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  1. Article ; Online: Clinical and radiological septic joint analysis of spontaneous sternoclavicular joint infections: achieving the best outcomes-a systems engineering approach.

    Pothini, Tanushri / Wilmot, Charles D / Waters, John K / Wait, Michael A / Reznik, Scott I / Jordan, Kirk G / Caire, Jacqueline T / Ashworth, John M / Cady, Leah C / Lysikowski, Jerzy R / Yen, Christina F / Weinschenk, Robert C / Samade, Richard / Jessen, Michael E / Kusiak, Andrew / Kernstine, Kemp H

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2024  Volume 65, Issue 4

    Abstract: Objectives: Spontaneous sternoclavicular joint infection (SSCJI) is a rare and poorly understood disease process. This study aims to identify factors guiding effective management strategies for SSCJI by using data mining.: Methods: An Institutional ... ...

    Abstract Objectives: Spontaneous sternoclavicular joint infection (SSCJI) is a rare and poorly understood disease process. This study aims to identify factors guiding effective management strategies for SSCJI by using data mining.
    Methods: An Institutional Review Board-approved retrospective review of patients from 2 large hospitals (2010-2022) was conducted. SSCJI is defined as a joint infection without direct trauma or radiation, direct instrumentation or contiguous spread. An interdisciplinary team consisting of thoracic surgeons, radiologists, infectious disease specialists, orthopaedic surgeons, hospital information experts and systems engineers selected relevant variables. Small set data mining algorithms, utilizing systems engineering, were employed to assess the impact of variables on patient outcomes.
    Results: A total of 73 variables were chosen and 54 analysed against 11 different outcomes. Forty-seven patients [mean age 51 (22-82); 77% male] met criteria. Among them, 34 underwent early joint surgical resection (<14 days), 5 patients received delayed surgical intervention (>14 days) and 8 had antibiotic-only management. The antibiotic-only group had comparable outcomes. Indicators of poor outcomes were soft tissue fluid >4.5 cm, previous SSCJI, moderate/significant bony fragments, HgbA1c >13.9% and moderate/significant bony sclerosis.
    Conclusions: This study suggests that targeted antibiotic-only therapy should be considered initially for SSCJI cases while concurrently managing comorbidities. Patients displaying indicators of poor outcomes or no symptomatic improvement after antibiotic-only therapy should be considered for surgical joint resection.
    MeSH term(s) Humans ; Male ; Middle Aged ; Female ; Sternoclavicular Joint/diagnostic imaging ; Sternoclavicular Joint/surgery ; Arthritis, Infectious/drug therapy ; Arthritis, Infectious/surgery ; Retrospective Studies ; Tomography, X-Ray Computed ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezae128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2303: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Behavioral consequences of dietary exposure to crude oil extracts in the Siamese fighting fish (Betta splendens).

    Bautista, Naim M / Pothini, Tanushri / Meng, Kelly / Burggren, Warren W

    Aquatic toxicology (Amsterdam, Netherlands)

    2018  Volume 207, Page(s) 34–42

    Abstract: Uptake by fishes of crude oil and its polycyclic aromatic hydrocarbons (PAHs) components occurs via gills, dietary intake, or diffusion through the skin. Dietary exposure to crude oil and its components is environmentally relevant, and induces ... ...

    Abstract Uptake by fishes of crude oil and its polycyclic aromatic hydrocarbons (PAHs) components occurs via gills, dietary intake, or diffusion through the skin. Dietary exposure to crude oil and its components is environmentally relevant, and induces physiological and morphological disruptions in fish. However, the impacts of crude oil on fish social and reproductive behaviors and thus the possible influences on reproductive success are poorly understood. As a part of their intraspecific interactions, male Siamese fighting fish (Betta splendens) exhibit highly stereotypic behavioral and territorial displays. This makes this species a tractable model for testing crude oil effects on behavior. After 2 weeks of acclimation at 29 °C, male adult betta fish were divided into three groups and fed for 4 weeks with food spiked with water (control), low oil concentrations or high oil concentrations (∑Total PAH concentrations 340, 3960 or 8820 ng/g dw, respectively) to determine subsequent alterations in behavioral displays. Compared with control fish, the aggressive display of "opercular flaring" was significantly increased (P < 0.03, n = 14-16) in oil-exposed fish. Bubble nest building, as well as testis and brain mass, were significantly reduced in treated fish (P < 0.05). Hematocrit of treated groups was increased significantly (P < 0.02) from 21% in control fish to ∼27% in both oil exposure groups. Dietary exposure over a 4-week period to low, relevant levels of crude oil thus leads to an increase in aggressive behavioral displays, a decrease in reproductive activity and additional morphological changes.
    MeSH term(s) Aggression/drug effects ; Animal Feed/analysis ; Animals ; Behavior, Animal/drug effects ; Body Weight/drug effects ; Dietary Exposure ; Fishes/anatomy & histology ; Fishes/physiology ; Male ; Oils/analysis ; Organ Size/drug effects ; Petroleum/toxicity ; Polycyclic Aromatic Hydrocarbons/analysis ; Water Pollutants, Chemical/toxicity
    Chemical Substances Oils ; Petroleum ; Polycyclic Aromatic Hydrocarbons ; Water Pollutants, Chemical
    Language English
    Publishing date 2018-11-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2018.11.025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4376: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Prescription opioids are commonly unused after ambulatory head and neck surgeries: Opioids prescription presence and size has no effect on patient satisfaction with pain control.

    Elsharydah, Ahmad / Karani, Sadia Y / Pothini, Tanushri / Truong, Kevin H / Shu, David J / Ruikar, Kinnari V / Huynh, Tinh / Tran, Coby K

    American journal of otolaryngology

    2021  Volume 42, Issue 6, Page(s) 103093

    Abstract: Purpose: To explore the opioid prescribing practices after common ambulatory head and neck surgeries in a large academic institution; and to examine the association between opioid prescription and the patient's satisfaction with pain control.: Methods! ...

    Abstract Purpose: To explore the opioid prescribing practices after common ambulatory head and neck surgeries in a large academic institution; and to examine the association between opioid prescription and the patient's satisfaction with pain control.
    Methods: This retrospective cohort study conducted in a tertiary academic medical center. Phone interviews of patients who underwent ambulatory head and neck surgeries one month after their procedures were conducted. The interview included, among several questions, the amount of opioid prescribed and consumed, the use of non-opioid pain medications, and the patient's satisfaction with pain control. Logistic regression models were used to investigate the significant factors affecting the patient's satisfaction with pain control.
    Results: Most patients were prescribed opioids at discharge (84%). Of those, 17% did not use their prescriptions. The median of leftover opioid was 76.50 morphine milligram equivalents (MMEs) with IQR (45-130.95). Patient satisfaction with pain control is not associated with opioid prescription at discharge (OR 0.195 [95% CL, 0.036-1.036], p = 0.059) or the amount of the prescribed opioid (OR 1.001 [95% CL, 0.997-1.004], p = 0.717) after controlling for other patient and procedural factors.
    Conclusion: A significant portion of ambulatory head and neck surgery patients were discharged with opioid prescriptions they may not use. Patient satisfaction with pain control is not associated with the presence or the amount of opioid prescribed.
    MeSH term(s) Adult ; Aged ; Ambulatory Surgical Procedures ; Analgesics, Opioid/administration & dosage ; Drug Utilization/statistics & numerical data ; Female ; Humans ; Inappropriate Prescribing/statistics & numerical data ; Male ; Middle Aged ; Otorhinolaryngologic Surgical Procedures ; Pain Management/statistics & numerical data ; Pain, Postoperative/prevention & control ; Pain, Postoperative/psychology ; Patient Satisfaction/statistics & numerical data ; Practice Patterns, Physicians'/statistics & numerical data ; Prescriptions/statistics & numerical data ; Retrospective Studies ; Tertiary Care Centers/statistics & numerical data ; Time Factors
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2021-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2021.103093
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1637: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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