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  1. Article ; Online: Acute promyelocytic leukemia: progress far and wide.

    Powell, Bayard L

    Blood

    2013  Volume 121, Issue 11, Page(s) 1925–1926

    Abstract: In this issue of Blood, Rego and colleagues describe the exciting accomplishments of the International Consortium on Acute Promyelocytic Leukemia (IC-APL), an initiative of the International Members Committee of the American Society of Hematology (ASH).( ... ...

    Abstract In this issue of Blood, Rego and colleagues describe the exciting accomplishments of the International Consortium on Acute Promyelocytic Leukemia (IC-APL), an initiative of the International Members Committee of the American Society of Hematology (ASH).(1) The purpose of this initiative is to create a network of institutions in developing countries that will work in partnership with cooperative groups in the United States and Europe in order to close the gap in quality of care and outcomes in acute promyelocytic leukemia (APL) between developed and developing countries.
    MeSH term(s) Community Networks/organization & administration ; Developing Countries ; Female ; Humans ; Leukemia, Promyelocytic, Acute/diagnosis ; Leukemia, Promyelocytic, Acute/therapy ; Male ; Quality Improvement/organization & administration
    Language English
    Publishing date 2013-03-13
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2012-12-470757
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  2. Article: CPX-351 Pharmacokinetics and Safety in Adults with Hematologic Malignancies and Renal Function Impairment: Phase 1 Trial.

    Solomon, Scott R / Powell, Bayard L / Koprivnikar, Jamie / Lai, Catherine / Male, Heather / Michaelis, Laura C / Newell, Laura F / Sanford, David / Jenkins, Jack / Zelaya, Amy / Coppola, Sheryl / Faderl, Stefan / Walter, Roland B

    Cancers

    2024  Volume 16, Issue 5

    Abstract: This open-label phase 1 study (clinicaltrials.gov, NCT03555955) assessed CPX-351 pharmacokinetics (PK) and safety in patients with hematologic malignancies with normal or impaired renal function. Patients were enrolled into three cohorts based on their ... ...

    Abstract This open-label phase 1 study (clinicaltrials.gov, NCT03555955) assessed CPX-351 pharmacokinetics (PK) and safety in patients with hematologic malignancies with normal or impaired renal function. Patients were enrolled into three cohorts based on their creatinine clearance (CrCl): ≥90 mL/min (Cohort 1, normal renal function,
    Language English
    Publishing date 2024-02-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16050915
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  3. Article ; Online: Arsenic trioxide in acute promyelocytic leukemia: potion not poison.

    Powell, Bayard L

    Expert review of anticancer therapy

    2011  Volume 11, Issue 9, Page(s) 1317–1319

    MeSH term(s) Antineoplastic Agents/therapeutic use ; Arsenicals/therapeutic use ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Oxides/therapeutic use
    Chemical Substances Antineoplastic Agents ; Arsenicals ; Oxides ; arsenic trioxide (S7V92P67HO)
    Language English
    Publishing date 2011-09
    Publishing country England
    Document type Editorial ; Review
    ZDB-ID 2112544-2
    ISSN 1744-8328 ; 1473-7140
    ISSN (online) 1744-8328
    ISSN 1473-7140
    DOI 10.1586/era.11.128
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    Zs.A 5907: Show issues Location:
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  4. Article ; Online: Real-world outcomes of adult patients with acute lymphoblastic leukemia treated with a modified CALGB 10102 regimen.

    Reed, Daniel R / Wooster, Margaux / Isom, Scott / Ellis, Leslie R / Howard, Dianna S / Manuel, Megan / Dralle, Sarah / Lyerly, Susan / Bhave, Rupali / Powell, Bayard L / Pardee, Timothy S

    Annals of hematology

    2023  Volume 102, Issue 4, Page(s) 897–906

    Abstract: Acute lymphoblastic leukemia (ALL) is an aggressive bone marrow cancer with disparate outcomes. Data on patient outcomes in real world settings outside of clinical trials is limited. The current study reports on outcomes for 137 ALL patients who received ...

    Abstract Acute lymphoblastic leukemia (ALL) is an aggressive bone marrow cancer with disparate outcomes. Data on patient outcomes in real world settings outside of clinical trials is limited. The current study reports on outcomes for 137 ALL patients who received an adult induction and consolidation regimen derived from the CALGB 10102 trial modified without alemtuzumab. Of the 137 patients, 32 were < 40 years old, 52 were between 40 and 59, and 53 were ≥ 60 years old. Overall, 109 (79.6%) patients achieved a complete remission (< 40: 96.1%, 40-59: 86.5%, and 62.3% ≥ 60 (p = 0.0002)). Progression free survival for the entire cohort was 13.5 months and by age was 19.8 months for less than 40, 23.4 months for 40 to 59 and 6.7 months for ≥ 60; p = 0.0002. Median survival was 22.1 months for the entire cohort (32.9 months for ages < 40, 26.6 months ages 40-59, 7.8 months ≥ 60, p < 0.001).
    MeSH term(s) Humans ; Adult ; Child, Preschool ; Infant ; Middle Aged ; Treatment Outcome ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Remission Induction ; Alemtuzumab/therapeutic use
    Chemical Substances Alemtuzumab (3A189DH42V)
    Language English
    Publishing date 2023-03-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-023-05141-5
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  5. Article ; Online: Frequency of infusion-related reactions with CPX-351 treatment in an observational study in adults with newly diagnosed therapy-related AML or AML with myelodysplasia-related changes (AML-MRC).

    Jacoby, Meagan A / Finn, Laura / Emadi, Ashkan / Saba, Nakhle S / Powell, Bayard L / Seiter, Karen / Garcia, Rosella / Faderl, Stefan / Male, Heather J

    Leukemia & lymphoma

    2021  Volume 62, Issue 10, Page(s) 2539–2542

    MeSH term(s) Adult ; Cytarabine ; Daunorubicin ; Humans ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/etiology ; Myelodysplastic Syndromes/diagnosis ; Myelodysplastic Syndromes/epidemiology ; Myelodysplastic Syndromes/etiology
    Chemical Substances CPX-351 ; Cytarabine (04079A1RDZ) ; Daunorubicin (ZS7284E0ZP)
    Language English
    Publishing date 2021-05-11
    Publishing country United States
    Document type Letter ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1919668
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    Zs.A 2997: Show issues Location:
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  6. Article ; Online: Devimistat in combination with high dose cytarabine and mitoxantrone compared with high dose cytarabine and mitoxantrone in older patients with relapsed/refractory acute myeloid leukemia: ARMADA 2000 Phase III study.

    Pardee, Timothy S / Luther, Sanjeev / Buyse, Marc / Powell, Bayard L / Cortes, Jorge

    Future oncology (London, England)

    2019  Volume 15, Issue 28, Page(s) 3197–3208

    Abstract: Devimistat (CPI- ... ...

    Abstract Devimistat (CPI-613
    MeSH term(s) Aged ; Female ; Humans ; Male ; Middle Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Caprylates/administration & dosage ; Cytarabine/administration & dosage ; Drug Resistance, Neoplasm/drug effects ; Follow-Up Studies ; International Agencies ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/pathology ; Mitoxantrone/administration & dosage ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Prospective Studies ; Salvage Therapy ; Sulfides/administration & dosage ; Survival Rate ; Randomized Controlled Trials as Topic ; Clinical Trials, Phase III as Topic ; Multicenter Studies as Topic
    Chemical Substances Caprylates ; Cytarabine (04079A1RDZ) ; devimistat (E76113IR49) ; Mitoxantrone (BZ114NVM5P) ; Sulfides
    Language English
    Publishing date 2019-09-12
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2274956-1
    ISSN 1744-8301 ; 1479-6694
    ISSN (online) 1744-8301
    ISSN 1479-6694
    DOI 10.2217/fon-2019-0201
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    Zs.A 6478: Show issues Location:
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  7. Article ; Online: Framework of clonal mutations concurrent with WT1 mutations in adults with acute myeloid leukemia: Alliance for Clinical Trials in Oncology study.

    Bhatnagar, Bhavana / Kohlschmidt, Jessica / Orwick, Shelley J / Buelow, Daelynn R / Fobare, Sydney / Oakes, Christopher C / Kolitz, Jonathan E / Uy, Geoff / Stock, Wendy / Powell, Bayard L / Nicolet, Deedra / Hertlein, Erin K / Mrózek, Krzysztof / Blachly, James S / Eisfeld, Ann-Kathrin / Baker, Sharyn D / Byrd, John C

    Blood advances

    2023  Volume 7, Issue 16, Page(s) 4671–4675

    MeSH term(s) Adult ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Mutation ; WT1 Proteins/genetics
    Chemical Substances WT1 protein, human ; WT1 Proteins
    Language English
    Publishing date 2023-08-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010482
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    Zs.A 7153: Show issues Location:
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  8. Article ; Online: Prognostic factors for adult patients with Burkitt lymphoma treated with dose-adjusted EPOCH-R.

    Lakhotia, Rahul / Dunleavy, Kieron / Abramson, Jeremy S / Link, Brian K / Powell, Bayard L / Melani, Christopher / Lucas, Andrea N / Steinberg, Seth M / Friedberg, Jonathan W / Kahl, Brad S / Little, Richard F / Bartlett, Nancy L / Noy, Ariela / Wilson, Wyndham H / Roschewski, Mark

    Blood advances

    2023  Volume 7, Issue 18, Page(s) 5320–5324

    MeSH term(s) Humans ; Adult ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/drug therapy ; Prognosis ; Cyclophosphamide/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Rituximab/therapeutic use
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Letter
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2023010223
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  9. Article ; Online: Tailoring a physical activity intervention to older adults receiving intensive chemotherapy for acute myeloid leukemia (AML): One size does not fit all.

    Klepin, Heidi D / Tooze, Janet A / Rejeski, Jack / Mihalko, Shannon / Pardee, Timothy S / Demark-Wahnefried, Wendy / Powell, Bayard L / Geiger, Ann M / Kritchevsky, Stephen

    Journal of geriatric oncology

    2022  Volume 13, Issue 4, Page(s) 511–515

    MeSH term(s) Aged ; Exercise ; Humans ; Leukemia, Myeloid, Acute/drug therapy
    Language English
    Publishing date 2022-04-29
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2556813-9
    ISSN 1879-4076 ; 1879-4068
    ISSN (online) 1879-4076
    ISSN 1879-4068
    DOI 10.1016/j.jgo.2021.11.017
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  10. Article ; Online: Obesity in children with acute promyelocytic leukemia: What is its prevalence and prognostic significance?

    Laurie, Kathryn L / Lee, Paul / Rademaker, Alfred / Alonzo, Todd A / Wang, Yi-Cheng / Powell, Bayard L / Wu, Diana / Larson, Richard / Kutny, Matthew / Gregory, John / Hijiya, Nobuko / Feusner, James

    Pediatric blood & cancer

    2022  Volume 69, Issue 6, Page(s) e29613

    Abstract: Objective: To compare outcomes of obese and nonobese pediatric patients with acute promyelocytic leukemia (APL) from the Cancer and Leukemia Group B trial (CALGB) 9710 and the Children's Oncology Group trial AAML0631.: Methods: Data including ... ...

    Abstract Objective: To compare outcomes of obese and nonobese pediatric patients with acute promyelocytic leukemia (APL) from the Cancer and Leukemia Group B trial (CALGB) 9710 and the Children's Oncology Group trial AAML0631.
    Methods: Data including demographics, adverse events, overall and event-free survival (EFS) were analyzed.
    Results: The prevalence of obesity was 34% on C9710 and 35% on AAML0631. There was significantly lower overall and EFS in the obese population on multivariable analysis on AAML0631 but not on CALGB 9710. Eleven patients died during therapy or in follow-up.
    Conclusion: The prevalence of obesity is higher in pediatric patients with APL compared to the general population. The decreased EFS and OS in obese patients on AAML0631 suggest that the presence of obesity can influence outcomes using the most current treatment. These findings support the need for further research on the potential role of obesity in pediatric APL leukemogenesis.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Child ; Disease-Free Survival ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Pediatric Obesity ; Prevalence ; Prognosis ; Treatment Outcome
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131448-2
    ISSN 1545-5017 ; 1545-5009
    ISSN (online) 1545-5017
    ISSN 1545-5009
    DOI 10.1002/pbc.29613
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