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  1. Article ; Online: Re: Effect of Extended Pelvic Lymph Node Dissection on Oncologic Outcomes in Patients with D'Amico Intermediate and High Risk Prostate Cancer Treated with Radical Prostatectomy: A Multi-Institutional Study.

    Hajiran, Ali / Pow-Sang, Julio

    The Journal of urology

    2020  Volume 204, Issue 1, Page(s) 159

    MeSH term(s) Humans ; Lymph Node Excision ; Male ; Prostatectomy ; Prostatic Neoplasms/surgery
    Language English
    Publishing date 2020-03-19
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial Comment.

    Hajiran, Ali / Pow-Sang, Julio

    The Journal of urology

    2020  Volume 204, Issue 2, Page(s) 266

    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/JU.0000000000001011.02
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  3. Article: Analysis of MRI radiomic pelvimetry and correlation with margin status after robotic prostatectomy.

    Youssef, Irini / Poch, Michael / Raghunand, Natarajan / Pow-Sang, Julio / Johnstone, Peter A S

    The Canadian journal of urology

    2022  Volume 29, Issue 1, Page(s) 10976–10978

    Abstract: Introduction: To evaluate the use of preoperative magnetic resonance imaging (MRI) as a predictor of positive margins after radical prostatectomy (RP). This is important as such patients may benefit from postoperative radiotherapy. With the advent of ... ...

    Abstract Introduction: To evaluate the use of preoperative magnetic resonance imaging (MRI) as a predictor of positive margins after radical prostatectomy (RP). This is important as such patients may benefit from postoperative radiotherapy. With the advent of preoperative MRI, we posited that pelvimetry could predict positive margins after RP in patients with less-than ideal pelvic dimensions undergoing robotic-assisted laparoscopic surgery.
    Materials and methods: After IRB approval, data from patients undergoing RP at our center between 1/1/2018 and 12/31/2019 (n = 314) who had undergone prior prostate MRI imaging (n = 102) were analyzed. All RPs were performed using robotic-assisted laparoscopic technique. Data from the cancer center data warehouse were retrieved, to include postoperative T-stage, gland size, responsible surgeon, PSA, patient body mass index, and surgical margin status. These data were analyzed with corresponding pelvimetry data from 91 preoperative scans with complete data and imaging.
    Results: On multivariable analysis, pathologic T-stage (p = 0.004), anteroposterior pelvic outlet (p = 0.015) and pelvic depth (length of the pubic symphysis; p = 0.019) were all statistically correlated with positive surgical margins.
    Conclusions: With the widespread use of MRI in the initial staging of prostate cancer, automated radiomic analysis could augment the critical data already being accumulated in terms of seminal vesical involvement, extracapsular extension, and suspicious lymph nodes as risk factors for postoperative salvage radiation. Such automated data could help screen patients preoperatively for robotic RP.
    MeSH term(s) Humans ; Magnetic Resonance Imaging ; Male ; Margins of Excision ; Pelvimetry ; Prostate-Specific Antigen ; Prostatectomy/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Retrospective Studies ; Robotic Surgical Procedures/adverse effects
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2022-02-25
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 2064475-9
    ISSN 1195-9479
    ISSN 1195-9479
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  4. Article ; Online: Editorial Comment.

    Aydin, Ahmet M / Pow-Sang, Julio M

    The Journal of urology

    2019  Volume 201, Issue 6, Page(s) 1125–1126

    MeSH term(s) Anesthesia, Local ; Biopsy ; Humans ; Male ; Prostatic Neoplasms
    Language English
    Publishing date 2019-04-02
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3176-8
    ISSN 1527-3792 ; 0022-5347
    ISSN (online) 1527-3792
    ISSN 0022-5347
    DOI 10.1097/01.JU.0000554643.78812.6a
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  5. Article: Legends in urology.

    Pow-Sang, Julio E

    The Canadian journal of urology

    2014  Volume 21, Issue 1, Page(s) 7092–7093

    MeSH term(s) History, 20th Century ; History, 21st Century ; Peru ; Urology/history
    Language English
    Publishing date 2014-02
    Publishing country Canada
    Document type Autobiography ; Editorial ; Historical Article ; Portraits
    ZDB-ID 2064475-9
    ISSN 1195-9479
    ISSN 1195-9479
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  6. Article ; Online: The improving landscape of urologic oncology.

    Pow-Sang, Julio M

    Cancer control : journal of the Moffitt Cancer Center

    2013  Volume 20, Issue 3, Page(s) 158–159

    MeSH term(s) Humans ; Periodicals as Topic ; Precision Medicine ; Urologic Neoplasms/diagnosis ; Urologic Neoplasms/prevention & control
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 1328503-8
    ISSN 1526-2359 ; 1073-2748
    ISSN (online) 1526-2359
    ISSN 1073-2748
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    Zs.A 4467: Show issues Location:
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  7. Article ; Online: A phase II randomized clinical trial using aglycone isoflavones to treat patients with localized prostate cancer in the pre-surgical period prior to radical prostatectomy.

    Kumar, Nagi B / Pow-Sang, Julio / Spiess, Philippe / Dickinson, Shohreh / Schell, Michael J

    Oncotarget

    2020  Volume 11, Issue 14, Page(s) 1218–1234

    Abstract: Prostate cancer (PCa) is the most common cancer in American men. Additionally, African American Men (AAM) are 60% more likely to be diagnosed with PCa and 2.4 times more likely to die from this disease compared to Caucasian men (CM). To date, there are ... ...

    Abstract Prostate cancer (PCa) is the most common cancer in American men. Additionally, African American Men (AAM) are 60% more likely to be diagnosed with PCa and 2.4 times more likely to die from this disease compared to Caucasian men (CM). To date, there are few strategies effective for chemoprevention for men with localized PCa. There is thus a need to continue to evaluate agents and strategies for chemoprevention of prostate cancer. Epidemiological, laboratory and early phase clinical trials have shown that the isoflavones modulates several biomarkers implicated in prostate carcinogenesis. The goal of this phase II randomized clinical trial was to explore the comparative effectiveness and safety of 40 mgs of aglycone isoflavones in AAM and CM with localized PCa in the pre-surgical period prior to radical prostatectomy. Thirty six participants (25 CM, 6AAM) were randomized to the isoflavone arm and 34 (25 CM, 7AAM) to the placebo arm, with 62 completing the intervention. Results indicated that isoflavones at a dose of 20 mgs BID for 3-6 weeks was well tolerated but did not reduce tissue markers of proliferation. A significant reduction in serum PSA was observed with isoflavone supplementation in CM compared to the placebo arm, but not observed in AAM. We observed no changes in serum steroid hormones with isoflavone supplementation. In AAM, a reduction in serum IGF-1 concentrations and IGF1: IGFBP-3 ratios were observed with isoflavone supplementation. Well-powered studies for longer duration of intervention may inform future trials with isoflavones, for chemoprevention of PCa.
    Language English
    Publishing date 2020-04-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.27529
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  8. Article ; Online: Editorial comment.

    Pow-Sang, Julio M

    Urology

    2011  Volume 77, Issue 2, Page(s) 367; author reply 367

    MeSH term(s) Hand-Assisted Laparoscopy ; Humans ; Nephrectomy/methods ; Patient Positioning ; Renal Dialysis ; Retroperitoneal Space ; Supine Position ; Ureter/surgery
    Language English
    Publishing date 2011-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2010.05.060
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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  9. Article: Classifying Malignancy in Prostate Glandular Structures from Biopsy Scans with Deep Learning.

    Fogarty, Ryan / Goldgof, Dmitry / Hall, Lawrence / Lopez, Alex / Johnson, Joseph / Gadara, Manoj / Stoyanova, Radka / Punnen, Sanoj / Pollack, Alan / Pow-Sang, Julio / Balagurunathan, Yoganand

    Cancers

    2023  Volume 15, Issue 8

    Abstract: Histopathological classification in prostate cancer remains a challenge with high dependence on the expert practitioner. We develop a deep learning (DL) model to identify the most prominent Gleason pattern in a highly curated data cohort and validate it ... ...

    Abstract Histopathological classification in prostate cancer remains a challenge with high dependence on the expert practitioner. We develop a deep learning (DL) model to identify the most prominent Gleason pattern in a highly curated data cohort and validate it on an independent dataset. The histology images are partitioned in tiles (14,509) and are curated by an expert to identify individual glandular structures with assigned primary Gleason pattern grades. We use transfer learning and fine-tuning approaches to compare several deep neural network architectures that are trained on a corpus of camera images (ImageNet) and tuned with histology examples to be context appropriate for histopathological discrimination with small samples. In our study, the best DL network is able to discriminate cancer grade (GS3/4) from benign with an accuracy of 91%, F
    Language English
    Publishing date 2023-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15082335
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  10. Article ; Online: Progress in treatment of genitourinary malignancies.

    Pow-Sang, Julio M

    Cancer control : journal of the Moffitt Cancer Center

    2010  Volume 17, Issue 4, Page(s) 212

    MeSH term(s) Humans ; Urogenital Neoplasms/therapy
    Language English
    Publishing date 2010-10
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1328503-8
    ISSN 1526-2359 ; 1073-2748
    ISSN (online) 1526-2359
    ISSN 1073-2748
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