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Article ; Online: Ocular Inflammatory Events Following COVID-19 Vaccination in the Paediatric Population: A Multinational Case Series.

Testi, Ilaria / Brandão-de-Resende, Camilo / De-La-Torre, Alejandra / Concha-Del-Rio, Luz Elena / Cheja-Kalb, Rashel / Mahendradas, Padmamalini / Habot-Wilner, Zohar / Yalçındağ, Nilüfer / Markelj, Špela / Iriqat, Salam / Portero, Alejandro / Petrushkin, Harry / Pavesio, Carlos / Solebo, Ameenat Lola

Ocular immunology and inflammation

2023 , Page(s) 1–6

Abstract: Background: Ocular inflammatory events following COVID-19 vaccination have been reported in the adult population.: Methods: Multinational case series of patients under the age of 18 diagnosed with ocular inflammatory events within 28 days of COVID-19 ...

Abstract	Background: Ocular inflammatory events following COVID-19 vaccination have been reported in the adult population. Methods: Multinational case series of patients under the age of 18 diagnosed with ocular inflammatory events within 28 days of COVID-19 vaccination. Results: Twenty individuals were included. The most common event was anterior uveitis ( Conclusion: Ocular inflammatory events may happen in the paediatric population following COVID-19 vaccination. Most events were successfully treated, and all showed a good visual outcome.
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2023.2220782
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Article ; Online: Frosted branch angiitis diagnosed as neuro-behçet: a diagnostic and etiologic dilemma.

Portero, Alejandro / Herreras, J M

Case reports in ophthalmology

2011 Volume 2, Issue 2, Page(s) 170–175

Abstract: Purpose: To report a case of frosted branch angiitis (FBA) secondary to neuro-Behçet.: Methods: Description, diagnosis, angiogram imaging and follow-up of a 28-year-old female with FBA.: Results: 'Frosted branch angiitis' is a clinical term ... ...

Abstract	Purpose: To report a case of frosted branch angiitis (FBA) secondary to neuro-Behçet. Methods: Description, diagnosis, angiogram imaging and follow-up of a 28-year-old female with FBA. Results: 'Frosted branch angiitis' is a clinical term applied to three conditions: infiltration of vessels by malignant cells, and sheathing of vessels either secondary to an active disorder or subsequently to a previous inflammatory disease. Our patient's history of two optic neuropathies and the lack of demyelinating signs in neuroimaging made us consider FBA in the context of neuro-Behçet. Conclusion: Recognition of the category of FBA from the clinical signs is essential to establish the correct diagnosis and prescribe the appropriate treatment.
Language	English
Publishing date	2011-05-13
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699 ; 1663-2699
ISSN (online)	1663-2699
ISSN	1663-2699
DOI	10.1159/000328747
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Article: Frosted Branch Angiitis Diagnosed as Neuro-Behçet: A Diagnostic and Etiologic Dilemma

Portero, Alejandro / Herreras, J.M.

Case Reports in Ophthalmology

2011 Volume 2, Issue 2, Page(s) 170–175

Abstract: Purpose: To report a case of frosted branch angiitis (FBA) secondary to neuro-Behçet. Methods: Description, diagnosis, angiogram imaging and follow-up of a 28-year-old female with FBA. Results: ‘Frosted branch angiitis’ is a clinical term applied to ... ...

Institution	Ophthalmology Department, University Hospital of Valladolid and IOBA, Valladolid, Spain
Abstract	Purpose: To report a case of frosted branch angiitis (FBA) secondary to neuro-Behçet. Methods: Description, diagnosis, angiogram imaging and follow-up of a 28-year-old female with FBA. Results: ‘Frosted branch angiitis’ is a clinical term applied to three conditions: infiltration of vessels by malignant cells, and sheathing of vessels either secondary to an active disorder or subsequently to a previous inflammatory disease. Our patient’s history of two optic neuropathies and the lack of demyelinating signs in neuroimaging made us consider FBA in the context of neuro-Behçet. Conclusion: Recognition of the category of FBA from the clinical signs is essential to establish the correct diagnosis and prescribe the appropriate treatment.
Keywords	Frosted branch angiitis ; Neuro-Behçet ; Uveitis ; Behçetߣs disease
Language	English
Publishing date	2011-05-13
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
ZDB-ID	2577666-6
ISSN	1663-2699 ; 1663-2699
ISSN (online)	1663-2699
ISSN	1663-2699
DOI	10.1159/000328747
Database	Karger publisher's database

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Article ; Online: Corneal inflammation from pine processionary caterpillar hairs.

Portero, Alejandro / Carreño, Ester / Galarreta, David / Herreras, José M

Cornea

2013 Volume 32, Issue 2, Page(s) 161–164

Abstract: Purpose: Hairs from the caterpillar of the pine processionary moth, Thaumetopoea pityocampa, located in the pine forests of southern Europe and elsewhere, can become embedded in the cornea and conjunctiva. Disorders produced by the urticating hairs can ... ...

Abstract	Purpose: Hairs from the caterpillar of the pine processionary moth, Thaumetopoea pityocampa, located in the pine forests of southern Europe and elsewhere, can become embedded in the cornea and conjunctiva. Disorders produced by the urticating hairs can be classified into a broad spectrum of severity from mild keratoconjunctivitis to anaphylactic shock. This report presents 3 cases that illustrate the range of corneal responses to embedded hairs of the processionary moth caterpillar. Methods: Case series and review of the literature. Results: A 51-year-old man (case 1), a 46-year-old woman (case 2), and a 67-year-old man (case 3) presented different manifestations as a result of contact with pine processionary caterpillar hairs. Case 1 had acute keratitis with decreased vision. He was treated with a corneal depot steroid 4 times daily for 3 months. After 4 months, he was asymptomatic. Case 2 had acute keratitis without vision symptoms. She was released without treatment, and 1 month later was asymptomatic. Case 3 experienced dry gritty sensations, probably because of blepharitis, but also presented asymptomatic caterpillar hairs embedded in the corneal stroma. He was instructed regarding lid hygiene for his blepharitis, and after 3 months the embedded caterpillar hairs had disappeared. Conclusions: The most common ocular presentation of embedded hairs from the pine processionary moth caterpillar is keratitis. The urticating hairs can cause corneal infiltrates that disappear progressively over time. Steroid eye drops accelerate the resorption of these infiltrates.
MeSH term(s)	Acute Disease ; Aged ; Animals ; Corneal Stroma/injuries ; Eye Foreign Bodies/diagnosis ; Eye Foreign Bodies/drug therapy ; Eye Foreign Bodies/etiology ; Eye Injuries, Penetrating/diagnosis ; Eye Injuries, Penetrating/drug therapy ; Eye Injuries, Penetrating/etiology ; Female ; Fluorometholone/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Keratitis/diagnosis ; Keratitis/drug therapy ; Keratitis/etiology ; Lepidoptera ; Male ; Middle Aged ; Pinus
Chemical Substances	Glucocorticoids ; Fluorometholone (SV0CSG527L)
Language	English
Publishing date	2013-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0b013e318254234b
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Article: Interface fluid syndrome associated with cataract surgery.

Carreño, Ester / Portero, Alejandro / Galarreta, David J / Merayo, Jesús M

Journal of refractive surgery (Thorofare, N.J. : 1995)

2012 Volume 28, Issue 4, Page(s) 243–244

MeSH term(s)	Corneal Transplantation/adverse effects ; Epithelium, Corneal/pathology ; Humans ; Keratitis/etiology ; Laser Therapy/adverse effects ; Male
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Comment ; Letter
ISSN	1081-597X
ISSN	1081-597X
DOI	10.3928/1081597X-20120308-01
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Article ; Online: Update on twice-daily bromfenac sodium sesquihydrate to treat postoperative ocular inflammation following cataract extraction.

Carreño, Ester / Portero, Alejandro / Galarreta, David J / Herreras, José M

Clinical ophthalmology (Auckland, N.Z.)

2012 Volume 6, Page(s) 637–644

Abstract: Ophthalmic bromfenac sodium sesquihydrate is a topically applied selective cyclooxygenase (COX)-2 inhibitor. It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo ... ...

Abstract	Ophthalmic bromfenac sodium sesquihydrate is a topically applied selective cyclooxygenase (COX)-2 inhibitor. It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo potency, extends the duration of anti-inflammatory activity, and enhances its inhibitory effect on COX-2 absorption across the cornea and penetration into ocular tissues. The United States Food and Drug Administration approved bromfenac in 2005 for the treatment of postoperative inflammation and the reduction of ocular pain in patients who have undergone cataract surgery. Nonsteroidal anti-inflammatory drugs (NSAIDs), and among them bromfenac, could be even more effective than steroids at reestablishing the blood-aqueous barrier, as revealed by flare on slit-lamp examination and as quantitatively measured using ocular fluorophotometry. Similar to other NSAIDs, it has a role in inhibiting intraoperative miosis during cataract surgery. However, bromfenac also seems to be useful in other situations, such as refractive surgery, allergic conjunctivitis (not useful in dry eye), choroidal neovascularization, and even ocular oncology. No reports of systemic toxicity have been published and bromfenac has good topical tolerance with a low incidence of adverse effects.
Language	English
Publishing date	2012-04-27
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2415713-2
ISSN	1177-5483 ; 1177-5483
ISSN (online)	1177-5483
ISSN	1177-5483
DOI	10.2147/OPTH.S23381
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Article ; Online: Infectious nontuberculous serpiginous choroiditis.

Portero, Alejandro / Careño, Ester / Real, Luis A / Villarón, Sonia / Herreras, José M

Archives of ophthalmology (Chicago, Ill. : 1960)

2012 Volume 130, Issue 9, Page(s) 1207–1208

MeSH term(s)	Adult ; Anti-Infective Agents/therapeutic use ; Antibodies, Bacterial/blood ; Aza Compounds/therapeutic use ; Bartonella henselae/immunology ; Bartonella henselae/isolation & purification ; Cat-Scratch Disease/diagnosis ; Cat-Scratch Disease/drug therapy ; Cat-Scratch Disease/microbiology ; Choroiditis/diagnosis ; Choroiditis/drug therapy ; Choroiditis/microbiology ; Ciprofloxacin/therapeutic use ; Eye Infections, Bacterial/diagnosis ; Eye Infections, Bacterial/drug therapy ; Eye Infections, Bacterial/microbiology ; Fluorescein Angiography ; Fluoroquinolones ; Francisella tularensis/immunology ; Francisella tularensis/isolation & purification ; Humans ; Immunoglobulin G/blood ; Male ; Middle Aged ; Quinolines/therapeutic use ; Tularemia/diagnosis ; Tularemia/drug therapy ; Tularemia/microbiology ; Vision Disorders ; Visual Acuity/physiology
Chemical Substances	Anti-Infective Agents ; Antibodies, Bacterial ; Aza Compounds ; Fluoroquinolones ; Immunoglobulin G ; Quinolines ; Ciprofloxacin (5E8K9I0O4U) ; moxifloxacin (U188XYD42P)
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	211580-3
ISSN	1538-3601 ; 0003-9950 ; 0093-0326
ISSN (online)	1538-3601
ISSN	0003-9950 ; 0093-0326
DOI	10.1001/archophthalmol.2012.539
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Article ; Online: Distinctive clinical features of idiopathic versus infectious serpiginous choroidopathy.

Carreño, Ester / Portero, Alejandro / Herreras, José M / Calonge, Margarita / Foster, C Stephen

Ocular immunology and inflammation

2012 Volume 20, Issue 6, Page(s) 448–452

Abstract: Purpose: Serpiginous choroidopathy (SC) is an inflammatory disease of unknown etiology. Infectious diseases that mimic SC are termed serpiginous-like choroidopathy (SLC). The aim of this study is to determine the clinical features of infectious SLC in ... ...

Abstract	Purpose: Serpiginous choroidopathy (SC) is an inflammatory disease of unknown etiology. Infectious diseases that mimic SC are termed serpiginous-like choroidopathy (SLC). The aim of this study is to determine the clinical features of infectious SLC in comparison to SC. Methods: Multicenter case series. Variables analyzed were age, gender, laterality, visual acuity, intraocular inflammation, multifocal pattern, choroidal neovascularization, involvement of juxtapapillary area, and posterior pole. Statistical significance was assessed by Mann-Whitney U test and Fisher's exact test. Results: Twenty-four patients had SC and 5 patients had SLC. Mean ages were 50 and 46 years (SC and SLC, respectively). In the SC group, 54% of the patients were males, and in the SC group, 80% were males. The disease was bilateral in 87.5% in the SC group and in 80% in the SLC group. The juxtapapillary area was involved in 91% in SC eyes and 0% in the SLC group (p < .05). Conclusions: In cases where the peripapillary area is disease-free, an infectious etiology has to be strongly suspected, as an immunomodulatory treatment could have severe consequences.
MeSH term(s)	Choroid/pathology ; Choroid Diseases/diagnosis ; Diagnosis, Differential ; Eye Infections/diagnosis ; Female ; Fluorescein Angiography ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Pigment Epithelium of Eye/pathology ; Retrospective Studies
Language	English
Publishing date	2012-12
Publishing country	England
Document type	Comparative Study ; Journal Article ; Multicenter Study
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.3109/09273948.2012.723236
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Article ; Online: Cytokine and chemokine tear levels in patients with uveitis.

Carreño, Ester / Portero, Alejandro / Herreras, José M / García-Vázquez, Carmen / Whitcup, Scott M / Stern, Michael E / Calonge, Margarita / Enríquez-de-Salamanca, Amalia

Acta ophthalmologica

2017 Volume 95, Issue 5, Page(s) e405–e414

Abstract: Purpose: To determine whether the levels of cytokines and chemokines in tears differ in uveitis patients and healthy subjects.: Methods: Ninety-two uveitis patients (mean age 46.4 years) and 157 control healthy subjects (mean age 49.5 years) were ... ...

Abstract	Purpose: To determine whether the levels of cytokines and chemokines in tears differ in uveitis patients and healthy subjects. Methods: Ninety-two uveitis patients (mean age 46.4 years) and 157 control healthy subjects (mean age 49.5 years) were recruited. Subjects with ocular surface diseases such as dry eye were excluded from the study. Using multiplex bead-based assays, tears (4 μl) were analysed for the concentration of interleukin (IL)-1β, IL-1RA, IL-2, IL-6, IL-7, IL-8/CXCL8, IL-10, IL-12p70, IL-15, IL-17A, IL-23, epidermal growth factor (EGF), fractalkine/CX3CL1, interferon-γ, IP-10/CXCL10, monocyte chemo-attractant protein (MCP)-1/CCL2, tumour necrosis factor-α, vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, TGF-β2 and TGF-β3. Tear molecule levels were compared between the groups and among the different forms of uveitis and disease severity. Results: Epidermal growth factor, IL-1RA, IL-7, IL-8/CXCL8, IP-10/CXCL10, MCP-1/CCL2, TGF-β2 and VEGF were detected in more than 75% of the samples in both groups. Statistically significant differences in percentage of detection between control and patient groups were found for IL-23, IL-1β, IL-15, EGF, fractalkine/CX3CL1 and MCP-1/CCL2. The concentrations of IL-1RA, IL-8/CXCL8, fractalkine/CX3CL1, IP-10/CXCL10, VEGF and TGF-β2 in uveitis tear samples were elevated compared to controls (p < 0.05). Significant differences in tear levels of those molecules and also EGF were also present depending on the anatomic classification of uveitis. Conclusion: There were significant differences in the levels of several cytokines and chemokines in tears of patients with uveitis compared with healthy subjects. These results can help understand the underlying pathophysiology of the uveitis and could potentially aid in diagnosis.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/metabolism ; Chemokines/metabolism ; Child ; Cytokines/metabolism ; Female ; Humans ; Male ; Middle Aged ; Severity of Illness Index ; Tears/metabolism ; Uveitis/diagnosis ; Uveitis/metabolism ; Young Adult
Chemical Substances	Biomarkers ; Chemokines ; Cytokines
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.13292
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Article ; Online: Surgical outcomes of uveitic glaucoma.

Carreño, Ester / Villarón, Sonia / Portero, Alejandro / Herreras, José M / Maquet, José A / Calonge, Margarita

Journal of ophthalmic inflammation and infection

2010 Volume 1, Issue 2, Page(s) 43–53

Abstract: Purpose: Secondary glaucoma is a difficult and frequent complication of uveitis. The aim of this study is to describe the results of surgery in uveitic glaucoma and to identify situations linked to a high risk of failure of the surgery.: Methods: ... ...

Abstract	Purpose: Secondary glaucoma is a difficult and frequent complication of uveitis. The aim of this study is to describe the results of surgery in uveitic glaucoma and to identify situations linked to a high risk of failure of the surgery. Methods: Retrospective observational study. Clinical and surgical data from 27 cases of uveitic glaucoma that underwent glaucoma surgery over a period of 9 years were collected. Results: The main diagnosis and aetiology were anterior uveitis (61.90%) and herpes (38.10%) respectively. Trabeculectomy with mitomycin C was performed in 51.9% of the cases. An intraocular pressure lower than 16 mmHg and managed with less than two drugs was achieved in 48.15% of the cases. Higher risks of surgical failure were associated with intermediate uveitis, idiopathic uveitis, Fuchs' cyclitis, combined surgery with phacoemulsification, omission of mitomycin C, intraocular inflammation at surgery and relapse of the uveitis. Conclusions: There are some situations linked to a high risk of failure of surgery in uveitic glaucoma, which should be avoided when possible, mainly the association of higher risk with combined approaches.
Language	English
Publishing date	2010-11-18
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2592309-2
ISSN	1869-5760 ; 1869-5760
ISSN (online)	1869-5760
ISSN	1869-5760
DOI	10.1007/s12348-010-0012-8
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