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Book ; Online: Cigarette Smoke and Oxidative Stress

Halliwell, Barry B. / Poulsen, Henrik E.

2006

Author's details	edited by Barry B. Halliwell, Henrik E. Poulsen
Keywords	Biochemistry ; Oncology ; Pneumology
Language	English
Publisher	Springer-Verlag GmbH
Publishing place	Berlin Heidelberg
Document type	Book ; Online
HBZ-ID	TT050387662
ISBN	978-3-540-31410-3 ; 978-3-540-32232-0 ; 3-540-31410-5 ; 3-540-32232-9
DOI	10.1007/3-540-32232-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Associations of urinary metabolites of oxidized DNA and RNA with the incidence of diabetes mellitus using UPLC-MS/MS and ELISA methods.

Schöttker, Ben / Larsen, Emil L / Weimann, Allan / Henriksen, Trine / Brenner, Hermann / Poulsen, Henrik E

Free radical biology & medicine

2022 Volume 183, Page(s) 51–59

Abstract: Background: To evaluate the association of urinary oxidized guanine/guanosine (OxGuo) levels with incident type 2 diabetes (T2D) among older adults.: Methods: A nested case-control design was applied with 440 cases of incident T2D and 440 controls, ... ...

Abstract	Background: To evaluate the association of urinary oxidized guanine/guanosine (OxGuo) levels with incident type 2 diabetes (T2D) among older adults. Methods: A nested case-control design was applied with 440 cases of incident T2D and 440 controls, randomly sampled from all 65-75 year-old study participants of the ESTHER study, which is a population-based German cohort study with 14 years of follow-up. Analyses of 8-hydroxy-2'-deoxyguanosine (8-oxo-dGuo; DNA oxidation product) and 8-hydroxyguanosine (8-oxo-Guo; RNA oxidation product) were measured by ultra-performance liquid chromatography tandem-mass spectrometry (UPLC-MS/MS). The sum of the two OxGuo molecule concentrations was calculated and called OxGuo-UPLC-MS/MS. The corresponding OxGuo-ELISA levels were measured by Cayman's DNA/RNA oxidative damage ELISA, which detects a mix of 8-oxo-dGuo, 8-oxo-Guo and one other OxGuo molecule. Logistic regression was applied and models were adjusted for age, sex, BMI, HbA Results: 8-oxo-dGuo and 8-oxo-Guo were highly correlated with each other (r = 0.642) and weakly correlated with OxGuo-ELISA (r = 0.22 and r = 0.14, respectively). OxGuo-ELISA levels were statistically significant associated with T2D incidence (odds ratio (OR) and 95% confidence interval [95%CI] for comparison of top and bottom quartile: 1.77 [1.14; 2.76]). In contrast, the ORs did not increase stepwise from quartile 2 to 4 for neither 8-oxo-Guo, 8-oxo-dGuo levels nor OxGuo-UPLC-MS/MS and comparisons of top and bottom quartile were not statistically significant. In a post-hoc analysis comparing bottom quartile 1 with a combined group of quartile 2-4, the association of OxGuo-UPLC-MS/MS with T2D incidence reached statistical significance (OR [95%CI]: 0.66 [0.46; 0.96]) and was very similar with the one obtained for OxGuo-ELISA (OR [95%CI]: 0.66 [0.45; 0.95]). Conclusions: Although only the measurements of the DNA/RNA oxidative damage ELISA kit of Cayman were statistically significantly associated with T2D incidence in the main analysis, confidence intervals overlapped and the post-hoc analysis showed that results for OxGuo-UPLC-MS/MS were quite comparable.
MeSH term(s)	Aged ; Biomarkers/urine ; Chromatography, High Pressure Liquid/methods ; Chromatography, Liquid/methods ; Cohort Studies ; DNA ; DNA Damage ; Deoxyguanosine/urine ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/epidemiology ; Enzyme-Linked Immunosorbent Assay ; Humans ; Incidence ; RNA/metabolism ; Tandem Mass Spectrometry/methods
Chemical Substances	Biomarkers ; RNA (63231-63-0) ; DNA (9007-49-2) ; Deoxyguanosine (G9481N71RO)
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2022.03.007
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Article ; Online: Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans.

Jorgensen, Anders / Brandslund, Ivan / Ellervik, Christina / Henriksen, Trine / Weimann, Allan / Andersen, Per Kragh / Poulsen, Henrik E

Aging cell

2023 Volume 22, Issue 6, Page(s) e13839

Abstract: Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause ... ...

Abstract	Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause mortality by a marker of systemic oxidation of RNA in patients with T2D (n = 2672) and in nondiabetic control subjects (n = 4079). The finding persisted after the adjustment of established modifiers of oxidative stress (including BMI, smoking, and glycated hemoglobin). In contrast, systemic levels of DNA damage from oxidation, which traditionally has been causally linked to both T2D and aging, failed to predict mortality. Strikingly, these findings were subsequently replicated in an independent general population study (n = 3649). The data demonstrate a specific importance of RNA damage from oxidation in T2D and general aging.
MeSH term(s)	Humans ; RNA/genetics ; RNA/metabolism ; Diabetes Mellitus, Type 2/genetics ; Oxidative Stress ; Aging/genetics ; DNA/metabolism ; DNA Damage/genetics
Chemical Substances	RNA (63231-63-0) ; DNA (9007-49-2)
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.13839
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Article ; Online: Tobacco smoking and oxidative stress to DNA: a meta-analysis of studies using chromatographic and immunological methods.

Ellegaard, Pernille K / Poulsen, Henrik E

Scandinavian journal of clinical and laboratory investigation

2016 Volume 76, Issue 2, Page(s) 151–158

Abstract: Oxidative stress to DNA from smoking was investigated in one randomized smoking cessation study and in 36 cohort studies from excretion of urinary 8-oxo-7-hydrodeoxyguanosine (8-oxodG). Meta-analysis of the 36 cohort studies showed smoking associated ... ...

Abstract	Oxidative stress to DNA from smoking was investigated in one randomized smoking cessation study and in 36 cohort studies from excretion of urinary 8-oxo-7-hydrodeoxyguanosine (8-oxodG). Meta-analysis of the 36 cohort studies showed smoking associated with a 15.7% (95% CL 11.0:20.3, p < 0.0001) increased oxidative stress to DNA, in agreement with the reduction of oxidative stress to DNA found in the smoking cessation study. Meta-analysis of the 22 studies that used chromatography methodology on 1709 persons showed a significant 29.3% increase in smokers (95% CL 17.3;41.3), but meta-analysis of 14 studies on 3668 persons using ELISA methodology showed a non-significant effect of 8.7% [95% CL -1.2;18.6]. Tobacco smoke induces oxidative damage to DNA; however, this is not detected with ELISA methodology. Currently, the use of existing ELISA methodology to measure urinary excretion of 8-oxo-7-hydrodeoxyguanosine cannot be recommended.
MeSH term(s)	Biomarkers/urine ; Chromatography, Liquid ; DNA Damage ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/isolation & purification ; Deoxyguanosine/urine ; Enzyme-Linked Immunosorbent Assay ; Humans ; Oxidative Stress ; Smoking/urine ; Smoking Cessation
Chemical Substances	Biomarkers ; 8-oxo-7-hydrodeoxyguanosine (88847-89-6) ; Deoxyguanosine (G9481N71RO)
Language	English
Publishing date	2016
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.3109/00365513.2015.1127407
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Article ; Online: Quantification of biotin in plasma samples by column switching liquid chromatography - tandem mass spectrometry.

Weimann, Allan / Plomgaard, Peter / Hilsted, Linda M / Poulsen, Henrik E / Larsen, Emil L

Scandinavian journal of clinical and laboratory investigation

2021 Volume 81, Issue 2, Page(s) 127–136

Abstract: Biotin (or Vitamin B7) is a vitamin where deficiency can be caused by inadequate intake. Biotin deficiency is rare, as most people get enough biotin from diet, since many foods contain biotin. In addition to biotin from food, intestinal bacteria can ... ...

Abstract	Biotin (or Vitamin B7) is a vitamin where deficiency can be caused by inadequate intake. Biotin deficiency is rare, as most people get enough biotin from diet, since many foods contain biotin. In addition to biotin from food, intestinal bacteria can synthesize biotin, which can then be absorbed by the body. Supplementation with biotin has been advocated, mainly due to proposed beneficial effects on skin, nail and hair growth. There is no evidence that high biotin intakes are toxic, but a high intake may interfere with diagnostic assays that use biotin-streptavidin technology. These tests are commonly used to measure plasma concentrations of a wide range of hormones. Erroneous results may lead to misdiagnosis of various endocrine disorders. Supplementation with high-dose biotin has been used experimental for the treatment of diseases (e.g. multiple sclerosis) and high doses are used to obtain effect on nail and hair growth. On this background a demand for tests to determine if there is a risk of obtaining false test results when using biotin-streptavidin based tests have appeared. In this paper we present a method based on column switching liquid chromatography tandem mass spectrometry for the quantification of biotin in plasma and serum and explore the effects of biotin on an immunoassay based on biotin strept(avidin) chemistry.
MeSH term(s)	Biotin/blood ; Chromatography, Liquid ; Humans ; Immunoassay ; Reference Standards ; Tandem Mass Spectrometry ; Thyrotropin/blood ; Triiodothyronine/blood
Chemical Substances	Triiodothyronine (06LU7C9H1V) ; Biotin (6SO6U10H04) ; Thyrotropin (9002-71-5)
Language	English
Publishing date	2021-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	3150-1
ISSN	1502-7686 ; 0036-5513
ISSN (online)	1502-7686
ISSN	0036-5513
DOI	10.1080/00365513.2020.1871504
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Article ; Online: Measurement of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydro-guanosine in cerebrospinal fluid by ultra performance liquid chromatography-tandem mass spectrometry.

Weimann, Allan / Simonsen, Anja Hviid / Poulsen, Henrik E

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2018 Volume 1073, Page(s) 110–117

Abstract: Increased levels of nucleosides modified by oxidation in human cerebrospinal fluid (CSF) have several times been reported in Alzheimer patients and patients suffering from Parkinson's disease. The focus has especially been on nucleosides containing the 8- ...

Abstract	Increased levels of nucleosides modified by oxidation in human cerebrospinal fluid (CSF) have several times been reported in Alzheimer patients and patients suffering from Parkinson's disease. The focus has especially been on nucleosides containing the 8-hydroxylation of guanine. Only few reports on quantification of the ribonucleoside 8-oxo-7,8-dihydro-guanosine (8oxoGuo) in CSF have been published, whereas more have been published on the quantification of the deoxy-ribonucleoside 8-oxo-7,8-dihydro-2'-deoxyguanosine (8oxodGuo). The reports on the quantification of 8oxodGuo concentrations in CSF report absolute concentrations varying by a factor >10
MeSH term(s)	Aged ; Child ; Chromatography, High Pressure Liquid/methods ; Deoxyguanosine/analogs & derivatives ; Deoxyguanosine/cerebrospinal fluid ; Guanosine/analogs & derivatives ; Guanosine/cerebrospinal fluid ; Humans ; Linear Models ; Middle Aged ; Oxidative Stress ; Reproducibility of Results ; Sensitivity and Specificity ; Tandem Mass Spectrometry/methods
Chemical Substances	Guanosine (12133JR80S) ; 8-hydroxyguanosine (3868-31-3) ; 8-oxo-7-hydrodeoxyguanosine (88847-89-6) ; Deoxyguanosine (G9481N71RO)
Language	English
Publishing date	2018-01-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2017.12.011
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Article: Effects of 2-Year Nutritional and Lifestyle Intervention on Oxidative and Inflammatory Statuses in Individuals of 55 Years of Age and over at High Cardiovascular Risk

Monserrat-Mesquida, Margalida / Quetglas-Llabrés, Magdalena / Bouzas, Cristina / García, Silvia / Mateos, David / Gómez, Cristina / Gámez, José M. / Poulsen, Henrik E. / Tur, Josep A. / Sureda, Antoni

Antioxidants. 2022 July 05, v. 11, no. 7

2022

Abstract: Obesity and overweight are disorders with high impact on the morbidity and mortality of chronic diseases, such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). We aim to assess the effects of 2-year nutritional and lifestyle ... ...

Abstract	Obesity and overweight are disorders with high impact on the morbidity and mortality of chronic diseases, such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). We aim to assess the effects of 2-year nutritional and lifestyle intervention on oxidative and inflammatory status in individuals of 55 years of age and over at high CVD risk. Participants (n = 100 individuals of 55 years of age and over living in the Balearic Islands, Spain) were randomized into control and intervention group. Anthropometric and haematological parameters, blood pressure and physical activity were measured before and after the intervention. Oxidative and inflammatory biomarkers in plasma, urine, peripheral blood mononuclear cells (PBMCs) and neutrophils were determined. A higher reduction in abdominal obesity, blood pressure and triglycerides levels was observed after a 2-year intervention. An improvement of oxidative stress and proinflammatory status was demonstrated with a significant reduction in myeloperoxidase, xanthine oxidase, malondialdehyde and monocyte chemoattractant protein-1 (MCP1) levels, and an increase in polyphenols in plasma was observed. A decrease in reactive oxygen species production in PBMCs and neutrophils levels after zymosan and lipopolysaccharide activation was found in the intervention group with respect to the control group. The intervention with hypocaloric Mediterranean Diet and customized physical activity improves oxidative stress and proinflammatory status and could contribute to decreasing the CVD risk.
Keywords	Mediterranean diet ; biomarkers ; blood pressure ; chemokine CCL2 ; lifestyle ; lipopolysaccharides ; malondialdehyde ; morbidity ; mortality ; myeloperoxidase ; neutrophils ; noninsulin-dependent diabetes mellitus ; obesity ; oxidative stress ; physical activity ; polyphenols ; reactive oxygen species ; risk ; urine ; xanthine oxidase ; zymosan ; Spain
Language	English
Dates of publication	2022-0705
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11071326
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Urinary markers of nucleic acid oxidation increase with age, obesity and insulin resistance in Danish children and adolescents.

Jørs, Anna / Lund, Morten A V / Jespersen, Thomas / Hansen, Torben / Poulsen, Henrik E / Holm, Jens-Christian

Free radical biology & medicine

2020 Volume 155, Page(s) 81–86

Abstract: Purpose: Oxidative stress may play an important role in childhood obesity and increased cardiometabolic risk. 8-oxo-7,8-dihydroguanosine (8-oxoGuo) from oxidation of RNA and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) from oxidation of DNA are ... ...

Abstract	Purpose: Oxidative stress may play an important role in childhood obesity and increased cardiometabolic risk. 8-oxo-7,8-dihydroguanosine (8-oxoGuo) from oxidation of RNA and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) from oxidation of DNA are excreted into urine and function as biomarkers for oxidative stress reflecting the modification rate of nucleic acids by oxidation. This study investigates the associations between urinary markers of nucleic acid oxidation and Body Mass Index (BMI), age, sex and cardiometabolic risk factors in children and adolescents with and without obesity. Methods: We studied 543 children and adolescents from an obesity clinic cohort (n = 418) and a population-based cohort (n = 125), all aged 6-18 years. Anthropometrics, urine and blood samples were collected. A validated liquid chromatography-tandem mass spectrometry method was used to measure the nucleic acid oxidation markers. Results: Compared with the population-based cohort, children and adolescents in the obesity clinic cohort had higher calculated 24-h excretion of 8-oxoGuo (p = 0.045) and 8-oxodG (p = 0.014) adjusted for basal metabolic rate. Both oxidation markers were positively associated with age and female sex (all p < 0.002). In the obesity clinic cohort the RNA oxidation marker 8-oxoGuo correlated with serum insulin (rho = 0.18, p = <.001) and insulin resistance (rho = 0.19, p = <.001). Conclusions: Childhood obesity associate with higher urinary excretion of nucleic acid oxidation biomarkers, and increase with age throughout childhood, mirroring the obesity- and age-related increase shown in adults. Finally, children with obesity and insulin resistance had higher RNA oxidation markers than children with obesity and no insulin resistance, supporting a possible link between oxidative stress and the pathogenesis of cardiometabolic risk including type 2 diabetes.
MeSH term(s)	Adolescent ; Adult ; Biomarkers ; Child ; Denmark ; Deoxyguanosine ; Diabetes Mellitus, Type 2 ; Female ; Humans ; Insulin Resistance ; Nucleic Acids ; Obesity/epidemiology ; Oxidative Stress
Chemical Substances	Biomarkers ; Nucleic Acids ; Deoxyguanosine (G9481N71RO)
Language	English
Publishing date	2020-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	807032-5
ISSN	1873-4596 ; 0891-5849
ISSN (online)	1873-4596
ISSN	0891-5849
DOI	10.1016/j.freeradbiomed.2020.05.009
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Article ; Online: Effects of two- and twelve-weeks sodium-glucose cotransporter 2 inhibition on DNA and RNA oxidation: two randomized, placebo-controlled trials.

Larsen, Emil List / Andersen, Andreas / Kjær, Laura K / Eickhoff, Mie K / Frimodt-Møller, Marie / Persson, Frederik / Rossing, Peter / Lykkesfeldt, Jens / Knop, Filip K / Vilsbøll, Tina / Rungby, Jørgen / Poulsen, Henrik E

Free radical research

2023 Volume 57, Issue 2, Page(s) 140–151

Abstract: Animal studies have shown that SGLT2 inhibition decreases oxidative stress, which may explain the cardiovascular protective effects observed following SGLT2 inhibition treatment. Thus, we investigated the effects of two and twelve weeks SGLT2 inhibition ... ...

Abstract	Animal studies have shown that SGLT2 inhibition decreases oxidative stress, which may explain the cardiovascular protective effects observed following SGLT2 inhibition treatment. Thus, we investigated the effects of two and twelve weeks SGLT2 inhibition on DNA and RNA oxidation. Individuals with type 2 diabetes (
MeSH term(s)	Humans ; 8-Hydroxy-2'-Deoxyguanosine ; RNA ; Diabetes Mellitus, Type 2/drug therapy ; Sodium-Glucose Transporter 2/therapeutic use ; Creatinine/urine ; Cross-Over Studies ; DNA ; Glucose ; Sodium/therapeutic use
Chemical Substances	empagliflozin (HDC1R2M35U) ; 8-Hydroxy-2'-Deoxyguanosine (88847-89-6) ; dapagliflozin (1ULL0QJ8UC) ; RNA (63231-63-0) ; Sodium-Glucose Transporter 2 ; Creatinine (AYI8EX34EU) ; DNA (9007-49-2) ; Glucose (IY9XDZ35W2) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2023-05-19
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1194130-3
ISSN	1029-2470 ; 1071-5762
ISSN (online)	1029-2470
ISSN	1071-5762
DOI	10.1080/10715762.2023.2213820
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Article ; Online: Long-term stability of thyroid peroxidase antibody (anti-TPO) in serum in the Danish General Suburban Population Study.

Jensen, Christian Z / Nygaard, Birte / Faber, Jens / Pedersen, Palle L / Larsen, Morten K / Kanters, Jørgen K / Poulsen, Henrik E / Kellogg, Mark / Ellervik, Christina

Clinical chemistry and laboratory medicine

2023 Volume 61, Issue 9, Page(s) 1590–1596

Abstract: Objectives: We evaluated the long-term stability of thyroid peroxidase antibody (anti-TPO).: Methods: In the Danish General Suburban Population Study (GESUS), serum samples were biobanked at -80 °C during 2010-2013. In a paired design with 70 ... ...

Abstract	Objectives: We evaluated the long-term stability of thyroid peroxidase antibody (anti-TPO). Methods: In the Danish General Suburban Population Study (GESUS), serum samples were biobanked at -80 °C during 2010-2013. In a paired design with 70 subjects, we compared anti-TPO (30-198 U/mL) measured on fresh serum on Kryptor Classic in 2010-2011 (anti-TPO Results: The mean follow-up time was 11.9 years (SD: 0.43). For anti-TPO Conclusions: Anti-TPO serum samples in the range 30-198 U/mL were stable after 12-years of storage at -80 °C with an estimated nonsignificant average percentage deviation of +2.22%. This comparison is based on Kryptor Classic and Kryptor Compact Plus, which used identical assays, reagents, and calibrator, but for which the agreement in the range 30-198 U/mL is unclarified.
MeSH term(s)	Humans ; Iodide Peroxidase ; Suburban Population ; Autoantibodies ; Denmark
Chemical Substances	Iodide Peroxidase (EC 1.11.1.8) ; Autoantibodies
Language	English
Publishing date	2023-03-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2022-0845
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