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Article ; Online: Obituary for Prof. Ludovico Dalla Palma.

Pozzi Mucelli, Roberto

2017 Volume 27, Issue 7, Page(s) 2677–2678

Language	English
Publishing date	2017-05-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-017-4837-5
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Article ; Online: Secretin-enhanced MR Imaging of the Pancreas.

Manfredi, Riccardo / Pozzi Mucelli, Roberto

Radiology

2016 Volume 279, Issue 1, Page(s) 29–43

Abstract: Secretin is a hormone that stimulates the exocrine pancreatic secretion of bicarbonate-rich fluid from the acinar cells of the pancreas that accumulates within the pancreatic ductal lumen. The exogenous administration of secretin improves the ... ...

Abstract	Secretin is a hormone that stimulates the exocrine pancreatic secretion of bicarbonate-rich fluid from the acinar cells of the pancreas that accumulates within the pancreatic ductal lumen. The exogenous administration of secretin improves the visualization of pancreatic ducts at magnetic resonance (MR) cholangiopancreatography (MRCP), because of an enlargement of the pancreatic duct system and an increase of the fluid content within the lumen of the pancreatic ducts, responsible of an increase of MR signal. In this review, the technique of secretin-enhanced MRCP, which has the aim to depict the whole pancreatic duct system, the biliary tree, the major and minor papillae, and the duodenum, will be described. Because of the anatomic contiguity between the pancreas and the gastrointestinal tract, the presence of fluid within the stomach may overlap with the pancreatic duct system and therefore the pancreatic duct may be difficult to visualize, representing a potential source of diagnostic pitfalls. The technique to reduce the signal intensity of the static fluid present within the stomach and in the duodenal lumen is also described. The technique of secretin administration will be illustrated, with emphasis on the synchronization of secretin administration and MR image acquisition. Furthermore, the frequency and number of MRCP images necessary to achieve a temporal resolution adequate to visualize the physiologic changes in the pancreatic gland, induced by the administration of secretin, is described. The assessment of pancreatic, morphologic, and functional response to the administration of secretin, as depicted on MRCP images, will be illustrated. Finally, the indications for secretin-enhanced MRCP will be discussed to define which patients will benefit from secretin-enhanced MR imaging for their treatment planning. (©) RSNA, 2016.
MeSH term(s)	Humans ; Magnetic Resonance Imaging/methods ; Pancreatic Diseases/diagnosis ; Pancreatic Diseases/pathology ; Secretin/administration & dosage
Chemical Substances	Secretin (1393-25-5)
Language	English
Publishing date	2016-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80324-8
ISSN	1527-1315 ; 0033-8419
ISSN (online)	1527-1315
ISSN	0033-8419
DOI	10.1148/radiol.2015140622
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Article: Major pancreatic resections: normal postoperative findings and complications.

Chincarini, Marco / Zamboni, Giulia A / Pozzi Mucelli, Roberto

Insights into imaging

2018 Volume 9, Issue 2, Page(s) 173–187

Abstract: Objectives: (1) To illustrate and describe the main types of pancreatic surgery; (2) to discuss the normal findings after pancreatic surgery; (3) to review the main complications and their radiological findings.: Background: Despite the decreased ... ...

Abstract	Objectives: (1) To illustrate and describe the main types of pancreatic surgery; (2) to discuss the normal findings after pancreatic surgery; (3) to review the main complications and their radiological findings. Background: Despite the decreased postoperative mortality, morbidity still remains high resulting in longer hospitalisations and greater costs. Imaging findings following major pancreatic resections can be broadly divided into "normal postoperative alterations" and real complications. The former should regress within a few months whereas complications may be life-threatening and should be promptly identified and treated. Imaging findings: CT is the most effective postoperative imaging technique. MRI and fluoroscopy are used less often and only in specific cases such as assessing the gastro-intestinal function or the biliary tree. The most common normal postoperative findings are pneumobilia, perivascular cuffing, fluid collections, lymphadenopathy, acute anastomotic oedema and stranding of the peri-pancreatic/mesenteric fat. Imaging depicts the anastomoses and the new postoperative anatomy. It can also demonstrate early and late complications: pancreatic fistula, haemorrhage, delayed gastric emptying, hepatic infarction, acute pancreatitis of the remnant, porto-mesenteric thrombosis, abscess, biliary anastomotic leaks, anastomotic stenosis and local recurrence. Conclusions: Radiologists should be aware of surgical procedures, postoperative anatomy and normal postoperative imaging findings to better detect complications and recurrent disease. Teaching points: • Morbidity after pancreatic resections is high. • CT is the most effective postoperative imaging technique. • Imaging depicts the anastomoses and the new postoperative anatomy. • Pancreatic fistula is the most common complication after partial pancreatic resection.
Language	English
Publishing date	2018-02-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1007/s13244-018-0595-4
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Book ; Online: MRI of the Female and Male Pelvis

Manfredi, Riccardo / Pozzi Mucelli, Roberto

2015

Abstract: Based on the experience of two Italian referral centers, the book depicts the characteristic findings obtained when using MR imaging to study the male and female pelvis including the obstetric applications. Each chapter provides a comprehensive account ... ...

Author's details	edited by Riccardo Manfredi, Roberto Pozzi Mucelli
Abstract	Based on the experience of two Italian referral centers, the book depicts the characteristic findings obtained when using MR imaging to study the male and female pelvis including the obstetric applications. Each chapter provides a comprehensive account of the use of the imaging technique of examination, including the most recent advances in MR imaging, the anatomy and MR possibilities in the identification, characterization and staging of the different pelvic diseases highlighting its diagnostic possibilities. The advances in fetal MRI, representing the cutting edge of pelvic MR imaging, will also be depicted. The text is complemented by numerous illustrations, as well as clinical cases that make this a very practice-oriented work, presenting the role of diagnostic imaging in every-day clinical activity. The volume will prove an invaluable guide for both residents and professionals with core interest in gynecology, obstetrics and urology
Keywords	Gynecology ; Medicine ; Obstetrics ; Radiology, Medical ; Urology
Language	English
Size	Online-Ressource (VI, 289 p. 192 illus., 16 illus. in color), online resource
Publisher	Springer International Publishing
Publishing place	Cham ;s.l
Document type	Book ; Online
ISBN	9783319096582 ; 9783319096599 ; 3319096583 ; 3319096591
DOI	10.1007/978-3-319-09659-9
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Article ; Online: Evaluation of periprostatic neurovascular fibers before and after radical prostatectomy by means of 1.5 T MRI diffusion tensor imaging.

Di Paola, Valerio / Cybulski, Adam / Belluardo, Salvatore / Cavicchioli, Francesca / Manfredi, Riccardo / Pozzi Mucelli, Roberto

The British journal of radiology

2018 Volume 91, Issue 1085, Page(s) 20170318

Abstract: Objective: To evaluate if diffusion tensor imaging (DTI) is able to detect changes of periprostatic neurovascular fibers (PNFs) before and after radical prostatectomy (RP), and if these changes are related to post-surgical urinary incontinence and ... ...

Abstract	Objective: To evaluate if diffusion tensor imaging (DTI) is able to detect changes of periprostatic neurovascular fibers (PNFs) before and after radical prostatectomy (RP), and if these changes are related to post-surgical urinary incontinence and erectile dysfunction. Methods: 22 patients (mean age 62.6 years) with biopsy-proven prostate cancer underwent 1.5 T DTI before and after RP. The number, fractional anisotropy (FA) values and length of PNFs before and after RP were compared using Student's t-test. Each patient filled out two questionnaires before and after RP, one for the evaluation of urinary continence (ICIQ-SF) and one for the evaluation of erectile function (IIEF-5). The ratios of the number, FA values and length of PNFs before and after RP (DTI B-A RATIOs) and the ratios between the scores obtained before and after RP for both ICIQ-SF and IIEF-2 (ICIQ-SF B-A RATIOs and IIEF-2 B-A RATIOs) were calculated to perform the Kendall's τ-test between them. Results: There was a statistically significant decrease of the number of PNFs after RP at base, midgland, and apex (p < 0.01) and of FA values at midgland (p < 0.05), with positive statistically significant correlation between the DTI B-A RATIOs of the number of PNFs and IIEF-2 B-A RATIOs (p < 0.05, ρ = 0.47). Conclusion: DTI was able to detect that the decrease of the number of the PNFs after RP was statistically related to the post-surgical erectile dysfunction (p < 0.05). Advances in knowledge: This work demonstrates that: (1) 1.5 T MRI DTI is able to detect the decrease of the number and of the FA of PNFs after prostatectomy; (2) the decrease of the number of PNFs after prostatectomy is related with the post-surgical erectile dysfunction; (3) 1.5 T MRI DTI has demonstrated to be a reproducible technique in detecting the changes of the PNFs induced by RP, with high interobserver agreement.
MeSH term(s)	Diffusion Magnetic Resonance Imaging/methods ; Diffusion Tensor Imaging/methods ; Humans ; Male ; Middle Aged ; Postoperative Care/methods ; Prospective Studies ; Prostate/diagnostic imaging ; Prostate/surgery ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/surgery ; Reproducibility of Results
Language	English
Publishing date	2018-02-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20170318
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Article ; Online: Incidental optochiasmatic cavernoma: Case report of an unusual finding on 3 Tesla MRI.

Trentadue, Mirko / Pozzi Mucelli, Roberto / Piovan, Enrico / Pizzini, Francesca Benedetta

The neuroradiology journal

2016 Volume 29, Issue 4, Page(s) 289–294

Abstract: Cavernoma is a vascular hamartoma, which represents 10-20% of all central nervous system vascular malformations. The majority (80%) of them are supratentorial, while involvement of the cranial nerves and the optic pathways is extremely rare. The main ... ...

Abstract	Cavernoma is a vascular hamartoma, which represents 10-20% of all central nervous system vascular malformations. The majority (80%) of them are supratentorial, while involvement of the cranial nerves and the optic pathways is extremely rare. The main clinical presentation of optochiasmatic cavernomas consists of chiasmatic apoplexy, which is a neurosurgical emergency. Here, we report a case in which the finding was incidentally detected in a 49-year-old man. We describe the imaging characteristics of the lesion in such a rare location, highlighting the role of magnetic resonance imaging (MRI) (specifically 3 Tesla) in the management of asymptomatic patients.
MeSH term(s)	Hemangioma, Cavernous, Central Nervous System/diagnostic imaging ; Hemangioma, Cavernous, Central Nervous System/surgery ; Humans ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Optic Chiasm/diagnostic imaging ; Optic Chiasm/pathology ; Tomography Scanners, X-Ray Computed
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2257770-1
ISSN	2385-1996 ; 1971-4009 ; 1120-9976
ISSN (online)	2385-1996
ISSN	1971-4009 ; 1120-9976
DOI	10.1177/1971400916648335
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Article: ARFI: from basic principles to clinical applications in diffuse chronic disease-a review.

Bruno, Costanza / Minniti, Salvatore / Bucci, Alessandra / Pozzi Mucelli, Roberto

Insights into imaging

2016 Volume 7, Issue 5, Page(s) 735–746

Abstract: Unlabelled: The many factors influencing the shear wave velocity (SWV) measured with Acoustic Radiation Force Impulse (ARFI) are examined in order to define the most correct examination technique. In particular, attention is given to the information ... ...

Abstract	Unlabelled: The many factors influencing the shear wave velocity (SWV) measured with Acoustic Radiation Force Impulse (ARFI) are examined in order to define the most correct examination technique. In particular, attention is given to the information achieved by experimental models, such as phantoms and animal studies. This review targets the clinical applications of ARFI in the evaluation of chronic diffuse disease, especially of liver and kidneys. The contribution of ARFI to the clinical workout of these patients and some possible perspectives are described. Teaching points: • Stiffness significantly varies among normal and abnormal biological tissues. • In clinical applications physical, geometrical, anatomical and physiological factors influence the SWV. • Elastographic techniques can quantify fibrosis, which is directly related to stiffness. • ARFI can be useful in chronic diffuse disease of liver and kidney.
Language	English
Publishing date	2016-08-23
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1007/s13244-016-0514-5
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Article: Can diffusion-weighted MRI without breath-holding be used to evaluate renal abnormalities?

Pozzi-Mucelli, Roberto

Nature clinical practice. Nephrology

2006 Volume 2, Issue 3, Page(s) 126–127

Language	English
Publishing date	2006-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2228557-X
ISSN	1745-8331 ; 1745-8323
ISSN (online)	1745-8331
ISSN	1745-8323
DOI	10.1038/ncpneph0123
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Article ; Online: Chronic Asymptomatic Pancreatic Hyperenzymemia: A Long-term Follow-up.

Amodio, Antonio / De Marchi, Giulia / Granato, Anna / de Pretis, Nicolò / Gabbrielli, Armando / Manfredi, Riccardo / Pozzi Mucelli, Roberto / Frulloni, Luca

Pancreas

2019 Volume 48, Issue 4, Page(s) 544–547

Abstract: Objectives: Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate ...

Abstract	Objectives: Chronic asymptomatic pancreatic hyperenzymemia (CAPH) was described as a benign disease. However, we already described clinically relevant findings requiring surgery or follow-up in half of the subjects. The aim of this study was to evaluate the long-term outcome of CAPH in terms of symptoms and evolution toward chronic pancreatitis. Methods: Subjects previously enrolled in the first phase of the study (from 2005 to 2010) were reinvestigated from December 2013 to January 2017 with a phone call ± magnetic resonance cholangiopancreatography with secretin stimulation. Results: A total of 133 subjects were eligible for the follow-up study (75 males, 58 females; age, 48.4 [standard deviation {SD}, 14] years); 24 (18%) of them dropped out. During a mean follow-up of 9.3 (SD, 5.2) years after the first diagnosis of CAPH, no episode of acute pancreatitis or abdominal pain was reported. Sixty-three subjects (58%) of 109 underwent magnetic resonance cholangiopancreatography with secretin stimulation with a mean follow-up of 5.7 [SD, 3.1] years (range, 1-11 years). Secretin stimulation-MRCP resulted unchanged in 54 (90%) of 60 subjects, worsened in 3 (5%) and improved in 3 (5%). Two subjects died from causes unrelated to pancreatic disease. Conclusions: Excluding subjects with a pancreatic disease at index magnetic resonance imaging, CAPH is a benign condition.
MeSH term(s)	Adult ; Amylases/blood ; Cholangiopancreatography, Magnetic Resonance/methods ; Chronic Disease ; Female ; Follow-Up Studies ; Humans ; Lipase/blood ; Male ; Middle Aged ; Pancreas/diagnostic imaging ; Pancreas/enzymology ; Pancreas/pathology ; Pancreatic Diseases/blood ; Pancreatic Diseases/diagnostic imaging ; Pancreatic Diseases/enzymology ; Pancreatitis, Chronic/blood ; Pancreatitis, Chronic/diagnostic imaging ; Pancreatitis, Chronic/enzymology ; Time Factors
Chemical Substances	Lipase (EC 3.1.1.3) ; Amylases (EC 3.2.1.-)
Language	English
Publishing date	2019-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	632831-3
ISSN	1536-4828 ; 0885-3177
ISSN (online)	1536-4828
ISSN	0885-3177
DOI	10.1097/MPA.0000000000001272
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Article ; Online: Added value of MRI tractography of peri-prostatic nerve plexus to conventional T2-WI in detection of extra-capsular extension of prostatic cancer.

Cybulski, Adam Jerzy / Catania, Matteo / Brancato, Sara / Cogo, Nicola / di Paola, Valerio / Pozzi Mucelli, Roberto / Mansueto, Giancarlo

La Radiologia medica

2019 Volume 124, Issue 10, Page(s) 946–954

Abstract: Purpose: To evaluate the role of DTI (with fibretracking) and T2-weighted imaging (T2-WI) used together for predicting extra-capsular extension in patients with localized prostate cancer.: Method and materials: Thirty-six patients with biopsy-proven ... ...

Abstract	Purpose: To evaluate the role of DTI (with fibretracking) and T2-weighted imaging (T2-WI) used together for predicting extra-capsular extension in patients with localized prostate cancer. Method and materials: Thirty-six patients with biopsy-proven diagnosis of prostatic neoplasia performed MRI and underwent radical prostatectomy. Histopathological analysis showed ECE in 15/36 and capsule sparing in 21/36. By means of T2-WI, ECE was evaluated in a qualitative manner, according to PI-RADS v.2 (two groups with low and high risk of ECE); sensitivity and specificity were calculated for both groups. We performed a quantitative analysis on two tractographic parameters, fractional anisotropy (FA) and apparent diffusion coefficient (ADC) and computed the ratio between the lesion quadrant and its contralateral (L/H ratio). We compared L/H ratios of patients with and without ECE; ROC analyses were performed to determinate ECE cut-off values of tractographic parameters. These cut-off values were used in association with T2-WI to reassess patients and to evaluate whether specificity and sensitivity of ECE detection change. Results: T2-WI showed a sensitivity of 80% and a specificity of 71% in detection of ECE. Tractography displayed a significant difference in L/H ratio for FA and ADC between patients with and without ECE. The simultaneous use of T2-WI and tractography revealed high sensitivity (100%) on patients with low suspect of ECE (on T2-WI) and high specificity (83%) on patients with high suspect of ECE (on T2-WI). Conclusion: The morphologic component of T2-weighted imaging and functional aspect of DTI should be interpreted together to more successfully assess the presence of ECE.
MeSH term(s)	Adult ; Aged ; Anisotropy ; Biopsy ; Contrast Media ; Diffusion Magnetic Resonance Imaging ; Humans ; Image Interpretation, Computer-Assisted ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Neoplasm Invasiveness/diagnostic imaging ; Neoplasm Invasiveness/pathology ; Organometallic Compounds ; Prospective Studies ; Prostatectomy ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Prostatic Neoplasms/surgery ; Reproducibility of Results ; Sensitivity and Specificity
Chemical Substances	Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L)
Language	English
Publishing date	2019-06-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-019-01047-3
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