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Article ; Online: Identification of biomarker candidates for exfoliative glaucoma from autoimmunity profiling.

Potter, Ryan / Ayala, Marcelo / Tilevik, Andreas

2024 Volume 24, Issue 1, Page(s) 44

Abstract: Background: Exfoliative glaucoma (XFG) is a subtype of open-angle glaucoma characterized by distinctive extracellular fibrils and a yet unknown pathogenesis potentially involving immune-related factors. The aim of this exploratory study was to identify ... ...

Abstract	Background: Exfoliative glaucoma (XFG) is a subtype of open-angle glaucoma characterized by distinctive extracellular fibrils and a yet unknown pathogenesis potentially involving immune-related factors. The aim of this exploratory study was to identify biomarkers for XFG using data from autoimmunity profiling performed on blood samples from a Scandinavian cohort of patients. Methods: Autoantibody screening was analyzed against 258 different protein fragments in blood samples taken from 30 patients diagnosed with XFG and 30 healthy donors. The 258 protein fragments were selected based on a preliminary study performed on 3072 randomly selected antigens and antigens associated with the eye. The "limma" package was used to perform moderated t-tests on the proteomic data to identify differentially expressed reactivity between the groups. Results: Multiple associated genes were highlighted as possible biomarker candidates including FUT2, CDH5, and the LOX family genes. Using seven variables, our binary logistic regression model was able to classify the cases from the controls with an AUC of 0.85, and our reduced model using only one variable corresponding to the FUT2 gene provided an AUC of 0.75, based on LOOCV. Furthermore, over-representation gene analysis was performed to identify pathways that were associated with antigens differentially bound to self-antibodies. This highlighted the enrichment of pathways related to collagen fibril formation and the regulatory molecules mir-3176 and mir-876-5p. Conclusions: This study suggests several potential biomarkers that may be useful in developing further models of the pathology of XFG. In particular, CDH5, FUT2, and the LOX family seem to have a relationship which merits additional exploration.
MeSH term(s)	Humans ; Glaucoma, Open-Angle/diagnosis ; Proteomics ; Autoimmunity ; Exfoliation Syndrome/genetics ; Exfoliation Syndrome/diagnosis ; Biomarkers ; MicroRNAs
Chemical Substances	Biomarkers ; MIRN876 microRNA, human ; MicroRNAs
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-024-03314-y
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Article ; Online: Early Childhood Obesity Prevention: Challenges and Barriers of Implementing Child and Adult Care Food.

White, Elizabeth / Potter, Ryan / Rasmussen, Cary / Kleven, Jennifer

WMJ : official publication of the State Medical Society of Wisconsin

2020 Volume 119, Issue 2, Page(s) 110–114

Abstract: Introduction: The Child and Adult Care Food Program requirements promote healthy eating behaviors and increased physical activity in the daycare setting to help prevent childhood obesity. Some of these standards can be difficult to meet for early ... ...

Abstract	Introduction: The Child and Adult Care Food Program requirements promote healthy eating behaviors and increased physical activity in the daycare setting to help prevent childhood obesity. Some of these standards can be difficult to meet for early childhood education centers. This study examines the challenges and barriers daycare centers face when implementing these guidelines. Methods: Focus groups consisting of participants from early childhood education centers within our community were conducted in April and May of 2018. Results: Three focus groups were conducted, with a total of 7 childcare center directors. Eight themes that affect nutrition and physical activity curriculums at early childhood education centers arose: teacher philosophy and involvement, training/expertise of staff, parental involvement, financial constraints, children's interests, food availability, physical environment, and regulations/guidelines. Overall, participants expressed their sense that child care facilities are undervalued. They agreed that healthy, fresh food choices are expensive, difficult to obtain due to the volume needed, and require additional training to prepare. Emphasis on gross motor development has a varied level of support from families and teachers. Challenges and barriers to providing adequate gross motor activities include limited financial support, lack of physical space, lack of teacher willingness to engage in outdoor activity, and parental resistance. Conclusions: Financial constraints and the "undervaluing" of childcare contribute greatly to many of the challenges and barriers early childhood education centers face in meeting nutrition and physical activity standards. Findings from this study shed light on the significant role early childcare centers play in nurturing child development and the efforts these centers undertake in the interest of children.
Language	English
Publishing date	2020-07-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	441051-8
ISSN	2379-3961 ; 0043-6542 ; 1098-1861
ISSN (online)	2379-3961
ISSN	0043-6542 ; 1098-1861
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Article: Introducing debriefing post-cardiac arrest at University Hospitals Dorset NHS Foundation Trust: a QI project.

La, Chuiki Jasmine / Charan, Mahima / Eden, Pat / Ridout, Luke / Potter, Ryan / White, Nigel

Future healthcare journal

2022 Volume 9, Issue Suppl 2, Page(s) 89–90

Language	English
Publishing date	2022-10-05
Publishing country	England
Document type	Journal Article
ZDB-ID	3016427-8
ISSN	2514-6653 ; 2514-6645
ISSN (online)	2514-6653
ISSN	2514-6645
DOI	10.7861/fhj.9-2-s89
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Article ; Online: Can rescuers accurately deliver subtle changes to chest compression depth if recommended by future guidelines?

Deakin, Charles D / Sidebottom, David B / Potter, Ryan

Resuscitation

2018 Volume 124, Page(s) 58–62

Abstract: Background: A recent study reported that a compression depth of 4.56 cm optimised survival following cardiac arrest, which is at variance with the current guidelines of 5.0-6.0 cm. A reduction in recommended compression depth is only likely to improve ... ...

Abstract	Background: A recent study reported that a compression depth of 4.56 cm optimised survival following cardiac arrest, which is at variance with the current guidelines of 5.0-6.0 cm. A reduction in recommended compression depth is only likely to improve survival if healthcare professionals can accurately deliver a relatively small change in target depth. This study aimed to determine if healthcare professionals could accurately judge their delivered compression depth by 0.5 cm increments. Method: This randomised interventional trial asked BLS-trained healthcare professionals to complete two minutes of continuous chest compressions on an adult manikin, randomised (without any feedback device), to compress to one of three target depth ranges of 4.0-5.0 cm, 4.5-5.5 cm or 5.0-6.0 cm, at the recommended rate of 100-120 compressions min Results: One hundred and one participants were recruited, of whom one withdrew. Median depths of 3.66 cm (IQR: 3.37-4.16 cm), 4.13 cm (IQR: 3.65-4.36 cm) and 4.76 cm (IQR: 4.16-5.24 cm) were found for the target depths of 4.0-5.0 cm (n = 30), 4.5-5.5 cm (n = 35) and 5.0-6.0 cm (n = 35) respectively (P < 0.001). Overall, 18 participants successfully compressed to their target depth. Conclusions: Rescuers are able to judge 0.5 cm differences in compression depth with precision, but remain unable to accurately judge overall target depth. Reducing the current recommended compression depth to 4.56 cm is likely to result in delivered compressions significantly below the optimal depth.
MeSH term(s)	Cardiopulmonary Resuscitation/methods ; Cardiopulmonary Resuscitation/standards ; Clinical Competence ; Female ; Heart Massage/standards ; Humans ; Male ; Manikins ; Practice Guidelines as Topic ; Prospective Studies
Language	English
Publishing date	2018-01-05
Publishing country	Ireland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2018.01.010
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Article: Aging impairs the osteocytic regulation of collagen integrity and bone quality.

Schurman, Charles A / Kaya, Serra / Dole, Neha / Luna, Nadja M Maldonado / Castillo, Natalia / Potter, Ryan / Rose, Jacob P / Bons, Joanna / King, Christina D / Burton, Jordan B / Schilling, Birgit / Melov, Simon / Tang, Simon / Schaible, Eric / Alliston, Tamara

Bone research

2024 Volume 12, Issue 1, Page(s) 13

Abstract: Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are thought to be primarily determined by osteocytes. We ... ...

Abstract	Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are thought to be primarily determined by osteocytes. We hypothesize that the age-related decline in bone quality results from the suppression of osteocyte perilacunar/canalicular remodeling (PLR), which maintains bone material properties. We examined bones from young and aged mice with osteocyte-intrinsic repression of TGFβ signaling (TβRII
MeSH term(s)	Humans ; Aged ; Male ; Animals ; Mice ; Osteocytes ; Bone Remodeling/physiology ; Collagen/pharmacology ; Aging ; Transforming Growth Factor beta/pharmacology
Chemical Substances	Collagen (9007-34-5) ; Transforming Growth Factor beta
Language	English
Publishing date	2024-02-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2803313-9
ISSN	2095-6231 ; 2095-4700
ISSN (online)	2095-6231
ISSN	2095-4700
DOI	10.1038/s41413-023-00303-7
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Article ; Online: Micro RNA-411 Expression Improves Cardiac Phenotype Following Myocardial Infarction in Mice.

Nugroho, Ardiansah Bayu / Stafford, Nicholas / Zi, Min / Prehar, Sukhpal / Potter, Ryan / Kwon, Dowan / Kohar, Yulia Suciati / Triastuti, Efta / Bui, Thuy Anh / Cartwright, Elizabeth J / Oceandy, Delvac

JACC. Basic to translational science

2022 Volume 7, Issue 9, Page(s) 859–875

Abstract: Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ... ...

Abstract	Induction of endogenous regenerative capacity has emerged as one promising approach to repair damaged hearts following myocardial infarction (MI). Re-expression of factors that are exclusively expressed during embryonic development may reactivate the ability of adult cardiomyocytes to regenerate. Here, we identified miR-411 as a potent inducer of cardiomyocyte proliferation. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a model MI. We found that miR-411 enhances the activity of YAP, the main downstream effector of the Hippo pathway, in cardiomyocytes. In conclusion, miR-411 induces cardiomyocyte regeneration and improves cardiac function post-MI likely by modulating the Hippo/YAP pathway.
Language	English
Publishing date	2022-08-17
Publishing country	United States
Document type	Journal Article
ISSN	2452-302X
ISSN (online)	2452-302X
DOI	10.1016/j.jacbts.2022.05.008
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Article ; Online: Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

Saxton, Sophie N / Whitley, Alice S / Potter, Ryan J / Withers, Sarah B / Grencis, Richard / Heagerty, Anthony M

American journal of physiology. Heart and circulatory physiology

2020 Volume 319, Issue 6, Page(s) H1387–H1397

Abstract: Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development of ... ...

Abstract	Perivascular adipose tissue (PVAT) depots are metabolically active and play a major vasodilator role in healthy lean individuals. In obesity, they become inflamed and eosinophil-depleted and the anticontractile function is lost with the development of diabetes and hypertension. Moreover, eosinophil-deficient ΔdblGATA-1 mice lack PVAT anticontractile function and exhibit hypertension. Here, we have investigated the effects of inducing eosinophilia on PVAT function in health and obesity. Control, obese, and ΔdblGATA-1 mice were administered intraperitoneal injections of interleukin-33 (IL-33) for 5 days. Conscious restrained blood pressure was measured, and blood was collected for glucose and plasma measurements. Wire myography was used to assess the contractility of mesenteric resistance arteries. IL-33 injections induced a hypereosinophilic phenotype. Obese animals had significant elevations in blood pressure, blood glucose, and plasma insulin, which were normalized with IL-33. Blood glucose and insulin levels were also lowered in lean treated mice. In arteries from control mice, PVAT exerted an anticontractile effect on the vessels, which was enhanced with IL-33 treatment. In obese mice, loss of PVAT anticontractile function was rescued by IL-33. Exogenous application of IL-33 to isolated arteries induced a rapidly decaying endothelium-dependent vasodilation. The therapeutic effects were not seen in IL-33-treated ΔdblGATA-1 mice, thereby confirming that the eosinophil is crucial. In conclusion, IL-33 treatment restored PVAT anticontractile function in obesity and reversed development of hypertension, hyperglycemia, and hyperinsulinemia. These data suggest that targeting eosinophil numbers in PVAT offers a novel approach to the treatment of hypertension and type 2 diabetes in obesity.
MeSH term(s)	Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue/physiopathology ; Animals ; Arterial Pressure/drug effects ; Blood Glucose/drug effects ; Blood Glucose/metabolism ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/prevention & control ; Disease Models, Animal ; Eosinophils/drug effects ; Eosinophils/metabolism ; GATA1 Transcription Factor/genetics ; GATA1 Transcription Factor/metabolism ; Hypertension/metabolism ; Hypertension/physiopathology ; Hypertension/prevention & control ; Hypoglycemic Agents/pharmacology ; Interleukin-33/pharmacology ; Male ; Mesenteric Arteries/drug effects ; Mesenteric Arteries/metabolism ; Mesenteric Arteries/physiopathology ; Mice, Inbred C57BL ; Mice, Knockout ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Obesity/drug therapy ; Obesity/metabolism ; Obesity/physiopathology ; Vasodilation/drug effects ; Vasodilator Agents/pharmacology
Chemical Substances	Blood Glucose ; GATA1 Transcription Factor ; Gata1 protein, mouse ; Hypoglycemic Agents ; Interleukin-33 ; Vasodilator Agents ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Nos3 protein, mouse (EC 1.14.13.39)
Language	English
Publishing date	2020-10-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603838-4
ISSN	1522-1539 ; 0363-6135
ISSN (online)	1522-1539
ISSN	0363-6135
DOI	10.1152/ajpheart.00491.2020
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Article ; Online: Saving lives with public access defibrillation: A deadly game of hide and seek.

Sidebottom, David B / Potter, Ryan / Newitt, Laura K / Hodgetts, Gillian A / Deakin, Charles D

Resuscitation

2018 Volume 128, Page(s) 93–96

Abstract: Background: Early defibrillation is a critical link in the chain of survival. Public access defibrillation (PAD) programmes utilising automated external defibrillators (AEDs) aim to decrease the time-to-first-shock, and improve survival from out-of- ... ...

Abstract	Background: Early defibrillation is a critical link in the chain of survival. Public access defibrillation (PAD) programmes utilising automated external defibrillators (AEDs) aim to decrease the time-to-first-shock, and improve survival from out-of-hospital cardiac arrest. Effective use of PADs requires rapid location of the device, facilitated by adequate signage. We aimed to therefore assess the quality of signage for PADs in the community. Method: From April 2017 to January 2018 we surveyed community PADs available for public use on the 'Save a Life' AED locator mobile application in and around Southampton, UK. Location and signage characteristics were collected, and the distance from the furthest sign to the AED was measured. Results: Researchers evaluated 201 separate PADs. All devices visited were included in the final analysis. No signage at all was present for 135 (67.2%) devices. Only 15/201 (7.5%) AEDs had signage at a distance from AED itself. In only 5 of these cases (2.5%) was signage mounted more than 5.0 m from the AED. When signage was present, 46 used 2008 ILCOR signage and 15 used 2006 Resuscitation Council (UK) signage. Signage visibility was partially or severely obstructed at 27/66 (40.9%) sites. None of the 45 GP surgeries surveyed used exterior signage or an exterior 24/7 access box. Conclusions: Current signage of PADs is poor and limits the device effectiveness by impeding public awareness and location of AEDs. Recommendations should promote visible signage within the operational radius of each AED.
MeSH term(s)	Cardiopulmonary Resuscitation/mortality ; Cross-Sectional Studies ; Defibrillators/supply & distribution ; England/epidemiology ; Humans ; Location Directories and Signs/statistics & numerical data ; Out-of-Hospital Cardiac Arrest/mortality ; Out-of-Hospital Cardiac Arrest/therapy ; Quality Improvement ; Surveys and Questionnaires ; Time Factors ; Time-to-Treatment
Language	English
Publishing date	2018-04-11
Publishing country	Ireland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2018.04.006
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Article ; Online: The developing shoulder has a limited capacity to recover after a short duration of neonatal paralysis.

Potter, Ryan / Havlioglu, Necat / Thomopoulos, Stavros

Journal of biomechanics

2014 Volume 47, Issue 10, Page(s) 2314–2320

Abstract: Mechanical stimuli are required for the proper development of the musculoskeletal system. Removal of muscle forces during fetal or early post-natal timepoints impairs the formation of bone, tendon, and their attachment (the enthesis). The goal of the ... ...

Abstract	Mechanical stimuli are required for the proper development of the musculoskeletal system. Removal of muscle forces during fetal or early post-natal timepoints impairs the formation of bone, tendon, and their attachment (the enthesis). The goal of the current study was to examine the capacity of the shoulder to recover after a short duration of neonatal rotator cuff paralysis, a condition mimicking the clinical condition neonatal brachial plexus palsy. We asked if reapplication of muscle load to a transiently paralyzed muscle would allow for full recovery of tissue properties. CD-1 mice were injected with botulinum toxin A to paralyze the supraspinatus muscle from birth through 2 weeks and subsequently allowed to recover. The biomechanics of the enthesis was determined using tensile testing and the morphology of the shoulder joint was determined using microcomputed tomography and histology. A recovery period of at least 10 weeks was required to achieve control properties, demonstrating a limited capacity of the shoulder to recover after only two weeks of muscle paralysis. Although care must be taken when extrapolating results from an animal model to the human condition, the results of the current study imply that treatment of neonatal brachial plexus palsy should be aggressive, as even short periods of paralysis could lead to long-term deficiencies in enthesis biomechanics and shoulder morphology.
MeSH term(s)	Animals ; Biomechanical Phenomena ; Bone and Bones/pathology ; Botulinum Toxins, Type A ; Brachial Plexus Neuropathies/physiopathology ; Mice ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/physiology ; Muscles/pathology ; Paralysis/chemically induced ; Paralysis/physiopathology ; Rotator Cuff/pathology ; Shoulder/growth & development ; Shoulder Joint/pathology ; Stress, Mechanical ; Tendons/pathology ; X-Ray Microtomography
Chemical Substances	Botulinum Toxins, Type A (EC 3.4.24.69)
Language	English
Publishing date	2014-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218076-5
ISSN	1873-2380 ; 0021-9290
ISSN (online)	1873-2380
ISSN	0021-9290
DOI	10.1016/j.jbiomech.2014.04.036
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Article ; Online: Fragile X testing as a second-tier test.

Hartley, Taila / Potter, Ryan / Badalato, Lauren / Smith, Amanda C / Jarinova, Olga / Boycott, Kym M

Genetics in medicine : official journal of the American College of Medical Genetics

2017 Volume 19, Issue 12

MeSH term(s)	Fragile X Syndrome/genetics ; Genetic Testing
Language	English
Publishing date	2017-09-14
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1455352-1
ISSN	1530-0366 ; 1098-3600
ISSN (online)	1530-0366
ISSN	1098-3600
DOI	10.1038/gim.2017.147
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