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  1. AU="Potenza, Duilio M"
  2. AU="Marcos-Pinto, Ricardo"
  3. AU="Rejali, Zulida"
  4. AU="Phelps, Robert"
  5. AU="Seeger, Kate"
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  1. Article ; Online: Aging Increases Hypoxia-Induced Endothelial Permeability and Blood-Brain Barrier Dysfunction by Upregulating Arginase-II.

    Cheng, Xin / Potenza, Duilio M / Brenna, Andrea / Ajalbert, Guillaume / Yang, Zhihong / Ming, Xiu-Fen

    Aging and disease

    2024  

    Abstract: Increased endothelial permeability plays an important role in blood-brain barrier (BBB) dysfunction and is implicated in neuronal injury in many diseased conditions. BBB disruption is primarily determined by dysfunction of endothelial cell-cell junctions. ...

    Abstract Increased endothelial permeability plays an important role in blood-brain barrier (BBB) dysfunction and is implicated in neuronal injury in many diseased conditions. BBB disruption is primarily determined by dysfunction of endothelial cell-cell junctions. Deprivation of oxygen supply or hypoxia, a common feature of a variety of human diseases, is a major risk factor for BBB disruption. The molecular regulatory mechanisms of hypoxia-induced BBB dysfunction remain incompletely understood. The mitochondrial enzyme, arginase type II (Arg-II), has been shown to promote endothelial dysfunction. However, its role in hypoxia-induced BBB dysfunction has not been explored. In the C57BL/6J mouse model, hypoxia (8% O
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2625789-0
    ISSN 2152-5250 ; 2152-5250
    ISSN (online) 2152-5250
    ISSN 2152-5250
    DOI 10.14336/AD.2023.1225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Elevation of Arginase-II in Podocytes Contributes to Age-Associated Albuminuria in Male Mice.

    Ajalbert, Guillaume / Brenna, Andrea / Ming, Xiu-Fen / Yang, Zhihong / Potenza, Duilio M

    International journal of molecular sciences

    2023  Volume 24, Issue 13

    Abstract: One of the manifestations of renal aging is podocyte dysfunction and loss, which are associated with proteinuria and glomerulosclerosis. Studies show a male bias in glomerular dysfunction and chronic kidney diseases, and the underlying mechanisms remain ... ...

    Abstract One of the manifestations of renal aging is podocyte dysfunction and loss, which are associated with proteinuria and glomerulosclerosis. Studies show a male bias in glomerular dysfunction and chronic kidney diseases, and the underlying mechanisms remain obscure. Recent studies demonstrate the role of an age-associated increase in arginase-II (Arg-II) in proximal tubules of both male and female mice. However, it is unclear whether Arg-II is also involved in aging glomeruli. The current study investigates the role of the sex-specific elevation of Arg-II in podocytes in age-associated increased albuminuria. Young (3-4 months) and old (20-22 months) male and female mice of
    MeSH term(s) Animals ; Female ; Male ; Mice ; Albuminuria/metabolism ; Arginase/genetics ; Arginase/metabolism ; Kidney Glomerulus/metabolism ; Podocytes/metabolism ; Proteinuria/metabolism
    Chemical Substances Arginase (EC 3.5.3.1)
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241311228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of pulmonary epithelial arginase-II in activation of fibroblasts and lung inflammaging.

    Zhu, Cui / Potenza, Duilio M / Yang, Yang / Ajalbert, Guillaume / Mertz, Kirsten D / von Gunten, Stephan / Ming, Xiu-Fen / Yang, Zhihong

    Aging cell

    2023  Volume 22, Issue 4, Page(s) e13790

    Abstract: Elevated arginases including type-I (Arg-I) and type-II isoenzyme (Arg-II) are reported to play a role in aging, age-associated organ inflammaging, and fibrosis. A role of arginase in pulmonary aging and underlying mechanisms are not explored. Our ... ...

    Abstract Elevated arginases including type-I (Arg-I) and type-II isoenzyme (Arg-II) are reported to play a role in aging, age-associated organ inflammaging, and fibrosis. A role of arginase in pulmonary aging and underlying mechanisms are not explored. Our present study shows increased Arg-II levels in aging lung of female mice, which is detected in bronchial ciliated epithelium, club cells, alveolar type 2 (AT2) pneumocytes, and fibroblasts (but not vascular endothelial and smooth muscle cells). Similar cellular localization of Arg-II is also observed in human lung biopsies. The age-associated increase in lung fibrosis and inflammatory cytokines, including IL-1β and TGF-β1 that are highly expressed in bronchial epithelium, AT2 cells, and fibroblasts, are ameliorated in arg-ii deficient (arg-ii
    MeSH term(s) Male ; Female ; Mice ; Humans ; Animals ; Transforming Growth Factor beta1/metabolism ; Arginase/genetics ; Arginase/metabolism ; Lung/pathology ; Cytokines/metabolism ; Fibroblasts/metabolism ; Fibrosis
    Chemical Substances Transforming Growth Factor beta1 ; Arginase (EC 3.5.3.1) ; Cytokines
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2113083-8
    ISSN 1474-9726 ; 1474-9718
    ISSN (online) 1474-9726
    ISSN 1474-9718
    DOI 10.1111/acel.13790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response.

    Potenza, Duilio M / Janicek, Radoslav / Fernandez-Tenorio, Miguel / Camors, Emmanuel / Ramos-Mondragón, Roberto / Valdivia, Héctor H / Niggli, Ernst

    The Journal of general physiology

    2018  Volume 151, Issue 2, Page(s) 131–145

    Abstract: During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent " ... ...

    Abstract During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)-mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent "hyperphosphorylation" of the RyR2 channel has been proposed as a major impairment that contributes to progression of heart failure. However, the sites of PKA phosphorylation and their phosphorylation status in cardiac diseases are not well defined. Among the known RyR2 phosphorylation sites, serine 2030 (S2030) remains highly controversial as a site of functional impact. We examined the contribution of RyR2-S2030 to Ca
    MeSH term(s) Adrenergic beta-Agonists/pharmacology ; Animals ; Calcium Signaling ; Cells, Cultured ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Excitation Contraction Coupling ; Isoproterenol/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/physiology ; Phosphorylation ; Ryanodine Receptor Calcium Release Channel/chemistry ; Ryanodine Receptor Calcium Release Channel/metabolism ; Serine/metabolism
    Chemical Substances Adrenergic beta-Agonists ; Ryanodine Receptor Calcium Release Channel ; Serine (452VLY9402) ; Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Isoproterenol (L628TT009W)
    Language English
    Publishing date 2018-12-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.201812155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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