related donors and haploidentical hematopoietic stem cell transplants, the potential size of the donor pool for curative therapies may be increased. Recent advances in gene therapy demonstrate that even patients lacking a matched donor can be rendered transfusion independent with an autograft of genetically modified autologous stem cells, with a low short-term risk. Noncurative treatments are also of potential value by decreasing use of blood and chelators and decreasing hospital visits. An example is luspatercept, an activin-receptor trap that modifies transforming growth factor-β signaling, thereby increasing the efficiency of erythropoiesis. This has entered phase 3 clinical trials for TDT and non-TDT and, usefully increases in both Hb and quality of life in non-TDT as well as decreasing transfusion requirements in TDT. Other novel noncurative treatments are entering clinical trials such improvement of erythropoiesis through pharmacological manipulation of hepcidin and iron metabolism.
    MeSH term(s) Allografts ; Autografts ; Genetic Therapy/methods ; Humans ; Stem Cell Transplantation/methods ; Thalassemia/genetics ; Thalassemia/metabolism ; Thalassemia/therapy ; Unrelated Donors
    Language English
    Publishing date 2018-11-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/asheducation-2018.1.361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Vaccines, social measures and Covid19 - A European evidence-based analysis

    Porter, John R

    medRxiv

    Abstract: Background A fully quantitative picture of national effectiveness in controlling the spread of the Covid19 virus should consider the percentage of a population vaccinated in relation to the percentage of a population as active cases. Results Mean ... ...

    Abstract Background A fully quantitative picture of national effectiveness in controlling the spread of the Covid19 virus should consider the percentage of a population vaccinated in relation to the percentage of a population as active cases. Results Mean European V ratio increased from January 11 2021 onwards; inverse correlation was found between V ratio and R statistic (p<0.001, r2=0.15, df=234). Initial threshold V ratio of 10-15 resulted in an R statistic of 1.0 or lower; this threshold increased to 30-40 with further vaccinations. Variation between countries in the V ratio increased with time. This quantitative assessment and use of a summary data-derived threshold index showed the integrated effectiveness of vaccinations and social measures for European countries for Covid19. It established a threshold range for an R value of 1 and calculation of the number of vaccinations needed in Europe to reduce the infectivity of the virus to unity. Results can be used to quantify the relation between transmission following vaccination and social measures to control the spread of Covid19.
    Keywords covid19
    Language English
    Publishing date 2021-04-20
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.04.15.21255558
    Database COVID19

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  9. Book: Tuberculosis

    Porter, John D. H.

    an interdisciplinary perspective

    1999  

    Author's details ed. by John D. H. Porter
    Language English
    Size XVII, 509 S. : graph. Darst.
    Edition Reprinted
    Publisher Imperial College Press
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012823049
    ISBN 1-86094-143-5 ; 978-1-86094-143-6
    Database Catalogue ZB MED Medicine, Health

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  10. Audio / Video ; Online: CLIFF-GRADS Science Series 2020 - Special Session

    Porter, John R.

    Global agriculture production & emission trends

    2020  

    Abstract: Learn more about the CLIFF-GRADS Program and Alumni: https://ccafs.cgiar.org/CLIFF-GRADS Featured Speaker: Professor Chevalier Dr. Porter, Emeritus Professor of Agriculture and Climate Change, University of Greenwich The 2020 CLIFF-GRADS Science ... ...

    Abstract Learn more about the CLIFF-GRADS Program and Alumni: https://ccafs.cgiar.org/CLIFF-GRADS Featured Speaker: Professor Chevalier Dr. Porter, Emeritus Professor of Agriculture and Climate Change, University of Greenwich The 2020 CLIFF-GRADS Science Collaboration Series was developed to facilitate technical capability building, knowledge transfer and international collaboration for the CLIFF-GRADS Alumni. Particularly for the Round 3 CLIFF-GRADS whose research stays have been delayed due to the global Covid-19 Pandemic. In addition to a series of special sessions with guest speakers, these webinars provide a platform for the Round 3 students to present their PhD research and research questions to their CLIFF-GRADS peers. Through establishing research connections, the CLIFF- GRADS Alumni network can connect internationally and across research institutes. Special Sessions A series of special sessions have been developed to facilitate knowledge sharing from senior researchers to CLIFF-GRADS Alumni, with emphasis on the science-policy interface for agricultural greenhouse gas emission management. Session topics include: i) the role of science in decision making, ii) national GHG inventories, iii) livestock MRV, iv) global agricultural production and emission trends, and v) farmer perspectives from the WFO young farmers Gymnasium program.
    Keywords climate change ; food security ; agriculture ; youth ; sciences ; covid19
    Language English
    Publishing date 2020-10-15T21:11:40Z
    Publisher Global Research Alliance on Agricultural Greenhouse Gases (GRA) & CGIAR Research Program on Climate Change Agriculture and Food Security (CCAFS)
    Publishing country fr
    Document type Audio / Video ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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