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  1. Article: Erratum to "What are the infectious risks with disease-modifying drugs for multiple sclerosis and how to reduce them? A review of literature" [Rev. Neurol. 176 (4) (2019) 235-243].

    Pourcher, V

    Revue neurologique

    2020  Volume 176, Issue 6, Page(s) 526

    Language English
    Publishing date 2020-04-29
    Publishing country France
    Document type Published Erratum
    ZDB-ID 4593-7
    ISSN 2213-0004 ; 0035-3787
    ISSN (online) 2213-0004
    ISSN 0035-3787
    DOI 10.1016/j.neurol.2020.04.008
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  2. Article: What are the infectious risks with disease-modifying drugs for multiple sclerosis and how to reduce them? A review of literature.

    Pourcher, V

    Revue neurologique

    2020  Volume 176, Issue 4, Page(s) 235–243

    Abstract: Patients with multiple sclerosis taking immunosuppressive therapy may be at risk of reactivating latent pathogens, community-acquired infections, worsening asymptomatic chronic infections, and contracting de novo infections. This risk was evaluated ... ...

    Abstract Patients with multiple sclerosis taking immunosuppressive therapy may be at risk of reactivating latent pathogens, community-acquired infections, worsening asymptomatic chronic infections, and contracting de novo infections. This risk was evaluated mainly in short-term clinical trials and few studies have investigated this risk in real-life settings. In clinical practice, this infectious risk should be evaluated when a multiple sclerosis diagnosis is made in order to propose specific follow-up or immunization as soon as possible and thus avoid contraindications or risk of lowered vaccination responses. Systematic screening should also be proposed for each patient before second-line therapy to ensure the risk is in line with the treatment plan. This systematic screening must include HIV and hepatitis B and C for all patients before treatment. The immunization schedule needs to be updated and influenza vaccine could be proposed each year for patients receiving disease-modifying drugs. Prevention is preferable to treatment, reducing both infectious morbidity and mortality, as well as interruptions in multiple sclerosis therapy. Therefore, preventive approaches should be tailored to individual patient and treatment risk factors. In this review, we describe the infectious risk with immunossuppressive therapies and propose minimal screening recommendations to evaluate the risk and adapt the prevention and strategy of immunization to each case at multiple sclerosis diagnosis and at specific follow-up visits to avoid difficulties using live-attenuated vaccines or risk reduced immune responses.
    MeSH term(s) Drug-Related Side Effects and Adverse Reactions/epidemiology ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/classification ; Immunosuppressive Agents/therapeutic use ; Infection Control/methods ; Infections/chemically induced ; Infections/diagnosis ; Infections/epidemiology ; Infections/immunology ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/immunology ; Patient Selection ; Remission Induction ; Risk Factors ; Vaccination/methods ; Vaccination/statistics & numerical data
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2020-01-23
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 4593-7
    ISSN 2213-0004 ; 0035-3787
    ISSN (online) 2213-0004
    ISSN 0035-3787
    DOI 10.1016/j.neurol.2019.08.012
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  3. Article: Acute Varicella-Zoster Virus meningitis in a multiple sclerosis patient treated with fingolimod.

    Dimitri, D / Pourcher, V

    Revue neurologique

    2022  Volume 178, Issue 4, Page(s) 393–394

    MeSH term(s) Fingolimod Hydrochloride/adverse effects ; Herpesvirus 3, Human ; Humans ; Meningitis ; Multiple Sclerosis/complications ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis, Relapsing-Remitting/complications ; Multiple Sclerosis, Relapsing-Remitting/drug therapy
    Chemical Substances Fingolimod Hydrochloride (G926EC510T)
    Language English
    Publishing date 2022-01-06
    Publishing country France
    Document type Letter
    ZDB-ID 4593-7
    ISSN 2213-0004 ; 0035-3787
    ISSN (online) 2213-0004
    ISSN 0035-3787
    DOI 10.1016/j.neurol.2021.09.009
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  4. Article ; Online: Can patients on methotrexate receive live vaccines?

    Pourcher, Valérie

    Joint bone spine

    2018  Volume 86, Issue 4, Page(s) 415–417

    MeSH term(s) Arthritis, Rheumatoid/drug therapy ; Chickenpox Vaccine/administration & dosage ; Chickenpox Vaccine/adverse effects ; Herpes Zoster Vaccine/administration & dosage ; Herpes Zoster Vaccine/adverse effects ; Humans ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Measles-Mumps-Rubella Vaccine/administration & dosage ; Measles-Mumps-Rubella Vaccine/adverse effects ; Methotrexate/immunology ; Methotrexate/therapeutic use ; Patient Safety ; Patient Selection ; Risk Assessment ; Vaccination/trends ; Vaccines, Attenuated/administration & dosage
    Chemical Substances Chickenpox Vaccine ; Herpes Zoster Vaccine ; Immunosuppressive Agents ; Measles-Mumps-Rubella Vaccine ; Vaccines, Attenuated ; Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2018-12-27
    Publishing country France
    Document type Editorial ; Review
    ZDB-ID 2020487-5
    ISSN 1778-7254 ; 1297-319X
    ISSN (online) 1778-7254
    ISSN 1297-319X
    DOI 10.1016/j.jbspin.2018.12.008
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  5. Article ; Online: Une lésion palpébrale.

    Lenfant, T / Pourcher, V

    La Revue de medecine interne

    2019  Volume 41, Issue 5, Page(s) 346–347

    Title translation A palpebral lesion.
    MeSH term(s) Coinfection/diagnosis ; Coinfection/virology ; Diagnosis, Differential ; Eyelid Neoplasms/complications ; Eyelid Neoplasms/diagnosis ; Eyelid Neoplasms/virology ; Eyelids/diagnostic imaging ; Eyelids/pathology ; Eyelids/virology ; Haiti ; Heart Transplantation ; Herpesvirus 6, Human/isolation & purification ; Herpesvirus 6, Human/physiology ; Herpesvirus 8, Human/isolation & purification ; Herpesvirus 8, Human/physiology ; Humans ; Immunocompromised Host ; Male ; Middle Aged ; Roseolovirus Infections/complications ; Roseolovirus Infections/diagnosis ; Roseolovirus Infections/pathology ; Roseolovirus Infections/virology ; Sarcoma, Kaposi/complications ; Sarcoma, Kaposi/diagnosis ; Sarcoma, Kaposi/pathology ; Sarcoma, Kaposi/virology ; Transplant Recipients
    Language French
    Publishing date 2019-11-10
    Publishing country France
    Document type Case Reports ; Journal Article
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2019.10.335
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  6. Article ; Online: Fiebre al regreso de un viaje a un país tropical

    Hentzien, M. / Pourcher, V.

    EMC - Tratado de Medicina

    Abstract: Resumen La fiebre es una causa frecuente de consulta después de regresar de un viaje a un país tropical. El punto clave es preguntar al paciente sobre los detalles del viaje y caracterizar los signos clínicos, incluida la fiebre, con la mayor precisión ... ...

    Abstract Resumen La fiebre es una causa frecuente de consulta después de regresar de un viaje a un país tropical. El punto clave es preguntar al paciente sobre los detalles del viaje y caracterizar los signos clínicos, incluida la fiebre, con la mayor precisión posible. Las principales causas de fiebre después de regresar de un viaje a un país tropical son el paludismo, las infecciones digestivas, las infecciones respiratorias y urinarias, y las patologías de la piel. Es esencial y urgente descartar el paludismo, cualesquiera que sean los síntomas asociados. Deberían considerarse otras posibles etiologías en función del plazo de aparición de la fiebre en relación con el período de incubación, los signos asociados y los resultados de las pruebas complementarias iniciales. Por último, no hay que pasar por alto una infección comunitaria o cosmopolita con un grave potencial evolutivo.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/s1636-5410(20)44015-2
    Database COVID19

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  7. Article ; Online: Factors Associated With Genotypic Resistance and Outcome Among Solid Organ Transplant Recipients With Refractory Cytomegalovirus Infection.

    Tamzali, Yanis / Pourcher, V / Azoyan, L / Ouali, N / Barrou, B / Conti, F / Coutance, G / Gay, F / Tourret, J / Boutolleau, D

    Transplant international : official journal of the European Society for Organ Transplantation

    2023  Volume 36, Page(s) 11295

    Abstract: Genotypically resistant cytomegalovirus (CMV) infection is associated with increased morbi-mortality. We herein aimed at understanding the factors that predict CMV genotypic resistance in refractory infections and disease in the SOTR (Solid Organ ... ...

    Abstract Genotypically resistant cytomegalovirus (CMV) infection is associated with increased morbi-mortality. We herein aimed at understanding the factors that predict CMV genotypic resistance in refractory infections and disease in the SOTR (Solid Organ Transplant Recipients) population, and the factors associated with outcomes. We included all SOTRs who were tested for CMV genotypic resistance for CMV refractory infection/disease over ten years in two centers. Eighty-one refractory patients were included, 26 with genotypically resistant infections (32%). Twenty-four of these genotypic profiles conferred resistance to ganciclovir (GCV) and 2 to GCV and cidofovir. Twenty-three patients presented a high level of GCV resistance. We found no resistance mutation to letermovir. Age (OR = 0.94 per year, IC95 [0.089-0.99]), a history of valganciclovir (VGCV) underdosing or of low plasma concentration (OR= 5.6, IC95 [1.69-20.7]), being on VGCV at infection onset (OR = 3.11, IC95 [1.18-5.32]) and the recipients' CMV negative serostatus (OR = 3.40, IC95 [0.97-12.8]) were independently associated with CMV genotypic resistance. One year mortality was higher in the resistant CMV group (19.2 %
    MeSH term(s) Humans ; Cytomegalovirus Infections/prevention & control ; Antiviral Agents/therapeutic use ; Ganciclovir/therapeutic use ; Valganciclovir/therapeutic use ; Cytomegalovirus/genetics ; Organ Transplantation/adverse effects ; Transplant Recipients
    Chemical Substances Antiviral Agents ; Ganciclovir (P9G3CKZ4P5) ; Valganciclovir (GCU97FKN3R)
    Language English
    Publishing date 2023-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2023.11295
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    Zs.A 2358: Show issues Location:
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  8. Article ; Online: Outcomes of coronavirus disease 2019-related hospitalization among people with HIV: historical cohort from the Greater Paris area multicenter hospital data warehouse.

    Pourcher, Valérie / Tubach, Florence / Rozes, Antoine / Boussouar, Samia / Estellat, Candice

    AIDS (London, England)

    2023  Volume 37, Issue 12, Page(s) 1915–1917

    MeSH term(s) Humans ; Data Warehousing ; Paris/epidemiology ; COVID-19 ; HIV Infections/complications ; Hospitalization ; Hospitals
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003655
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  9. Article ; Online: Infective endocarditis due to Neisseria elongata: A case report and literature review.

    Banjari, M / Haddad, E / Bonnet, I / Legrand, L / Cohen, F / Caumes, E / Pourcher, V

    Infectious diseases now

    2021  Volume 51, Issue 7, Page(s) 622–626

    Abstract: Introduction: Neisseria elongata (NE), a Gram-negative, rod-shaped organism, was previously thought to be non-pathogenic. However, in recent years it has become increasingly recognized as a rare cause of infective endocarditis. In this paper, we report ... ...

    Abstract Introduction: Neisseria elongata (NE), a Gram-negative, rod-shaped organism, was previously thought to be non-pathogenic. However, in recent years it has become increasingly recognized as a rare cause of infective endocarditis. In this paper, we report a case of NE infective endocarditis and provide a review of the literature.
    Objectives: To describe a case of NE endocarditis, and to review the literature in search of any similar cases of this rare condition.
    Case report: Our patient is a 77-year-old, otherwise healthy female patient who was found to have mitral valve endocarditis with valve regurgitation.
    Discussion: NE endocarditis is a rare condition that typically affects the left cardiac chambers and is associated with high risk of embolization. A literature review retrieved 35 other cases.
    Conclusions: Our report underlines the rarity of NE endocarditis, insofar as relatively few cases have been reported. The bacterium presents similarities with HACEK organisms and can potentially cause infective endocarditis.
    MeSH term(s) Aged ; Endocarditis ; Endocarditis, Bacterial/diagnosis ; Female ; Heart Valve Diseases ; Humans ; Neisseria elongata
    Language English
    Publishing date 2021-01-30
    Publishing country France
    Document type Case Reports ; Journal Article ; Review
    ISSN 2666-9919
    ISSN (online) 2666-9919
    DOI 10.1016/j.idnow.2021.01.013
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  10. Article ; Online: Febbre al ritorno da un viaggio in un paese tropicale

    Hentzien, M. / Pourcher, V.

    EMC - AKOS - Trattato di Medicina

    Abstract: La febbre è una causa frequente di visita al ritorno da un viaggio in un paese tropicale. Il punto chiave è interrogare il paziente circa i dettagli del suo viaggio e caratterizzare al meglio i segni clinici, tra cui la febbre. Le principali cause di ... ...

    Abstract La febbre è una causa frequente di visita al ritorno da un viaggio in un paese tropicale. Il punto chiave è interrogare il paziente circa i dettagli del suo viaggio e caratterizzare al meglio i segni clinici, tra cui la febbre. Le principali cause di febbre al ritorno da un viaggio in un paese tropicale sono la malaria, le infezioni gastrointestinali, le infezioni respiratorie e urinarie e le patologie cutanee. È fondamentale e urgente escludere la malaria, a prescindere dai sintomi associati. Le altre possibili eziologie devono essere considerate in funzione del ritardo di comparsa della febbre rispetto al tempo di incubazione, dei segni associati e dei risultati degli esami di laboratorio iniziali. Infine, non si deve trascurare un’infezione comunitaria o cosmopolita a potenziale evolutivo grave.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/s1634-7358(18)90432-8
    Database COVID19

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