LIVIVO - Search results -

Search results

Result 1 - 9 of total 9

Search options

Book ; Online: Green Is the New Red

Potter, Will

An Insider's Account of a Social Movement Under Siege

2011

Abstract: An insider tells how environmentalists and animal rights activists have become "the number one domestic terrorism ... ...

Abstract	An insider tells how environmentalists and animal rights activists have become "the number one domestic terrorism threat
Language	English
Size	Online-Ressource (475 p.)
Publisher	City Lights Publishers
Publishing place	New York
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780872865389 ; 087286538X
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Large-scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management.

Page, Andrew J / Mather, Alison E / Le-Viet, Thanh / Meader, Emma J / Alikhan, Nabil-Fareed / Kay, Gemma L / de Oliveira Martins, Leonardo / Aydin, Alp / Baker, David J / Trotter, Alexander J / Rudder, Steven / Tedim, Ana P / Kolyva, Anastasia / Stanley, Rachael / Yasir, Muhammad / Diaz, Maria / Potter, Will / Stuart, Claire / Meadows, Lizzie /

Bell, Andrew / Gutierrez, Ana Victoria / Thomson, Nicholas M / Adriaenssens, Evelien M / Swingler, Tracey / Gilroy, Rachel A J / Griffith, Luke / Sethi, Dheeraj K / Aggarwal, Dinesh / Brown, Colin S / Davidson, Rose K / Kingsley, Robert A / Bedford, Luke / Coupland, Lindsay J / Charles, Ian G / Elumogo, Ngozi / Wain, John / Prakash, Reenesh / Webber, Mark A / Smith, S J Louise / Chand, Meera / Dervisevic, Samir / O'Grady, Justin / The Covid-Genomics Uk Cog-Uk Consortium

Microbial genomics

2021 Volume 7, Issue 6

Abstract: The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3200 cases were reported between March and ...

Abstract	The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3200 cases were reported between March and August 2020. As part of the activities of the national COVID-19 Genomics Consortium (COG-UK) we undertook whole genome sequencing of the SARS-CoV-2 genomes present in positive clinical samples from the Norfolk region. These samples were collected by four major hospitals, multiple minor hospitals, care facilities and community organizations within Norfolk and surrounding areas. We combined clinical metadata with the sequencing data from regional SARS-CoV-2 genomes to understand the origins, genetic variation, transmission and expansion (spread) of the virus within the region and provide context nationally. Data were fed back into the national effort for pandemic management, whilst simultaneously being used to assist local outbreak analyses. Overall, 1565 positive samples (172 per 100 000 population) from 1376 cases were evaluated; for 140 cases between two and six samples were available providing longitudinal data. This represented 42.6 % of all positive samples identified by hospital testing in the region and encompassed those with clinical need, and health and care workers and their families. In total, 1035 cases had genome sequences of sufficient quality to provide phylogenetic lineages. These genomes belonged to 26 distinct global lineages, indicating that there were multiple separate introductions into the region. Furthermore, 100 genetically distinct UK lineages were detected demonstrating local evolution, at a rate of ~2 SNPs per month, and multiple co-occurring lineages as the pandemic progressed. Our analysis: identified a discrete sublineage associated with six care facilities; found no evidence of reinfection in longitudinal samples; ruled out a nosocomial outbreak; identified 16 lineages in key workers which were not in patients, indicating infection control measures were effective; and found the D614G spike protein mutation which is linked to increased transmissibility dominates the samples and rapidly confirmed relatedness of cases in an outbreak at a food processing facility. The large-scale genome sequencing of SARS-CoV-2-positive samples has provided valuable additional data for public health epidemiology in the Norfolk region, and will continue to help identify and untangle hidden transmission chains as the pandemic evolves.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/pathology ; COVID-19/virology ; Cluster Analysis ; Disease Outbreaks ; Genetic Linkage ; Genome, Viral ; Humans ; Longitudinal Studies ; Pandemics ; Phylogeny ; Polymorphism, Single Nucleotide ; SARS-CoV-2/classification ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics ; United Kingdom/epidemiology ; Whole Genome Sequencing
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835258-0
ISSN	2057-5858 ; 2057-5858
ISSN (online)	2057-5858
ISSN	2057-5858
DOI	10.1099/mgen.0.000589
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Large scale sequencing of SARS-CoV-2 genomes from one region allows detailed epidemiology and enables local outbreak management

Page, Andrew J / Mather, Alison E / Le Viet, Thanh / Meader, Emma J / Alikhan, Nabil-Fareed J / Kay, Gemma L / de Oliveira Martins, Leonardo / Aydin, Alp / Baker, David J / Trotter, Alexander J. / Rudder, Steven / Tedim, Ana P / Kolyva, Anastasia / Stanley, Rachael / Diaz, Maria / Potter, Will / Stuart, Claire / Meadows, Lizzie / Bell, Andrew /

medRxiv

Abstract	The COVID-19 pandemic has spread rapidly throughout the world. In the UK, the initial peak was in April 2020; in the county of Norfolk (UK) and surrounding areas, which has a stable, low-density population, over 3,200 cases were reported between March and August 2020. As part of the activities of the national COVID-19 Genomics Consortium (COG-UK) we undertook whole genome sequencing of the SARS-CoV-2 genomes present in positive clinical samples from the Norfolk region. These samples were collected by four major hospitals, multiple minor hospitals, care facilities and community organisations within Norfolk and surrounding areas. We combined clinical metadata with the sequencing data from regional SARS-CoV-2 genomes to understand the origins, genetic variation, transmission and expansion (spread) of the virus within the region and provide context nationally. Data were fed back into the national effort for pandemic management, whilst simultaneously being used to assist local outbreak analyses. Overall, 1,565 positive samples (172 per 100,000 population) from 1,376 cases were evaluated; for 140 cases between two and six samples were available providing longitudinal data. This represented 42.6% of all positive samples identified by hospital testing in the region and encompassed those with clinical need, and health and care workers and their families. 1,035 cases had genome sequences of sufficient quality to provide phylogenetic lineages. These genomes belonged to 26 distinct global lineages, indicating that there were multiple separate introductions into the region. Furthermore, 100 genetically-distinct UK lineages were detected demonstrating local evolution, at a rate of ~2 SNPs per month, and multiple co-occurring lineages as the pandemic progressed. Our analysis: identified a sublineage associated with 6 care facilities; found no evidence of reinfection in longitudinal samples; ruled out a nosocomial outbreak; identified 16 lineages in key workers which were not in patients indicating infection control measures were effective; found the D614G spike protein mutation which is linked to increased transmissibility dominates the samples and rapidly confirmed relatedness of cases in an outbreak at a food processing facility. The large-scale genome sequencing of SARS-CoV-2-positive samples has provided valuable additional data for public health epidemiology in the Norfolk region, and will continue to help identify and untangle hidden transmission chains as the pandemic evolves.
Keywords	covid19
Language	English
Publishing date	2020-09-30
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.09.28.20201475
Database	COVID19

Full text online

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Book: Daily Dialogues

Carr, Herbert Montcalm / Potter, Will

colloquial English as spoken by the educated classes in England

1947

Author's details	by Herbert Montcalm Carr and Will Dadley-Potter
Language	English
Size	VIII, 184 S, 8°
Edition	10. ed.
Publisher	D.E.F.-Verl
Publishing place	Duisburg
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book: Daily Dialogues

Carr, Herbert Montcalm / Potter, Will

colloquial English as spoken by the educated classes in England

1947

Author's details	by Herbert Montcalm Carr and Will Dadley-Potter
Language	English
Size	VIII, 184 S, 8°
Edition	10. ed.
Publisher	D.E.F.-Verl
Publishing place	Duisburg
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book: Daily Dialogues

Carr, Herbert Montcalm / Dadley-Potter, Will / Potter, Will Dadley-

Conversational "King's English"

1949

Author's details	Herbert Montcalm Carr; Will Dadley-Potter
Size	186 S, 8
Edition	11. Ed
Publisher	D.E.F.-Verl
Publishing place	Duisburg
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Book: Daily Dialogues

Carr, H. M / Potter, Will

1938

Author's details	H. M. Carr ; Will Potter
Language	English
Size	241 S
Publisher	Elwert
Publishing place	Marburg
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

Volz, Erik / Hill, Verity / McCrone, John T. / Price, Anna / Jorgensen, David / O’Toole, Áine / Southgate, Joel / Johnson, Robert / Jackson, Ben / Nascimento, Fabricia F. / Rey, Sara M. / Nicholls, Samuel M. / Colquhoun, Rachel M. / da Silva Filipe, Ana / Shepherd, James / Pascall, David J. / Shah, Rajiv / Jesudason, Natasha / Li, Kathy /

Jarrett, Ruth / Pacchiarini, Nicole / Bull, Matthew / Geidelberg, Lily / Siveroni, Igor / Goodfellow, Ian / Loman, Nicholas J. / Pybus, Oliver G. / Robertson, Dave / Thomson, Emma C. / Rambaut, Andrew / Connor, Thomas R. / Koshy, Cherian / Wise, Emma / Cortes, Nick / Lynch, Jessica / Kidd, Stephen / Mori, Matilde / Fairley, Derek J. / Curran, Tanya / McKenna, James P. / Adams, Helen / Fraser, Christophe / Golubchik, Tanya / Bonsall, David / Moore, Catrin / Caddy, Sarah L. / Khokhar, Fahad A. / Wantoch, Michelle / Reynolds, Nicola / Warne, Ben / Maksimovic, Joshua / Spellman, Karla / McCluggage, Kathryn / John, Michaela / Beér, Robert / Afifi, Safiah / Morgan, Siân / Marchbank, Angela / Kitchen, C. / Gulliver, Huw / Merrick, Ian / Guest, Martyn / Munn, Robert / Workman, Trudy / Fuller, William / Bresner, Catherine / Snell, Luke B. / Charalampous, Themoula / Nebbia, Gaia / Batra, Rahul / Edgeworth, Jonathan / Robson, Samuel C. / Beckett, Angela / Loveson, Katie F. / Aanensen, David M. / Underwood, Anthony P. / Yeats, Corin A. / Abudahab, Khalil / Taylor, Ben E.W. / Menegazzo, Mirko / Clark, Gemma / Smith, Wendy / Khakh, Manjinder / Fleming, Vicki M. / Lister, Michelle M. / Howson-Wells, Hannah C. / Berry, Louise / Boswell, Tim / Joseph, Amelia / Willingham, Iona / Bird, Paul / Helmer, Thomas / Fallon, Karlie / Holmes, Christopher / Tang, Julian / Raviprakash, Veena / Campbell, Sharon / Sheriff, Nicola / Loose, Matthew W. / Holmes, Nadine / Moore, Christopher / Carlile, Matthew / Wright, Victoria / Sang, Fei / Debebe, Johnny / Coll, Francesc / Signell, Adrian W. / Betancor, Gilberto / Wilson, Harry D. / Feltwell, Theresa / Houldcroft, Charlotte J. / Eldirdiri, Sahar / Kenyon, Anita / Davis, Thomas / Pybus, Oliver / Du Plessis, L. / Zarebski, Alex / Raghwani, Jayna / Kraemer, Moritz / Francois, Sarah / Attwood, Stephen / Vasylyeva, Tetyana / Török, Estée / Hamilton, William L. / Goodfellow, Ian G. / Hall, Grant / Jahun, Aminu S. / Chaudhry, Yasmin / Hosmillo, Myra / Pinckert, Malte L. / Georgana, Iliana / Yakovleva, Anna / Meredith, Luke W. / Moses, S. / Lowe, Hannah / Ryan, Felicity / Fisher, Chloe L. / Awan, Ali R. / Boyes, John / Breuer, Judith / Harris, Kathryn Ann / Brown, Julianne Rose / Shah, Divya / Atkinson, Laura / Lee, Jack C.D. / Alcolea-Medina, Adela / Moore, Nathan / Cortes, Nicholas / Williams, Rebecca / Chapman, Michael R. / Levett, Lisa J. / Heaney, Judith / Smith, Darren L. / Bashton, Matthew / Young, Gregory R. / Allan, John / Loh, Joshua / Randell, Paul A. / Cox, Ali / Madona, Pinglawathee / Holmes, Alison / Bolt, Frances / Price, James / Mookerjee, Siddharth / Rowan, Aileen / Taylor, Graham P. / Ragonnet-Cronin, Manon / Johnson, Rob / Boyd, Olivia / Volz, Erik M. / Brunker, Kirstyn / Smollett, Katherine L. / Quick, Joshua / McMurray, Claire / Stockton, Joanne / Nicholls, Sam / Rowe, William / Poplawski, Radoslaw / Martinez-Nunez, Rocio T. / Mason, Jenifer / Robinson, Trevor I. / O'Toole, Elaine / Watts, Joanne / Breen, Cassie / Cowell, Angela / Ludden, Catherine / Sluga, Graciela / Machin, Nicholas W. / Ahmad, Shazaad S.Y. / George, Ryan P. / Halstead, Fenella / Sivaprakasam, Venkat / Shepherd, James G. / Asamaphan, Patawee / Niebel, Marc O. / Li, Kathy K. / Shah, Rajiv N. / Jesudason, Natasha G. / Parr, Yasmin A. / Tong, Lily / Broos, Alice / Mair, Daniel / Nichols, Jenna / Carmichael, Stephen N. / Nomikou, Kyriaki / Aranday-Cortes, Elihu / Johnson, NaTasha / Starinskij, Igor / Orton, Richard J. / Hughes, Joseph / Vattipally, Sreenu / Singer, Joshua B. / Hale, Antony D. / Macfarlane-Smith, Louissa R. / Harper, Katherine L. / Taha, Yusri / Payne, Brendan A.I. / Burton-Fanning, Shirelle / Waugh, Sheila / Collins, Jennifer / Eltringham, Gary / Templeton, Kate E. / McHugh, Martin P. / Dewar, Rebecca / Wastenge, Elizabeth / Dervisevic, Samir / Stanley, Rachael / Prakash, Reenesh / Stuart, Claire / Elumogo, Ngozi / Sethi, Dheeraj K. / Meader, Emma J. / Coupland, Lindsay J. / Potter, Will / Graham, Clive / Barton, Edward / Padgett, Debra / Scott, Garren / Swindells, Emma / Greenaway, Jane / Nelson, Andrew / Yew, Wen C. / Resende Silva, Paola C. / Andersson, Monique / Shaw, Robert / Peto, Timothy / Justice, Anita / Eyre, David / Crooke, Derrick / Hoosdally, Sarah / Sloan, Tim J. / Duckworth, Nichola / Walsh, Sarah / Chauhan, Anoop J. / Glaysher, Sharon / Bicknell, Kelly / Wyllie, Sarah / Butcher, Ethan / Elliott, Scott / Lloyd, Allyson / Impey, Robert / Levene, Nick / Monaghan, Lynn / Bradley, Declan T. / Allara, Elias / Pearson, Clare / Muir, Peter / Vipond, Ian B. / Hopes, Richard / Pymont, Hannah M. / Hutchings, Stephanie / Curran, Martin D. / Parmar, Surendra / Lackenby, Angie / Mbisa, Tamyo / Platt, Steven / Miah, Shâhjahân / Bibby, David / Manso, Carmen / Hubb, Jonathan / Chand, Meera / Dabrera, Gavin / Ramsay, Mary / Bradshaw, Daniel / Thornton, Alicia / Myers, Richard / Schaefer, Ulf / Groves, Natalie / Gallagher, Eileen / Lee, David / Williams, David / Ellaby, Nicholas / Harrison, Ian / Hartman, Hassan / Manesis, Nikos / Patel, Vineet / Bishop, Chloe / Chalker, Vicki / Osman, Husam / Bosworth, Andrew / Robinson, Esther / Holden, Matthew T.G. / Shaaban, Sharif / Birchley, Alec / Adams, Alexander / Davies, Alisha / Gaskin, Amy / Plimmer, Amy / Gatica-Wilcox, Bree / McKerr, Caoimhe / Moore, Catherine / Williams, Chris / Heyburn, David / De Lacy, Elen / Hilvers, Ember / Downing, Fatima / Shankar, Giri / Jones, Hannah / Asad, Hibo / Coombes, Jason / Watkins, Joanne / Evans, Johnathan M. / Fina, Laia / Gifford, Laura / Gilbert, Lauren / Graham, Lee / Perry, Malorie / Morgan, Mari / Cronin, Michelle / Craine, Noel / Jones, Rachel / Howe, Robin / Corden, Sally / Rey, Sara / Kumziene-Summerhayes, Sara / Taylor, Sarah / Cottrell, Simon / Jones, Sophie / Edwards, Sue / O’Grady, Justin / Page, Andrew J. / Wain, John / Webber, Mark A. / Mather, Alison E. / Baker, David J. / Rudder, Steven / Yāsir, Muḥammad / Thomson, Nicholas M. / Aydin, Alp / Tedim, Ana P. / Kay, Gemma L. / Trotter, Alexander J. / Gilroy, Rachel A.J. / Alikhan, Nabil-Fareed / de Oliveira Martins, Leonardo / Le-Viet, Thanh / Meadows, Lizzie / Kolyva, Anastasia / Diaz, Maria / Bell, Andrew / Gutierrez, Ana Victoria / Charles, Ian G. / Adriaenssens, Evelien M. / Kingsley, Robert A. / Casey, Anna / Simpson, D. A. / Molnár, Zoltán / Thompson, Thomas / Acheson, Erwan / Masoli, Jane A.H. / Knight, Bridget A. / Hattersley, Andrew / Ellard, Sian / Auckland, Cressida / Mahungu, Tabitha W. / Irish-Tavares, Dianne / Haque, Tanzina / Bourgeois, Yann / Scarlett, Garry P. / Partridge, David G. / Raza, Mohammad / Evans, Cariad / Johnson, Kate / Liggett, Steven / Baker, Paul / Essex, Sarah / Lyons, Ronan A. / Caller, Laura G. / Castellano, Sergi / Williams, Rachel J. / Kristiansen, Mark / Roy, Sunando / Williams, Charlotte A. / Dyal, Patricia L. / Tutill, Helena J. / Panchbhaya, Yasmin N. / Forrest, Leysa M. / Niola, Paola / Findlay, Jacqueline / Brooks, Tony T. / Gavriil, Artemis / Mestek-Boukhibar, Lamia / Weeks, Sam / Pandey, Sarojini / Berry, Lisa / Jones, K. E. / Richter, Alex / Beggs, Andrew / Smith, Colin P. / Bucca, Giselda / Hesketh, Andrew R. / Harrison, Ewan M. / Peacock, Sharon J. / Eser, Sophie / Churcher, Carol M. / Bellis, Katherine L. / Girgis, Sophia T. / Naydenova, Plamena / Blane, Beth / Sridhar, Sushmita / Ruis, Chris / Forrest, Sally / Cormie, Claire / Gill, Harmeet K. / Dias, Joana / Higginson, Ellen E. / Maes, Mailis / Young, Jamie / Kermack, Leanne M. / Hadjirin, Nazreen F. / Aggarwal, Dinesh / Griffith, Luke / Swingler, Tracey / Davidson, Rose K. / Williams, Thomas / Balcazar, Carlos E. / Gallagher, Michael D. / O'Toole, Áine / Rooke, Stefan / Colquhoun, Rachel / Ashworth, Jordan / McCrone, J.T. / Scher, Emily / Yu, Xiaoyu / Williamson, Kathleen A. / Stanton, Thomas D. / Michell, Stephen L. / Bewshea, Claire M. / Temperton, Ben / Michelsen, Michelle L. / Warwick-Dugdale, Joanna / Manley, Robin / Farbos, Audrey / Harrison, James W. / Sambles, Christine M. / Studholme, David J. / Jeffries, Aaron R. / Darby, Alistair C. / Hiscox, Julian A. / Paterson, Steve / Iturriza-Gomara, Miren / Jackson, Kathryn A. / Lucaci, Anita O. / Vamos, Edith E. / Hughes, Margaret / Rainbow, Lucille / Eccles, Richard / Nelson, Charlotte / Whitehead, Mark / Turtle, Lance / Haldenby, Sam T. / Gregory, Richard / Gemmell, Matthew / Kwiatkowski, Dominic / de Silva, Thushan I. / Smith, Nikki / Angyal, Adrienn / Lindsey, Benjamin B. / Groves, Danielle C. / Green, Luke R. / Wang, Dennis / Freeman, Timothy M. / Parker, Matthew D. / Keeley, Alexander J. / Parsons, Paul J. / Tucker, Rachel M. / Brown, Rebecca / Wyles, Matthew / Constantinidou, Chrystala / Unnikrishnan, Meera / Ott, Sascha / Cheng, Jeffrey K.J. / Bridgewater, Hannah E. / Frost, Lucy R. / Taylor-Joyce, Grace / Stark, Richard / Baxter, Laura / Alam, Mohammad T. / Brown, Paul E. / McClure, Patrick C. / Chappell, Joseph G. / Tsoleridis, Theocharis / Ball, Jonathan / Gramatopoulos, Dimitris / Buck, David / Todd, John A. / Green, Angie / Trebes, Amy / MacIntyre-Cockett, George / de Cesare, Mariateresa / Langford, Cordelia / Alderton, Alex / Amato, Roberto / Goncalves, Sonia / Jackson, David K. / Johnston, Ian / Sillitoe, John / Palmer, Steve / Lawniczak, Mara / Berriman, Matt / Danesh, John / Livett, Rich / Shirley, Lesley / Farr, Ben / Quail, Mike / Thurston, Scott / Park, Naomi / Betteridge, Emma / Weldon, Danni / Goodwin, Scott / Nelson, Rachel / Beaver, Charlotte / Letchford, Laura / Jackson, David A. / Foulser, Luke / McMinn, Liz / Prestwood, Liam / Kay, Sally / Kane, Leanne / Dorman, Matthew J. / Martincorena, Inigo / Puethe, Christoph / Keatley, Jon-Paul / Tonkin-Hill, Gerry / Smith, Christen / Jamrozy, Dorota / Beale, Mathew A. / Patel, Minal / Ariani, Cristina / Spencer-Chapman, Michael / Drury, Eleanor / Lo, Stephanie / Rajatileka, Shavanthi / Scott, Carol / James, Keith / Buddenborg, Sarah K. / Berger, Duncan J. / Patel, Gaurang / Garcia-Casado, Maria V. / Dibling, Thomas / McGuigan, Samantha / Rogers, Hazel A. / Hunter, Adam D. / Souster, Emily / Neaverson, Alexandra S.

Cell. 2021 Jan. 07, v. 184, no. 1 p.64-75.e11

2021

Abstract: Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the ... ...

Institution	COG-UK Consortium
Abstract	Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; data collection ; founder effect ; genetic analysis ; genome ; mortality ; mutation ; pathogenicity ; phylogeny ; viral load ; United Kingdom ; COVID-19 ; SARS-CoV-2 ; evolution ; epidemiology ; spike
Language	English
Dates of publication	2021-0107
Size	p. 64-75.e11.
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	NAL-AP-2-clean
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.11.020
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 75/702: Show issues
Z 93: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

E., Alm / E. K., Broberg / T., Connor / E. B., Hodcroft / A. B., Komissarov / S., Maurer-Stroh / A., Melidou / R. A., Neher / A., O'Toole / Niko Beerenwinkel, Pereyaslov D. / Posada-Céspedes, Susana / Philipp Jablonski, Kim / Falé Ferreira, Pedro / Topolsky, Ivan / Avšič-Županc, Tatjana / Korva, Miša / Poljak, Mario / Zakotnik, Samo / Mark Zorec, Tomaž /

Bragstad, Karoline / Hungnes, Olav / Stene-Johansen, Kathrine / Reusken, Chantal / Meijer, Adam / Vennema, Harry / Ruiz-Roldán, Lidia / Alma Bracho, María / García-González, Neris / Chiner-Oms, Álvaro / Cancino-Muñoz, Irving / Comas, Iñaki / A Goig, Galo / Torres-Puente, Manuela / G López, Mariana / Martínez-Priego, Llúcia / D'Auria, Giuseppe / Ferrús-Abad, Loreto / de Marco, Griselda / Galan-Vendrell, Inmaculada / Carbó-Ramirez, Sandra / Ruíz-Hueso, Paula / Coscollá, Mireia / Polackova, Katerina / Kramna, Lenka / Cinek, Ondrej / Richter, Jan / Krashias, George / Tryfonos, Christina / Bashiardes, Stavros / Koptides, Dana / Christodoulou, Christina / Bartolini, Barbara / Em Gruber, Cesare / Di Caro, Antonino / Castilletti, Concetta / Stefani, Fabrizio / Giordana Rimoldi, Sara / Romeri, Francesca / Salerno, Franco / Polesello, Stefano / Nagy, Alexander / Jirincova, Helena / Vecerova, Jaromira / Novakova, Ludmila / Cordey, Samuel / Murtskhvaladze, Marine / Kotaria, Nato / Schär, Tobias / Beisel, Christian / Vugrek, Oliver / Rokić, Filip / Trgovec-Greif, Lovro / Jurak, Igor / Rukavina, Tomislav / Sučić, Neven / Schønning, Kristian / M Karst, Søren / H Kirkegaard, Rasmus / Y Michaelsen, Thomas / Aa Sørensen, Emil / Knutson, Simon / Brandt, Jakob / Le-Quy, Vang / Sørensen, Trine / Petersen, Celine / Schou Pedersen, Martin / Løkkegaard Larsen, Sanne / Nielsine Skov, Marianne / Rasmussen, Morten / Fonager, Jannik / Fomsgaard, Anders / Amirovich Maksyutov, Rinat / Vasil'Evna Gavrilova, Elena / Victorovich Pyankov, Oleg / Alexandrovich Bodnev, Sergey / Vladimirovna Tregubchak, Tatyana / Nikolayevich Shvalov, Alexander / Victorovich Antonets, Denis / Cristina Resende, Paola / Goya, Stephanie / Perrin, Amandine / Tc Lee, Raphael / Yadahalli, Shilpa / X Han, Alvin / A Russell, Colin / Schmutz, Stefan / Zaheri, Maryam / Kufner, Verena / Huber, Michael / Trkola, Alexandra / Antwerpen, Markus / C Walter, Mathias / van der Werf, Sylvie / Gambaro, Fabiana / Behillil, Sylvie / Enouf, Vincent / Donati, Flora / Ustinova, Monta / Rovite, Vita / Klovins, Janis / Savicka, Oksana / K Wienecke-Baldacchino, Anke / Ragimbeau, Catherine / Fournier, Guillaume / Mossong, Joël / W Aberle, Stephan / Haukland, Mattias / Enkirch, Theresa / Advani, Abdolreza / Lind Karlberg, Maria / Karlsson Lindsjö, Oskar / Broddesson, Sandra / Sláviková, Monika / Ličková, Martina / Klempa, Boris / Staroňová, Edita / Tichá, Elena / Szemes, Tomáš / Rusňáková, Diana / Stadler, Tanja / Quer, Josep / Anton, Andres / Andres, Cristina / Piñana, Maria / Garcia-Cehic, Damir / Pumarola, Tomas / Izopet, Jacques / Gioula, Georgia / Exindari, Maria / Papa, Anna / Chatzidimitriou, Dimitrios / Metallidis, Symeon / Pappa, Stella / Macek Jr, Milan / Geryk, Jan / Brož, Petr / Briksí, Aleš / Hubáček, Petr / Dřevínek, Pavel / Zajac, Miroslav / Kvapil, Petr / Holub, Michal / Kvapilová, Kateřina / Novotný, Adam / Kašný, Martin / Klempt, Petr / Vapalahti, Olli / Smura, Teemu / Sironen, Tarja / Selhorst, Philippe / Anthony, Colin / Ariën, Kevin / Simon-Loriere, Etienne / Rabalski, Lukasz / Bienkowska-Szewczyk, Krystyna / Borges, Vítor / Isidro, Joana / Paulo Gomes, João / Guiomar, Raquel / Pechirra, Pedro / Costa, Inês / Duarte, Sílvia / Vieira, Luís / Pyrc, Krzysztof / S Zuckerman, Neta / Turdikulova, Shahlo / Abdullaev, Alisher / Dalimova, Dilbar / Abdurakhimov, Abror / Tagliabracci, Adriano / Alessandrini, Federica / Melchionda, Filomena / Onofri, Valerio / Turchi, Chiara / Bagnarelli, Patrizia / Menzo, Stefano / Caucci, Sara / Di Sante, Laura / Popa, Alexandra / Genger, Jakob-Wendelin / Agerer, Benedikt / Lercher, Alexander / Endler, Lukas / Smyth, Mark / Penz, Thomas / Schuster, Michael / Senekowitsch, Martin / Laine, Jan / Bock, Christoph / Bergthaler, Andreas / Shevtsov, Alexandr / Kalendar, Ruslan / Ramanculov, Yerlan / Graf, Alexander / Muenchhoff, Maximilian / T Keppler, Oliver / Krebs, Stefan / Blum, Helmut / Marcello, Alessandro / Licastro, Danilo / D'Agaro, Pierlanfranco / Laubscher, Florian / Vidanovic, Dejan / Tesovic, Bojana / Volkening, Jeremy / Clementi, Nicola / Mancini, Nicasio / Rupnik, Maja / Mahnic, Aleksander / Walker, Andreas / Houwaart, Torsten / Wienemann, Tobias / Kohns Vasconcelos, Malte / Strelow, Daniel / Ole Jensen, Björn-Erik / Senff, Tina / Hülse, Lisanna / Adams, Ortwin / Andree, Marcel / Hauka, Sandra / Feldt, Torsten / Keitel, Verena / Kindgen-Milles, Detlef / Timm, Jörg / Pfeffer, Klaus / T Dilthey, Alexander / Moore, Catherine / Ozdarendeli, Aykut / Terkis Islam Pavel, Shaikh / Yetiskin, Hazel / Aydin, Gunsu / Holyavkin, Can / Ali Uygut, Muhammet / Cevik, Ceren / Shchetinin, Alexey / Gushchin, Vladimir / Dinler-Doganay, Gizem / Doganay, Levent / Kizilboga-Akgun, Tugba / Karacan, Ilker / Pancer, Katarzyna / Maes, Piet / Martí-Carreras, Joan / Wawina-Bokalanga, Tony / Vanmechelen, Bert / Thürmer, Andrea / Wedde, Marianne / Dürrwald, Ralf / Von Kleist, Max / Drechsel, Oliver / Wolff, Thorsten / Fuchs, Stephan / Kmiecinski, Rene / Michel, Janine / Nitsche, Andreas / Casas, Inmaculada / Iglesias Caballero, María / Zaballos, Ángel / Jiménez, Pilar / Jiménez, Mercedes / Monzón Fernández, Sara / Varona Fernández, Sarai / Cuesta De La Plaza, Isabel / Fadeev, Artem / Ivanova, Anna / Sergeeva, Mariia / Stefanelli, Paola / Estee Torok, M / Hall, Grant / da Silva Filipe, Ana / Turtle, Lance / Afifi, Safiah / Mccluggage, Kathryn / Beer, Robert / Ledesma, Juan / Maksimovic, Joshua / Spellman, Karla / L Hamilton, William / Marchbank, Angela / Alexander Southgate, Joel / Underwood, Anthony / Taylor, Ben / Yeats, Corin / Abudahab, Khalil / R Gemmell, Matthew / Eccles, Richard / Lucaci, Anita / Abigail Nelson, Charlotte / Rainbow, Lucille / Whitehead, Mark / Gregory, Richard / Haldenby, Sam / Paterson, Steve / A Hughes, Margaret / D Curran, Martin / Baker, David / Tucker, Rachel / R Green, Luke / Feltwell, Theresa / D Halstead, Fenella / Wyles, Matthew / S Jahun, Aminu / Y Ahmad, Shazaad S / Georgana, Iliana / Goodfellow, Ian / Yakovleva, Anna / W Meredith, Luke / Gavriil, Artemis / Raza Awan, Ali / Fisher, Chloe / Edgeworth, Jonathan / Lynch, Jessica / Moore, Nathan / Williams, Rebecca / P Kidd, Stephen / Cortes, Nicholas / Brunker, Kirstyn / T Mccrone, John / Quick, Joshua / Duckworth, Nichola / Walsh, Sarah / Sloan, Tim / Ludden, Catherine / P George, Ryan / Eltringham, Gary / R Brown, Julianne / Aranday-Cortes, Elihu / G Shepherd, James / Hughes, Joseph / K Li, Kathy / C Williams, Thomas / Johnson, Natasha / Jesudason, Natasha / Mair, Daniel / Thomson, Emma / Shah, Rajiv / A Parr, Yasmin / Carmichael, Stephen / L Robertson, David / Nomikou, Kyriaki / Broos, Alice / Niebel, Marc / Smollett, Katherine / Tong, Lily / Miah, Shahjahan / Wittner, Anita / Phillips, Nicole / Payne, Brendan / Dewar, Rebecca / Holmes, Alison / Bolt, Frances / R Price, James / Mookerjee, Siddharth / K Sethi, Dheeraj / Potter, Will / Stanley, Rachael / Prakash, Reenesh / Dervisevic, Samir / Clive Graham, Jonathan / Nelson, Andrew / Smith, Darren / R Young, Gregory / Chyin Yew, Wen / A Todd, John / Trebes, Amy / Andersson, Monique / Bull, Matthew / Watkins, Joanne / Birchley, Alec / Gatica-Wilcox, Bree / Gilbert, Lauren / Kumžiene-Summerhayes, Sara / Rey, Sara / Chauhan, Anoop / Butcher, Ethan / Bicknell, Kelly / Elliott, Scott / Glaysher, Sharon / Lackenby, Angie / Bibby, David / Platt, Steven / Mohamed, Hodan / William Machin, Nicholas / Lutamyo Mbisa, Jean / Evans, Jonathan / Perry, Malorie / Pacchiarini, Nicole / Corden, Sally / Geraint Adams, Alexander / Gaskin, Amy / Coombs, Jason / John Graham, Lee / Cottrell, Simon / Morgan, Mari / Gifford, Laura / Kolyva, Anastasia / John Rudder, Steven / J Trotter, Alexander / E Mather, Alison / Aydin, Alp / J Page, Andrew / L Kay, Gemma / de Oliveira Martins, Leonardo / Yasir, Muhammad / Alikhan, Nabil-Fareed / M Thomson, Nicholas / Gilroy, Rachel / A Kingsley, Robert / O'Grady, Justin / Victoria Gutierrez, Ana / Diaz, Maria / Le Viet, Thanh / P Tedim, Ana / M Adriaenssens, Evelien / Patrick Mcclure, C / Moore, Christopher / Sang, Fei / Clark, Gemma / C Howson-Wells, Hannah / Debebe, Johnny / Ball, Jonathan / Chappell, Joseph / Khakh, Manjinder / Carlile, Matthew / Loose, Matthew / M Lister, Michelle / Holmes, Nadine / Tsoleridis, Theocharis / M Fleming, Vicki / Wright, Victoria / Smith, Wendy / D Gallagher, Michael / Parker, Matthew / G Partridge, David / Evans, Cariad / Baker, Paul / Essex, Sarah / Liggett, Steven / J Keeley, Alexander / Bashton, Matthew / Rooke, Stefan / Jane Meader, Emma / Enrique Balcazar Lopez, Carlos / Angyal, Adrienn / Kristiansen, Mark / J Tutill, Helena / Findlay, Jacqueline / Mestek-Boukhibar, Lamia / Forrest, Leysa / Dyal, Patricia / J Williams, Rachel / Panchbhaya, Yasmin / A Williams, Charlotte / Roy, Sunando / Pandey, Sarojini / Stockton, Jo / J Loman, Nicholas / Poplawski, Radoslaw / Nicholls, Samuel / M Rowe, W P / Khokhar, Fahad / Lars Pinckert, Malte / Hosmillo, Myra / Chaudhry, Yasmin / G Caller, Laura / K Davidson, Rose / Griffith, Luke / Rambaut, Andrew / Jackson, Ben / Colquhoun, Rachel / Hill, Verity / Nichols, Jenna / Asamaphan, Patawee / Darby, Alistair / A Jackson, Kathryn / Iturriza-Gomara, Miren / Edith Vamos, Ecaterina / Green, Angie / Aanensen, David / Bonsall, David / Buck, David / Macintyre-Cockett, George / de Cesare, Mariateresa / Pybus, Oliver / Golubchik, Tanya / Scarlett, Garry / F Loveson, Katie / C Robson, Samuel / Beckett, Angela / Lindsey, Benjamin / C Groves, Danielle / J Parsons, Paul / P Mchugh, Martin / Daniel Barnes, James / F Manso, Carmen / Grammatopoulos, Dimitris / Elisabeth Menger, Katja / Harrison, Ewan / Gunson, Rory / J Peacock, Sharon / Gonzalez, Gabriel / Carr, Michael / Mihaela, Lazar / Popovici, Odette / Brytting, Mia / Bresner, Catherine / Fuller, William / Workman, Trudy / F Mentis, Andreas / Kossyvakis, Athanasios / Karamitros, Timokratis / Pogka, Vasiliki / Kalliaropoulos, Antonios / Horefti, Elina / Kontou, Aspasia / Martinez-Gonzalez, Beatriz / Labropoulou, Voula / Voulgari-Kokota, Androniki / Evangelidou, Maria / Bizta, Panagiota / Belimezi, Maria / Lambrechts, Laurens / Z Doymaz, Mehmet / Kalkan Yazici, Merve / S Cetin, Nesibe / Karaaslan, Elif / Kallio-Kokko, Hannimari / Virtanen, Jenni / Suvanto, Maija / Truong Nguyen, Phuoc / Ellonen, Pekka / Hannula, Sari / Kangas, Harri / B Sreenu, Vattipally / Burián, Katalin / Terhes, Gabriella / Gombos, Katalin / Gyenesei, Attila / Urbán, Péter / Herczeg, Róbert / Jakab, Ferenc / Kemenesi, Gábor / Endre Tóth, Gábor / Somogyi, Balázs / Zana, Brigitta / Zeghbib, Safia / Kuczmog, Anett / Földes, Fanni / Lanszki, Zsófia / Madai, Mónika / Papp, Henrietta / Nagy, Ágnes / István Pereszlényi, Csaba / Csaba Babinszky, Gergely / Dudás, Gábor / Csoma, Eszter / N Abou Tayoun, Ahmad / A Alsheikh-Ali, Alawi / Loney, Tom / Nowotny, Norbert / Abdul-Wahab, Osama / Gonzalez-Candelas, Fernando / H Andersen, Martin / Sarah Taylor, And

2020

Abstract: We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence ... ...

Abstract	We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2.
Keywords	COVID-19 ; Europe ; NGS ; nomenclature ; SARS-CoV-2 ; sequencing ; WGS ; Base Sequence ; Betacoronavirus ; Coronavirus ; Coronavirus Infections ; Genome ; Viral ; Humans ; Phylogeography ; Pneumonia ; RNA Replicase ; RNA ; Severe Acute Respiratory Syndrome ; Spatio-Temporal Analysis ; World Health Organization ; Pandemics ; covid19
Language	English
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED