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Article ; Online: "Bilan cardiovasculaire chez les diabétiques : faut-il dépister l’ischémie silencieuse ?"

Potier, Louis

2021 Volume 71, Issue 4, Page(s) 360–362

Title translation	"Cardiovascular assessment in diabetics: should silent ischemia be screened?"
MeSH term(s)	Diabetes Mellitus, Type 2 ; Humans ; Ischemia ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/epidemiology ; Prevalence ; Risk Factors
Language	French
Publishing date	2021-06-23
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Ua VI Zs.433: Show issues

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Article: Quand et comment passer à l'insuline chez le patient diabétique de type 2?

Potier, Louis

La Revue du praticien

2015 Volume 65, Issue 8, Page(s) 1042–1045

Abstract: Insulin initiation is a major step in medical management and life of patients with type 2 diabetes. Insulin is necessary if combination of 2 or 3 oral antidiabetic agents fail to achieve target glycemic goals, especially if HbA1c are superior to 1% from ... ...

Title translation	When and why start insulin in type 2 diabetes?.
Abstract	Insulin initiation is a major step in medical management and life of patients with type 2 diabetes. Insulin is necessary if combination of 2 or 3 oral antidiabetic agents fail to achieve target glycemic goals, especially if HbA1c are superior to 1% from target or weight loss. Insulin will be started with bedtime intermediate-acting insulin. Insulin can be initiated with 10 units or 0.2 units/kg then increase by 2 units every 3 days until fasting levels are consistantly in targets range. If hypoglycemia occurs, insulin dose will be reduced by 4 units. Insulin initiation requires specific educational program for the acceptation of injection and to learn insulin injection, capillary blood glucose test and adjustment of insulin regimens.
MeSH term(s)	Algorithms ; Diabetes Mellitus, Type 2/drug therapy ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Humans ; Hypoglycemic Agents/administration & dosage ; Insulin/administration & dosage
Chemical Substances	Hypoglycemic Agents ; Insulin
Language	French
Publishing date	2015-10
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Prediction of Wall Heat Fluxes in a Rocket Engine with Conjugate Heat Transfer Based on Large-Eddy Simulation.

Potier, Luc / Duchaine, Florent / Cuenot, Bénédicte / Saucereau, Didier / Pichillou, Julien

Entropy (Basel, Switzerland)

2022 Volume 24, Issue 2

Abstract: Although a lot of research and development has been done to understand and master the major physics involved in cryogenic rocket engines (combustion, feeding systems, heat transfer, stability, efficiency, etc.), the injection system and wall heat ... ...

Abstract	Although a lot of research and development has been done to understand and master the major physics involved in cryogenic rocket engines (combustion, feeding systems, heat transfer, stability, efficiency, etc.), the injection system and wall heat transfer remain critical issues due to complex physics, leading to atomization in the subcritical regime and the interactions of hot gases with walls. In such regimes, the fuel is usually injected through a coaxial annulus and triggers the atomization of the central liquid oxidizer jet. This type of injector is often referred to as air-assisted, or coaxial shear, injector, and has been extensively studied experimentally. Including such injection in numerical simulations requires specific models as simulating the atomization process is still out of reach in practical industrial systems. The effect of the injection model on the flame stabilization process and thus on wall heat fluxes is of critical importance when it comes to the design of wall-cooling systems. Indeed, maximizing the heat flux extracted from the chamber can lead to serious gain for the cooling and feeding systems for expander-type feeding cycles where the thermal energy absorbed by the coolant is converted into kinetic energy to drive the turbo-pumps of the feeding system. The methodology proposed in this work to numerically predict the flame topology and associated heat fluxes is based on state-of-the-art methods for turbulent reactive flow field predictions for rocket engines, including liquid injection, combustion model, and wall treatment. For this purpose, high-fidelity Large Eddy Simulation Conjugate Heat Transfer, along with a reduced kinetic mechanism for the prediction of H2/O2 chemistry, liquid injection model
Language	English
Publishing date	2022-02-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e24020256
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Article ; Online: Redox Genetic Risk Score and the Incidence of End-Stage Kidney Disease in People with Type 1 Diabetes.

Mohammedi, Kamel / Marre, Michel / Hadjadj, Samy / Potier, Louis / Velho, Gilberto

Cells

2022 Volume 11, Issue 24

Abstract: End-stage kidney disease (ESKD) is a multifactorial condition influenced by genetic background, but the extent to which a genetic risk score (GRS) improves ESKD prediction is unknown. We built a redox GRS on the base of previous association studies (six ... ...

Abstract	End-stage kidney disease (ESKD) is a multifactorial condition influenced by genetic background, but the extent to which a genetic risk score (GRS) improves ESKD prediction is unknown. We built a redox GRS on the base of previous association studies (six polymorphisms from six redox genes) and tested its relationship with ESKD in three cohorts of people with type 1 diabetes. Among 1012 participants, ESKD (hemodialysis requirement, kidney transplantation, eGFR < 15 mL/min/1.73 m
Language	English
Publishing date	2022-12-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11244131
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Article ; Online: Letter by Potier and Roussel Regarding Article, "Are We Ready to Bell the Cat? A Call for Cardiologists to Embrace Glucose-Lowering Therapies Proven to Improve Cardiovascular Outcomes".

Potier, Louis / Roussel, Ronan

Circulation

2019 Volume 139, Issue 2, Page(s) 303–304

MeSH term(s)	Cardiologists ; Cardiovascular System ; Glucose ; Humans ; Sodium-Glucose Transporter 2 Inhibitors
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2019-03-08
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80099-5
ISSN	1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
ISSN (online)	1524-4539
ISSN	0009-7322 ; 0069-4193 ; 0065-8499
DOI	10.1161/CIRCULATIONAHA.118.037118
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Article ; Online: Once-weekly semaglutide use in patients with type 2 diabetes: Results from the SURE France multicentre, prospective, observational study.

Mohammedi, Kamel / Belhatem, Narimene / Berentzen, Tina Landsvig / Catarig, Andrei-Mircea / Potier, Louis

Diabetes, obesity & metabolism

2023 Volume 25, Issue 7, Page(s) 1855–1864

Abstract: Aims: Real-world data are required to support glucagon-like peptide-1 receptor agonist use in type 2 diabetes (T2D). SURE France assessed once-weekly semaglutide in adults with T2D in real-world clinical practice.: Materials and methods: This ... ...

Abstract	Aims: Real-world data are required to support glucagon-like peptide-1 receptor agonist use in type 2 diabetes (T2D). SURE France assessed once-weekly semaglutide in adults with T2D in real-world clinical practice. Materials and methods: This multicentre, prospective, open-label, single-arm study included adults with T2D and ≥1 documented glycated haemoglobin (HbA1c) value ≤12 weeks before semaglutide initiation. The primary endpoint was HbA1c change from baseline to end of study (EOS; ~30 weeks). Secondary endpoints included change from baseline to EOS in body weight (BW) and waist circumference (WC); and proportion achieving HbA1c targets. Baseline characteristics and safety were reported for the full analysis set (patients initiating semaglutide). Analysis of other endpoints was based on the effectiveness analysis set (study completers receiving semaglutide at EOS). Results: Of 497 patients initiating semaglutide (41.6% female, mean age 58.3 years), 348 completed the study on treatment. Baseline HbA1c, diabetes duration, BW and WC, were 8.3%, 10.0 years, 98.2 kg and 114.2 cm, respectively. The most common reasons for initiating semaglutide were to improve glycaemic control (79.7%), reduce BW (69.8%) and address cardiovascular risk (24.1%). At EOS, mean changes were: HbA1c, -1.2% points [95% confidence interval (CI) -1.32; -1.10]; BW, -4.7 kg (95% CI -5.38; -4.07); and WC, -4.9 cm (95% CI -5.94; -3.88). At EOS, 81.7%, 67.7% and 51.6% of patients achieved an HbA1c target of <8.0%, <7.5% and <7.0%, respectively. No new safety concerns were identified. Conclusions: These results support the benefits of semaglutide in a real-world setting in adults with T2D in France showing a significant reduction in HbA1c and body weight.
MeSH term(s)	Adult ; Humans ; Female ; Middle Aged ; Male ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/chemically induced ; Hypoglycemic Agents/adverse effects ; Glycated Hemoglobin ; Prospective Studies ; Glucagon-Like Peptides/adverse effects ; Body Weight
Chemical Substances	semaglutide (53AXN4NNHX) ; Hypoglycemic Agents ; Glycated Hemoglobin ; Glucagon-Like Peptides (62340-29-8)
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Multicenter Study ; Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.15045
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Zs.A 5442: Show issues

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Article ; Online: SGLT2 inhibitors and lower limb complications: the diuretic-induced hypovolemia hypothesis.

Potier, Louis / Mohammedi, Kamel / Velho, Gilberto / Roussel, Ronan

Cardiovascular diabetology

2021 Volume 20, Issue 1, Page(s) 107

Abstract: In a recent meta-analysis of randomized controlled trials of sodium glucose co-transporter 2 inhibitors (SGLT2i) in patients with diabetes, Lin and colleagues showed a positive association between SGLT2i-induced blood pressure and weight reduction and ... ...

Abstract	In a recent meta-analysis of randomized controlled trials of sodium glucose co-transporter 2 inhibitors (SGLT2i) in patients with diabetes, Lin and colleagues showed a positive association between SGLT2i-induced blood pressure and weight reduction and the risk of lower limb events. These results support the potential mechanism of a volume depletion effect of SGLT2i to explain the increase risk of amputation observed with this pharmacological class. Since the first result of the CANVAS trial raised a concern regarding the risk of amputation with SGLT2i, this hypothesis emerged from studies showing a higher incidence of amputations in patients with diabetes using diuretics. Furthermore, recent data found that copeptin, a surrogate marker of hydration status was also associated with lower limb outcomes. In conclusion, this assumption of diuretic-induced hypovolemia explanation highlights the fact that medications that induce a contraction of plasma volume, both traditional and novel agents with a diuretic mode of action should be introduced cautiously in patients with diabetes at high risk of diabetic foot events.
MeSH term(s)	Diabetes Mellitus, Type 2 ; Diuretics ; Humans ; Hypovolemia ; Lower Extremity ; Sodium-Glucose Transporter 2 Inhibitors
Chemical Substances	Diuretics ; Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2021-05-13
Publishing country	England
Document type	Journal Article ; Comment
ISSN	1475-2840
ISSN (online)	1475-2840
DOI	10.1186/s12933-021-01301-x
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Article ; Online: Type III open tibia fractures in low-resources setting. Part 3: achievement of bone union and treatment of segmental bone defects.

Mathieu, L / Mongo, V / Potier, L / Bertani, A / Niang, C D / Rigal, S

Medecine et sante tropicales

2019 Volume 29, Issue 1, Page(s) 36–42

Abstract: After presentations of the principles of limb salvage and soft-tissue coverage for Gustilo III open tibia fractures, this third part is dedicated to management of tibial non-unions in low-resource settings. Inter-tibiofibular grafting and the induced ... ...

Title translation	Fractures ouvertes de jambe de type III en situation sanitaire dégradée. Partie 3 : relance de la consolidation et traitement des pertes de substances osseuses.
Abstract	After presentations of the principles of limb salvage and soft-tissue coverage for Gustilo III open tibia fractures, this third part is dedicated to management of tibial non-unions in low-resource settings. Inter-tibiofibular grafting and the induced membrane technique are preferred because they make it possible to deal with almost all situations. Key technical points of these methods are presented, followed by treatment guidelines based on Catagni's classification and bone defect size.
MeSH term(s)	Autografts ; Bone Transplantation ; Developing Countries ; Fracture Fixation, Intramedullary ; Fracture Healing ; Fractures, Open/classification ; Fractures, Open/surgery ; Humans ; Tibial Fractures/classification ; Tibial Fractures/surgery
Language	English
Publishing date	2019-04-26
Publishing country	France
Document type	Journal Article
ISSN	2261-2211
ISSN (online)	2261-2211
DOI	10.1684/mst.2019.0863
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Article ; Online: COVID-19 symptoms masking inaugural ketoacidosis of type 1 diabetes.

Potier, L / Julla, J B / Roussel, R / Boudou, P / Gauthier, D C / Ketfi, C / Gautier, J F

Diabetes & metabolism

2020 Volume 47, Issue 1, Page(s) 101162

MeSH term(s)	Adult ; COVID-19/complications ; COVID-19/diagnosis ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Ketoacidosis/complications ; Diabetic Ketoacidosis/diagnosis ; Humans ; Male
Keywords	covid19
Language	English
Publishing date	2020-05-21
Publishing country	France
Document type	Case Reports ; Letter
ZDB-ID	1315751-6
ISSN	1878-1780 ; 1262-3636 ; 0338-1684
ISSN (online)	1878-1780
ISSN	1262-3636 ; 0338-1684
DOI	10.1016/j.diabet.2020.05.004
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Zs.A 1267: Show issues

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Article ; Online: Type III open tibia fractures in low-resource setting. Part 2: soft-tissue coverage with simple, reliable and replicable pedicle flaps.

Mathieu, L / Potier, L / Niang, C D / Rongiéras, F / Duhamel, P / Bey, E

Medecine et sante tropicales

2018 Volume 28, Issue 3, Page(s) 230–236

Abstract: After limb salvage based on debridement and external fixation, Gustilo IIIB open tibia fractures must undergo soft-tissue repair within 7 days. In low-resource setting, the coverage is performed with pedicled flaps only, which can be used by any ... ...

Title translation	Fractures ouvertes de jambe de type III en situation sanitaire dégradée. Partie 2 : couverture par des lambeaux simples, fiables et reproductibles.
Abstract	After limb salvage based on debridement and external fixation, Gustilo IIIB open tibia fractures must undergo soft-tissue repair within 7 days. In low-resource setting, the coverage is performed with pedicled flaps only, which can be used by any orthopedic surgeon after minimal training. The authors describe here the simplified use of 7 basic flap transfers that can deal with almost all soft tissue defects. The diffusion of these techniques in developing countries is crucial for limiting functional and trophic effects related to prolonged exposure of the fracture site.
MeSH term(s)	Fractures, Open/classification ; Fractures, Open/complications ; Fractures, Open/surgery ; Health Resources/statistics & numerical data ; Humans ; Reconstructive Surgical Procedures/methods ; Soft Tissue Injuries/etiology ; Soft Tissue Injuries/surgery ; Surgical Flaps ; Tibial Fractures/classification ; Tibial Fractures/complications ; Tibial Fractures/surgery
Language	English
Publishing date	2018-09-30
Publishing country	France
Document type	Journal Article
ISSN	2261-2211
ISSN (online)	2261-2211
DOI	10.1684/mst.2018.0810
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