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  1. AU="Potnis, Ojas"
  2. AU="Twaroski, Kirk"
  3. AU="Wang, Jen-Chun"
  4. AU="Bisceglio, Gina D"
  5. AU=Sperling Brita
  6. AU="Koscianski, Christina A"
  7. AU="Carvalho, Ricardo de S"
  8. AU="David J. Jackson"

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  1. Article ; Online: Clinical outcomes of peripheral nerve interfaces for rehabilitation in paralysis and amputation: a literature review.

    Taghlabi, Khaled M / Cruz-Garza, Jesus G / Hassan, Taimur / Potnis, Ojas / Bhenderu, Lokeshwar S / Guerrero, Jaime R / Whitehead, Rachael E / Wu, Yu / Luan, Lan / Xie, Chong / Robinson, Jacob T / Faraji, Amir H

    Journal of neural engineering

    2024  Volume 21, Issue 1

    Abstract: Peripheral nerve interfaces (PNIs) are electrical systems designed to integrate with peripheral nerves in patients, such as following central nervous system (CNS) injuries to augment or replace CNS control and restore function. We review the literature ... ...

    Abstract Peripheral nerve interfaces (PNIs) are electrical systems designed to integrate with peripheral nerves in patients, such as following central nervous system (CNS) injuries to augment or replace CNS control and restore function. We review the literature for clinical trials and studies containing clinical outcome measures to explore the utility of human applications of PNIs. We discuss the various types of electrodes currently used for PNI systems and their functionalities and limitations. We discuss important design characteristics of PNI systems, including biocompatibility, resolution and specificity, efficacy, and longevity, to highlight their importance in the current and future development of PNIs. The clinical outcomes of PNI systems are also discussed. Finally, we review relevant PNI clinical trials that were conducted, up to the present date, to restore the sensory and motor function of upper or lower limbs in amputees, spinal cord injury patients, or intact individuals and describe their significant findings. This review highlights the current progress in the field of PNIs and serves as a foundation for future development and application of PNI systems.
    MeSH term(s) Humans ; Peripheral Nerves ; Amputation, Surgical ; Electrodes ; Amputees ; Paralysis/surgery
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ad200f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6071: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Racial disparities in the utilization of invasive neuromodulation devices for the treatment of drug-resistant focal epilepsy.

    Alcala-Zermeno, Juan Luis / Fureman, Brandy / Grzeskowiak, Caitlin L / Potnis, Ojas / Taveras, Maria / Logan, Margaret W / Rybacki, Delanie / Friedman, Daniel / Lowenstein, Daniel / Kuzniecky, Ruben / French, Jacqueline

    Epilepsia

    2024  Volume 65, Issue 5, Page(s) e61–e66

    Abstract: Racial disparities affect multiple dimensions of epilepsy care including epilepsy surgery. This study aims to further explore these disparities by determining the utilization of invasive neuromodulation devices according to race and ethnicity in a ... ...

    Abstract Racial disparities affect multiple dimensions of epilepsy care including epilepsy surgery. This study aims to further explore these disparities by determining the utilization of invasive neuromodulation devices according to race and ethnicity in a multicenter study of patients living with focal drug-resistant epilepsy (DRE). We performed a post hoc analysis of the Human Epilepsy Project 2 (HEP2) data. HEP2 is a prospective study of patients living with focal DRE involving 10 sites distributed across the United States. There were no statistical differences in the racial distribution of the study population compared to the US population using census data except for patients reporting more than one race. Of 154 patients enrolled in HEP2, 55 (36%) underwent invasive neuromodulation for DRE management at some point in the course of their epilepsy. Of those, 36 (71%) were patients who identified as White. Patients were significantly less likely to have a device if they identified solely as Black/African American than if they did not (odds ratio = .21, 95% confidence interval = .05-.96, p = .03). Invasive neuromodulation for management of DRE is underutilized in the Black/African American population, indicating a new facet of racial disparities in epilepsy care.
    MeSH term(s) Humans ; Drug Resistant Epilepsy/therapy ; Male ; Female ; Epilepsies, Partial/therapy ; Epilepsies, Partial/ethnology ; Healthcare Disparities/statistics & numerical data ; Healthcare Disparities/ethnology ; Adult ; Prospective Studies ; Black or African American/statistics & numerical data ; Middle Aged ; United States ; Deep Brain Stimulation/statistics & numerical data ; Deep Brain Stimulation/methods ; White People/statistics & numerical data ; Young Adult ; Adolescent
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17961
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 475: Show issues

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  3. Article: Nanofabricated Ultraflexible Electrode Arrays for High-Density Intracortical Recording.

    Wei, Xiaoling / Luan, Lan / Zhao, Zhengtuo / Li, Xue / Zhu, Hanlin / Potnis, Ojas / Xie, Chong

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2018  Volume 5, Issue 6, Page(s) 1700625

    Abstract: Understanding brain functions at the circuit level requires time-resolved simultaneous measurement of a large number of densely distributed neurons, which remains a great challenge for current neural technologies. In particular, penetrating neural ... ...

    Abstract Understanding brain functions at the circuit level requires time-resolved simultaneous measurement of a large number of densely distributed neurons, which remains a great challenge for current neural technologies. In particular, penetrating neural electrodes allow for recording from individual neurons at high temporal resolution, but often have larger dimensions than the biological matrix, which induces significant damage to brain tissues and therefore precludes the high implant density that is necessary for mapping large neuronal populations with full coverage. Here, it is demonstrated that nanofabricated ultraflexible electrode arrays with cross-sectional areas as small as sub-10 µm
    Language English
    Publishing date 2018-03-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.201700625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Ultraflexible nanoelectronic probes form reliable, glial scar-free neural integration.

    Luan, Lan / Wei, Xiaoling / Zhao, Zhengtuo / Siegel, Jennifer J / Potnis, Ojas / Tuppen, Catherine A / Lin, Shengqing / Kazmi, Shams / Fowler, Robert A / Holloway, Stewart / Dunn, Andrew K / Chitwood, Raymond A / Xie, Chong

    Science advances

    2017  Volume 3, Issue 2, Page(s) e1601966

    Abstract: Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic ... ...

    Abstract Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific and clinical applications. We showed that nanoelectronic thread (NET) electrodes with subcellular dimensions, ultraflexibility, and cellular surgical footprints form reliable, glial scar-free neural integration. We demonstrated that NET electrodes reliably detected and tracked individual units for months; their impedance, noise level, single-unit recording yield, and the signal amplitude remained stable during long-term implantation. In vivo two-photon imaging and postmortem histological analysis revealed seamless, subcellular integration of NET probes with the local cellular and vasculature networks, featuring fully recovered capillaries with an intact blood-brain barrier and complete absence of chronic neuronal degradation and glial scar.
    MeSH term(s) Animals ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Electrodes, Implanted ; Male ; Materials Testing ; Mice ; Mice, Transgenic ; Microscopy, Fluorescence, Multiphoton ; Nanostructures ; Neuroglia/metabolism ; Neuroglia/pathology
    Language English
    Publishing date 2017-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.1601966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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