Article ; Online: Lifetime alcohol consumption patterns and young-onset breast cancer by subtype among Non-Hispanic Black and White women in the Young Women's Health History Study.
2023 Volume 35, Issue 2, Page(s) 377–391
Abstract: Purpose: The role of alcohol in young-onset breast cancer (YOBC) is unclear. We examined associations between lifetime alcohol consumption and YOBC in the Young Women's Health History Study, a population-based case-control study of breast cancer among ... ...
| Abstract | Purpose: The role of alcohol in young-onset breast cancer (YOBC) is unclear. We examined associations between lifetime alcohol consumption and YOBC in the Young Women's Health History Study, a population-based case-control study of breast cancer among Non-Hispanic Black and White women < 50 years of age. Methods: Breast cancer cases (n = 1,812) were diagnosed in the Metropolitan Detroit and Los Angeles County SEER registry areas, 2010-2015. Controls (n = 1,381) were identified through area-based sampling and were frequency-matched to cases by age, site, and race. Alcohol consumption and covariates were collected from in-person interviews. Weighted multivariable logistic regression was conducted to calculate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for associations between alcohol consumption and YOBC overall and by subtype (Luminal A, Luminal B, HER2, or triple negative). Results: Lifetime alcohol consumption was not associated with YOBC overall or with subtypes (all p Conclusions: Our findings suggest alcohol consumption has a different association with YOBC than postmenopausal breast cancer-lifetime consumption was not linked to increased risk and younger age at alcohol use initiation was associated with a decreased risk of triple-negative YOBC. Future studies on alcohol consumption in YOBC subtypes are warranted. |
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| MeSH term(s) | Female ; Humans ; Alcohol Drinking/epidemiology ; Alcohol Drinking/adverse effects ; Breast Neoplasms/epidemiology ; Breast Neoplasms/etiology ; Case-Control Studies ; Receptor, ErbB-2 ; Receptors, Progesterone ; Risk Factors ; Triple Negative Breast Neoplasms/epidemiology ; Triple Negative Breast Neoplasms/etiology ; Black or African American ; White ; Age of Onset | |||||
| Chemical Substances | Receptor, ErbB-2 (EC 2.7.10.1) ; Receptors, Progesterone | |||||
| Language | English | |||||
| Publishing date | 2023-10-03 | |||||
| Publishing country | Netherlands | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1064022-8 | |||||
| ISSN | 1573-7225 ; 0957-5243 | |||||
| ISSN (online) | 1573-7225 | |||||
| ISSN | 0957-5243 | |||||
| DOI | 10.1007/s10552-023-01801-z | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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