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  1. Article ; Online: Total Synthesis of Macrocyclic Dysoxylactam A.

    Prabhakar Reddy, D / Yu, Biao

    Chemistry, an Asian journal

    2020  Volume 15, Issue 16, Page(s) 2467–2469

    Abstract: The total synthesis of dysoxylactam A, a novel 17-membered macrolactam with potent multi-drug-resistant reversing activities, has been achieved, starting from 4-pentene-1-al in a longest linear sequence of 17 steps and 9.5% overall yield. The key ... ...

    Abstract The total synthesis of dysoxylactam A, a novel 17-membered macrolactam with potent multi-drug-resistant reversing activities, has been achieved, starting from 4-pentene-1-al in a longest linear sequence of 17 steps and 9.5% overall yield. The key transformations consist of iterative aldol and ring-closing metathesis reactions for the construction of the stereochemically enriched polypropionate scaffold and the macrocycle, respectively.
    MeSH term(s) Aldehydes/chemistry ; Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Cyclization ; Drug Resistance, Multiple, Bacterial ; Esterification ; Lipopeptides/chemical synthesis ; Lipopeptides/chemistry ; Stereoisomerism
    Chemical Substances Aldehydes ; Anti-Bacterial Agents ; Lipopeptides ; dysoxylactam A ; 3-hydroxybutanal (8C6G962B53)
    Language English
    Publishing date 2020-07-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202000482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Total Synthesis of Kanamienamide

    Prabhakar Reddy, D / He Yun / Wang Zhen / Yu Zhimei / Zhang Ning

    Journal of organic chemistry. 2017 Oct. 20, v. 82, no. 20

    2017  

    Abstract: Kanamienamide is a novel enol ether containing enamide with a single digit micromolar inhibitory activity against cancer cell lines. An efficient and convergent total synthesis of kanamienamide has been developed for the first time, which features a Cu- ... ...

    Abstract Kanamienamide is a novel enol ether containing enamide with a single digit micromolar inhibitory activity against cancer cell lines. An efficient and convergent total synthesis of kanamienamide has been developed for the first time, which features a Cu-mediated amide coupling with vinyl iodide at the late stage. Other key transformations include Evans asymmetric alkylation, CBS asymmetric reduction, ring-closing metathesis reaction, and Stork–Zhao–Wittig olefination. This strategy is amenable for facile analogue preparation and SAR studies.
    Keywords alkylation ; chemical structure ; enol ethers ; iodides ; neoplasms ; organic chemistry
    Language English
    Dates of publication 2017-1020
    Size p. 11262-11268.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Facs.joc.7b01984
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/42: Show issues
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  3. Article ; Online: A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G.

    Banne, Sreenivas / Prabhakar Reddy, D / Li, Wenxi / Wang, Chenhui / Guo, Jian / He, Yun

    Organic letters

    2017  Volume 19, Issue 18, Page(s) 4996–4999

    Abstract: A unified modular synthetic strategy has been developed for the first total synthesis of dictyodendrins G and synthesis of dictyodendrin F, H and I in 11 steps. The synthesis features consecutive functionalization of the core aminoquinone by palladium- ... ...

    Abstract A unified modular synthetic strategy has been developed for the first total synthesis of dictyodendrins G and synthesis of dictyodendrin F, H and I in 11 steps. The synthesis features consecutive functionalization of the core aminoquinone by palladium-mediated Suzuki-Miyaura coupling reaction, 1,4-addition, acylation and base mediated formation of a pyrrolinone, and the formation of carbazolequinone moiety through a formal [3 + 2] cycloaddition using arynes generated in situ. Several dictyodendrin analogues were also synthesized using this strategy.
    Language English
    Publishing date 2017--15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.7b02511
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Total Synthesis of Kanamienamide.

    Prabhakar Reddy, D / Zhang, Ning / Yu, Zhimei / Wang, Zhen / He, Yun

    The Journal of organic chemistry

    2017  Volume 82, Issue 20, Page(s) 11262–11268

    Abstract: Kanamienamide is a novel enol ether containing enamide with a single digit micromolar inhibitory activity against cancer cell lines. An efficient and convergent total synthesis of kanamienamide has been developed for the first time, which features a Cu- ... ...

    Abstract Kanamienamide is a novel enol ether containing enamide with a single digit micromolar inhibitory activity against cancer cell lines. An efficient and convergent total synthesis of kanamienamide has been developed for the first time, which features a Cu-mediated amide coupling with vinyl iodide at the late stage. Other key transformations include Evans asymmetric alkylation, CBS asymmetric reduction, ring-closing metathesis reaction, and Stork-Zhao-Wittig olefination. This strategy is amenable for facile analogue preparation and SAR studies.
    MeSH term(s) Amides/chemical synthesis ; Amides/chemistry ; Ethers/chemical synthesis ; Ethers/chemistry ; Molecular Structure
    Chemical Substances Amides ; Ethers ; kanamienamide
    Language English
    Publishing date 2017--20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.7b01984
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G

    Banne, Sreenivas / Prabhakar Reddy D / Li Wenxi / Wang Chenhui / Guo Jian / He Yun

    Organic letters. 2017 Sept. 15, v. 19, no. 18

    2017  

    Abstract: A unified modular synthetic strategy has been developed for the first total synthesis of dictyodendrins G and synthesis of dictyodendrin F, H and I in 11 steps. The synthesis features consecutive functionalization of the core aminoquinone by palladium- ... ...

    Abstract A unified modular synthetic strategy has been developed for the first total synthesis of dictyodendrins G and synthesis of dictyodendrin F, H and I in 11 steps. The synthesis features consecutive functionalization of the core aminoquinone by palladium-mediated Suzuki–Miyaura coupling reaction, 1,4-addition, acylation and base mediated formation of a pyrrolinone, and the formation of carbazolequinone moiety through a formal [3 + 2] cycloaddition using arynes generated in situ. Several dictyodendrin analogues were also synthesized using this strategy.
    Keywords Suzuki reaction ; acylation ; cycloaddition reactions ; moieties ; organic compounds
    Language English
    Dates of publication 2017-0915
    Size p. 4996-4999.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021%2Facs.orglett.7b02511
    Database NAL-Catalogue (AGRICOLA)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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