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  1. AU="Pourahmad, Morteza"
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  1. Artikel: The effectiveness of colistin/levofloxacin compared to colistin/meropenem in the treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant

    Momenzadeh, Mahnaz / Soltani, Rasool / Shafiee, Fatemeh / Hakamifard, Atousa / Pourahmad, Morteza / Abbasi, Saeed

    Research in pharmaceutical sciences

    2022  Band 18, Heft 1, Seite(n) 39–48

    Abstract: Background and purpose: The treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant : Experimental approach: The patients with VAP were randomly assigned to experimental (n = 26) and control (n = 29) groups. The first group ... ...

    Abstract Background and purpose: The treatment of ventilator-associated pneumonia (VAP) caused by carbapenem-resistant
    Experimental approach: The patients with VAP were randomly assigned to experimental (n = 26) and control (n = 29) groups. The first group received IV colistin 4.5 MIU every 12 h + levofloxacin 750 mg IV daily, and the second group received IV colistin with the same dose + meropenem 1 g IV every 8 h for 10 days. The clinical (complete response, partial response, or treatment failure) and microbiological responses at the end of the intervention were recorded and compared between the two groups.
    Findings/results: The complete response rate was higher (n = 7; 35%) and the failure rate was lower (n = 4; 20%) in the experimental group than in the control group (n = 2; 8%, and n = 11; 44%, respectively), but the differences were not statistically significant. Even though the microbiological response rate was higher in the experimental group (n = 14; 70%) than in the control group (n = 12; 48%), the difference was not statistically significant. The mortality rate was 6 (23.10%) and 4 patients (13.8%) in the experimental and control groups, respectively (
    Conclusion and implication: The levofloxacin/colistin combination can be considered an alternative regimen to meropenem/colistin in the treatment of VAP caused by CRAB.
    Sprache Englisch
    Erscheinungsdatum 2022-12-24
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 2400156-9
    ISSN 1735-9414 ; 1735-5362
    ISSN (online) 1735-9414
    ISSN 1735-5362
    DOI 10.4103/1735-5362.363594
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  2. Artikel: Hepatitis E virus and serum level aminotransferases in blood donors.

    Sotoodeh Jahromi, Abdolreza / Pourahmad, Morteza

    Reports of biochemistry & molecular biology

    2016  Band 2, Heft 1, Seite(n) 48–51

    Abstract: Background: Hepatitis E virus (HEV) infection is a self-limiting viral infection that can lead to severe complications and death. In different regions the epidemiology of this infection varies. In this study we evaluated the seroepidemiology of ... ...

    Abstract Background: Hepatitis E virus (HEV) infection is a self-limiting viral infection that can lead to severe complications and death. In different regions the epidemiology of this infection varies. In this study we evaluated the seroepidemiology of hepatitis E infection in Jahrom, a city in southern Iran.
    Methods: This was a cross-sectional descriptive study of serum samples from 477 subjects, including 30 females and 447 males. HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) were measured by enzyme-linked immunosorbent assays (ELISA). Alanine transaminase (ALT) and aspartate transaminase (AST) levels were also determined. Four hundred forty-seven subjects were male and 30 were female. Subjects were classified by age and sex.
    Results: One woman (3.3%) and 25 men (5.5%) were positive for HEV antibodies (IgG and/or IgM). There was found an association between serum level of aminotransferases and seropositivity for HEV.
    Conclusion: The result of this study indicates that HEV is an etiological factor for hepatitis in this area of IRAN. The cost benefit of active immunization in endemic regions should be evaluated because an outbreak could have tragic consequences.
    Sprache Englisch
    Erscheinungsdatum 2016-03-01
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 2743890-9
    ISSN 2322-3480
    ISSN 2322-3480
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  3. Artikel ; Online: Phaeohyphomycosis caused by Neoscytalidiumdimidiatum in a COVID-19 patient.

    Dolatabadi, Somayeh / Nasirharandi, Sara / Pourahmad, Morteza / Ahmadikia, Kazem / Mokhtari, Mojgan / Najafzadeh, Mohammad Javad / Mohammadi, Rasoul

    Revista iberoamericana de micologia

    2022  

    Abstract: Background: Neoscytalidiumdimidiatum is an opportunistic dematiaceous fungus belonging to the class Dothideomycetes.: Case report: We report a case of N. dimidiatum cerebral phaeohyphomycosis post COVID-19 infection in a 32-year-old male from Iran. ... ...

    Abstract Background: Neoscytalidiumdimidiatum is an opportunistic dematiaceous fungus belonging to the class Dothideomycetes.
    Case report: We report a case of N. dimidiatum cerebral phaeohyphomycosis post COVID-19 infection in a 32-year-old male from Iran. The causative agent was identified by cytopathology, routine mycological methods, and DNA sequencing of the internal transcribed spacer (ITS) region of rDNA. Apart from COVID-19 complications and the corticosteroid therapy, no underlying condition was diagnosed. The symptoms suggesting the fungal infection were shown two weeks after being discharged from COVID-19 hospital stay. Magnetic resonance of the brain showed a multi-focal central nervous system infection. The delayed identification of the fungus and, thus, a late starting of the antifungal treatment with amphotericin B, might have affected the patient outcome as he finally died.
    Conclusions: Considering the rare incidence of N. dimidiatum infections, this case should aware us about them, leading to a timely antifungal management.
    Sprache Englisch
    Erscheinungsdatum 2022-11-28
    Erscheinungsland Spain
    Dokumenttyp Journal Article
    ISSN 2173-9188
    ISSN (online) 2173-9188
    DOI 10.1016/j.riam.2022.07.002
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  4. Artikel: Protective effect of salep on liver.

    Pourahmad, Morteza / Kargar Jahromi, Hossein / Kargar Jahromi, Zahra

    Hepatitis monthly

    2015  Band 15, Heft 4, Seite(n) e28137

    Abstract: Background: Salep is used for various purposes in food industries and traditional medicine. Therefore, evaluation of its effect on the liver seems to be necessary.: Objectives: The aim of this study was to assess salep effect on liver.: Materials ... ...

    Abstract Background: Salep is used for various purposes in food industries and traditional medicine. Therefore, evaluation of its effect on the liver seems to be necessary.
    Objectives: The aim of this study was to assess salep effect on liver.
    Materials and methods: In this experimental study, various concentrations of Salep were intraperitoneally administered to five groups of Wistar rats (control, placebo and 20, 40 and 80 mg/kg salep). After one month, liver enzymes and liver tissue were evaluated and compared between different groups.
    Results: Significant decreased level of liver enzymes, MDA (Malondialdehyde) and TOC (Total Oxidation Capacity) were found in various concentrations of salep administration. On the other hand, a significant increase was found in TAC (Total Antioxidant Capacity) level with various doses of salep.
    Conclusions: Elevated level of total protein and albumin and decreased level of liver enzyme by salep extract were found in this study. Therefore, this plant may be a useful medicine for patients with liver diseases.
    Sprache Englisch
    Erscheinungsdatum 2015-04-25
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 2236753-6
    ISSN 1735-3408 ; 1735-143X
    ISSN (online) 1735-3408
    ISSN 1735-143X
    DOI 10.5812/hepatmon.15(4)2015.28137
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  5. Artikel ; Online: Effect of honey on the common cold.

    Pourahmad, Morteza / Sobhanian, Saeed

    Archives of medical research

    2009  Band 40, Heft 3, Seite(n) 224–225

    Mesh-Begriff(e) Acetaminophen/administration & dosage ; Adult ; Chlorpheniramine/administration & dosage ; Common Cold/therapy ; Female ; Honey ; Humans ; Male ; Naproxen/administration & dosage ; Treatment Outcome
    Chemische Substanzen Acetaminophen (362O9ITL9D) ; Chlorpheniramine (3U6IO1965U) ; Naproxen (57Y76R9ATQ)
    Sprache Englisch
    Erscheinungsdatum 2009-04
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 1156844-6
    ISSN 1873-5487 ; 0188-4409 ; 0188-0128
    ISSN (online) 1873-5487
    ISSN 0188-4409 ; 0188-0128
    DOI 10.1016/j.arcmed.2009.01.001
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  6. Artikel: Protective effects of salep against isoniazid liver toxicity in wistar rats.

    Kargar Jahromi, Hossein / Pourahmad, Morteza / Abedi, Hassan Ali / Karimi, Mohadeseh / Kargar Jahromi, Zahra

    Journal of traditional and complementary medicine

    2017  Band 8, Heft 1, Seite(n) 239–243

    Abstract: Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this ... ...

    Abstract Introduction: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this side effect of isoniazid.
    Materials and methods: This study is an experimental study in which the preventive effect of salep on isoniazid hepatotoxicity is evaluated. In this study 56 rats were randomly placed in 7 eight members groups including: control group, sham, isoniazid and four isoniazid/salep groups. At the end of the study the laboratory criteria and histological features of liver toxicity were compared in different mentioned groups.
    Results: Significant lower serum levels of liver enzymes, billirubin, MDA and TOC; and significant higher levels of TAC and total proteins, were revealed in isoniazid/salep group in compare to isoniazid alone group.In addition, histological studies had not showed liver injury in isoniazid/salep group, while there was significant liver injury in isoniazid alone group.
    Conclusions: Orchid extract (salep), probably because of its antioxidant properties, prevent the destructive effects of isoniazid on the liver.
    Sprache Englisch
    Erscheinungsdatum 2017-06-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2709698-1
    ISSN 2225-4110
    ISSN 2225-4110
    DOI 10.1016/j.jtcme.2017.06.001
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  7. Artikel: Toxoplasma gondii

    Armand, Belal / Solhjoo, Kavous / Kordshooli, Manoochehr Shabani / Davami, Mohammad Hasan / Pourahmad, Morteza / Orfaee, Vahideh

    Veterinary world

    2017  Band 10, Heft 4, Seite(n) 386–392

    Abstract: Aim: This study was performed to determine the genetic diversity of : Materials and methods: The tissue samples of diaphragm and heart from 125 sheep were collected from the main slaughterhouses of Jahrom district in South of Fars province, Iran, ... ...

    Abstract Aim: This study was performed to determine the genetic diversity of
    Materials and methods: The tissue samples of diaphragm and heart from 125 sheep were collected from the main slaughterhouses of Jahrom district in South of Fars province, Iran, between Aprils and June 2013. The DNA were extracted and analyzed by nested-PCR using specific primers for SAG2 and GRA6 loci. RFLP was used to classify strains into one of the three major lineages of
    Results: T. gondii
    Conclusions: Although the previously published data indicated that Type II is the predominant
    Sprache Englisch
    Erscheinungsdatum 2017-04-07
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 2456277-4
    ISSN 2231-0916 ; 0972-8988
    ISSN (online) 2231-0916
    ISSN 0972-8988
    DOI 10.14202/vetworld.2017.386-392
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  8. Artikel: Occult hepatitis B demonstrated by anti-HBc and HBV DNA in HIV-positive patients.

    Honarmand, Arezoo / Pourahmad, Morteza / Solhjoo, Kavous / Kohan, Mahmoud / Davami, Mohamad Hassan / Mostafavi Zadeh, Seyed Kamyar

    Reports of biochemistry & molecular biology

    2016  Band 3, Heft 1, Seite(n) 38–42

    Abstract: Background: In patients who are hepatitis B virus (HBV) DNA-positive, but HBV surface antigen (HBsAg) -negative, the infection is referred to as occult hepatitis B infection (OBI). Occult HBV infection is harmful when other liver diseases are present, ... ...

    Abstract Background: In patients who are hepatitis B virus (HBV) DNA-positive, but HBV surface antigen (HBsAg) -negative, the infection is referred to as occult hepatitis B infection (OBI). Occult HBV infection is harmful when other liver diseases are present, and can aggravate liver damage in in patients with chronic liver diseases. In human immunodeficiency virus (HIV) infection the suppression of viral replication by the immune system might be inactivated, and classical HBV infection in OBI patients may occur. Health care professionals should be aware of OBI in HIV patients. The routine test for HBV infection in Iran is the enzyme-linked immunosorbent assay for the HBV surface antigen (ELISA HBsAg); therefore, the aim of this study was to evaluate the prevalence of OBI in Iranian HIV patients.
    Methods: This cross-sectional study was conducted in 2012 on sera from all the known and accessible HIV patients in Jahrom and Fassa, two cities in southern Iran. All samples were tested for the HBsAg, HBV core antibody (HBcAb). All the results were analyzed using SPSS.
    Results: Of the 91 patients, seven (7.7%) were HBsAg-positive and forty-five (49.5%) were HBcAb-positive. In patients with negative HBsAg (84 patients), 39 (46.4%) were HBcAb positive and 53 (63%) were positive for HBV DNA.
    Conclusion: The prevalence of HBV infection is relatively high in HIV patients, and more accurate tests than those presently in use should be used for diagnosis.
    Sprache Englisch
    Erscheinungsdatum 2016-03-01
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 2743890-9
    ISSN 2322-3480
    ISSN 2322-3480
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  9. Artikel ; Online: Evaluation of anti-varicella antibody in young women before their marriage: A sero-epidemiologic study in Iran.

    Pourahmad, Morteza / Davami, Mohammad Hassan / Jahromi, Abdol Reza Sotoodeh

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2010  Band 48, Heft 4, Seite(n) 260–263

    Abstract: Background: Chickenpox during pregnancy can cause severe complications in both the mother and her baby. However, no complications will occur in a mother with proper immunity. Therefore, physicians and health systems can make better decisions when they ... ...

    Abstract Background: Chickenpox during pregnancy can cause severe complications in both the mother and her baby. However, no complications will occur in a mother with proper immunity. Therefore, physicians and health systems can make better decisions when they know the immunologic status of the women in a community.
    Objectives: We conducted this study to clarify the Varicella zoster virus (VZV) immune status of engaged women in Iran.
    Study design: This cross-sectional descriptive study was carried out on 334 young women who intended to marry between 2006 and 2008. The subjects' VZV-immunoglobulin G (IgG) and demographic characteristics were evaluated.
    Results: The mean age of the subjects was 20.5+/-4.9 years and their mean anti-varicella value was 86.22+/-71.05 U ml(-1). Of 333 young women studied, 242 (72.7%) were positive, 89 (26.7%) were negative for anti-varicella antibody and two were equivocal (0.6%). The rate of immunity increased with increasing age; all of the subjects over 35 years of age were immune to varicella. The positive predictive value (PPV) for self-reported history of chickenpox in subjects was estimated to be 79.5% and the negative predictive value (NPV) of a negative or uncertain disease history was 30.5%. A higher immune ratio was seen in women with more siblings.
    Conclusions: The difference in the proportion of VZV-immune people in our country versus developed countries may be due to the introduction of varicella vaccine in developed nations. The mean age at first pregnancy in Iran is 25.7 years and the results of our study indicate that more than one-fourth of these women are not immune to varicella. We therefore recommend vaccination in women, especially those who are under 35 years of age. Number of siblings and positive history of varicella infection may be the indicators to determine the immunity level of a pregnant woman who has had contact with a patient with chickenpox.
    Mesh-Begriff(e) Adolescent ; Adult ; Antibodies, Viral/blood ; Chickenpox/epidemiology ; Child ; Cross-Sectional Studies ; Female ; Herpesvirus 3, Human/immunology ; Humans ; Iran/epidemiology ; Medical History Taking ; Middle Aged ; Seroepidemiologic Studies ; Young Adult
    Chemische Substanzen Antibodies, Viral
    Sprache Englisch
    Erscheinungsdatum 2010-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2010.04.015
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  10. Artikel ; Online: Effects of camel thorn distillate on recurrent oral aphthous lesions.

    Pourahmad, Morteza / Rahiminejad, Masood / Fadaei, Sara / Kashafi, Hamed

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2010  Band 8, Heft 5, Seite(n) 348–352

    Abstract: Background: Near 20 % of people suffer from recurrent oral aphthous ulcers. These painful ulcers are found on the oral mucosa. We conducted this study to evaluate the effect of the camel thorn distillate on this condition.: Patients and methods: 93 ... ...

    Abstract Background: Near 20 % of people suffer from recurrent oral aphthous ulcers. These painful ulcers are found on the oral mucosa. We conducted this study to evaluate the effect of the camel thorn distillate on this condition.
    Patients and methods: 93 patients with recurrent aphthous ulcers were selected and divided into two groups. One group was given a placebo (n = 44) and the other was given camel thorn distillate (n = 49). The diameter of the lesions and the severity of the pain were measured 3, 5, 7, 10 and 14 days after initiation of therapy. The lesion diameters and pain scores of the two groups were compared using the t-test.
    Results: Complete resolution time ranged from 3 to 7 days (mean = 4.02) in the group treated with camel thorn distillate, whereas in the control group, complete resolution time ranged from 7 to 14 days (mean = 8.9, p < 0.001).
    Conclusions: The efficacy of camel thorn distillate is comparable to that of other drugs used to treat oral aphthous ulcers. Its therapeutic effect may be due to the flavanones (alhagitin and alhagidin) that are present in this plant.
    Mesh-Begriff(e) Adult ; Chronic Disease ; Double-Blind Method ; Female ; Flavanones/therapeutic use ; Glycosides/therapeutic use ; Humans ; Iran ; Male ; Middle Aged ; Phytotherapy ; Plant Extracts/therapeutic use ; Secondary Prevention ; Stomatitis, Aphthous/drug therapy ; Treatment Outcome
    Chemische Substanzen Flavanones ; Glycosides ; Plant Extracts ; camel thorn distillate
    Sprache Deutsch
    Erscheinungsdatum 2010-05
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/j.1610-0387.2010.07316.x
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