Artikel ; Online: The clinical sensitivity of a single SARS-CoV-2 upper respiratory tract RT-PCR test for diagnosing COVID-19 using convalescent antibody as a comparator.
Clinical medicine (London, England)
2020 Band 20, Heft 6, Seite(n) e209–e211
Abstract: The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in ... ...
| Abstract | The clinical false negative rate of reverse transcriptase polymerase chain reaction (RT-PCR) testing for SARS-CoV-2 on a single upper respiratory tract sample was calculated using convalescent antibody testing as a comparator. The sensitivity in symptomatic individuals was 86.2% (25/29). Of the missed cases, one (3.5%) was detected by repeat RT-PCR, one by CT thorax and two (7.1%) by convalescent antibody. The clinical false negative rate of a single RT-PCR on an upper respiratory tract sample of 14% in symptomatic patients is reassuring when compared to early reports. This report supports a strategy of combining repeat swabbing, use of acute and convalescent antibody testing and CT thorax for COVID-19 diagnosis. |
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| Mesh-Begriff(e) | Antibodies, Viral/blood ; Asymptomatic Infections ; Betacoronavirus/genetics ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/standards ; Clinical Laboratory Techniques/statistics & numerical data ; Coronavirus Infections/blood ; Coronavirus Infections/diagnosis ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; False Negative Reactions ; Humans ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/virology ; Reverse Transcriptase Polymerase Chain Reaction/standards ; Reverse Transcriptase Polymerase Chain Reaction/statistics & numerical data ; SARS-CoV-2 ; Sensitivity and Specificity ; Thorax/virology |
| Chemische Substanzen | Antibodies, Viral |
| Schlagwörter | covid19 |
| Sprache | Englisch |
| Erscheinungsdatum | 2020-09-11 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2048646-7 |
| ISSN | 1473-4893 ; 1470-2118 |
| ISSN (online) | 1473-4893 |
| ISSN | 1470-2118 |
| DOI | 10.7861/clinmed.2020-0555 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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