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  1. Article: Microbial Dysbiosis and Male Infertility: Understanding the Impact and Exploring Therapeutic Interventions.

    Kaltsas, Aris / Zachariou, Athanasios / Markou, Eleftheria / Dimitriadis, Fotios / Sofikitis, Nikolaos / Pournaras, Spyridon

    Journal of personalized medicine

    2023  Volume 13, Issue 10

    Abstract: The human microbiota in the genital tract is pivotal for maintaining fertility, but its disruption can lead to male infertility. This study examines the relationship between microbial dysbiosis and male infertility, underscoring the promise of precision ... ...

    Abstract The human microbiota in the genital tract is pivotal for maintaining fertility, but its disruption can lead to male infertility. This study examines the relationship between microbial dysbiosis and male infertility, underscoring the promise of precision medicine in this field. Through a comprehensive review, this research indicates microbial signatures associated with male infertility, such as altered bacterial diversity, the dominance of pathogenic species, and imbalances in the genital microbiome. Key mechanisms linking microbial dysbiosis to infertility include inflammation, oxidative stress, and sperm structural deterioration. Emerging strategies like targeted antimicrobial therapies, probiotics, prebiotics, and fecal microbiota transplantation have shown potential in adjusting the genital microbiota to enhance male fertility. Notably, the application of precision medicine, which customizes treatments based on individual microbial profiles and specific causes of infertility, emerges as a promising approach to enhance treatment outcomes. Ultimately, microbial dysbiosis is intricately linked to male infertility, and embracing personalized treatment strategies rooted in precision medicine principles could be the way forward in addressing infertility associated with microbial factors.
    Language English
    Publishing date 2023-10-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13101491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Predominance of Recombinant Norovirus Strains in Greece, 2016-2018.

    Siafakas, Nikolaos / Anastassopoulou, Cleo / Lafazani, Maria / Chronopoulou, Genovefa / Rizos, Emmanouil / Pournaras, Spyridon / Tsakris, Athanasios

    Microorganisms

    2023  Volume 11, Issue 12

    Abstract: GII.4 noroviruses have caused the overwhelming majority of norovirus-related gastroenteritis cases during the past two decades. However, a trend towards the emergence of new genotypes and novel GII.4 variants provided the impetus to explore further the ... ...

    Abstract GII.4 noroviruses have caused the overwhelming majority of norovirus-related gastroenteritis cases during the past two decades. However, a trend towards the emergence of new genotypes and novel GII.4 variants provided the impetus to explore further the changing patterns in norovirus epidemiology during the present study. Genotyping of 60 norovirus strains detected during a period of 33 months (January 2016-October 2018) was performed on the basis of the capsid VP1-coding ORF2 gene sequence. All norovirus strains detected were classified into seven genotypes, six of which belonged to genogroup GII. GII.2 was the dominant genotype till February 2017, whereas GII.4 prevailed thereafter. Most of the GII.4 strains were of the Sydney_2012 variant, whereas five strains could not be classified. Further recombination analysis at the ORF1/ORF2 gene junction revealed that 23 out of 24 strains were recombinant, thereby showcasing the significant role of genetic recombination in norovirus evolution and epidemiology. Continuous genomic surveillance and molecular characterization are essential for tracking norovirus evolution, which could contribute to the elucidation of new aspects of virus-host interactions that potentially affect host morbidity and epidemiology.
    Language English
    Publishing date 2023-11-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11122885
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  3. Article ; Online: Use of point-of-care molecular tests reduces hospitalization and oseltamivir administration in children presenting with influenza-like illness.

    Dimopoulou, Dimitra / Vourli, Sophia / Douros, Konstantinos / Pournaras, Spyridon / Papaevangelou, Vassiliki

    Journal of medical virology

    2020  Volume 93, Issue 6, Page(s) 3944–3948

    Abstract: Influenza is associated with increased morbidity, healthcare costs, hospitalization rates, and mortality in children. Rapid immunochromatography assay (ICA), a test with low sensitivity, is often used as point-of-care (POC) test. Recently, the rapid ... ...

    Abstract Influenza is associated with increased morbidity, healthcare costs, hospitalization rates, and mortality in children. Rapid immunochromatography assay (ICA), a test with low sensitivity, is often used as point-of-care (POC) test. Recently, the rapid syndromic molecular test FilmArray has become available. This observational study aims to evaluate whether the use of FilmArray would decrease the use of antivirals and hospitalization rates among children presenting to the emergency room (ER) with influenza-like illness (ILI) symptoms. Nasopharyngeal swabs were prospectively collected from children, aged 0-16 years, presenting with ILI at the ER of a tertiary hospital during the peak endemic period. Patients were allocated to be tested by either FilmArray or ICA. The use of antivirals and hospitalization rates were noted. Logistic regression models were used to investigate the impact of testing methods on decision-making. Overall, 80 children were included (mean age: 5 years). Admissions were more likely to occur if an ICA test was performed (OR, 3.16; 95% CI, 1.01-9.82; p = .046). Oseltamivir administration was more likely among children who had undergone the ICA test (OR, 4.67; 95% CI, 1.06-20.43; p = .041). The implementation of rapid molecular test had no impact on complementary diagnostic testing or antibacterial prescription. The use of FilmArray significantly reduced both hospitalization and oseltamivir administration in children. Further knowledge on the use of POC tests is required to improve current management of children presenting with ILI and decrease associated healthcare costs.
    MeSH term(s) Adolescent ; Antiviral Agents/therapeutic use ; Child ; Child, Preschool ; Emergency Service, Hospital/statistics & numerical data ; Female ; Health Care Costs ; Hospitalization/statistics & numerical data ; Humans ; Immunoassay/standards ; Immunoassay/statistics & numerical data ; Infant ; Infant, Newborn ; Influenza, Human/diagnosis ; Influenza, Human/virology ; Male ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Molecular Diagnostic Techniques/statistics & numerical data ; Oseltamivir/therapeutic use ; Point-of-Care Testing/standards ; Point-of-Care Testing/statistics & numerical data ; Prospective Studies ; Virus Diseases/diagnosis ; Virus Diseases/virology
    Chemical Substances Antiviral Agents ; Oseltamivir (20O93L6F9H)
    Language English
    Publishing date 2020-10-08
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26538
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  4. Article ; Online: Molecular epidemiology of noroviruses in children in South Greece, 2013-2015.

    Siafakas, Nikolaos / Zerva, Loukia / Hatzaki, Despina / Lebessi, Evangelia / Chronopoulou, Genovefa / Paraskakis, Irene / Pournaras, Spyridon

    Journal of medical virology

    2018  Volume 90, Issue 11, Page(s) 1703–1711

    Abstract: Noroviruses constitute the leading cause of acute, nonbacterial gastroenteritis that affects both children and adults in healthcare and community settings. The current study attempted to provide insight on the molecular epidemiology of noroviruses in ... ...

    Abstract Noroviruses constitute the leading cause of acute, nonbacterial gastroenteritis that affects both children and adults in healthcare and community settings. The current study attempted to provide insight on the molecular epidemiology of noroviruses in children in South Greece. Genotypic characterization of 69 norovirus strains detected in stool samples from children with gastroenteritis during a period of 30 months (January 2013 to June 2015) was performed on the basis of ORF2 (VP1 capsid) gene sequences. The results revealed the circulation of a diverse variety of norovirus genotypes. GII.4 was the predominant genotype (74%), followed by GII.2 (8.7%), GII.3 (5.8%), GII.6 (2.9%), GI.2 (2.9%), and four strains identified as GII.1, GII.7, GII.8, and GII.13, respectively. Phylogenetic analysis showed that most of the strains were closely associated with norovirus strains that circulated globally either in outbreaks and sporadic cases of gastroenteritis or in the environment during the last 4 years. Οf the GII.4 strains, 80.4% were detected between January 2013 and February 2014, indicating a possible ongoing epidemic. The incidence of other genotypes remained constant throughout the study period. Genotypic and phylogenetic analysis showed the predominance of the "Sydney 2012" variant among the GII.4 strains, whereas one GII.4 strain was identified as a "New Orleans 2009" variant. Five GII.4 strains showed significant nucleotide and amino acid sequence divergence from either the "Sydney 2012" or the "New Orleans 2009" variant, and these divergent strains might represent an emerging GII.4 variant.
    MeSH term(s) Adolescent ; Caliciviridae Infections/epidemiology ; Caliciviridae Infections/virology ; Capsid Proteins/genetics ; Child ; Child, Preschool ; Feces/virology ; Female ; Genetic Variation ; Genotype ; Genotyping Techniques ; Greece/epidemiology ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Molecular Epidemiology ; Norovirus/classification ; Norovirus/genetics ; Norovirus/isolation & purification ; Phylogeny ; Sequence Analysis, DNA
    Chemical Substances Capsid Proteins
    Language English
    Publishing date 2018-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.25251
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  5. Article ; Online: Overview of Mpox Outbreak in Greece in 2022-2023: Is It Over?

    Mellou, Kassiani / Tryfinopoulou, Kyriaki / Pappa, Styliani / Gkolfinopoulou, Kassiani / Papanikou, Sofia / Papadopoulou, Georgia / Vassou, Evangelia / Kostaki, Evangelia-Georgia / Papadima, Kalliopi / Mouratidou, Elissavet / Tsintziloni, Maria / Siafakas, Nikolaos / Florou, Zoi / Katsoulidou, Antigoni / Sapounas, Spyros / Sourvinos, George / Pournaras, Spyridon / Petinaki, Efthymia / Goula, Maria /
    Paparizos, Vassilios / Papa, Anna / Zaoutis, Theoklis / Paraskevis, Dimitrios

    Viruses

    2023  Volume 15, Issue 6

    Abstract: In May 2022, for the first time, multiple cases of mpox were reported in several non-endemic countries. The first ever case of the disease in Greece was confirmed on 8 June 2022, and a total of 88 cases were reported in the country until the end of April ...

    Abstract In May 2022, for the first time, multiple cases of mpox were reported in several non-endemic countries. The first ever case of the disease in Greece was confirmed on 8 June 2022, and a total of 88 cases were reported in the country until the end of April 2023. A multidisciplinary response team was established by the Greek National Public Health Organization (EODY) to monitor and manage the situation. EODY's emergency response focused on enhanced surveillance, laboratory testing, contact tracing, medical countermeasures, and the education of health care providers and the public. Even though management of cases was considered successful and the risk from the disease was downgraded, sporadic cases continue to occur. Here, we provide epidemiological and laboratory features of the reported cases to depict the course of the disease notification rate. Our results suggest that measures for raising awareness as well as vaccination of high-risk groups of the population should be continued.
    MeSH term(s) Humans ; Contact Tracing ; Disease Outbreaks ; Greece/epidemiology ; Mpox (monkeypox) ; Public Health
    Language English
    Publishing date 2023-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v15061384
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  6. Article ; Online: Low-Dose Cotrimoxazole Administered in Hematopoietic Stem Cell Transplant Recipients as Prophylaxis for Pneumocystis jirovecii Pneumonia Is Effective in Prevention of Infection due to Nocardia.

    Gkirkas, Konstantinos / Stamouli, Maria / Thomopoulos, Thomas / Kontos, Fanouris / Kavatha, Dimitra / Siafakas, Nikolaos / Karagiannidou, Angeliki / Pournaras, Spyridon / Antoniadou, Anastasia / Tsirigotis, Panagiotis

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2019  Volume 25, Issue 9, Page(s) e298–e299

    MeSH term(s) Allografts ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Nocardia ; Nocardia Infections/prevention & control ; Pneumocystis carinii ; Pneumonia, Pneumocystis/prevention & control ; Retrospective Studies ; Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosage
    Chemical Substances Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Letter
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2019.07.018
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    Zs.A 5082: Show issues Location:
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  7. Article ; Online: Preliminary Data of a Quantitative Point of Care Test for SARS-CoV-2 Antibodies From Greece.

    Fragkou, Paraskevi C / Papaevangelou, Vassiliki / Antoniadou, Anastasia / Kavvatha, Dimitra / Ploussi, Agapi / Pantazis, Nikos / Sirmpilantze, Tamta / Psarrakis, Christos / Pournaras, Spyridon A / Tsiodras, Sotirios / Kelekis, Alexis

    In vivo (Athens, Greece)

    2020  Volume 34, Issue 5, Page(s) 3039–3045

    Abstract: Background: Antibody testing is necessary to identify immune individuals in the post-initial wave of the COVID-19 pandemic.: Patients and methods: We prospectively evaluated the performance of a quantitative point-of-care test (POCT) for SARS-CoV-2 ... ...

    Abstract Background: Antibody testing is necessary to identify immune individuals in the post-initial wave of the COVID-19 pandemic.
    Patients and methods: We prospectively evaluated the performance of a quantitative point-of-care test (POCT) for SARS-CoV-2 antibodies. The patient group (PG) comprised of hospitalized confirmed COVID-19 cases. Asymptomatic healthcare volunteers with negative rRT-PCR were included in the control group (CG). Measurement of IgM and IgG was obtained by dry fluorescence immunoassay.
    Results: Twenty-six PG (65.9±15.4 years old, male 57.7%) and 18 CG (45.6±10.1 years old, male 33.3%) were included. By manufacturer's cut-off (≥0.04 mIU/ml), sensitivity and specificity were 73.08% and 88.89% for IgM and 88.46% and 33.33% for IgG, respectively. Estimated areas under the ROC curve were 0.907 and 0.848 for IgM and IgG, respectively. Results were improved using a cut-off of IgM ≥0.05 mIU/ml and IgG ≥0.10 mIU/ml.
    Conclusion: Using stringent cut-off values, SARS-CoV-2 antibody POCT detects immune people and can be used during socioeconomic normalization of communities.
    MeSH term(s) Aged ; Antibodies, Viral/blood ; Antibodies, Viral/isolation & purification ; Betacoronavirus/isolation & purification ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Greece/epidemiology ; Humans ; Immunoglobulin G/blood ; Immunoglobulin G/isolation & purification ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Point-of-Care Systems ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Keywords covid19
    Language English
    Publishing date 2020-08-14
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.12138
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    Zs.A 2288: Show issues Location:
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  8. Article ; Online: Oral ribavirin is a highly effective treatment for lower respiratory tract infections due to respiratory syncytial virus or parainfluenza after allogeneic stem cell transplantation.

    Stamouli, Maria / Tsonis, Ioannis / Gkirkas, Konstantinos / Economopoulou, Christina / Siafakas, Nikolaos / Pournaras, Spyridon / Antoniadou, Anastasia / Chondropoulos, Spyros / Karagiannidi, Angeliki / Meletiadis, Josef / Gigantes, Stavros / Baltadakis, Ioannis / Goussetis, Evgenios / Karakasis, Dimitrios / Tsirigotis, Panagiotis

    Bone marrow transplantation

    2020  Volume 56, Issue 2, Page(s) 511–513

    MeSH term(s) Antiviral Agents/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Humans ; Paramyxoviridae Infections/drug therapy ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Viruses ; Respiratory Tract Infections/therapy ; Ribavirin/therapeutic use
    Chemical Substances Antiviral Agents ; Ribavirin (49717AWG6K)
    Language English
    Publishing date 2020-08-08
    Publishing country England
    Document type Letter
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-020-01022-x
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  9. Article ; Online: Update in COVID-19 in the intensive care unit from the 2020 HELLENIC Athens International symposium.

    Rello, Jordi / Belliato, Mirko / Dimopoulos, Meletios-Athanasios / Giamarellos-Bourboulis, Evangelos J / Jaksic, Vladimir / Martin-Loeches, Ignacio / Mporas, Iosif / Pelosi, Paolo / Poulakou, Garyphallia / Pournaras, Spyridon / Tamae-Kakazu, Maximiliano / Timsit, Jean-François / Waterer, Grant / Tejada, Sofia / Dimopoulos, George

    Anaesthesia, critical care & pain medicine

    2020  Volume 39, Issue 6, Page(s) 723–730

    Abstract: The 2020 International Web Scientific Event in COVID-19 pandemic in critically ill patients aimed at updating the information and knowledge on the COVID-19 pandemic in the intensive care unit. Experts reviewed the latest literature relating to the COVID- ... ...

    Abstract The 2020 International Web Scientific Event in COVID-19 pandemic in critically ill patients aimed at updating the information and knowledge on the COVID-19 pandemic in the intensive care unit. Experts reviewed the latest literature relating to the COVID-19 pandemic in critically ill patients, such as epidemiology, pathophysiology, phenotypes of infection, COVID-19 as a systematic infection, molecular diagnosis, mechanical ventilation, thromboprophylaxis, COVID-19 associated co-infections, immunotherapy, plasma treatment, catheter-related bloodstream infections, artificial intelligence for COVID-19, and vaccination. Antiviral therapy and co-infections are out of the scope of this review. In this review, each of these issues is discussed with key messages regarding management and further research being presented after a brief review of available evidence.
    MeSH term(s) COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; COVID-19 Nucleic Acid Testing/methods ; COVID-19 Vaccines ; Congresses as Topic ; Global Health/statistics & numerical data ; Humans ; Immunization, Passive/methods ; Immunotherapy/methods ; Intensive Care Units ; Pandemics ; Phenotype ; SARS-CoV-2 ; Symptom Assessment ; Thromboembolism/prevention & control ; Videoconferencing ; Virus Internalization ; COVID-19 Serotherapy
    Chemical Substances COVID-19 Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-10-22
    Publishing country France
    Document type Journal Article ; Review
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2020.10.008
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  10. Article ; Online: A study of the evolution of the third COVID-19 pandemic wave in the Athens metropolitan area, Greece, through two cross-sectional seroepidemiological surveys: March, June 2021.

    Maltezou, Helena C / Krumbholz, Bettina / Mavrouli, Maria / Tseroni, Maria / Gamaletsou, Maria N / Botsa, Evanthia / Anastassopoulou, Cleo / Gikas, Aristofanis / Fournarakou, Evanthia / Kavieri, Maria / Koureli, Aikaterini / Mandilara, Dionysia / Marinopoulou, Aikaterini / Theodorikakou, Argyro / Tsiahris, Panagiotis / Zarzali, Anastasia / Pournaras, Spyridon / Lourida, Athanasia / Elefsiniotis, Ioannis /
    Vrioni, Georgia / Sipsas, Nikolaos V / Tsakris, Athanasios

    Journal of medical virology

    2021  Volume 94, Issue 4, Page(s) 1465–1472

    Abstract: We studied the third coronavirus disease 2019 (COVID-19) pandemic wave in Athens metropolitan area (3 738 901 inhabitants) through two seroepidemiological surveys. Persons presenting in 12 healthcare facilities across Athens in March and June 2021 were ... ...

    Abstract We studied the third coronavirus disease 2019 (COVID-19) pandemic wave in Athens metropolitan area (3 738 901 inhabitants) through two seroepidemiological surveys. Persons presenting in 12 healthcare facilities across Athens in March and June 2021 were studied (764 and 901, respectively). Immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein were measured by a chemiluminescent microparticle immunoassay. In March the seroprevalence rate was 11.6%, meaning that 435 208 residents of Athens had evidence of immunity. The respective values in June were 55.7% and 2 082 568 residents. The highest seroprevalence rates attributed to SARS-CoV-2 infection were recorded in persons <18 years (16.3% in March and 31.6% in June), while immunity was mainly vaccine-induced in persons 18-64 years and >65 years. Infection-attributed immunity also increased in older-age groups. Wide ranges in seroprevalence rates were noted across areas in March and June. The highest seroprevalence rates were recorded in Piraeus (47.2%) and West Attica (37.5%). However, the highest increase (>5 times) occurred in Piraeus and the South Section of Athens, which are among the most densely populated areas in Athens. In both study periods, history of COVID-19 or febrile episode, and having a cohabitant with COVID-19 were associated with increased risk for seropositivity among unvaccinated persons (p values <0.001 for all). Residing in Piraeus, the South Section or West Attica was associated with increased risk for seropositivity in June (p values <0.001). Wide heterogeneity in seroprevalence rates was found across areas in Athens, which is mainly attributed to population density. The impact of population mobility and socioeconomic status should be explored.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antibodies, Viral/blood ; COVID-19/blood ; COVID-19/epidemiology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Greece/epidemiology ; Humans ; Infant ; Male ; Middle Aged ; Prevalence ; SARS-CoV-2/immunology ; Seroepidemiologic Studies ; Young Adult
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2021-12-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.27465
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