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Article: Primary glioblastoma multiforme of the cerebellum; report of a case.

POWELL, C B

Journal of neuropathology and experimental neurology

2010 Volume 6, Issue 3, Page(s) 279–285

MeSH term(s)	Cerebellar Neoplasms ; Cerebellum ; Glioblastoma ; Humans ; Neoplasms ; Nerve Tissue
Language	English
Publishing date	2010-03-09
Publishing country	England
Document type	Journal Article
ZDB-ID	3088-0
ISSN	1554-6578 ; 0022-3069
ISSN (online)	1554-6578
ISSN	0022-3069
DOI	10.1097/00005072-194707000-00008
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Article: Roentgen Ray Diagnosis of the Diseases of the Thoracic Viscera.

Powell, C B

Journal of the National Medical Association

2010 Volume 18, Issue 2, Page(s) 73–75

Language	English
Publishing date	2010-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	419737-9
ISSN	0027-9684
ISSN	0027-9684
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Article: The Early Diagnosis of Pulmonary Tuberculosis: With Roentgen Diagnosis (illustrated).

Nelson, M R / Powell, C B

Journal of the National Medical Association

2010 Volume 13, Issue 2, Page(s) 81–87

Language	English
Publishing date	2010-10-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	419737-9
ISSN	0027-9684
ISSN	0027-9684
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Article: [Evaluation of methods of determining operative intervention in acute trauma to the nervous system].

LINDSTROM, P A / POWELL, C B

American journal of surgery

2003 Volume 93, Issue 4, Page(s) 654–656

MeSH term(s)	Central Nervous System/injuries ; Central Nervous System Depressants ; Humans
Chemical Substances	Central Nervous System Depressants
Language	French
Publishing date	2003-04-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/0002-9610(57)90525-1
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Article: Discordance between beliefs and recommendations of gynecologic oncologists in ovarian cancer management.

Chen, L / Learman, L A / Weinberg, V / Powell, C B

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2004 Volume 14, Issue 6, Page(s) 1055–1062

Abstract: Purpose: The purpose of this study was to determine how physician experts make decisions for clinical scenarios in ovarian cancer and describe a profile of factors reported to influence treatment decisions.: Methods: A questionnaire was sent to Full ... ...

Abstract	Purpose: The purpose of this study was to determine how physician experts make decisions for clinical scenarios in ovarian cancer and describe a profile of factors reported to influence treatment decisions. Methods: A questionnaire was sent to Full Members of the Society of Gynecologic Oncologists regarding surgery and chemotherapy for scenarios of primary and recurrent ovarian cancer. Results: In a scenario of primary presentation, 94% of respondents chose a treatment of tumor resection over chemotherapy. Despite the preference for surgery in a clinical scenario, 50% agreed with a statement that neoadjuvant chemotherapy is equivalent to primary surgery. In a scenario of recurrent disease, a comparable number of respondents chose a treatment of secondary cytoreductive surgery (45%) versus direct retreatment with chemotherapy (49%). Those choosing surgery responded that they believed in extensive surgery to achieve optimal cytoreduction. Most (62%) respondents described themselves as collaborative in treatment planning, yet only 24% reported that patient preference strongly influences their decision making. Conclusions: Although a plan for primary cytoreduction is favored, in specific scenarios, views were divided for the role of neoadjuvant chemotherapy. For a recurrent disease scenario, support was divided between secondary cytoreductive surgery and direct retreatment with chemotherapy. Further clinical research is necessary to minimize the discordance between physician beliefs and recommendations.
MeSH term(s)	Combined Modality Therapy ; Decision Making ; Female ; Gynecology/methods ; Gynecology/statistics & numerical data ; Humans ; Male ; Medical Oncology/methods ; Medical Oncology/statistics & numerical data ; Middle Aged ; Ovarian Neoplasms/therapy ; Patient Care Planning ; Practice Patterns, Physicians' ; Surveys and Questionnaires ; United States/epidemiology
Language	English
Publishing date	2004-04-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1070385-8
ISSN	1048-891X
ISSN	1048-891X
DOI	10.1111/j.1048-891X.2004.14602.x
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Article: Comparison of TNFalpha and TNFbeta cytolytic mechanisms in human ovarian and cervical carcinoma cell lines.

Powell, C B / Scott, J H / Collins, J L

Gynecologic oncology

1998 Volume 71, Issue 2, Page(s) 258–265

Abstract: Objectives: The aim of this study was to determine the potential and mechanism of tumor necrosis factor beta (TNFbeta) mediated cytolysis in human ovarian and cervical carcinoma cells.: Methods: The cytolytic potential of tumor necrosis factor alpha ( ...

Abstract	Objectives: The aim of this study was to determine the potential and mechanism of tumor necrosis factor beta (TNFbeta) mediated cytolysis in human ovarian and cervical carcinoma cells. Methods: The cytolytic potential of tumor necrosis factor alpha (TNFalpha) and TNFbeta was determined using the TNF reference cell line L929 and human ovarian (SK-OV-3, CaOV-3) and cervical (SiHa, HT-3) carcinoma cell lines. We have previously reported the effects of the lipoxygenase enzyme inhibitor, nordihydroguaiaretic acid, the oxygen radical scavenger glutathione, and fragmented DNA-specific staining with diamidino-2-phenylindole and ApopTag on TNFalpha-mediated cytolysis in these cells. The effects of these agents on TNFbeta-mediated cytolysis were determined. Results: All of the cell lines express a protein-synthesis-dependent TNFalpha and TNFbeta resistance mechanisms. When protein synthesis is inhibited the cytolytic activity of TNFbeta was fivefold greater than that of TNFalpha in L929 cells. In contrast, the cytolytic activity of TNFalpha was fivefold greater than that of TNFbeta in the human cells. Like the TNFalpha cytolytic mechanism, the TNFbeta cytolytic mechanism is dependent on lipoxygenase enzymes, but not oxygen radicals, and results in apoptosis. Conclusions: To date there is little information about the cytolytic potential of TNFbeta in human cells. The fact that the cytolytic mechanism of TNFbeta appears very similar to that of TNFalpha could be important to our understanding of the potential of these closely related cytokines in anticancer therapies. Although the cytolytic potential of TNFbeta is greater than that of TNFalpha in mouse cells, this is not true in human cells and could limit the efficacy of TNFbeta in anticancer therapies.
MeSH term(s)	Animals ; Antineoplastic Agents/pharmacology ; Dactinomycin/pharmacology ; Emetine/pharmacology ; Female ; Humans ; Lymphotoxin-alpha/pharmacology ; Mice ; Ovarian Neoplasms/pathology ; Ovarian Neoplasms/therapy ; Receptors, Tumor Necrosis Factor/analysis ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/pharmacology ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/therapy
Chemical Substances	Antineoplastic Agents ; Lymphotoxin-alpha ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha ; Dactinomycin (1CC1JFE158) ; Emetine (X8D5EPO80M)
Language	English
Publishing date	1998-11
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1006/gyno.1998.5178
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Article ; Online: Long term follow up of BRCA1 and BRCA2 mutation carriers with unsuspected neoplasia identified at risk reducing salpingo-oophorectomy.

Powell, C B / Swisher, E M / Cass, I / McLennan, J / Norquist, B / Garcia, R L / Lester, J / Karlan, B Y / Chen, L

Gynecologic oncology

2013 Volume 129, Issue 2, Page(s) 364–371

Abstract: Objectives: The reported incidence of neoplasia identified at the time of risk-reducing salpingo-oophorectomy (RRSO) in germline BRCA1/2 mutation carriers ranges from 4 to 12% but long-term outcomes have not been described. We evaluated recurrence and ... ...

Abstract	Objectives: The reported incidence of neoplasia identified at the time of risk-reducing salpingo-oophorectomy (RRSO) in germline BRCA1/2 mutation carriers ranges from 4 to 12% but long-term outcomes have not been described. We evaluated recurrence and survival outcomes of mutation carriers with neoplastic lesions identified at RRSO. Methods: We identified BRCA1/2 mutation carriers with neoplasia at RRSO at three institutions. Data was collected on clinical variables, adjuvant treatment and follow-up. Results: We identified 32 mutation carriers with invasive carcinomas (n=15) or high-grade intraepithelial neoplasia (n=17) that were not suspected prior to surgery. 26 occurred in BRCA1 and 6 in BRCA2 mutation carriers. Median and mean age for carcinomas were 50 years and 49.3 respectively, significantly younger than for intraepithelial neoplasm, median 53 years, and mean 55 years (p=0.04). For the 15 invasive carcinomas, median follow up was 88 months (range 45-172 months), 7 recurred (47%), median time to recurrence was 32.5 months and 3 have died of disease; 1 additional patient died of breast cancer. Overall survival was 73%, disease specific overall survival was 80% and disease free survival was 66%. For the 17 high-grade intraepithelial neoplasms, median follow up was 80 months (range 40-150), 4 were treated with chemotherapy. One recurred at 43 months and is currently not on therapy with a normal CA125, 16 months later. All patients with noninvasive neoplasia are alive. Conclusions: BRCA1 and BRCA2 mutation carriers with unsuspected invasive carcinoma at RRSO have a relatively high rate of recurrence despite predominantly early stage, small volume disease. High-grade intraepithelial neoplasms rarely recur as carcinoma and may not require adjuvant chemotherapy.
MeSH term(s)	Adult ; Aged ; Carcinoma in Situ/diagnosis ; Carcinoma in Situ/genetics ; Carcinoma in Situ/mortality ; Carcinoma in Situ/therapy ; Chemotherapy, Adjuvant ; Fallopian Tube Neoplasms/diagnosis ; Fallopian Tube Neoplasms/genetics ; Fallopian Tube Neoplasms/mortality ; Fallopian Tube Neoplasms/therapy ; Female ; Follow-Up Studies ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Humans ; Middle Aged ; Mutation ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/mortality ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/mortality ; Ovarian Neoplasms/therapy ; Ovariectomy ; Salpingectomy ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2013-02-04
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2013.01.029
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Article: Postarthroplasty histiocytic lymphadenopathy in gynecologic oncology patients. A benign reactive process that clinically may be mistaken for cancer.

Zaloudek, C / Treseler, P A / Powell, C B

Cancer

1996 Volume 78, Issue 4, Page(s) 834–844

Abstract: Background: A distinctive histiocytosis occurs in the regional draining lymph nodes after large joint replacements, resulting in lymphadenopathy that may mimic cancer both grossly and microscopically. Postarthroplasty histiocytic lymphadenopathy has ... ...

Abstract	Background: A distinctive histiocytosis occurs in the regional draining lymph nodes after large joint replacements, resulting in lymphadenopathy that may mimic cancer both grossly and microscopically. Postarthroplasty histiocytic lymphadenopathy has most often been observed in males during surgery for prostate cancer. Methods: The authors present three examples of postarthroplasty histiocytic lymphadenopathy that occurred in gynecologic oncology patients. We studied the clinical, histologic, and immunohistochemical features of all three cases and the ultrastructure of one of them. Results: Most involved lymph nodes were enlarged, but histiocytosis was also seen in normal sized lymph nodes. Microscopically, histiocytes with abundant granular cytoplasm were present in the lymph node parenchyma, and, to a lesser extent, in the sinuses. Normal lymph node architecture was variably effaced and the histiocytic infiltrate extended focally into the perinodal tissue. Small, black metal particles were present in the histiocytes in every case. Birefringent polyethylene particles were a prominent finding in all three cases as confirmed by positive modified oil red O staining, and, in one case, by electron microscopy. The histiocytes were strongly immunoreactive for CD68, but immunostains for S100 protein, MAC 387, and cytokeratin were negative. Conclusions: Enlargement of the lymph nodes in cancer patients who have had large joint replacements may be due to a benign histiocytosis rather than to metastatic cancer. The histologic features of the lymphadenopathy are distinctive and recognizable in routine histologic preparations. Polyethylene wear particles shed from joint prostheses are the most common substances in the histiocytes and are the most likely cause of the histiocytosis.
MeSH term(s)	Aged ; Female ; Genital Neoplasms, Female/pathology ; Hip Prosthesis/adverse effects ; Histiocytosis/diagnosis ; Histiocytosis/etiology ; Histiocytosis/pathology ; Humans ; Immunohistochemistry ; Infant, Newborn ; Lymph Nodes/pathology ; Middle Aged
Language	English
Publishing date	1996-08-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	1429-1
ISSN	1097-0142 ; 0008-543X ; 1934-662X
ISSN (online)	1097-0142
ISSN	0008-543X ; 1934-662X
DOI	10.1002/(SICI)1097-0142(19960815)78:4<834::AID-CNCR21>3.0.CO;2-V
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Article: Characterization of the protein synthesis independent TNFalpha lytic mechanism in human ovarian and cervical carcinoma cell lines.

Powell, C B / Scott, J H / Collins, J L

Gynecologic oncology

1996 Volume 62, Issue 1, Page(s) 42–48

Abstract: The analysis of the lytic mechanism initiated by TNFalpha in three human ovarian cell lines (CAOV-3, SK-OV-3, and OVCAR-3) and in three human cervical cell lines (SIHa, HT-3, and ME-180) in the presence of inhibitors of protein synthesis indicates that ... ...

Abstract	The analysis of the lytic mechanism initiated by TNFalpha in three human ovarian cell lines (CAOV-3, SK-OV-3, and OVCAR-3) and in three human cervical cell lines (SIHa, HT-3, and ME-180) in the presence of inhibitors of protein synthesis indicates that this lytic mechanism is similar to the protein synthesis-independent lytic mechanism initiated by TNFalpha in L929 cells. In addition to being independent of protein synthesis, the lytic mechanism initiated by TNFalpha in human ovarian and cervical carcinoma cells is also not dependent on the formation of oxygen radicals, as shown by the inability of the oxygen radical scavengers DMSO or glutathione to inhibit lysis. In spite of the fact that oxygen radicals are not involved in lysis, the TNFalpha lytic mechanism initiated in the human ovarian and cervical carcinoma cells is dependent on the activity of lipoxygenase enzymes. This was shown by the ability of the lipoxygenase enzyme inhibitor, NDGA, to block TNFalpha-mediated lysis. Using DNA-specific staining (DAPI and Apoptag) it was shown that when the human ovarian and cervical carcinoma cells are lysed by TNFalpha, death occurs via apoptosis.
MeSH term(s)	Apoptosis ; Female ; Humans ; Ovarian Neoplasms/metabolism ; Protein Biosynthesis ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/physiology ; Uterine Cervical Neoplasms/metabolism
Chemical Substances	Tumor Necrosis Factor-alpha
Language	English
Publishing date	1996-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1006/gyno.1996.0187
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Article ; Online: Endometrial stromal sarcoma: a population-based analysis.

Chan, J K / Kawar, N M / Shin, J Y / Osann, K / Chen, L-M / Powell, C B / Kapp, D S

British journal of cancer

2008 Volume 99, Issue 8, Page(s) 1210–1215

Abstract: To determine independent prognostic factors for the survival of patients with endometrial stromal sarcoma (ESS), data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute from 1988 to 2003. ...

Abstract	To determine independent prognostic factors for the survival of patients with endometrial stromal sarcoma (ESS), data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute from 1988 to 2003. Kaplan-Meier and Cox proportional hazards models were used for analyses. Of 831 women diagnosed with ESS, the median age was 52 years (range: 17-96 years). In total, 59.9% had stage I, 5.1% stage II, 14.9% stage III, and 20.1% had stage IV disease. Overall, 13.0, 36.1, and 34.7% presented with grades 1, 2, and 3, respectively. Patients with stage I-II vs III-IV disease had 5 years DSS of 89.3% vs 50.3% (P<0.001) and those with grades 1, 2, and 3 cancers had survivals of 91.4, 95.4, and 42.1% (P<0.001). In multivariate analysis, older patients, black race, advanced stage, higher grade, lack of primary surgery, and nodal metastasis were independent prognostic factors for poorer survival. In younger women (<50 years) with stage I-II disease, ovarian-sparing procedures did not adversely impact survival (91.9 vs 96.2%; P=0.1). Age, race, primary surgery, stage, and grade are important prognostic factors for ESS. Excellent survival in patients with grade 1 and 2 disease of all stages supports the concept that these tumors are significantly different from grade 3 tumors. Ovarian-sparing surgeries may be considered in younger patients with early-stage disease.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Endometrial Neoplasms/mortality ; Endometrial Neoplasms/pathology ; Endometrial Neoplasms/surgery ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Prognosis ; SEER Program ; Sarcoma, Endometrial Stromal/mortality ; Sarcoma, Endometrial Stromal/pathology ; Sarcoma, Endometrial Stromal/surgery
Language	English
Publishing date	2008-10-21
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/sj.bjc.6604527
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