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  1. Article ; Online: [No title information]

    Steuder, Regina / Pott, Hendrik / Maxheim, Michael / Schmeck, Bernd

    Pneumo news

    2021  Volume 13, Issue 5, Page(s) 30–35

    Title translation Pneumonie und COVID-19 bei COPD-Patienten.
    Language German
    Publishing date 2021-10-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2806668-6
    ISSN 2199-3866 ; 1865-5467
    ISSN (online) 2199-3866
    ISSN 1865-5467
    DOI 10.1007/s15033-021-2749-1
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  2. Article: A mRNA panel for differentiation between acute exacerbation or pneumonia in COPD patients.

    Bertrams, Wilhelm / Wilhelm, Jochen / Veeger, Pia-Marie / Hanko, Carolina / Brinke, Kristina Auf dem / Klabunde, Björn / Pott, Hendrik / Weckler, Barbara / Greulich, Timm / Vogelmeier, Claus F / Schmeck, Bernd

    Frontiers in medicine

    2024  Volume 11, Page(s) 1234068

    Abstract: Introduction: Patients suffering from chronic obstructive pulmonary disease (COPD) are prone to acute exacerbations (AECOPD) or community acquired pneumonia (CAP), both posing severe risk of morbidity and mortality. There is no available biomarker that ... ...

    Abstract Introduction: Patients suffering from chronic obstructive pulmonary disease (COPD) are prone to acute exacerbations (AECOPD) or community acquired pneumonia (CAP), both posing severe risk of morbidity and mortality. There is no available biomarker that correctly separates AECOPD from COPD. However, because CAP and AECOPD differ in aetiology, treatment and prognosis, their discrimination would be important.
    Methods: This study analysed the ability of selected candidate transcripts from peripheral blood mononuclear cells (PBMCs) to differentiate between patients with AECOPD, COPD & CAP, and CAP without pre-existing COPD.
    Results: In a previous study, we identified differentially regulated genes between CAP and AECOPD in PBMCs. In the present new cohort, we tested the potential of selected candidate PBMC transcripts to differentiate at early time points AECOPD, CAP+COPD, and CAP without pre-existing COPD. Expression of
    Discussion: In summary, in our cohort expression levels of YWHAG,
    Language English
    Publishing date 2024-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2024.1234068
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  3. Book ; Online ; Thesis: Acetabulumfrakturen im Alter

    Pott, Hendrik [Verfasser] / Pohlemann, Tim [Akademischer Betreuer]

    Charakterisierung einer stetig wachsenden Patientengruppe und Langzeitergebnisse der offenen Frakturstabilisierung

    2020  

    Author's details Hendrik Pott ; Betreuer: Tim Pohlemann
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Saarländische Universitäts- und Landesbibliothek
    Publishing place Saarbrücken
    Document type Book ; Online ; Thesis
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  4. Article: Patients' acceptance of outcome and experience measurements during hospitalisation for COPD exacerbations: a CICERO Clinical Research Collaboration-European Lung Foundation online patient survey.

    Gyselinck, Iwein / Ramakrishnan, Sanjay / Vermeersch, Kristina / Halner, Andreas / Pott, Hendrik / Dobbels, Fabienne / Coleman, Courtney / Collis, Philip / Watz, Henrik / Greulich, Timm / Franssen, Frits M E / Burgel, Pierre-Régis / Bafadhel, Mona / Janssens, Wim

    ERJ open research

    2023  Volume 9, Issue 4

    Abstract: Background: The lack of standardised outcome assessments during hospitalisation and follow-up for acute COPD exacerbations has hampered scientific progress and clinical proficiency. The objective of the present study was to evaluate patients' acceptance ...

    Abstract Background: The lack of standardised outcome assessments during hospitalisation and follow-up for acute COPD exacerbations has hampered scientific progress and clinical proficiency. The objective of the present study was to evaluate patients' acceptance of selected outcome and experience measurements during hospitalisations for COPD exacerbations and follow-up.
    Methods: An online survey was held amongst COPD patients in France, Belgium, The Netherlands, Germany and the UK. The European Lung Foundation COPD Patient Advisory Group was involved in the conceptualisation, development and dissemination of the survey. The survey was complementary to a previously obtained expert consensus. We assessed patients' views and acceptance of selected patient-reported outcomes or experiences and corresponding measurement instruments (for dyspnoea, frequent productive cough, health status and hospitalisation experience), and of selected clinical investigations (blood draw, pulmonary function test, 6-min walk test, chest computed tomography, echocardiography).
    Findings: 200 patients completed the survey. All selected outcomes and experiences were deemed important, and acceptance of their methods of assessment was high. The modified Medical Research Council scale and a numerical rating scale to address dyspnoea, the COPD Assessment Test for quality of life and frequent productive cough, and the Hospital Consumer Assessment of Healthcare Providers and Systems for hospital experiences were the instruments preferred by patients. Consensus on importance of blood draw and spirometry was higher compared with the other investigations.
    Interpretation: The survey results endorse the use of the selected outcome and experience measurements during hospitalisations for COPD exacerbations. They can be used to optimise standardised and patient-centred care and facilitate multicentric data collection.
    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00148-2023
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  5. Article: Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study.

    Jung, Anna Lena / Han, Maria / Griss, Kathrin / Bertrams, Wilhelm / Nell, Christoph / Greulich, Timm / Klemmer, Andreas / Pott, Hendrik / Heider, Dominik / Vogelmeier, Claus F / Hippenstiel, Stefan / Suttorp, Norbert / Schmeck, Bernd

    Frontiers in medicine

    2023  Volume 10, Page(s) 1180746

    Abstract: Introduction: Community-acquired pneumonia (CAP) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in high morbidity, mortality, and socio-economic burden. The usage of easily accessible biomarkers informing on disease ... ...

    Abstract Introduction: Community-acquired pneumonia (CAP) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in high morbidity, mortality, and socio-economic burden. The usage of easily accessible biomarkers informing on disease entity, severity, prognosis, and pathophysiological endotypes is limited in clinical practice. Here, we have analyzed selected plasma markers for their value in differential diagnosis and severity grading in a clinical cohort.
    Methods: A pilot cohort of hospitalized patients suffering from CAP (
    Results: In CAP patients and healthy volunteers, we found significantly different levels of ELA2, HGF, IL-2R, IL-6, IL-8, LBP, resistin, LTF, and TRAIL. The panel of LBP, sFas, and TRAIL could discriminate between uncomplicated and severe CAP. AECOPD patients showed significantly different levels of LTF and TRAIL compared to healthy subjects. Ensemble feature selection revealed that CAP and AECOPD can be discriminated by IL-6, resistin, together with IL-2R. These factors even allow the differentiation between COPD patients suffering from an exacerbation or pneumonia.
    Discussion: Taken together, we identified immune mediators in patient plasma that provide information on differential diagnosis and disease severity and can therefore serve as biomarkers. Further studies are required for validation in bigger cohorts.
    Language English
    Publishing date 2023-06-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1180746
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  6. Article ; Online: Truncating VPS16 Mutations Are Rare in Early Onset Dystonia.

    Pott, Hendrik / Brüggemann, Norbert / Reese, Rene / Zeuner, Kirsten E / Gandor, Florin / Gruber, Doreen / Klein, Christine / Volkmann, Jens / Lohmann, Katja

    Annals of neurology

    2020  Volume 89, Issue 3, Page(s) 625–626

    MeSH term(s) Dystonia/genetics ; Dystonic Disorders/genetics ; Humans ; Lysosomes ; Mutation/genetics ; Vesicular Transport Proteins/genetics
    Chemical Substances VPS16 protein, human ; VPS41 protein, human ; Vesicular Transport Proteins
    Language English
    Publishing date 2020-12-28
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80362-5
    ISSN 1531-8249 ; 0364-5134
    ISSN (online) 1531-8249
    ISSN 0364-5134
    DOI 10.1002/ana.25990
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1370: Show issues Location:
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  7. Article ; Online: Geriatric Acetabular Surgery: Letournel's Contraindications Then and Now-Data From the German Pelvic Registry.

    Herath, Steven C / Pott, Hendrik / Rollmann, Mika F R / Braun, Benedikt J / Holstein, Jörg H / Höch, Andreas / Stuby, Fabian M / Pohlemann, Tim

    Journal of orthopaedic trauma

    2019  Volume 33 Suppl 2, Page(s) S8–S13

    Abstract: Objective: In his original series of 129 surgically treated acetabular fractures, Letournel did not operate on patients older than 60 years. Almost 30 years later, he still emphasized that no patients with reduced bone quality should be operated on. The ...

    Abstract Objective: In his original series of 129 surgically treated acetabular fractures, Letournel did not operate on patients older than 60 years. Almost 30 years later, he still emphasized that no patients with reduced bone quality should be operated on. The aim of the study was to analyze epidemiologic characteristics and treatment modes for today's cohort of elderly patients with acetabular fractures.
    Design: Retrospective analysis.
    Setting: Multicenter registry/Level I trauma center.
    Patients: Three thousand seven hundred ninety-three patients who had sustained a fracture of the acetabulum.
    Intervention: Operative and nonoperative treatment of acetabular fractures.
    Main outcome measurements: Epidemiologic characteristics, treatment mode, in-hospital mortality, rate of secondary hip arthroplasty, and quality of life indicated by EQ-5D score.
    Results: For the multicenter registry, more than 50% of all patients with acetabular fractures had an age of 60 years or over. The age peak was found at 75-80 years. Fifty percent of the elderly patients were treated surgically. The in-hospital mortality was significantly higher in elderly patients than patients younger than 60 years. In our Level I trauma center, surgical treatment by open reduction and internal fixation did not influence in-hospital mortality or quality of life of elderly patients with acetabular fractures.
    Conclusions: Today, elderly persons represent the dominant cohort among patients with fractures of the acetabulum. Fifty-five years after the publication of Letournel's original case series, data indicate that currently, surgical treatment is a common and necessary option in the therapy of acetabular fractures in elderly patients.
    Level of evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Acetabulum/injuries ; Acetabulum/surgery ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Cohort Studies ; Contraindications, Procedure ; Female ; Fracture Fixation/adverse effects ; Fractures, Bone/epidemiology ; Fractures, Bone/surgery ; Germany ; Humans ; Male ; Middle Aged ; Registries ; Retrospective Studies
    Language English
    Publishing date 2019-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639099-7
    ISSN 1531-2291 ; 0890-5339
    ISSN (online) 1531-2291
    ISSN 0890-5339
    DOI 10.1097/BOT.0000000000001406
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    Zs.A 2234: Show issues Location:
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  8. Book ; Article ; Online: Effects of regional meteorological and air conditions on community-acquired pneumonia

    Brenner, Thomas / Link, Ann-Christine / Reudenbach, Christoph / Pott, Hendrik / Rupp, Jan / Witzenrath, Martin / Rohde, Gernot / Pletz, Mathias / Bertrams, Wilhelm / Schmeck, Bernd

    Examining the interaction of individual, meteorological, and air characteristics

    2022  

    Abstract: Climate change will further increase not only the frequency but also the intensity of extreme weather events. As a result, weather conditions favouring pneumonia occurrence - suddenly warmer weather during cold seasons - can increase due to higher ... ...

    Abstract Climate change will further increase not only the frequency but also the intensity of extreme weather events. As a result, weather conditions favouring pneumonia occurrence - suddenly warmer weather during cold seasons - can increase due to higher meteorological variability which is also linked with climate change. These meteorological trends are expected to lead to adverse effects on peoples' health (Sohn et al., 2019). Community-acquired pneumonia, in the following simply called pneumonia, is one of the most common causes of death worldwide (Aliberti et al., 2021). At the same time, clear linkages between this disease and both meteorological and air conditions are present (Wang et al., 2021). Consequently, it is crucial to understand the effect of these meteorological and air conditions on pneumonia cases more deeply but also more specifically how these effects interact and depend on the personal characteristics and medical backgrounds of patients. It is well studied that especially extreme weather and air conditions, the latter including air quality and wind conditions, have an impact on the number of people hospitalized for pneumonia (Y. Liu et al., 2014; Onozuka et al., 2009). However, many studies analyse the effects of meteorological and air conditions separately with mortality data as an endpoint while predominantly covering the Asian continent and specifically larger cities (Basu & Samet, 2002; Chung et al., 2009; Ge et al., 2013). Therefore, data on other geographical regions and combinations of rural and metropolitan areas are required. Additionally, little is known about how personal characteristics (age, sex) and health background (smoking history, chronic lung diseases, heart insufficiency, overweight) affect the sensitivity of pneumonia cases regarding meteorological and air conditions. We close this research gap by analysing a prospective multicenter cohort that was treated in an in- or outpatient setting for pneumonia in 22 German hospitals or outpatient clinics. The dataset contains ...
    Keywords ddc:330 ; I10 ; Q53 ; Q54 ; R10 ; pneumonia ; climate change ; meteorology ; air conditions ; Germany
    Subject code 333
    Language English
    Publisher Marburg: Philipps-University Marburg, Department of Geography
    Publishing country de
    Document type Book ; Article ; Online
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  9. Article ; Online: Familial Cerebellar Ataxia and Amyotrophic Lateral Sclerosis/Frontotemporal Dementia with DAB1 and C9ORF72 Repeat Expansions: An 18-Year Study.

    Rosenbohm, Angela / Pott, Hendrik / Thomsen, Mirja / Rafehi, Haloom / Kaya, Sabine / Szymczak, Silke / Volk, Alexander E / Mueller, Kathrin / Silveira, Isabel / Weishaupt, Jochen H / Tönnies, Holger / Seibler, Philip / Zschiedrich, Katja / Schaake, Susen / Westenberger, Ana / Zühlke, Christine / Depienne, Christel / Trinh, Joanne / Ludolph, Albert C /
    Klein, Christine / Bahlo, Melanie / Lohmann, Katja

    Movement disorders : official journal of the Movement Disorder Society

    2022  Volume 37, Issue 12, Page(s) 2427–2439

    Abstract: Background: Coding and noncoding repeat expansions are an important cause of neurodegenerative diseases.: Objective: This study determined the clinical and genetic features of a large German family that has been followed for almost 2 decades with an ... ...

    Abstract Background: Coding and noncoding repeat expansions are an important cause of neurodegenerative diseases.
    Objective: This study determined the clinical and genetic features of a large German family that has been followed for almost 2 decades with an autosomal dominantly inherited spinocerebellar ataxia (SCA) and independent co-occurrence of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
    Methods: We carried out clinical examinations and telephone interviews, reviewed medical records, and performed magnetic resonance imaging and positron emission tomography scans of all available family members. Comprehensive genetic investigations included linkage analysis, short-read genome sequencing, long-read sequencing, repeat-primed polymerase chain reaction, and Southern blotting.
    Results: The family comprises 118 members across seven generations, 30 of whom were definitely and five possibly affected. In this family, two different pathogenic mutations were found, a heterozygous repeat expansion in C9ORF72 in four patients with ALS/FTD and a heterozygous repeat expansion in DAB1 in at least nine patients with SCA, leading to a diagnosis of DAB1-related ataxia (ATX-DAB1; SCA37). One patient was affected by ALS and SCA and carried both repeat expansions. The repeat in DAB1 had the same configuration but was larger than those previously described ([ATTTT]
    Conclusion: We demonstrate genetic and clinical findings during an 18-year period in a unique family carrying two different pathogenic repeat expansions, providing novel insights into their genotypic and phenotypic spectrums. © 2022 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
    MeSH term(s) Humans ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/genetics ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/genetics ; C9orf72 Protein/genetics ; DNA Repeat Expansion/genetics ; Cerebellar Ataxia/genetics ; Spinocerebellar Ataxias/genetics ; Nerve Tissue Proteins/genetics ; Adaptor Proteins, Signal Transducing/genetics
    Chemical Substances C9orf72 Protein ; DAB1 protein, human ; Nerve Tissue Proteins ; Adaptor Proteins, Signal Transducing ; C9orf72 protein, human
    Language English
    Publishing date 2022-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 607633-6
    ISSN 1531-8257 ; 0885-3185
    ISSN (online) 1531-8257
    ISSN 0885-3185
    DOI 10.1002/mds.29221
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